Articles tagged with Single Cell Sequencing
A new study reveals that marine viruses are more important to microbial ecology below sunlit surface waters than previously suspected. The research focused on a sulfur-oxidizing bacterium called SUP05, which is dominant in oxygen minimum zones and has not been successfully cultivated in a lab setting.
Researchers at UC San Diego have developed a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters. This approach enables the generation of more complete genome sequences from single cells, including E. coli and individual neurons from the human brain.
Researchers at Salk Institute discovered a patchwork of genetic variation in individual brain neurons, contrary to the long-held belief that each cell possesses identical DNA code. The study found that up to 41% of neurons have unique, massive copy number variations (CNVs) that arose spontaneously.
Scientists have cracked the genetic code of bacteria linked to periodontitis, a disease marked by inflammation and infection of the teeth's supporting ligaments and bones. The unique genetic code allows SR1 bacteria to introduce a glycine amino acid, limiting gene exchange with other bacteria.
Researchers develop SPAdes, a new algorithm to sequence genomes from single cells, enabling analysis of 'dark matter' bacteria and human pathogens. The breakthrough could lead to early detection of cancer progression by monitoring normal cells before they turn malignant.
BGI's single-cell sequencing technology enables researchers to analyze genetic characteristics of essential thrombocythemia and clear cell renal cell carcinoma. The method provides clearer intratumoral genetic pictures and developmental history than previous bulk tissue sequencing, opening new ways for the genetic study of tumors.
The DOE JGI has selected 71 new genomic sequencing projects for its 2010 Community Sequencing Program, focused on bioenergy, climate, and environmental applications. The program aims to improve the clean energy pathways and understanding of the global carbon cycle.
Researchers have successfully sequenced the genomes of two uncultured flavobacteria using a novel single-cell approach. This technique allows for the analysis of minute quantities of DNA and has potential applications in biotechnology and understanding microbial communities.