Articles tagged with Genetic Methods
Exposure to common workplace agents is associated with a heightened risk of developing rheumatoid arthritis, which can be exacerbated by smoking and genetic predisposition. The study found that certain agents, such as quartz dust and gasoline fumes, are strongly linked to an increased risk of ACPA-positive disease.
Researchers developed a pedigree for aquarium-bred corals, revealing relationships between individuals and identifying genetic differences. The study provides insights into maximizing genetic diversity and adaptability in corals bred for conservation, crucial for their resilience to threats like ocean warming and acidification.
A new study from the University of South Australia found that severe vitamin D deficiency is associated with a higher risk of mortality. The research evaluated 307,601 records from the UK Biobank and found that individuals with low vitamin D levels had a significantly decreased risk of death over a 14-year follow-up period.
The study reveals that environmental conditions cause RNA structures to change, affecting plant flowering times and potentially leading to more desirable traits. This technology can also be applied to human cells, enabling the design of RNA-based therapies for diseases like SARS-COV-2.
A preliminary study published in eLife suggests that sperm screening can identify potentially harmful new genetic mutations and help prevent them from being passed on to offspring. The study found that 55 mutations were detected in the men's sperm, including 15 passed on to an embryo.
Researchers have developed a new method for precisely altering gene expression by supplying and removing electrons, enabling controlled biomedical implants and bioreactors. The improved system allows for accurate control of gene expression in the presence of oxygen, opening up new possibilities for synthetic biology.
Researchers studied peptide bond formation between tRNA molecules and a ribosomal RNA segment, revealing the potential for minihelices to bind to the primordial peptidyl transferase center. The study suggests that functional interactions between tRNA and PTC could have been 'revised' in evolution.
A new study from MIT suggests that genome loops, which were believed to play a crucial role in controlling gene expression, are actually short-lived and fleeting. The researchers found that these loops only exist for about 3-6% of the time and last for only 10-30 minutes.
Researchers found that mutation frequencies in mitochondrial DNA of developing egg cells are lower and increase less with age compared to non-reproductive cells. This suggests a protective mechanism may keep reproductive cells relatively stable, potentially related to human propensity to reproduce at later ages.
The T2T consortium's completed human genome has shown significant improvements in DNA sequencing accuracy, correcting tens of thousands of errors and revealing millions of genetic variations. This new reference genome can support the analysis of over 200 genes of medical relevance, potentially propelling research into genetic disorders.
Researchers at Northwestern University developed an AI-assisted Nanofountain Probe Electroporation system to engineer stem cells. The new method reduces cell loss and increases throughput, enabling selective manipulation of individual cells in micro-arrays.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
The Southeastern Consortium for Lung Cancer Health Equity aims to address disparities in lung cancer screening among racially and ethnically diverse populations. Researchers will develop more precise methods for identifying those at highest risk of lung cancer diagnoses.
A new study predicts rheumatoid arthritis progression using a polygenic risk score. The score, generated from genetic variants associated with the disease, significantly differed between severe and non-severe progression groups. Higher scores were linked to higher risks of severe progression, particularly among younger patients.
Xue Sherry Gao has won a prestigious CAREER Award to create versatile toolkits for controlling gene expression. Her research aims to develop broadly applicable platforms for gene regulation, with a focus on precision dosing and safety features.
CROPSR, an open-source software tool, accelerates CRISPR experiment design and evaluation by addressing challenges in complex crop genomes. The genome-wide approach significantly shortens the time required to design a CRISPR experiment, reducing failed experiments.
A UMass Amherst researcher has received a $3 million grant to study the complex interplay of risk factors for autism, including early life exposure to environmental pollutants and genetic susceptibility. The study aims to better understand how multiple pollutants and the folate system are associated with autistic traits.
A recent study has identified 29 new genetic variants associated with acne, providing potential new targets for treatment and helping clinicians identify individuals at high risk of severe disease. The research, involving over 20,000 individuals with acne, also found a link between genetic risk and disease severity.
A new DNA benchmark, developed by NIST and collaborators, enables more accurate detection of genetic variants linked to diseases such as spinal muscular atrophy. The benchmark, based on HiFi sequencing technology, helps labs and clinics sequence genes with high accuracy, critical for disease diagnosis and treatment.
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
Researchers have successfully developed CRISPR-Cas9 inheritance control in male mice by shifting the gene editing window to match the timing of meiosis. This achievement expands the potential for human disease research and environmental applications, offering benefits such as laboratory efficiency improvements and cost savings.
Phages weigh all options and make an informed decision whether to exit the dormant state and attack their bacterial host. The study found that some phage families have developed a complex decision-making strategy, receiving information from neighboring bacteria and controlling communication via arbitrium.
A Tel Aviv University study found a significant link between changes in G-protein-coupled receptors and brain adaptability. Disabling the voltage sensor of these proteins caused uncontrolled brain flexibility, leading to excessive habituation to odors.
Researchers developed a new method to complete genetic data gaps using haplotype blocks, improving breeding efficiency in plants. The approach has shown comparable quality to collecting more information from DNA strands, reducing costs in animal and plant breeding.
A new inoculation method can identify resistance against one of the CLB pathogens, allowing breeders to select candidates for genetic material against the disease. This method uses detached leaflets for inoculation and offers an advantage in small experimental designs, enabling screening of soybean genetic materials.
Researchers at the University of Helsinki have developed a method to precisely and rapidly correct genetic alterations in cultured patient cells. The new technique combines two Nobel Prize-winning approaches to produce genetically corrected autologous pluripotent stem cells, paving the way for potential therapeutic applications.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
Researchers used a yeast model to understand the dynamics of early-stage ribosomal subunit assembly, discovering snR190 functions as an RNA chaperone. The study also identified Dbp7 as the enzyme responsible for dissociating snR190 from ribosomal RNA precursors.
Researchers at Osaka University analyzed data from over 200 health-related traits and diseases in an Asian population to identify specific genomic loci related to medical indications. The study found 14,000 genomic loci of phenotypic significance, including 5,000 novel discoveries.
Researchers at Rutgers University have linked Fragile X and SHANK3 deletion syndrome, both associated with autism and health problems, to walking patterns. The study used motion-sensored sneakers to detect gait problems 15-20 years before clinical diagnosis, offering a potential framework for early intervention.
Researchers found that ancient Siberian human populations interacted with outside dog populations at least 2,000 years ago, suggesting dogs were traded as goods. The study reveals that modern dog breeds like Samoyeds and Siberian Huskies maintain significant ancestry from a lineage established prior to 9,500 years ago.
Researchers analyzed 1,785 ancient human genomes to determine parental relatedness, revealing that cousin marriages occurred only 3% of the time. The new method allowed for more efficient screening of ancient DNA, also providing insights into population dynamics and demographic impact of agriculture.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Researchers in Japan have created a method to preserve mouse sperm by freeze-drying it on a plastic sheet, enabling easy transportation via postcard. The 'sperm book' stored at -30°C, can hold thousands of sperm samples, and the mailing method has shown promising results with high offspring rates.
Researchers develop a two-step encryption technique that improves complexity and energy efficiency, and has been proven safe for various attacks. The new algorithm simulates genetic coding processes to generate a complex key.
Researchers at CU Denver developed Summix to adjust population structure in genetic summary data, increasing utility and equity. The method estimates ancestry proportions with high accuracy, reducing bias in genetic information.
Dr. Malene Hansen receives the Irving S. Wright Award for her work on cellular recycling and aging, while Dr. Morgan Levine wins the Vincent Cristofalo Rising Star Award for her biomarkers of aging research. Both awards recognize their contributions to advancing healthy aging through biomedical research.
Fiber optic sensors have been upgraded with an advanced encoding and decoding system, allowing for faster and more accurate data transmission over wider areas. This technology, developed by EPFL engineers, enables real-time monitoring of hazards such as pipeline cracks and civil engineering deformations.
A new study proposes a method to extend polygenic scores for individuals with multiple ancestral origins, improving personalized medicine for recently admixed populations. The approach combines knowledge from homogeneous populations to create a model suitable for diverse genetic backgrounds.
Researchers used dimensionality reduction analyses to identify fine-scale differences in the Japanese population, revealing greater population structure than previously thought. The study found eight sub-clusters within one of the populations, correlated with distinct islands in the Ryukyu region of Japan.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
Researchers have published protocols for culturing Liberibacter crescens, a genetically similar bacterium, to study citrus greening. This advance enables the scientific community to use L. crescens as a realistic surrogate host for Ca. L. asiaticus.
Researchers at ANU have discovered a new syndrome with an immune deficiency and inflammatory diseases of the skin, lymph nodes, and spleen. The study provides a powerful method for resolving potentially important genetic variants using whole genome sequencing and gene editing.
Researchers at the Buck Institute have developed a new method to pinpoint genetic differences between closely related species, which could lead to breakthroughs in understanding human longevity, disease resistance, and regenerative abilities. The technique was tested using an ancient divergence in yeast and has wide applicability to pl...
Researchers at Peter the Great St. Petersburg Polytechnic University developed a computational method predicting harmful mutations in mammalian species. This approach enables classification of damaging mutations in other mammals, facilitating optimized animal breeding programs.
A new imaging machine developed at the University of Illinois estimates the number of kernels per ear and provides detailed information about each kernel's shape, size, and location. The technology has the potential to revolutionize plant breeding and genetic research by enabling high-throughput phenotyping.
Researchers found that prehistoric migration rates increased in three distinct pulses, coinciding with the spread of agriculture, Bronze Age advancements, and Iron Age population growth. This suggests a strong link between technological innovation and human mobility.
Researchers have developed a nanolock-nanopore sensor to detect a specific cancer mutation with single-molecule resolution. The approach can accurately identify disease-causing mutations in various types of cancer.
Researchers discovered a repeat of four genes controlling resistance to soybean cyst nematode and developed an assay to quantify gene repeats. This new method improves breeding programs by selecting for more copies of the gene sequence, potentially leading to stronger resistance.
Researchers have developed a new method to analyze scrambled cancer genomes, allowing for the simultaneous identification of two types of genetic changes and their connections. This tool, called Weaver, may help identify characteristics that distinguish cancers and inform personalized treatments.
Researchers use diffusion equation and geographical data to simulate prehistoric human migration into England, Scotland, and Wales. The method accurately predicts points of contact between migratory paths, providing insights into early human dynamics.
Researchers have raised laboratory-bred colonies of a threatened Caribbean coral species to sexual maturity, reproducing simultaneously with their natural population. This breakthrough technique increases genetic diversity and provides new hope for the recovery of dwindling elkhorn coral populations.
The American Society for Cell Biology announced the winners of the 2015 Kaluza Prizes, recognizing outstanding graduate student bioscience research. Ten young scientists received cash and travel awards for their contributions to cell biology.
The Methodology Center at Penn State has received a $13 million grant to support ongoing and new research on developing new analysis methods. The projects aim to improve experimental design, data analysis, and intervention delivery through the use of complex behavioral data.
Scientists have developed a shape-shifting molecule that tricks viruses into mutating themselves to death. This breakthrough could lead to the development of more effective anti-viral treatments.
A UC Irvine-led study has revealed that a gene called grainyhead triggers a repair pathway for psoriasis lesions. The researchers found that targeting this mechanism may lead to pharmaceutical products that limit the itchy, painful lesions of psoriasis.
Researchers have developed a new method for using engineered gene circuits in a cell-free, paper-based system to detect deadly viruses like Ebola. The low-cost platform could enable rapid detection of different strains of the virus.
Researchers at UT Arlington have developed a method using laser technology and magnetic carbon nanoparticles to deliver drugs and genes directly into cancer cells. The new photothermal delivery method has shown promise in lab experiments, offering an alternative to viruses for gene therapy and potentially treating genetic conditions, c...
Researchers at the University of Wisconsin-Madison have developed a new screening process that simplifies non-viral transfection, providing more precise control over stem cell behavior. The method uses calcium phosphate coatings to deliver genetic material to cells, resulting in up to a 70-fold increase in successful gene expression.