Articles tagged with Genome Editing
Researchers have developed a new crop through genome editing, combining the benefits of wild plants with desirable traits. The new tomato variant boasts increased antioxidant content, larger fruit size, and improved compact growth, offering potential health benefits.
Researchers aim to elucidate biological function of DPLG1-4 genes, which are co-opted by organisms to build new gene regulatory pathways linked to reproduction. They will use CRISPR-Cas9 genome editing techniques on fruit flies to test hypotheses.
A study by University of Oulu researchers has identified novel genes and mechanisms associated with aggressive prostate cancer progression. The research suggests ways to improve risk stratification and clinical treatment for advanced prostate cancer.
Researchers at Penn School of Medicine successfully reduced cholesterol levels in rhesus macaques using genome editing, offering a new approach to treating heart disease patients who don't tolerate PCSK9 inhibitors. The study demonstrates the potential of this therapy for large-scale clinical trials and future treatment options.
A new rabbit model with clinical similarity to human patients has been developed for Duchenne muscular dystrophy (DMD) research. The model exhibits signs of muscular dystrophy, including impaired physical activity and muscle loss, making it a promising tool for advancing DMD research and developing novel therapies.
Researchers are investigating genome elimination in organisms, a process crucial for survival and evolution. Studies aim to uncover the mechanisms of this complex phenomenon, which could lead to the treatment of hereditary diseases.
The review discusses potential applications of genetic modification and genome editing in cattle for food production, highlighting the need for clear information about methods and their consequences. The authors emphasize the importance of stakeholder involvement and international cooperation to address ethical concerns and ensure publ...
The new eMAGE method eliminates DNA breakage errors, enabling efficient genetic modifications with high accuracy. This technology has the potential to revolutionize disease treatment, antibiotic production, and industrial biotechnology applications.
A survey of genetics professionals found high support for research into somatic uses of gene editing, but more divided views on germline uses. Most geneticists felt it would be acceptable for therapeutic purposes in the future, differing from public opinions.
Researchers at Max Planck Florida Institute for Neuroscience have developed a new tool called vSLENDR, which enables precise genome editing in post-mitotic neurons of the brain. This breakthrough technology utilizes CRISPR-Cas9 and an adeno-associated virus to increase the efficiency and flexibility of HDR DNA repair.
The Leopoldina Annual Assembly explores the ethical, legal, and technological aspects of genome editing. Researchers will discuss its applications in humans, plants, and animals, as well as its potential impact on food production and human therapies.
Researchers used CRISPR-Cas9 genome editing to study the optix gene's role in butterfly wing patterns. In four species, deleting optix resulted in black pigment replacing red and orange pigment, with changes in expression of genes involved in pigment production.
A group of 11 organizations has issued a statement on germline genome editing in humans, recommending against human pregnancy-related editing and supporting publicly funded in vitro research. The statement outlines scientific and societal steps necessary before implementation of such clinical applications is considered.
The National Institutes of Health has instituted a policy to consider sex as a biological variable in funded research, with recommendations provided by coauthors Terri Lynn Cornelison and Janine Austin Clayton. Guidelines include including both male and female subjects in studies and generalizing findings appropriately.
Dr. Tuuli Lappalainen is awarded a 5-year, $1.7 million NIH grant to investigate why identical genetic mutations cause disease in some individuals but not others. The study aims to understand the role of haplotype epistasis in human evolution and disease.
Researchers find that members of the DUX family of proteins, specifically DUX4, trigger gene expression program in human embryos. DUX4 stimulates expression of genes induced during zygotic genome activation by binding to their regulatory regions.
The Jackson Laboratory is developing a high-throughput approach to improve the efficiency of targeted nuclease-mediated HDR for genome editing. The goal is to significantly enhance the reliability and accuracy of CRISPR-Cas9 technology, enabling faster and more cost-effective therapeutic delivery.
Genome editing offers promise for treating genetic disorders but raises major technological and ethical concerns. The ACMG Board of Directors emphasizes the need to overcome current limitations and address issues such as off-target effects and epigenetic marks.
Researchers have successfully corrected the mutated gene responsible for sickle cell disease in stem cells using CRISPR-Cas9 gene editing. The study holds promise for a new treatment by re-infusing edited stem cells into patients, potentially alleviating symptoms and improving lifespan.
Recent advances in genomics, physiology, and genetic manipulation enable the bioengineering of new strains of algae. Eukaryotic microalgae are being utilized to produce environmentally friendly, renewable biomaterials and biofuels.
Researchers at Cornell University and Florida State University identified a tiny percentage of regulatory DNA in the maize genome that accounts for roughly half of the variation in observable traits found in corn. This discovery enables breeders to focus on these areas for more efficient plant breeding.
Researchers identified a novel syndrome resulting from multiple genomic lesions in two male siblings with similar phenotypic features. Whole exome sequencing and cytogenetic testing revealed terminal duplications of Chromosome 16q and deletions of Chromosome 5p, which likely contribute to the complex clinical presentation.
A new research essay in Cell journal suggests that the US can follow the UK's approach to regulate germline editing and mitochondrial replacement therapy. The authors argue that the UK's experience with MR therapy provides a well-drawn regulatory framework for evaluating the safety and ethics of germline editing.
McGill University researchers suggest a model for guiding policy on germline gene editing, based on pre-implantation genetic diagnosis after in vitro fertilization. The PGD model provides a robust approach to regulation, outlining medically determined requirements and substantial risk of occurrence for genetic testing.
Researchers at Broad Institute of MIT and Harvard have engineered changes to the CRISPR-Cas9 system, significantly cutting down on 'off-target' editing errors. The newly-engineered enzyme, eSpCas9, will be useful for genome editing applications requiring high specificity.
Researchers presented various applications of Bio-Rad's Droplet Digital PCR, including copy number determination, genome editing, and liquid biopsy. The technology demonstrated precision, reproducibility, and sensitivity in detecting complex genomic rearrangements and biomarker levels.
The National Academies have launched an international initiative to address the technical, social, and ethical issues surrounding human genome editing. The initiative aims to provide a comprehensive understanding of human genome editing and its implications for improving human health and boosting food production.
Researchers at the Max Delbrück Center for Molecular Medicine have discovered a method to increase the efficiency of precise genetic modifications using the CRISPR-Cas9 technique. By inhibiting a key enzyme, they achieved an eightfold increase in precision, paving the way for more accurate gene editing applications.
Scientists have created a new model organism for studying aging in the naturally short-lived African turquoise killifish. The researchers developed a genome-editing toolkit, allowing them to rapidly manipulate genes and study aging-related diseases.
Researchers successfully corrected disease-causing mutations in cells from patients with beta-thalassemia using CRISPR/Cas9 technology. The corrected cells showed restored expression of hemoglobin and could differentiate into mature blood cells.
Researchers developed genome-scale editing tools, replacing instances of a stop codon in E. coli with another, creating novel cell strains with increased functionality and safety. The new method, CAGE, surpasses current methods by two orders of magnitude.