Global Transcriptional Regulation | Topics

Articles tagged with Global Transcriptional Regulation

Cancer Research: Mini-Antibodies Reactivate the Guardian of the Genome

A research consortium has developed mini-antibodies that can reactivate mutated p53, a key tumor suppressor protein. These DARPins bind selectively to p53 mutants, restoring stability and functionality, making them potentially useful against various types of tumors.

UMass Chan scientists annotate largest map yet of human genome’s regulatory switches

Researchers have created a comprehensive map of the DNA sequences that control gene expression in human cells, identifying 2.37 million potential regulatory elements. This registry reveals previously unrecognized classes of elements and illuminates how noncoding genetic variation contributes to cell type-specific traits.