Articles tagged with Genetic Methods
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers used a yeast model to understand the dynamics of early-stage ribosomal subunit assembly, discovering snR190 functions as an RNA chaperone. The study also identified Dbp7 as the enzyme responsible for dissociating snR190 from ribosomal RNA precursors.
Researchers at Osaka University analyzed data from over 200 health-related traits and diseases in an Asian population to identify specific genomic loci related to medical indications. The study found 14,000 genomic loci of phenotypic significance, including 5,000 novel discoveries.
Researchers at Rutgers University have linked Fragile X and SHANK3 deletion syndrome, both associated with autism and health problems, to walking patterns. The study used motion-sensored sneakers to detect gait problems 15-20 years before clinical diagnosis, offering a potential framework for early intervention.
Researchers found that ancient Siberian human populations interacted with outside dog populations at least 2,000 years ago, suggesting dogs were traded as goods. The study reveals that modern dog breeds like Samoyeds and Siberian Huskies maintain significant ancestry from a lineage established prior to 9,500 years ago.
Researchers analyzed 1,785 ancient human genomes to determine parental relatedness, revealing that cousin marriages occurred only 3% of the time. The new method allowed for more efficient screening of ancient DNA, also providing insights into population dynamics and demographic impact of agriculture.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Researchers in Japan have created a method to preserve mouse sperm by freeze-drying it on a plastic sheet, enabling easy transportation via postcard. The 'sperm book' stored at -30°C, can hold thousands of sperm samples, and the mailing method has shown promising results with high offspring rates.
Researchers develop a two-step encryption technique that improves complexity and energy efficiency, and has been proven safe for various attacks. The new algorithm simulates genetic coding processes to generate a complex key.
Researchers at CU Denver developed Summix to adjust population structure in genetic summary data, increasing utility and equity. The method estimates ancestry proportions with high accuracy, reducing bias in genetic information.
Dr. Malene Hansen receives the Irving S. Wright Award for her work on cellular recycling and aging, while Dr. Morgan Levine wins the Vincent Cristofalo Rising Star Award for her biomarkers of aging research. Both awards recognize their contributions to advancing healthy aging through biomedical research.
Fiber optic sensors have been upgraded with an advanced encoding and decoding system, allowing for faster and more accurate data transmission over wider areas. This technology, developed by EPFL engineers, enables real-time monitoring of hazards such as pipeline cracks and civil engineering deformations.
A new study proposes a method to extend polygenic scores for individuals with multiple ancestral origins, improving personalized medicine for recently admixed populations. The approach combines knowledge from homogeneous populations to create a model suitable for diverse genetic backgrounds.
Researchers used dimensionality reduction analyses to identify fine-scale differences in the Japanese population, revealing greater population structure than previously thought. The study found eight sub-clusters within one of the populations, correlated with distinct islands in the Ryukyu region of Japan.
The scTRIP method allows for the study of genetic variations within a single cell and measures genetic changes directly as they form in new cells. Researchers found four times more variants in patient-derived leukaemia cells using scTRIP compared to standard clinical diagnostics.
Researchers have published protocols for culturing Liberibacter crescens, a genetically similar bacterium, to study citrus greening. This advance enables the scientific community to use L. crescens as a realistic surrogate host for Ca. L. asiaticus.
Researchers at ANU have discovered a new syndrome with an immune deficiency and inflammatory diseases of the skin, lymph nodes, and spleen. The study provides a powerful method for resolving potentially important genetic variants using whole genome sequencing and gene editing.
Researchers at the Buck Institute have developed a new method to pinpoint genetic differences between closely related species, which could lead to breakthroughs in understanding human longevity, disease resistance, and regenerative abilities. The technique was tested using an ancient divergence in yeast and has wide applicability to pl...
Researchers at Peter the Great St. Petersburg Polytechnic University developed a computational method predicting harmful mutations in mammalian species. This approach enables classification of damaging mutations in other mammals, facilitating optimized animal breeding programs.
A new imaging machine developed at the University of Illinois estimates the number of kernels per ear and provides detailed information about each kernel's shape, size, and location. The technology has the potential to revolutionize plant breeding and genetic research by enabling high-throughput phenotyping.
Researchers found that prehistoric migration rates increased in three distinct pulses, coinciding with the spread of agriculture, Bronze Age advancements, and Iron Age population growth. This suggests a strong link between technological innovation and human mobility.
Researchers have developed a nanolock-nanopore sensor to detect a specific cancer mutation with single-molecule resolution. The approach can accurately identify disease-causing mutations in various types of cancer.
Researchers discovered a repeat of four genes controlling resistance to soybean cyst nematode and developed an assay to quantify gene repeats. This new method improves breeding programs by selecting for more copies of the gene sequence, potentially leading to stronger resistance.
Researchers have developed a new method to analyze scrambled cancer genomes, allowing for the simultaneous identification of two types of genetic changes and their connections. This tool, called Weaver, may help identify characteristics that distinguish cancers and inform personalized treatments.
Researchers use diffusion equation and geographical data to simulate prehistoric human migration into England, Scotland, and Wales. The method accurately predicts points of contact between migratory paths, providing insights into early human dynamics.
Researchers have raised laboratory-bred colonies of a threatened Caribbean coral species to sexual maturity, reproducing simultaneously with their natural population. This breakthrough technique increases genetic diversity and provides new hope for the recovery of dwindling elkhorn coral populations.
The American Society for Cell Biology announced the winners of the 2015 Kaluza Prizes, recognizing outstanding graduate student bioscience research. Ten young scientists received cash and travel awards for their contributions to cell biology.
The Methodology Center at Penn State has received a $13 million grant to support ongoing and new research on developing new analysis methods. The projects aim to improve experimental design, data analysis, and intervention delivery through the use of complex behavioral data.
Scientists have developed a shape-shifting molecule that tricks viruses into mutating themselves to death. This breakthrough could lead to the development of more effective anti-viral treatments.
A UC Irvine-led study has revealed that a gene called grainyhead triggers a repair pathway for psoriasis lesions. The researchers found that targeting this mechanism may lead to pharmaceutical products that limit the itchy, painful lesions of psoriasis.
Researchers have developed a new method for using engineered gene circuits in a cell-free, paper-based system to detect deadly viruses like Ebola. The low-cost platform could enable rapid detection of different strains of the virus.
Researchers at UT Arlington have developed a method using laser technology and magnetic carbon nanoparticles to deliver drugs and genes directly into cancer cells. The new photothermal delivery method has shown promise in lab experiments, offering an alternative to viruses for gene therapy and potentially treating genetic conditions, c...
Researchers at the University of Wisconsin-Madison have developed a new screening process that simplifies non-viral transfection, providing more precise control over stem cell behavior. The method uses calcium phosphate coatings to deliver genetic material to cells, resulting in up to a 70-fold increase in successful gene expression.
Researchers developed a new method to track TB outbreaks by analyzing the genetic information of infected individuals, enabling faster response times and more targeted efforts. The approach has the potential to identify
The Botanical Society of America (BSA) has launched an open-access journal, Applications in Plant Sciences (APPS), to promote the rapid dissemination of new tools and protocols. APPS will be part of BioOne's Open Access Collection, fostering communication within the botanical community to advance plant sciences.
New research in epigenetics explores the impact of environmental factors on gene expression, shedding light on the relationship between diet, lifestyle, and disease. The study suggests that environmentally induced epigenetic changes may not persist across generations, challenging the idea of an 'epigenetic designer baby'.
A new review of scientific knowledge on kava reveals no consensus on its toxicity, with various theories including preparation methods and genetic differences. Pacific Island cultures have safely consumed kava for centuries, but Western countries have reported liver damage and banned or regulated kava products.
A new imaging approach allows scientists to watch spliceosome assembly in motion, revealing a surprise: the process is reversible and has 'dead ends'. This breakthrough helps understand alternative splicing, crucial for gene expression and protein diversity.
Researchers from Cold Spring Harbor Laboratory present a method for targeting hematopoietic stem cells using engineered lentiviral vectors. An alternative approach using DNA transposons offers a safer and effective way for non-viral gene transfer.
A systematic review methodology is proposed to collate and synthesize high-quality research evidence on gene-disease associations. The approach emphasizes identifying true genetic associations amidst a large volume of false positives.
Zebrafish embryos exposed to 11 common pollutants showed distinct gene-expression profiles, allowing researchers to identify individual toxins. The new method offers a potential solution for evaluating developmental toxicity of pharmaceuticals and industrial chemicals.
A recent study published in Neurology has dispelled a common myth about smoking and multiple sclerosis (MS). Contrary to previous reports, the research reveals that cigarette smoking has no effect on the progression of MS, contradicting earlier studies suggesting a link between the two.
A review of 77 articles found that most claims of sex-related genetic differences in disease associations are insufficiently documented and validated. Only one out of 60 seemingly well-documented claims was consistently replicated in other studies.
Researchers debate the validity of published research findings, exploring the role of replication in confirming hypotheses. New models suggest that probabilities for accepting false research findings depend on benefits and harms, sparking discussion on acceptable levels of error.
Researchers discovered that cells in young fruit flies use simpler DNA repair mechanisms compared to older flies. The findings suggest that these simpler methods may contribute to genetic damage and aging, but also leave behind residual damage from earlier years.
Researchers at Albert Einstein College of Medicine have developed a novel technique to insert genes into the P. falciparum genome, providing valuable information about its virulence and resistance to antimalarial drugs. This breakthrough should significantly speed up research efforts to bring malaria under control.
A new method called microCT-based virtual histology allows scientists to quickly examine large numbers of mouse embryos with different genetic mutations or damage from toxic chemicals. This enables them to determine the normal function of many genes faster than existing methods, improving drug safety and efficacy.
Researchers have developed imaging methods to track gene expression and protein production in individual cells, providing precise data on single molecular events. This breakthrough enables the study of low-abundance proteins and sheds light on cellular regulation.
A study found that 41% of infertile women would use preimplantation sex selection at no cost, with racial groups having a stronger preference for selecting the sex of their child. Women without children and those seeking family balancing were more likely to choose nonmedical sex selection.
Scientists at Johns Hopkins will pursue novel biological therapies to prevent abnormal heart rhythms and sudden death in patients recovering from heart attacks. They will also use modern imaging techniques to define the features of the heart posing the greatest risk for life-threatening arrhythmias.
Researchers developed a new FISH-based method for detecting recurring bladder cancer, showing improved accuracy compared to urine cytology. The test detected high-grade cancers with over 95% accuracy and recurrence up to three months earlier than traditional methods.
Scientists at University of Illinois have developed a new PCR-based detection method for soybean fungus, detecting even minute traces of the disease-causing strain in soil and plant tissues. The method shows high sensitivity and accuracy, allowing for precise identification of the pathogen and its implications on crop yields.
Researchers are using lasers to aid embryonic development by precision-drilling the 'shell' of human eggs. This technique has shown improved IVF success rates and increased implantation rates, allowing embryos to embed themselves in the womb more effectively.
A study by Kermyt Anderson found that stepfathers invest significant amounts of money and time in their stepchildren. Despite initial assumptions portraying stepfathers negatively, the research suggests they gain mating benefits and opportunities for lifetime reproductive success.
Researchers at University of Michigan and Swiss Federal Institute of Technology propose alternative theory on Earth's formation. They found that tungsten isotopic compositions of Earth do not match those of enstatite chondrites, supporting the idea that planets received materials from broad regions of the solar system.
Researchers developed an optimization tool to reduce long-term sampling and monitoring costs at contaminated groundwater sites. The methodology combines simulation and plume-interpolation tools to accurately quantify contaminant mass while minimizing costs.
Researchers at UW-Madison have perfected a method for creating designer influenza viruses, which can be tailored to solve mysteries about flu strain mutations, spread, and illness. This technology may lead to more efficient influenza vaccines and safer gene therapies.
A study found that some boys will be infertile due to inherited Y chromosome deletions from their fathers, who underwent intracytoplasmic sperm injection (ICSI). The deletion region AZFc accounts for 10% of male infertility cases. Genetic counseling is recommended for couples concerned about passing on the condition to their sons.
A study found that a significant number of infertile men have cystic fibrosis gene mutations undetected by routine screening. This raises concerns about the risk of passing on defective genes to future generations. The researchers suggest improving screening methods for men and testing women for gene mutations to mitigate this risk.
Scientists have developed a new marking system that allows them to visualize and track immune memory cells for the first time. This breakthrough has significant implications for vaccine development, organ transplantation, and the treatment of autoimmune diseases.