Articles tagged with Protein Coding Genes
A Duke team has identified two proteins, MIF and CyP-A, that are elevated in lung cancer cells but not in normal cells. These proteins may be potential targets for new therapies and a simple blood test to diagnose lung cancer without biopsies.
Researchers found that antisense RNA regulates core timing genes in Neurospora's circadian clock, which drives the 24-hour light-dark cycle. The discovery provides an unexpected link between antisense RNA and circadian timing.
Researchers have discovered that chromatin folds at a much higher level than previously thought, leading to surprisingly large enzyme complexes. This finding has significant implications for understanding gene expression and regulation.
Researchers found that healthy individuals vary in gene expression levels in circulating blood cells, with some genes used at varying levels depending on time of day and age. Despite these differences, the study revealed remarkable similarity in the genes used among the subjects.
Researchers at Wake Forest have identified a gene responsible for two rare kidney diseases, familial juvenile hyperuricemic nephropathy and medullary cystic kidney disease Type 2. The discovery may lead to early detection and improved treatment options for affected individuals.
The MLL protein edits the histone code at specific sites, regulating Hox gene expression and contributing to leukemia. This study highlights the importance of the histone code in developmental biology and disease.
Scientists have discovered an unusual protein structure, known as a 'knot', which defies traditional understanding of protein folding. The newly found knot may stabilize amino acid subunits in the protein, shedding light on its mysterious function and potential applications in disease diagnosis and drug development.
Researchers discovered a key molecule regulating multiple genes in yeast and humans, potentially enabling rapid response to stress. The molecule, inositol polyphosphate, affects hundreds of genes by regulating enzymes that alter chromatin structure.
Researchers identified Ski's role in disrupting nuclear signaling proteins, preventing cells from slowing down and stopping division. This finding provides crucial insight into the development of cancerous tumors and offers a potential target for new anticancer drugs.
Researchers at Whitehead Institute have created a global script describing how the yeast genome produces life, revealing the complex relationships between genes and proteins. This breakthrough allows for a vast network of interactions to be mapped, enabling targeted pharmaceutical approaches for diseases such as cancer.
A genome-wide scanning study has identified eight genes, including RET and EDNRB, as contributing to Hirschsprung disease, a complex disorder affecting bowel function. The research used gene chips and computer software to analyze thousands of genetic variations, providing new insights into the disease's causes.
Researchers found that hormones bind to specific receptors in cells, recruiting co-activators to regulate gene expression and alter protein production. This process enables a vast range of protein diversity from relatively few genetic sources.
Researchers identified Kir6.2 as a protective mechanism against stress in the heart, which helps maintain equilibrium under peak workloads. The study found that mice lacking this protein experienced severe cardiac distress and died, while those with it survived stress tests.
Researchers used genome-wide scanning to uncover genetic causes of Hirschsprung disease, a complex disorder resulting from subtle gene mutations. The study identified two key genes, RET and EDNRB, which must co-exist to cause the disease, providing new insights into its underlying mechanisms.
SMU and UNC researchers discovered that the E(Z) protein silences genes by modifying a specific chromatin protein, a mechanism found to be conserved in both humans and Drosophila. This breakthrough sheds light on how Polycomb-group proteins regulate gene expression during development.
Researchers at UT Southwestern Medical Center have discovered a protein called Homeodomain-Only Protein (HOP) that regulates heart growth from fetal stage to adulthood. HOP helps control the balance of cardiac cell proliferation and differentiation, with disrupted levels leading to abnormal heart development.
Researchers found that a single fly gene encodes two proteins with opposing actions: one inhibits the other's activity. This discovery provides insight into complex biological phenomena and may lead to novel treatments for human cancers, particularly those with overactive STAT proteins. The study highlights the importance of considerin...
Researchers at U.Va. have identified a new component called Npap60 that helps load cargo and ensures correct delivery into the cell nucleus. The study reveals an unusual switch mechanism that allows the protein to distinguish between different nuclear entry codes.
Dartmouth researchers identify a multi-tasking circadian protein called White Collar-1 that plays a critical role in regulating biological clocks. The protein is found to be both the photoreceptor and the mechanism that turns on the frequency gene, revealing a relatively simple process between light perception and gene activation.
Researchers have discovered a gene associated with both macular degeneration and retinitis pigmentosa, two eye diseases affecting different segments of vision. The RPGR gene is linked to early-onset macular degeneration primarily affecting males.
A team of scientists has discovered a mechanism for neuron-specific expression of Pcdh proteins, allowing individual neurons to generate distinct combinations of genes and proteins. This discovery may underlie the specificity of neural connectivity.
Researchers have found that a gene repair mechanism called MBD4 enzyme can reduce gene mutations in mice, which are up to three times more common without the enzyme. This discovery may aid in understanding how cancer develops and finding new treatments.
Researchers at Dartmouth have discovered a novel photoreceptor protein that absorbs light and regulates the circadian rhythm. The protein, White Collar-1, is part of a genetic system that can be exploited to develop new drug delivery systems for treating fungal diseases.
Researchers at Penn State College of Medicine have discovered that a protein previously thought to be in the nucleus resides in the cytoplasm, correcting a scientific theory since 1992. This finding offers new parameters for understanding gene switches and their role in human diseases.
Researchers found over 200 groups of adjacent and similarly expressed genes in Drosophila melanogaster, accounting for approximately 20% of the genome. The 'sloppy' regulation may reflect chromatin's packaging and influence gene expression more by accident than design.
Researchers at Duke University Medical Center discovered a gene linked to male infertility in mice, which may also be associated with human infertility. The study found that the miwi gene plays an essential role in sperm production and its deficiency can lead to complete sterility in mice.
Researchers have developed a new TB vaccine by fusing a Mycobacterium tuberculosis antigen with a gene that highly expresses a thiol-specific-antioxidant protein from Leishmania major. This hybrid DNA vaccine increased protein production, leading to a more robust immune response in mice.
Researchers at the University of North Carolina at Chapel Hill have identified a protein called ATR that senses damaged DNA and triggers the body's natural repair system. This discovery is significant as it highlights a crucial step in maintaining genome stability and preventing mutations that can lead to cancer.
Researchers from Stanford University analyzed thousands of proteins shared by yeast and roundworms, finding that those with more interactions evolve slower. The study confirms a prediction made over 20 years ago, suggesting protein networks play a crucial role in shaping evolutionary rates.
Scientists developed a new technique to chronicle protein development, movement and interactions in living cells. The technology uses small binding domains that interact with other compounds, allowing researchers to distinguish old from new proteins and explore dynamics at different resolution levels.
Researchers found that certain proteasome proteins, Sug1 and Sug2, are involved in gene activation when genes are turned on. This discovery challenges conventional wisdom and could lead to a better understanding of human development and disease causes.
A study using mice found that mutations in the Lmx1b gene cause a reduction in two proteins necessary for mature podocytes to function properly. This disruption leads to immature podocytes and impaired kidney filtering, increasing the risk of kidney problems associated with nail-patella syndrome.
Researchers have successfully mapped the genetic regions responsible for Hirschsprung disease, a rare inherited disorder affecting the intestines. The study reveals that three crucial regions on chromosomes 3, 10, and 19 contribute to the disease's complex inheritance pattern.
Golan Yona creates a multi-dimensional map of known proteins to predict structure and function. By analyzing physical shape, topology, and amino acid sequences, researchers can guess protein functions and predict structures for new genes.
A new mechanism called nonstop decay recognizes and destroys abnormal messenger RNA, potentially interfering with drug treatments for genetic diseases like cystic fibrosis. Thwarting this mechanism may make these treatments more effective.
Researchers discovered a gene, atrogin-1, that plays a critical role in muscle atrophy. This protein triggers excessive protein breakdown, leading to muscle loss in various conditions, including space-related muscle wasting.
Researchers at Massachusetts General Hospital have developed a gene therapy approach that inhibits phospholamban, a protein blocking normal calcium flow in the heart. This treatment strategy has shown promise in improving contraction and relaxation in diseased cells.
Johns Hopkins researchers have identified a protein called stat3-beta that regulates genes involved in systemic inflammation. In mice engineered to lack this protein, researchers found fatal kidney failure due to uncontrolled inflammation, highlighting the potential of stat3-beta as a therapeutic target for human inflammatory diseases.
Researchers James E. Darnell and Ali H. Brivanlou propose a reclassification of all known transcription factors, grouping them by their behavior rather than physical structure. This framework aims to provide a better understanding of how cells 'read' genetic instructions and may lead to new drug therapies for diseases such as cancer an...
Researchers will study the functions of beta-glucosidase and beta-galactosidase gene families in Arabidopsis, a small but useful model for understanding genetic processes. The goal is to determine the functions of approximately 25,000 genes, which can be extrapolated to other plants like wheat and soybeans.
A team of researchers led by Jeannie T. Lee has identified the CTCF protein as a central regulator of X-chromosome inactivation, sparking new insights into the mechanism behind this process. The discovery sheds light on how the developing embryo chooses which X chromosome to inactivate.
Yale researchers have created a microchip that can analyze virtually all yeast proteins, holding promise for advances in studying protein function in other organisms. The technology allows for faster understanding of protein interactions and could lead to breakthroughs in diagnostic methods, drug discovery, and therapies.
Researchers identified genetic basis of two rare disorders, familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome, linked to mutations in the cryopyrin protein. The study sheds light on the role of cryopyrin in orchestrating immune defenses and may lead to a better understanding of related autoimmune diseases.
Researchers have determined the function of the Hairless protein, revealing its role in regulating gene expression dependent on the thyroid hormone receptor. The discovery provides molecular insight into congenital hair loss disorders and represents a stepping stone for designing therapeutic agents.
A new analytical platform has been developed to rapidly identify and characterize proteins. The system uses Fourier-Transform Mass Spectrometry and a liquid-helium cooled superconducting magnet to analyze protein data, enabling efficient processing of multiple proteins simultaneously.
Researchers found protein Nrd1 helps RNA polymerase II recognize 'stop sign' for certain genes. This mechanism may help understand HIV's hijacking process and fundamental mechanisms of regulating gene expression in yeast.
The Penn team will focus on contusions and examine individual neurons' responses to injury. They aim to identify patterns of genes and proteins that are activated or suppressed, which could lead to new medications and treatments.
Case Western Reserve University has received a $2.2 million grant from the Charles B. Wang Foundation to establish the Center for Computational Genomics. The center will tackle cutting-edge problems in genomics and bioinformatics, focusing on genomic analysis and disease prevention.
The study identifies the carbohydrate response element-binding protein (ChREBP) as a key player in transforming excess glucose into fat. ChREBP binds to specific genes, activating enzymes that catalyze the transformation of excess glucose into fat, which can lead to weight gain.
Researchers have identified two distinct clusters of genes in the Arabidopsis genome that code for pollen coat proteins. These proteins enable the dry pollen coat to interact with stigma cells during pollination. The discovery provides insights into how plants recognize pollen and could lead to new techniques for crossing plants, preve...
Researchers at the University of Pennsylvania School of Medicine found that activation of vitamin A receptors can regulate the human circadian clock. This discovery provides an important clue to how the master clock in the brain regulates distal organs by controlling clocks throughout the body.
A clearer picture has been obtained on why the protein doesn't function properly in the milder form of cystic fibrosis, attributed to segments sticking together and interfering with chloride flow. This discovery opens doors for new avenues of research in rational drug design.