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A built-in “hairpin” prevents rogue CRISPR RNAs

A research team at HIRI discovered that CRISPR-Cas13 systems produce an RNA-based 'hairpin' structure to prevent the formation of waste RNAs, known as ecrRNAs. This mechanism optimizes the system's interaction and enhances its efficacy in immune defense and gene editing.

SourceHelmholtz Centre for Infection Research·JournalThe EMBO Journal·TypeExperimental study·DateApr 14, 2026
Creality K1 Max 3D Printer

Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.

Uncovering the structural and regulatory mechanisms underlying translation arrest

Two previously unknown ribosome-arresting peptides (RAPs), PepNL and NanCL, were identified in E. coli, inducing translation arrest through a unique mini-hairpin conformation in the exit tunnel of the ribosome. This discovery provides valuable insights into deciphering the hidden genetic codes within polypeptide sequences.

SourceOkayama University·JournalNature Communications·TypeExperimental study·DateApr 18, 2025