Genomic Analysis
Articles tagged with Genomic Analysis
How the Atlantic herring adapted to the brackish water of the Baltic Sea
A new study reveals that four specific genes are crucial for the Atlantic herring's adaptation to low salinity in the Baltic Sea. The genes, expressed in sperm, eggs, and early embryos, enable the fish to reproduce successfully in brackish water.
Plants survived the dinosaur-killing asteroid by duplicating genomes
Largest study on genetics of blood proteins uncovers new disease mechanisms and drug repurposing opportunities
A massive study involving 78,000 participants reveals new insights into the genetic regulation of blood proteins and their role in diseases. The findings hold potential to transform our understanding of different diseases and inform drug development.
Brain Health honors J. Craig Venter (1946–2026), the genomicist whose earliest breakthroughs began at the National Institute of Neurological Disorders and Stroke
J. Craig Venter's pioneering work in expressed sequence tags revolutionized brain-expressed genes identification, while his synthetic cells paved the way for synthetic biology as a working discipline. His legacy has reshaped our understanding of genomes and their functions.
MIT-based team releases first AI foundation model for Alzheimer's prevention
FINGERS-7B integrates lifestyle, clinical, genomic, and proteomic data to discover multi-omic biomarkers for preclinical Alzheimer's. The model delivers 4× more accurate preclinical diagnosis and 130% better responder stratification than prior art.
Modern humans share genomic innovations for complex language with ancient Neanderthals
Scientists found that specific genetic sequences, known as HAQERs, have a significant impact on human language abilities. These regions evolved before humans and Neanderthals diverged and are thought to be responsible for the development of modern human language.
Unlocking the value of biodiversity in the UK and Ireland
A new report estimates that sequencing DNA of all complex life in UK and Ireland could benefit the economy through improved crop resilience, medicine, and conservation. The Darwin Tree of Life Project has already saved research costs by providing over 2,500 reference genomes.
Trends and disparities in the use of next-generation sequencing in patients with cancer in the US
Advanced or metastatic cancers often go without tumor genomic testing, with those from low-income backgrounds facing longer wait times. JAMA Network Open highlights the need for targeted healthcare policies to bridge these gaps.
New research reveals autism risk genes are shared across ancestries
A study analyzing over 15,000 Latin American individuals identifies 35 genes significantly associated with autism, showing extensive overlap with previously identified genes in European-ancestry cohorts. The findings support the universal biological foundations of autism and highlight the need for diverse populations to be represented ...
New computational biology tool automates and standardizes genome sequencing analysis
A new tool, metapipeline-DNA, automates and standardizes genome sequencing analysis, reducing the complexity of large and complicated data. The open-access resource, developed by Sanford Burnham Prebys and the University of California Los Angeles, aims to improve collaboration and reproducibility across research labs.
Decoding intercontinental disjunction: Phylogenomic study unravels evolutionary history of hylodesmum
A comprehensive study using integrated genomic approach resolves Hylodesmum's taxonomic uncertainties and EA-ENA disjunct distribution. The study confirms Verdesmum as nested within Hylodesmum and reveals a complex bidirectional dispersal pattern likely facilitated by mammal-mediated epizoochory.
The complete genome of the golden lancehead reveals how genes responsible for venom toxins evolved
The study's findings reveal the evolution of venom toxins in the golden lancehead, a venom-rich species isolated from its mainland counterparts. The genome sequencing data can inform conservation policies and potentially lead to the development of anticoagulant drugs or blood pressure-lowering treatments.
What changes happen in the aging brain?
Researchers created the most comprehensive single-cell atlas of epigenetic changes in the aging mouse brain, revealing how DNA methylation, genome structure, and gene activity change across brain regions and cell types. The atlas has already shown clear epigenetic differences between different age groups and allowed the development of ...
Decoding a medicinal plant genome uncovers the molecular blueprint of loganin biosynthesis
Researchers decode loganin biosynthesis in Cornus officinalis, revealing genome evolution's role in specialized metabolite production. The study identifies a highly efficient enzyme for C-9 hydroxylation, paving the way for bioengineering high-yield medicinal compounds.
DEGU debuts with better AI predictions and explanations
Researchers have developed DEGU, a tool that improves the accuracy and efficiency of deep neural networks in predicting genomic experiment results. DEGU reduces the size of models while maintaining predictive capabilities, making it easier to understand uncertainty and drive reliable discoveries.
How age, sex and genetics shape our antibodies
A study found that age, biological sex, and human genetic factors determine the quantity and specificity of antibodies produced in response to viral infections. The research has significant implications for vaccine and therapeutic design, as it shows that individual profiles can be tailored to improve treatment effectiveness.
False alarm in newborn screening: how zebrafish can prevent unnecessary SMA therapies
A zebrafish model was used to test the functional significance of rare SMN1 variants in children with false positive SMA diagnoses. The research found that both variants were functional and did not cause the disease. This breakthrough could prevent unnecessary SMA therapies and provide families with security.
Researchers find genomics offers a faster path to restoring the American chestnut
Researchers used genome sequencing to identify blight-resistant trees with high American chestnut ancestry, preserving the species' ecological and cultural importance. The approach, known as genomic selection, allows breeders to predict resistance and make better decisions earlier in the breeding process.
University of Oklahoma researcher awarded NIH grant to advance tribally defined approaches to genomic research
A University of Oklahoma researcher has been awarded a competitive NIH grant to advance tribally defined genomic research approaches. The project, called Partnerships for Indigenous-led ELSI Research (PIER), will strengthen meaningful collaboration with Indigenous communities and promote Indigenous-driven approaches to genomic research.
Scientists find potential for better soybean harvests by mining genomes for cyst nematode resistance
Researchers have identified novel sources of soybean resistance to cyst nematode that could help protect global soybean production. The study reveals a wealth of previously untapped genetic resistance to SCN by mining deep into soybean genomes.
Ecology: Mummified cheetahs discovery gives hope for species’ Arabic reintroduction
The discovery of seven naturally-mummified cheetahs in Saudi Arabia reveals that at least two subspecies inhabited the peninsula before their extinction. This finding may open new possibilities for the reintroduction of cheetahs to the peninsula, with a genetic pool supporting rewilding efforts.
Brazil's genetic treasure trove: supercentenarians reveal secrets of extreme human longevity
A recent genomic study by Dr. Mayana Zatz and colleagues reveals that Brazil's admixed population may hold the key to understanding exceptional aging. The study identifies over 8 million novel genetic variants in the Brazilian population, with potential protective mechanisms against age-related diseases.
Scientists map the human genome in 4D
Researchers created detailed maps of the human genome's three-dimensional organization across time and space, revealing how genes interact and fold as cells function. The study provides a powerful framework for predicting which genes are likely to be affected by pathogenic variants.
Smarter tools for peering into the microscopic world
Researchers at Arizona State University introduce powerful tools to analyze microbial family trees and biological data, strengthening microbiome research, disease tracking and environmental monitoring. The new software library scikit-bio provides a foundation for analyzing large biological datasets.
Influenza clade K viruses prolong the influenza season in Australia and New Zealand
The emergence of A(H3N2) subclade K viruses in Australia and New Zealand extended their influenza seasons, with Australia experiencing a record-breaking season. The viruses were likely imported from the US and accounted for half of Australian viruses and over two-thirds of New Zealand viruses.
ARC at Sheba Medical Center and Mount Sinai launch collaboration with NVIDIA to crack the hidden code of the human genome through AI
The initiative aims to decipher the basic function of human genomic sequences, enabling personalized diagnosis and therapy. The partnership will analyze genomic regions to identify underlying mechanisms that contribute to disease and uncover potential therapeutic targets.
Africa acacias ‘go for broke’ to grow, use up water to survive drought
Researchers studied the genetic response of umbrella acacia and splendid thorn acacia to drought stress. The study found that umbrella acacias prioritize continued growth over water conservation when water is scarce, using up all accessible water to survive severe droughts. In contrast, splendid thorn acacias invest in water conservati...
The Josep Carreras Institute, at the forefront of spatial biology
The Josep Carreras Institute is pioneering Spatial Transcriptomics to understand tumor structure at the cellular level. The institute's guidance on this methodology offers practical solutions for improving reproducibility and clinical application.
Genetics pioneer transforms global depression research through multi-omics discoveries
Dr. Amin's transformative insights reshape international understanding of depression genetics, identifying novel therapeutic targets and biomarkers for diagnosis and treatment. Her systemic disease model challenges traditional views of depression as a brain disorder.
Bipolar disorder heterogeneity decoded: transforming global psychiatric treatment approaches
A renowned geneticist, Dr. Martin Alda, has made a groundbreaking discovery that bipolar disorder is composed of multiple genetically distinct disorders, transforming treatment approaches worldwide. His research also highlights the importance of combining basic research with clinical observations to advance psychiatric care.
‘Genomic-first’ approach can identify rare genetic disorders earlier
A 'genomic-first' approach can identify rare genetic disorders earlier and more frequently than standard genetic testing driven by clinical symptoms. The study found that a majority of participants with associated genetic variants did not have matching diagnoses in their electronic health records.
By studying yellow warbler, researchers hope to better understand response to rapid climate change in wild species
A new research paper from Colorado State University finds that precipitation levels are the key environmental factor influencing genetic variation in the warbler's beak, which is crucial for heat retention. The study reveals that birds struggling to adapt to climate change experience higher stress levels and population declines.
Multi-omics machine learning can detect ALS 10 years before symptom appears
Researchers identified 33 plasma proteins that differ significantly in patients with ALS, suggesting the disease could be detected up to 10 years before symptoms appear. Machine learning models showed strong performance in separating ALS cases from non-ALS cases, with an accuracy of over 98.3%.
Want to save an endangered species? Start with the right DNA blueprint
A new study published in Cell found that relying on stand-in reference DNA from similar but different species can significantly distort research findings for vulnerable species. Using the wrong genome can miss up to a third of genetic variations and lead to misleading conservation decisions.
Computational neurogenomics revolution unlocks personalized treatments for brain disorders worldwide
Dr. Rentería's Australian Parkinson's Genetics Study (APGS) includes nearly 20,000 volunteers, generating a comprehensive genetic database to understand Parkinson's disease variability. He incorporates wearable sensors and digital biomarkers to address clinical heterogeneity.
Fern leaf pockets hide secrets of plant-microbe symbiosis
Researchers at OIST found that only cyanobacteria Trichormus azollae are true symbionts of Azolla ferns, with their genomes showing extreme decay and loss of genes. The study sheds light on the genomic impacts of symbiosis and its potential applications in food security.
ORC2 regulation of human gene expression shows unexpected breadth and scale
A recent study reveals that ORC2 subunit regulates epigenetics and gene expression by compacting chromatin and attracting repressive histone marks at some sites, but activating gene expression at others. This regulation also prevents CTCF binding at certain sites, leading to changes in chromatin structure and gene expression.
BTI, Meiogenix and FFAR announce $2 million breakthrough tomato genetics collaboration
A $2 million collaboration will use genomics and targeted recombination to create drought-tolerant and disease-resistant tomatoes. This project seeks to improve global food security by leveraging cutting-edge technologies to address environmental stress and pathogens.
Genetic rescue of endangered species may risk bad mutations slipping through
A new study suggests that genetic rescue of endangered species may not be as effective as previously thought, and could even introduce more harmful mutations. Analysis of Eastern massasauga rattlesnakes found more deleterious than adaptive mutations in donor animals selected for relocation.
New AI tool illuminates “dark side” of the human genome
Researchers at Salk Institute launched a machine learning framework called ShortStop to explore overlooked DNA regions and discover microproteins with potential roles in disease. The tool identified 210 new microprotein candidates in lung cancer data, including one validated target for therapeutic treatment.
Hibernator “superpowers” may lie hidden in human DNA
Researchers discovered hibernator-specific DNA regions near the FTO locus that regulate metabolism, allowing hibernators to pack on fat reserves before hibernation. These findings could lead to treatments for human metabolic disorders by tuning up or down gene activity like an orchestra conductor fine-tunes music volume.
Why some strep infections turn deadly: A genetic clue
Japanese scientists have identified a novel genetic mutation in Streptococcus pyogenes associated with severe invasive infections. The mutation weakens bacterial growth in human blood and has been found unique to Japanese isolates, indicating a new pathogenic mechanism.
ASHG announces 2025 Professional Award Recipients
The American Society of Human Genetics recognizes Dr. Harry Dietz for his work on Marfan Syndrome, Dr. Eric Green for his leadership in advancing human genetics and genomics, Dr. Mike Talkowski for his pioneering contributions to cytogenetics and genomic medicine, and Dr. Elizabeth Bhoj for her extensive work in translational genetics.
First ever one-day island-wide soil microbiome study completed on Crete
A groundbreaking single-day study on Crete's soil microbiome has provided new insights into the environmental factors influencing microbial diversity. The researchers identified several key drivers, including soil moisture and nutrient availability, which can inform strategies for preserving biodiversity.
New research simulates cancer cell behavior
Researchers developed a software fueled by genomics to predict cancer cell behavior, combining genomics technologies with computational modeling. The new 'grammar' enables communication between biology and code, allowing scientists to build digital representations of multicellular biological systems and simulate diseases like cancer.
Reference genomes for rice’s wild relatives may boost future crops
A near-complete genomic framework of wild Oryza species has been developed, offering insights into the evolution of the genus and new avenues for crop improvement. The resource enables researchers to explore genetic diversity and detect adaptive traits useful for domestication.
ADLM 2025 to address medical misinformation, health risks posed by plastics, AI integration into care, precision medicine, and more
ADLM 2025 will tackle urgent topics like clinical AI integration and fake medical news, as well as leveraging genomics for personalized healthcare. The meeting also explores the health threat of plastics and microbiome medicine to combat diseases.
New insights into ovarian cancer: why whole-genome doubling may hold the key to future HGSOC treatment strategies
A new study found that over 65% of ovarian cancer tumors exhibit whole-genome doubling, making them more resistant to treatments. WGD-high tumors suppress the immune response by repressing key pathways.
Genetic testing beneficial in critically ill adults
A study of 365 adults found nearly one in four had a genetic condition causing their ICU admission, which was unknown to nearly half of those patients and their doctors. The researchers recommend offering genetic testing to all adults admitted to the ICU to improve care and reduce health disparities.
Major autism study uncovers biologically distinct subtypes, paving the way for precision diagnosis and care
Researchers identified four clinically and biologically distinct subtypes of autism, each with distinct developmental, medical, behavioral, and psychiatric traits. The study linked subtypes to genetic profiles and developmental trajectories, offering new insights into the biology underlying autism.
ADA Forsyth announces Version 4 update to Human Oral Microbiome Database, including expanded whole-genome sequence information
The Human Oral Microbiome Database has been updated with a greater breadth of data, including 44 new human oral taxa and a total of 834 identified species. This expansion enables researchers to study the oral microbiome with greater precision and depth.
Protecting the most vulnerable: ECDC recommendations to address the ongoing local transmission of diphtheria
Diphtheria is still being reported in Europe, with cases higher than before 2020, affecting vulnerable populations like homeless individuals, migrants, and those who use or inject drugs. ECDC recommends tailored public health response measures to protect these groups.
DNA markers associated with facial features of the Spanish population
Researchers from BIOMICs group found significant genetic marker associations with facial areas, including eyes, nose, and forehead. The study aimed to predict external human features using DNA analysis for forensic purposes.
Harnessing big data for apple breeding: Genomic models to meet climate challenges
A recent study utilizes genomic data and environmental factors to predict key apple traits, improving the selection process for climate-resilient cultivars. Deep learning models outperform traditional methods for traits with complex genetic architectures.
Scientists complete the most thorough analysis yet of India's genetic diversity
A comprehensive analysis of 2,762 Indian genomes reveals a complex history of genetic mixing, endogamy, and population bottlenecks that shaped the country's genetic variation, health, and disease. The study found that most genetic variation in India can be explained by a single migration out of Africa about 50,000 years ago.
Genomes from people across modern-day India shed light on 50,000 years of evolutionary history
Researchers analyzed genomic data from over 2,700 Indians to reconstruct evolutionary history, revealing ancestry tied to Neolithic Iranian farmers, Eurasian Steppe pastoralists, and South Asian hunter-gatherers. The study highlights the impact of ancient migrations on genetic variation and disease susceptibility.
"Shrinking" cod: how humans have altered the genetic make-up of fish
A study reveals that decades of overfishing have significantly altered the genetic composition of Eastern Baltic cod, leading to reduced growth rates and smaller sizes. The researchers found a correlation between slower growth and increased survival under high fishing pressure.
New ‘molecular GPS’ will fast-track drug discovery
The Northwestern University-developed SOAR platform helps researchers understand diseases and find potential treatments by analyzing gene activity across various tissues. This tool enables prioritization of drugs to be sent to clinical studies, reducing development time.
Metabolic markers found in obese adolescents guide vascular aging intervention
Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.