Articles tagged with Genetic Variation
Research implicates genetic variants affecting NMDAR functioning as a risk factor for schizophrenia. Variants in four genes, including GRIN1 and GRIN2B, were found to be more common in people with schizophrenia.
A large international study has identified 124 genetic variants linked to risk tolerance, revealing biological mechanisms underlying willingness to take risks. The findings shed light on the shared genetic influences across various specific risky behaviors.
A Penn study reveals that individual genetic variation can predict how well patients respond to certain anti-diabetes drugs, including thiazolidinediones. The researchers identified a specific genetic variation associated with increased cholesterol levels in response to rosiglitazone treatment.
Researchers have developed a novel way to streamline genetic analysis by utilizing the blacklist computing concept. This method has shown promise as a key to faster therapeutic innovation, enabling clinicians and researchers to focus on true disease-causing mutations., By removing non-pathogenic genetic variants from consideration, thi...
New research suggests sex-specific dominance reversal for fitness is a strong and common phenomenon throughout the genome. This mechanism helps maintain genetic variation that has led to life's spectacular diversity.
Researchers discovered 40 new genetic variants associated with an increased risk of colon cancer, validating 55 previously identified variants. The study also identified a rare protective variant for sporadic colorectal cancer, offering hope for targeted treatments.
A major international collaboration has identified genetic variants that increase the risk of ADHD, providing new insights into the biology behind the disorder. The study found twelve locations in the genome where people with a particular genetic variant have an increased risk of ADHD compared to those who do not.
Research reveals that variation in opsin gene expression affects guppy females' preferences for male orange colors, highlighting the interplay between visual properties and mate choice. Genetic polymorphisms and environmental factors contribute to differing light sensitivity, driving the evolution of diverse male sexual colors.
Scientists at La Jolla Institute for Immunology have created an immune cell atlas, DICE, to decipher how natural genetic variation shapes the immune system's ability to protect health. The database provides detailed profiles of 15 immune cell types and 91 healthy donors, revealing a wide impact of genetic variation on gene activity.
A study on female guppies reveals that genetic variation and light exposure during rearing impact their color preferences. The findings suggest a link between female guppies' responsiveness to visual signals and the evolution of diverse male color patterns.
Researchers found three genetic variations linked to increased liver fat, which could lead to new treatment options for non-alcoholic fatty liver disease (NAFLD). The study, led by Westmead Institute for Medical Research, identified the mechanisms behind hepatic steatosis, a major risk factor for NAFLD.
A genetic variation in TMEM106B has been identified as a potential risk factor for chronic traumatic encephalopathy (CTE) disease severity and pathology. The study found that this variation may predict increased CTE pathology and brain inflammation, and is associated with a higher risk of developing dementia.
Researchers found that common genetic variations can significantly increase breast cancer risk for female pediatric cancer survivors, with a two-fold higher risk compared to average survivors. The collective effect of these variations is comparable to having a high-risk mutation in breast cancer predisposition genes.
A study by University of Colorado researchers found genetic variants in the FUT2 gene increase the risk of recurrent or chronic middle ear infections in children. The variants affect the microbiome of the middle ear, making it more susceptible to specific bacteria.
Researchers have assembled the largest sets of African genomic data, creating a resource to study genetic structure, disease, and protein function. They identified 10 new associations specific to African populations, including links between genetic variants and diseases such as alpha thalassemia and diabetes.
Researchers developed a polygenic risk score for lifespan based on weighted contributions from relevant genetic variants, predicting which participants were likely to live longest. They also found associations between genetic variants and Alzheimer's disease, heart disease, and smoking-related conditions with overall lifespan.
Researchers at ANU have discovered a new syndrome with an immune deficiency and inflammatory diseases of the skin, lymph nodes, and spleen. The study provides a powerful method for resolving potentially important genetic variants using whole genome sequencing and gene editing.
Two projects have analyzed 5,000 disease-associated genes and found unanticipated risk variants in 14.5% of adults and 11.3% of infants, leading to discoveries of previously unrecognized genetic conditions.
The Center for Human Genetics is conducting research to better understand the genetic causes of rare diseases using a combination of genome-wide association analysis and gene-editing techniques. The team has identified novel transcribed regions that play a crucial role in regulating complex traits.
A genome-wide association study has identified a genetic locus near the SIM1 gene as a significant risk factor for erectile dysfunction. The link to this locus is independent of previously known risk factors, suggesting a unique mechanism specific to sexual function.
Researchers identified two genetic variants associated with meaning in life and six with happiness in a massive study. The findings suggest that biological differences play a role in variations in meaning and purpose in life.
A new study reveals that common genetic variants can affect the risk of rare developmental disorders, changing our understanding of their causes. The research found that these variants can contribute to a range of conditions, including autism and schizophrenia.
A $929,475 project aims to understand genetic variation and its role in optimizing smoking cessation treatment choice using data from nine existing clinical trials. The research will provide unparalleled precision medicine to improve the prediction of who is more likely to quit smoking based on their genetics.
Researchers at Michigan State University have developed a new genetics tool called conStruct to analyze large datasets of genetic variation. The tool helps identify patterns of relatedness among individuals and populations, overcoming previous statistical challenges.
Researchers from University of Otago identify genetic variant that controls urate levels and gout risk in the gut as well as kidney. This discovery has significant implications for developing new medical interventions in gout and kidney disease.
The study of Flores pygmy humans shows they have Neanderthal and Denisovan ancestry, but no direct link to Homo floresiensis. The short-statured phenotype is a result of recent polygenic selection on standing genetic variation.
Researchers from Michigan Medicine have identified 151 genes associated with atrial fibrillation through a large genome-wide association study involving over one million individuals. The study also developed a genetic risk score that could help identify high-risk individuals and monitor them accordingly.
Researchers identified nearly 1,300 genetic variants associated with educational attainment, explaining about 4% of variation in individuals. The polygenic score combining these variants predicts the length of formal education as well as demographic factors.
Researchers used gene editing and stem cell technologies to predict genetic variants associated with hypertrophic cardiomyopathy, a condition that can lead to sudden cardiac death. The study showed promise for improving the accuracy of gene variant interpretation and diagnostic testing.
A recent study published in Proceedings of the Royal Society B found that the Bahamian anole lizard's genetic variation is surprisingly low, making it unlikely to adapt quickly to future climate scenarios. The research suggests that strong selection pressure in the past may have eliminated future genetic variation.
A Vanderbilt-led research team discovered genetic variations that increase heart attack risk even when patients are on statin drugs. The study found seven genetic variations associated with increased heart events in patients receiving statins, suggesting new targets for reducing cardiovascular risk.
A recent study published in Neuron reveals the significant contribution of common and rare genetic variations to the familial aggregation of migraine. The researchers found that common polygenic variation significantly contributes to the disease in families, with some subtypes showing a higher genetic load.
A global research project has identified 44 genetic variants linked to major depression, 30 of which are newly discovered. These findings suggest a shared genetic basis with other psychiatric disorders like schizophrenia.
Researchers found that Great Barrier Reef corals have enough genetic variation to adapt to rising ocean temperatures, allowing them to potentially survive for at least another century. This offers a glimmer of hope for conservation efforts, but also highlights the need to take action against global warming.
A study identifies genetic variants related to consonant processing, dyslexia, and reading performance. Variations in the READ1 sequence are tied to modern human-specific changes acquired between 4 million and 550,000 years ago.
Research found that a genetic variation in FGF21 is associated with lower body fat percentage and increased blood pressure. The study of over 450,000 individuals suggests that people with this genetic predisposition tend to consume more sugar than others.
Researchers have found a newly identified subset of a known genetic variant associated with an increased risk of hypertrophic cardiomyopathy in individuals of South Asian descent. The study suggests that this genetic variant and its subset may be better markers for carriers of heart dysfunction in this population.
A recent study published in PLOS ONE has confirmed the association of a chromosomal genetic variant with increased risk of atrial fibrillation (AFib) in Latinos. Latino individuals carrying the rs10033464 SNP at chromosome 4q25 are found to be at a 2.3-fold increased risk for developing AFib.
Researchers have identified genetic variants associated with type 2 diabetes and blood sugar levels in a large Chinese population study. The findings suggest that these variants can reduce gene activity, leading to elevated blood sugar levels. Further analysis is needed to understand the role of these variants in human insulin secretion.
A new method developed by researchers at Vanderbilt University Medical Center identifies rare genetic diseases in patients with heart failure, stroke, infertility, and kidney failure. The study found that phenotype risk scores can help predict the presence of disease-causing genetic variants.
Research from Imperial College London found that girls who start puberty earlier are more likely to be overweight as adults. The study used genetic variants to investigate the causal link between early puberty and body mass index (BMI) in women, suggesting that early puberty itself is a risk factor for obesity.
A University of Guelph study found that genetic variants in taste receptors influence the snacks chosen by preschoolers. Nearly 80% of kids carried at-risk genotypes, leading to a high intake of calories from sugar and fat.
A Canadian Medical Association Journal study has found genetic variants associated with diseases and adverse drug reactions in 56 healthy participants. The results suggest that whole genome sequencing can benefit Canada's health care, but also highlight potential pitfalls and the need for careful evaluation.
Scientists discovered clues to disease risk lie in molecular switches controlling genes, not just the genes themselves. The study used human induced pluripotent stem cells to model immune response variation between people, revealing that genetic effects are often hidden if not thoroughly searched for.
A new study reveals the vaginal tract harbors a more genetically diverse HIV-1 population than the blood, with an average of 5.7 variants vs. 1.7 in blood plasma. This finding supports the existence of a genetic bottleneck that filters out variants between the two compartments.
A large-scale study published in Nature Genetics identified 13 genes associated with body mass index (BMI) and obesity. The study found that genetic variations in these genes can affect the function of the genes and their proteins, leading to weight gain or loss. The researchers hope that this discovery will lead to personalized treatm...
A single gene variant can have a significant impact on human facial features, according to a new study published in Proceedings of the National Academy of Sciences. The research found three genetic variants tied to specific facial characteristics, including those related to steroid biosynthesis and mucolipidosis type IV.
Research reveals that genetic diversity impacts learned birdsong tempo, with heritable contributions explaining up to 55% of variability. The quality of instruction also plays a role in shaping the relationship between genes and song tempo.
Scientists used genetic variability to map a plant species' ability to adapt to climate change, finding that Scandinavian plants can cope with severe drought. The study suggests that relocating populations with genetic variants supporting drought adaptation could help rescue endangered species and improve crop performance.
Researchers have identified a low incidence of disease-causing IGF mutations and common polymorphisms in the IGF protein family. Dr. Rotwein's analysis suggests that most medical problems associated with IGF mutations are not caused by rare genetic mutations, but rather by prevalent genetic variations within the human population.
Researchers identified 126 genetic variations in wild fruit flies that affect sleep duration, with some individuals needing more or less sleep than others. The study suggests that multiple signaling pathways contribute to sleep duration and may explain why a single purpose for sleep has been difficult to pin down.
Researchers are investigating genetic variations that offer protection against Alzheimer's disease in elderly Amish individuals. They will also explore the causes of rapidly progressing late-onset Alzheimer's disease, which is characterized by a faster rate of cognitive decline and death compared to typical cases.
A study found that genetic variations account for 7-12% of chronic postsurgical pain cases, while clinical risk factors like age and sex contribute to 3-6%. Patients under 65 years old, males, and those with a prior history of chronic pain were at increased risk.
A team of researchers at Brigham Young University has identified a specific gene variant that protects people with high-risk genetic factors from developing Alzheimer's disease. The study reveals that this genetic function could be targeted with drugs to reduce the risk of Alzheimer's.
A recent study found a link between genetic variants and lower GLP-1 levels, which may predict increased cardiovascular mortality risks in type 2 diabetes patients. The research could lead to personalized patient care by testing genetic risk markers and tailoring treatments accordingly.
Researchers at The Feinstein Institute discovered dozens of genetic variations linked to general cognitive ability. These findings have the potential to aid in targeted treatment for cognitive disorders, including Alzheimer's disease, schizophrenia, and attention deficit hyperactivity disorder.
A study found that genetic determinants of puberty timing are associated with lower bone mineral density in childhood and adulthood. Later puberty is linked to lower bone mineral density, especially in the lower spine, increasing the risk of osteoporosis and bone fractures.
A new study has identified a genetic basis for natural variation in aging rates, found to be regulated by a novel neuropeptide coding gene (rgba-1) and its receptor gene npr-28. This discovery provides new insights into the biological regulation of healthy aging.
A recent study published in Science Advances suggests that corals can adapt to warmer oceans if global emissions are controlled. The research found genetic variants in some corals that make them more heat tolerant, but may not be enough to keep up with the rapid warming predicted by climate models.
A major study identifies 72 new genetic variants that contribute to the risk of developing breast cancer, bringing the total number of known common variants to around 180. These variants are found in regions regulating gene activity and differ from those involved in other diseases.