Articles tagged with Next Generation Sequencing
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Environmental scientists use next-generation sequencing to track population adaptations to climate change, finding gene variants and altered expression that point to selection for climate-adapted traits. However, funding constraints may hinder the technology's adoption in ecological studies.
Genomic tests using next generation sequencing technologies face access issues due to inadequate evidence on clinical utility. Experts suggest a four-pronged approach to improve access, including robust validation studies, prioritizing research and evidence, and evolving the evidence review process.
Researchers have used next-generation sequencing to rapidly identify pathogens in the United States. A recent discovery of porcine enterovirus G highlights the importance of this technique in detecting viruses that can cause disease. The virus is thought to be benign but raises concerns about other viruses getting through borders.
A study using Sequenta's LymphoSIGHT platform reveals that patients with longer survival have lower numbers of T cell clones that decrease in frequency after treatment. This association holds for both prostate cancer and melanoma patients, suggesting that immune repertoire sequencing could predict clinical benefit of immunotherapies.
ZENBU integrates genome browsers with data analysis and linked expression views to facilitate interactive visualization of next-generation sequencing results. The tool allows for dynamic combination of thousands of experimental datasets, enabling scientists to discover new biological mechanisms.
A new tool called REALPHY reconstructs evolutionary trees from sequencing data without errors and biases. The method is simple enough for biologists to use, generating accurate phylogenies quickly.
Researchers have developed a new approach using long-range PCR and next-generation sequencing to obtain large phylogenomic data sets, increasing accuracy in reconstructing evolutionary history. This method allows for the amplification of larger DNA fragments, enabling the targeting of specific genomic regions.
A new RNA extraction protocol for land plants has been developed, allowing for the extraction of high-quality RNA from a wide variety of plant species and tissue types. This protocol will greatly facilitate RNA-based studies of non-model plant species and enable comparative analyses of transcriptomes across diverse lineages.
New DNA sequencing techniques enable plant scientists to analyze complex genomes, revealing new insights into plant diversity and evolutionary history. Targeted enrichment methods facilitate the study of specific genes and regions, accelerating discovery in crop production, ecosystem health, and understanding plant diversity.
The Wellcome Trust Sanger Institute has sequenced 300 human genomes in six months, producing over 1 trillion letters of genetic code. This data will revolutionize human medical genetics and allow researchers to answer questions previously unthinkable.