Articles tagged with Genetic Methods
CROPSR, an open-source software tool, accelerates CRISPR experiment design and evaluation by addressing challenges in complex crop genomes. The genome-wide approach significantly shortens the time required to design a CRISPR experiment, reducing failed experiments.
A UMass Amherst researcher has received a $3 million grant to study the complex interplay of risk factors for autism, including early life exposure to environmental pollutants and genetic susceptibility. The study aims to better understand how multiple pollutants and the folate system are associated with autistic traits.
A recent study has identified 29 new genetic variants associated with acne, providing potential new targets for treatment and helping clinicians identify individuals at high risk of severe disease. The research, involving over 20,000 individuals with acne, also found a link between genetic risk and disease severity.
A new DNA benchmark, developed by NIST and collaborators, enables more accurate detection of genetic variants linked to diseases such as spinal muscular atrophy. The benchmark, based on HiFi sequencing technology, helps labs and clinics sequence genes with high accuracy, critical for disease diagnosis and treatment.
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
Researchers have successfully developed CRISPR-Cas9 inheritance control in male mice by shifting the gene editing window to match the timing of meiosis. This achievement expands the potential for human disease research and environmental applications, offering benefits such as laboratory efficiency improvements and cost savings.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
A Tel Aviv University study found a significant link between changes in G-protein-coupled receptors and brain adaptability. Disabling the voltage sensor of these proteins caused uncontrolled brain flexibility, leading to excessive habituation to odors.
Researchers developed a new method to complete genetic data gaps using haplotype blocks, improving breeding efficiency in plants. The approach has shown comparable quality to collecting more information from DNA strands, reducing costs in animal and plant breeding.
A new inoculation method can identify resistance against one of the CLB pathogens, allowing breeders to select candidates for genetic material against the disease. This method uses detached leaflets for inoculation and offers an advantage in small experimental designs, enabling screening of soybean genetic materials.
Researchers at the University of Helsinki have developed a method to precisely and rapidly correct genetic alterations in cultured patient cells. The new technique combines two Nobel Prize-winning approaches to produce genetically corrected autologous pluripotent stem cells, paving the way for potential therapeutic applications.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
Researchers used a yeast model to understand the dynamics of early-stage ribosomal subunit assembly, discovering snR190 functions as an RNA chaperone. The study also identified Dbp7 as the enzyme responsible for dissociating snR190 from ribosomal RNA precursors.
Researchers at Osaka University analyzed data from over 200 health-related traits and diseases in an Asian population to identify specific genomic loci related to medical indications. The study found 14,000 genomic loci of phenotypic significance, including 5,000 novel discoveries.
Researchers at Rutgers University have linked Fragile X and SHANK3 deletion syndrome, both associated with autism and health problems, to walking patterns. The study used motion-sensored sneakers to detect gait problems 15-20 years before clinical diagnosis, offering a potential framework for early intervention.
Researchers found that ancient Siberian human populations interacted with outside dog populations at least 2,000 years ago, suggesting dogs were traded as goods. The study reveals that modern dog breeds like Samoyeds and Siberian Huskies maintain significant ancestry from a lineage established prior to 9,500 years ago.
Researchers analyzed 1,785 ancient human genomes to determine parental relatedness, revealing that cousin marriages occurred only 3% of the time. The new method allowed for more efficient screening of ancient DNA, also providing insights into population dynamics and demographic impact of agriculture.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Researchers in Japan have created a method to preserve mouse sperm by freeze-drying it on a plastic sheet, enabling easy transportation via postcard. The 'sperm book' stored at -30°C, can hold thousands of sperm samples, and the mailing method has shown promising results with high offspring rates.
Researchers develop a two-step encryption technique that improves complexity and energy efficiency, and has been proven safe for various attacks. The new algorithm simulates genetic coding processes to generate a complex key.
Researchers at CU Denver developed Summix to adjust population structure in genetic summary data, increasing utility and equity. The method estimates ancestry proportions with high accuracy, reducing bias in genetic information.
Dr. Malene Hansen receives the Irving S. Wright Award for her work on cellular recycling and aging, while Dr. Morgan Levine wins the Vincent Cristofalo Rising Star Award for her biomarkers of aging research. Both awards recognize their contributions to advancing healthy aging through biomedical research.
Fiber optic sensors have been upgraded with an advanced encoding and decoding system, allowing for faster and more accurate data transmission over wider areas. This technology, developed by EPFL engineers, enables real-time monitoring of hazards such as pipeline cracks and civil engineering deformations.
A new study proposes a method to extend polygenic scores for individuals with multiple ancestral origins, improving personalized medicine for recently admixed populations. The approach combines knowledge from homogeneous populations to create a model suitable for diverse genetic backgrounds.
Researchers used dimensionality reduction analyses to identify fine-scale differences in the Japanese population, revealing greater population structure than previously thought. The study found eight sub-clusters within one of the populations, correlated with distinct islands in the Ryukyu region of Japan.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
Researchers have published protocols for culturing Liberibacter crescens, a genetically similar bacterium, to study citrus greening. This advance enables the scientific community to use L. crescens as a realistic surrogate host for Ca. L. asiaticus.
Researchers at ANU have discovered a new syndrome with an immune deficiency and inflammatory diseases of the skin, lymph nodes, and spleen. The study provides a powerful method for resolving potentially important genetic variants using whole genome sequencing and gene editing.
Researchers at the Buck Institute have developed a new method to pinpoint genetic differences between closely related species, which could lead to breakthroughs in understanding human longevity, disease resistance, and regenerative abilities. The technique was tested using an ancient divergence in yeast and has wide applicability to pl...
Researchers at Peter the Great St. Petersburg Polytechnic University developed a computational method predicting harmful mutations in mammalian species. This approach enables classification of damaging mutations in other mammals, facilitating optimized animal breeding programs.
A new imaging machine developed at the University of Illinois estimates the number of kernels per ear and provides detailed information about each kernel's shape, size, and location. The technology has the potential to revolutionize plant breeding and genetic research by enabling high-throughput phenotyping.
Researchers found that prehistoric migration rates increased in three distinct pulses, coinciding with the spread of agriculture, Bronze Age advancements, and Iron Age population growth. This suggests a strong link between technological innovation and human mobility.
Researchers have developed a nanolock-nanopore sensor to detect a specific cancer mutation with single-molecule resolution. The approach can accurately identify disease-causing mutations in various types of cancer.
Researchers discovered a repeat of four genes controlling resistance to soybean cyst nematode and developed an assay to quantify gene repeats. This new method improves breeding programs by selecting for more copies of the gene sequence, potentially leading to stronger resistance.
Researchers have developed a new method to analyze scrambled cancer genomes, allowing for the simultaneous identification of two types of genetic changes and their connections. This tool, called Weaver, may help identify characteristics that distinguish cancers and inform personalized treatments.
Researchers use diffusion equation and geographical data to simulate prehistoric human migration into England, Scotland, and Wales. The method accurately predicts points of contact between migratory paths, providing insights into early human dynamics.
Researchers have raised laboratory-bred colonies of a threatened Caribbean coral species to sexual maturity, reproducing simultaneously with their natural population. This breakthrough technique increases genetic diversity and provides new hope for the recovery of dwindling elkhorn coral populations.
The American Society for Cell Biology announced the winners of the 2015 Kaluza Prizes, recognizing outstanding graduate student bioscience research. Ten young scientists received cash and travel awards for their contributions to cell biology.
The Methodology Center at Penn State has received a $13 million grant to support ongoing and new research on developing new analysis methods. The projects aim to improve experimental design, data analysis, and intervention delivery through the use of complex behavioral data.
Scientists have developed a shape-shifting molecule that tricks viruses into mutating themselves to death. This breakthrough could lead to the development of more effective anti-viral treatments.
A UC Irvine-led study has revealed that a gene called grainyhead triggers a repair pathway for psoriasis lesions. The researchers found that targeting this mechanism may lead to pharmaceutical products that limit the itchy, painful lesions of psoriasis.
Researchers have developed a new method for using engineered gene circuits in a cell-free, paper-based system to detect deadly viruses like Ebola. The low-cost platform could enable rapid detection of different strains of the virus.
Researchers at UT Arlington have developed a method using laser technology and magnetic carbon nanoparticles to deliver drugs and genes directly into cancer cells. The new photothermal delivery method has shown promise in lab experiments, offering an alternative to viruses for gene therapy and potentially treating genetic conditions, c...
Researchers at the University of Wisconsin-Madison have developed a new screening process that simplifies non-viral transfection, providing more precise control over stem cell behavior. The method uses calcium phosphate coatings to deliver genetic material to cells, resulting in up to a 70-fold increase in successful gene expression.
Researchers developed a new method to track TB outbreaks by analyzing the genetic information of infected individuals, enabling faster response times and more targeted efforts. The approach has the potential to identify
The Botanical Society of America (BSA) has launched an open-access journal, Applications in Plant Sciences (APPS), to promote the rapid dissemination of new tools and protocols. APPS will be part of BioOne's Open Access Collection, fostering communication within the botanical community to advance plant sciences.
New research in epigenetics explores the impact of environmental factors on gene expression, shedding light on the relationship between diet, lifestyle, and disease. The study suggests that environmentally induced epigenetic changes may not persist across generations, challenging the idea of an 'epigenetic designer baby'.
A new review of scientific knowledge on kava reveals no consensus on its toxicity, with various theories including preparation methods and genetic differences. Pacific Island cultures have safely consumed kava for centuries, but Western countries have reported liver damage and banned or regulated kava products.
A new imaging approach allows scientists to watch spliceosome assembly in motion, revealing a surprise: the process is reversible and has 'dead ends'. This breakthrough helps understand alternative splicing, crucial for gene expression and protein diversity.
Researchers from Cold Spring Harbor Laboratory present a method for targeting hematopoietic stem cells using engineered lentiviral vectors. An alternative approach using DNA transposons offers a safer and effective way for non-viral gene transfer.
A systematic review methodology is proposed to collate and synthesize high-quality research evidence on gene-disease associations. The approach emphasizes identifying true genetic associations amidst a large volume of false positives.
Zebrafish embryos exposed to 11 common pollutants showed distinct gene-expression profiles, allowing researchers to identify individual toxins. The new method offers a potential solution for evaluating developmental toxicity of pharmaceuticals and industrial chemicals.
A recent study published in Neurology has dispelled a common myth about smoking and multiple sclerosis (MS). Contrary to previous reports, the research reveals that cigarette smoking has no effect on the progression of MS, contradicting earlier studies suggesting a link between the two.
A review of 77 articles found that most claims of sex-related genetic differences in disease associations are insufficiently documented and validated. Only one out of 60 seemingly well-documented claims was consistently replicated in other studies.
Researchers debate the validity of published research findings, exploring the role of replication in confirming hypotheses. New models suggest that probabilities for accepting false research findings depend on benefits and harms, sparking discussion on acceptable levels of error.
Researchers discovered that cells in young fruit flies use simpler DNA repair mechanisms compared to older flies. The findings suggest that these simpler methods may contribute to genetic damage and aging, but also leave behind residual damage from earlier years.
Researchers at Albert Einstein College of Medicine have developed a novel technique to insert genes into the P. falciparum genome, providing valuable information about its virulence and resistance to antimalarial drugs. This breakthrough should significantly speed up research efforts to bring malaria under control.
A new method called microCT-based virtual histology allows scientists to quickly examine large numbers of mouse embryos with different genetic mutations or damage from toxic chemicals. This enables them to determine the normal function of many genes faster than existing methods, improving drug safety and efficacy.
Researchers have developed imaging methods to track gene expression and protein production in individual cells, providing precise data on single molecular events. This breakthrough enables the study of low-abundance proteins and sheds light on cellular regulation.