A recent study published in the Journal of Aging and Physical Activity found that higher levels of light physical activity and moderate-to-vigorous physical activity were associated with lower risk of death. In contrast, higher sedentary time was linked to increased mortality risk, regardless of genetic predisposition for longevity.
SourceUniversity of California - San Diego·JournalJournal of Aging and Physical Activity·TypeObservational study·DateAug 24, 2022
A new study published in Cell Reports Methods introduces a dating method called Temporal Population Structure (TPS) that uses artificial intelligence to accurately date human remains up to 10,000 years old. The method has shown promise in analyzing approximately 5,000 human remains from the Late Mesolithic period and modern times.
SourceLund University·JournalCell Reports Methods·DateAug 23, 2022
A study found that genetically unrelated individuals with extreme facial similarities share common genetic variants, but differ in epigenetic and microbiome landscapes. The results suggest a molecular basis for human resemblance, with potential implications in forensics and biomedicine.
SourceCell Press·JournalCell Reports·TypeExperimental study·DateAug 23, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A genome-wide analysis of five reading- and language-based skills in thousands of people identified shared biological bases. The study found genetic links with language-related brain areas and individual differences in neuroanatomy, highlighting the complex interplay between nature and nurture.
SourceMax Planck Institute for Psycholinguistics·JournalProceedings of the National Academy of Sciences·TypeMeta-analysis·DateAug 23, 2022
Researchers discovered that pairs of unrelated 'look-alikes' share similar genetic variations, physical characteristics, and even behavior. Genome-wide analyses found common single nucleotide polymorphisms (SNPs) in nine out of 16 pairs, with similarities in weights and lifestyle factors.
SourceJosep Carreras Leukaemia Research Institute·JournalCell Reports·TypeExperimental study·DateAug 23, 2022
A Rutgers scientist has developed a highly sensitive DNA test that can detect Lyme disease in horses, a condition that can cause long-term complications. The test, called genomic hybrid capture assay, was tested on a sick horse and successfully identified the pathogen, allowing for early diagnosis and treatment.
SourceRutgers University·JournalJournal of Veterinary Diagnostic Investigation·TypeExperimental study·DateAug 17, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A study of Y chromosome genomic analysis reveals evidence of a South American settlement pre-18,000 years ago. The findings also suggest a profound genomic impact during the Younger Dryas period.
Researchers discovered a rare genetic mutation that may lead to better diabetes treatments for patients, regardless of whether they inherited the mutation. The study found that carriers of the mutation had lower levels of adiponectin and higher levels of ceramides in their blood.
SourceUniversity of Utah Health·Journalnpj Genomic Medicine·TypeExperimental study·DateAug 16, 2022
Researchers found that the APOE4 gene variant associated with Alzheimer's disease decreases risk of glaucoma by blocking a disease cascade. They also identified a potential treatment strategy using Galectin-3 inhibitors to prevent vision loss in mice with glaucoma.
SourceMass Eye and Ear·JournalImmunity·TypeExperimental study·DateAug 16, 2022
Researchers identify small molecules that can restore wild-type p53 tumor suppression function to mutated p53 in both lab and mouse models. The approach has potential for developing new pharmaceuticals for treating cancers with p53 mutations.
SourceUniversity of California - Irvine·JournalCell Chemical Biology·TypeExperimental study·DateAug 10, 2022
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at IRB Barcelona have found that CRISPR/Cas9 gene editing can trigger cell toxicity and genomic instability, particularly in regions near the tumour suppressor protein p53. The study identified 3,300 targeted spots with strong toxic effects, highlighting the need for safer CRISPR reagents.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Communications·DateAug 9, 2022
The research team will analyze the remaining two enzymes necessary for riboflavin production and build a 'riboflavinator' in a test tube. This understanding could lead to improved methods for treating diseases and improving public health.
SourceUniversity of Texas at San Antonio·DateAug 8, 2022
Researchers used single-nucleus RNA-sequencing to study heart tissue from patients with cardiomyopathies and found distinct cell types involved in pathogenesis. Genotype-associated pathways were also identified, providing evidence that genotype influences pathological remodeling of the heart.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateAug 4, 2022
The study investigated the effects of combined endocrine-disrupting chemicals (EDCs) on liver function and metabolic homeostasis in mice models. Significant changes were observed at high EDC exposure levels, including liver weight increase, lipid buildup, and elevated blood glucose levels.
SourceChung Ang University·JournalJournal of Hazardous Materials·TypeExperimental study·DateAug 4, 2022
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
The Gerlich Group at IMBA found that histone acetylation establishes a sharp surface boundary on chromosomes, resisting microtubule perforation. Chromatin phase separation and DNA looping by condensin cooperates to build mitotic chromosomes with unique physical properties.
SourceIMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences·JournalNature·TypeExperimental study·DateAug 3, 2022
SLFN11 acts as a surveillance factor for protein homeostasis by alleviating proteotoxic stress derived from protein synthesis and maturation. Its lack makes cells vulnerable to anticancer drugs inducing ER and proteotoxic stress, leading to chemoresistance. SLFN11 is also involved in regulating immune response and inflammation.
SourceImpact Journals LLC·JournalOncoscience·DateAug 3, 2022
A team of researchers proposes a program to collect astronauts' biological samples, enabling the use of cutting-edge technologies to understand gene, mRNA, protein, and metabolite changes in space. This approach aims to mitigate spaceflight risks and advance personalized medicine for astronauts.
The study proposes a new statistical method to analyse population admixture, enabling more accurate determination of migration wave timing. The authors applied this method to Colombians and Mexicans, revealing two episodes of admixture in different time periods.
SourceNational Research University Higher School of Economics·JournalPLOS Genetics·DateJul 27, 2022
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
A study of over 500 patients with multiple myeloma reveals a high prevalence of genetic alterations in oncogenic pathways, leading to treatment resistance. The research found a specific link between RASopathies and mutations in these pathways, offering new insights into the development of resistance mechanisms.
SourceMichigan Medicine - University of Michigan·JournalNature Communications·DateJul 26, 2022
Researchers at Joslin Diabetes Center identified a human gut bacterium that makes a protein mimicking the insulin peptide targeted by the immune system in type 1 diabetes. The presence of this bacterium accelerates the onset of diabetes in a mouse model and is linked to its development in children at genetic risk.
SourceJoslin Diabetes Center·JournalProceedings of the National Academy of Sciences·DateJul 25, 2022
A team of scientists has discovered a key link between the protein αSyn and Parkinson's disease, finding that it interacts with immune responses in neurons. This interaction may play a critical role in the development of the disease, suggesting a potential new approach for treatments by targeting inflammatory pathways.
SourceUniversity of Colorado Anschutz Medical Campus·JournalBrain·DateJul 21, 2022
Researchers have dated the emergence of genetic variants characteristic of modern humans to two distinct periods: one around 40,000 years ago, linked to population growth and divergence from Africa, and an older one over 100,000 years ago, reflecting the species' greatest diversity in Africa. These findings complement the mosaic nature...
SourceUniversity of Barcelona·JournalScientific Reports·DateJul 19, 2022
Researchers used deactivated Cas9 proteins to target key segments of the human genome and synthetically trigger gene transcription. The study revealed that enhancers can send messages in both directions, but with a predominant regulatory mode where an enhancer tracks toward corresponding promoters.
SourceRice University·JournalNucleic Acids Research·TypeExperimental study·DateJul 18, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Loss of the Y chromosome in white blood cells causes fibrosis in the heart, impaired heart function, and death from cardiovascular diseases in men. Men with this genetic change have an increased risk of developing age-related diseases such as cancer and Alzheimer's disease.
SourceUppsala University·JournalScience·TypeExperimental study·DateJul 14, 2022
Researchers at Edith Cowan University have found a genetic link between human leukocyte antigens and immunotherapy side effects in non-small cell lung cancer patients. The discovery enables doctors to tailor treatment to individual patients, reducing the risk of toxicities and improving overall outcomes.
SourceEdith Cowan University·JournalEuropean Journal of Cancer·TypeRandomized controlled/clinical trial·DateJul 13, 2022
Researchers analyzed germline variants in breast cancer patients to identify their role in metastasis development. The study found that host genetic makeup contributes to metastasis through dysregulation of gene expression, promoting the dispersion of metastatic seeds and establishing a conducive environment for their growth.
SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateJul 13, 2022
Researchers at Cleveland Clinic discovered that pathogenic POLE/POLD1 genetic mutations in tumors lead to a high level of immune cell infiltration and improved response to immune checkpoint blockade therapy. The study's findings contribute to the growing list of discoveries that prove certain classes of drugs are more effective based o...
SourceCleveland Clinic·JournalNature Genetics·DateJul 12, 2022
A new molecule, inosine, has been identified as a key booster of fat burning through activation of brown fat cells. Studies have shown that inosine can increase energy consumption and protect against diabetes in mice fed high-energy diets.
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalJournal of Nanobiotechnology·DateJul 3, 2022
A new study published in PLOS Biology found that IVF embryos often undergo genetic and metabolic changes that inhibit development. The researchers discovered that certain embryos enter a senescent-like state, but treating them with resveratrol can help overcome this arrest and promote further development.
SourcePLOS·JournalPLOS Biology·TypeExperimental study·DateJun 30, 2022
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
SourceTokyo University of Science·JournalCommunications Biology·TypeExperimental study·DateJun 27, 2022
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers at MIT have created a new liver tissue model that identifies one molecule playing a key role in human liver regeneration. The study also reveals several other candidates that will be explored further to discover new human-specific pathways.
SourceMassachusetts Institute of Technology·JournalProceedings of the National Academy of Sciences·DateJun 27, 2022
Researchers have discovered the process of incorporating selenium into 25 specialized proteins, essential for various cellular and metabolic processes. The study provides critical insights into the workings of these vital mechanisms, which could lead to the development of new medical therapies.
SourceRutgers University·JournalScience·TypeObservational study·DateJun 20, 2022
Researchers developed a low-cost 3D model of the brain to study SARS-CoV-2's neurological effects. The adapted virus replicates 30 times more efficiently in astrocytes than neurons, highlighting the importance of these cells in central nervous system infection.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalAdvanced Biology·DateJun 20, 2022
Researchers discuss Hepatitis D's life cycle and interactions with its host, exploring strategies for further research to combat this overlooked virus. HDV coinfects people with hepatitis B, rapidly progressing to liver cirrhosis and cancer if left untreated, with a review published in the Chinese Medical Journal.
SourceCactus Communications·JournalChinese Medical Journal·TypeLiterature review·DateJun 16, 2022
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers at the University of Houston have made a groundbreaking discovery in repairing and regenerating heart muscle cells in mice. The technology uses synthetic mRNA to deliver mutated transcription factors, which increases the replication of cardiomyocytes. This finding has the potential to become a powerful clinical strategy for...
SourceUniversity of Houston·JournalThe Journal of Cardiovascular Aging·TypeExperimental study·DateJun 16, 2022
Researchers found thalidomide to be an effective treatment for severe arteriovenous malformations (AVMs), reducing symptoms and improving quality of life in patients. The study showed a striking reduction in symptoms, with some patients experiencing complete cure after treatment.
SourceEuropean Society of Human Genetics·JournalNature Cardiovascular Research·TypeCase study·DateJun 10, 2022
Researchers elucidated the protease-inhibitory mechanism of A2ML1 using cryo-EM structures, shedding light on its role in severe autoimmune blistering diseases. The study improves understanding of related proteins and their function.
SourceAarhus University·JournalNature Communications·TypeExperimental study·DateJun 10, 2022
Researchers analyzed 16 ancient genomes from Wallacea, revealing striking differences between regions and a previously unknown ancestry contribution from Mainland Southeast Asia. The findings suggest multiple human dispersals into Wallacea and major implications for the understanding of Neolithic dispersals into Island Southeast Asia.
SourceMax Planck Institute for Evolutionary Anthropology·JournalNature Ecology & Evolution·DateJun 9, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers identify genetic determinants of immune phenotypes in type 1 diabetes, highlighting 11 genes as potential candidates for new treatments. Genetic variants affecting T-cell composition and cytokine production were found to be significantly involved in the disease.
Researchers discovered a novel mechanism by which non-coding 7S RNA regulates mitochondrial gene expression in human cells. The study found that 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization, shedding light on the molecular basis of this process.
SourceUniversity of Gothenburg·JournalCell·DateJun 2, 2022
A study found that Brazil's Salmonella vaccine for poultry contributed to the emergence of antibiotic-resistant strains. However, these resistant bacteria have not increased food poisoning cases in humans in the UK.
SourcePLOS·JournalPLOS Genetics·TypeExperimental study·DateJun 2, 2022
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Cedars-Sinai have identified a key gene, NLRP11, that plays a crucial role in the innate human immune system. Deleting this gene prevented an immune sensor from triggering an inflammatory response, highlighting its potential as a target for therapies to prevent or treat inflammatory diseases.
SourceCedars-Sinai Medical Center·JournalNature Immunology·DateJun 1, 2022
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
SourceArizona State University·JournalFrontiers in Cellular and Infection Microbiology·TypeExperimental study·DateMay 31, 2022
A new platform and genomic database has been developed to monitor and control multidrug-resistant bacteria, with over 500 human pathogens already available. The database aims to provide strategic information on microorganisms classified as a “critical priority” by the World Health Organization.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalMicrobiology Spectrum·DateMay 30, 2022
A gene associated with Nascimento Syndrome triggers cells' defenses against environmental attacks by modifying proteins under stress. Rad6, a master regulator of this process, helps cells adapt to stressful conditions, shedding light on the disease's progression.
SourceDuke University·JournalCell Reports·TypeExperimental study·DateMay 27, 2022
Researchers discovered that chromatin entropy increases during aging, leading to epigenetic dysregulation and cellular senescence. The study found that aberrant expression of placenta-related genes is a key driver of cellular aging.
SourceChinese Academy of Sciences Headquarters·JournalDevelopmental Cell·TypeExperimental study·DateMay 26, 2022
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Scientists have successfully sequenced the first human genome from an individual who died in Pompeii, Italy, after the eruption of Mount Vesuvius in 79 CE. The study provides new insights into the genetic history and lives of the population, including evidence of high levels of genetic diversity across the Italian Peninsula.
SourceScientific Reports·JournalScientific Reports·DateMay 26, 2022
Researchers have found that gamma delta T cells can be trained to become extreme killers by recognizing abnormal target cells. This discovery has implications for developing novel cellular therapies to treat cancer and infectious diseases.
SourceUniversity of Birmingham·JournalCell Reports·TypeExperimental study·DateMay 24, 2022
A study led by Tel Aviv University researchers reveals a common mechanism underlying genetic mutations associated with autism, schizophrenia, and other neurological disorders. The discovery points to an experimental drug developed by the team as a potential treatment for these conditions.
SourceTel-Aviv University·JournalMolecular Psychology Brain Behavior and Society·DateMay 24, 2022
A new study suggests that the world's first farmers did not originate from a single group but from the mixing of two groups of hunter-gatherers. The research team used deep sequencing to analyze ancient DNA and found evidence of population divergence, expansions, and admixture dates, providing a more detailed understanding of the demog...
SourceCell Press·JournalCell·TypeExperimental study·DateMay 12, 2022
Whole genome sequences of ancient Uruguayan Indigenous people provide a genetic snapshot of populations before European military campaigns decimated them. The results support the theory of separate migrations into South America, contradicting the idea of a single Native American race across North and South America.
SourceEmory University·JournalPNAS Nexus·TypeData/statistical analysis·DateMay 11, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A new study identifies 152 genetic variants shared across multiple psychiatric disorders, including schizophrenia and bipolar disorder. This finding could lead to the development of therapies addressing multiple disorders with one treatment.
SourceUniversity of Colorado at Boulder·JournalNature Genetics·TypeData/statistical analysis·DateMay 10, 2022
A collaboration between researchers identified crucial minerals regulating gene expression to control tissue renewal and growth. Minerals such as silicon, magnesium, and lithium induce endochondral ossification by turning on key genes, leading to the transformation of stem cells into bone cells.
SourceTexas A&M University·JournalScience Advances·DateMay 6, 2022
Researchers at NC State University have created a stem cell-derived model that sheds light on the effect of dopamine on gene activity in neurons, revealing gene desensitization in human cells. The study provides a blueprint for future research into the relationship between dopamine and addiction.
SourceNorth Carolina State University·JournalCells·TypeExperimental study·DateMay 4, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A gene defect among people of Inuit ancestry has been discovered, putting children at risk of dying from child vaccines or simple viral infections. The defect is found in 1 out of 1500 Inuits and can be screened for using heel prick blood test samples.
SourceAarhus University·JournalJournal of Experimental Medicine·TypeExperimental study·DateApr 26, 2022
Research suggests that EMFs can cause Alzheimer's disease by building up calcium levels in brain cells. This increase leads to changes in the brain, which develop conditions for Alzheimer's. The study highlights the importance of reducing EMF exposure to prevent or delay the onset of Alzheimer's.
SourceBentham Science Publishers·JournalCurrent Alzheimer Research·DateApr 25, 2022
A recent study on the Maniq population found they exhibit high levels of genetic differentiation, similar to other isolated populations. The researchers also discovered that the Maniq retain a unique hunter-gatherer lifestyle and Hòabìnhian-related ancestry, setting them apart from other Southeast Asian groups.
SourceSMBE Journals (Molecular Biology and Evolution and Genome Biology and Evolution)·JournalGenome Biology and Evolution·TypeObservational study·DateApr 18, 2022
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
The article highlights the need to move beyond continental ancestry categories in research and medicine, as they can perpetuate medical stereotypes and exacerbate health disparities. Instead, researchers are adopting a multidimensional approach to genetic ancestry, one that reflects continuous variation and historical depth.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateApr 14, 2022
A new study by an international team of scientists links early human habitats to past climate shifts using a supercomputer model and fossil records. The research suggests that climate change played a central role in determining where different hominin groups lived and their remains were found.
SourceInstitute for Basic Science·JournalNature·TypeExperimental study·DateApr 13, 2022