Articles tagged with Target Mrna
Researchers at Johns Hopkins Medicine discovered a peptide on the SARS-CoV-2 spike protein that triggers an immune response in humans and is also recognized by cells of the immune system, suggesting potential for protection against future zoonotic outbreaks. The study supports the development of multivalent vaccines against a broad spe...
A University of Minnesota-led study found that COVID-19 boosters significantly reduce infections and hospitalizations. The research showed that booster doses are particularly effective in reducing hospitalizations among the elderly and those with comorbidities.
Researchers have discovered a spray-induced gene silencing technique that effectively controls late blight, a devastating disease affecting potatoes and tomatoes. This environmentally friendly method has potential to reduce the usage of chemical pesticides and can be quickly adapted for new targets.
Researchers have developed a new system called Species Agnostic Nanoparticle Delivery Screening (SANDS) that improves the screening process for drug-delivering nanoparticles. SANDS allows for simultaneous testing of nanoparticles in mouse, primate, and human cells, enabling more accurate predictions of delivery in humans.
Researchers have developed a method to assess drug potential for rare disorders by profiling FDA-approved drugs. The study identified NMD modulators that could potentially treat hundreds of disorders associated with nonsense-mediated RNA decay.
Researchers at Yale University shed new light on the formation and function of mRNAs, a critical molecule involved in protein production. The study found that pseudouridine plays a key role in mRNA genesis and guides splicing, which regulates gene activity.
Researchers found that knocking down LCDR in lung cancer cells promotes apoptosis, providing a potential new target for diagnosis and treatment. Additionally, targeting LCDR shows promise as a therapeutic strategy and has diagnostic value for lung adenocarcinoma.
Researchers at Penn Medicine have discovered a new method to prevent the body's proteins from attacking treatment-carrying nanoparticles, allowing for more effective delivery of therapies. By coating nanoparticles with natural suppressors of complement activation, such as Factor I, the team has shown improved protection against immune ...
An AI-driven solution identifies sites on RNA and DNA molecules where interaction with potential drug candidates can occur. This allows pharmaceutical companies to discover new medications in a more focused and efficient manner.
Researchers found that mRNA vaccines were highly effective (86%) in preventing SARS-CoV-2-related deaths among vaccinated individuals, especially in the elderly population. However, vaccine effectiveness against infection was lower (69%) and decreased with increasing age and comorbidity burden.
Researchers at Mayo Clinic found that mRNA therapy improves the response of patients who weren't responding to cancer immunotherapy. The study identified a weak spot in T cells, white blood cells crucial for fighting cancer, and developed an mRNA-based strategy to enhance their response.
A novel mRNA-based HIV vaccine has been shown to be safe and elicit desired immune responses in mice and non-human primates. The vaccine prompted a 79% lower per-exposure risk of infection by simian-human immunodeficiency virus compared to unvaccinated animals.
Scientists at UC San Diego create nanoparticles that mimic the flu virus's ability to escape endosomes, enabling efficient delivery of mRNA into cells. This breakthrough could lead to improved delivery of mRNA vaccines and therapies.
Researchers at University of Technology Sydney identified microRNA-21 as a potential therapeutic target for chronic obstructive pulmonary disease (COPD). Inhibition of microRNA-21 using antagomir-21 reduced inflammation and improved lung capacity in experimental models.
Researchers developed a novel model to identify specific genes and genetic alterations in multiple myeloma, stratifying the cancer's severity via DNA and RNA sequencing. This model revealed diverse subtypes and high-risk patients beyond current classifications.
Researchers at MIT and Harvard University have developed a way to selectively turn on gene therapies in target cells by detecting specific messenger RNA sequences. This technology can fine-tune gene therapies for applications ranging from regenerative medicine to cancer treatment, potentially reducing side effects and increasing efficacy.
Pediatric transplant recipients have a more robust immune response to COVID-19 vaccines, achieving higher antibody levels after two doses compared to adult counterparts. This study suggests that the standard two-dose regimen may be safe and effective in pediatric transplant recipients.
Researchers at DTU Health Tech have invented a one-pot assay, NISDA, for rapid detection of SARS-CoV-2 RNA without the need for enzyme-based methods. The assay detects low concentrations of RNA in 30 minutes and has shown high accuracy and sensitivity.
A team of researchers from IOCB Prague has discovered a new type of nanoparticles capable of safely transporting various types of nucleic acids used for therapeutic purposes into cells. The universal nature of their system sets it apart from existing solutions, allowing for efficient transport of mRNA and other RNA molecules into cells.
Researchers found that viral fossils in Australian marsupials are used to make non-coding RNAs that protect against outside infection. The study suggests that these viral fossils may be helping to immunize animals, potentially providing a mechanism similar to vaccination.
A new study reveals that multiple pathways regulate poly(A) tail lengths in yeast, involving poly(A) binding proteins and a self-regulating pathway. This discovery sheds light on the complex control of mRNA tails and their impact on protein production.
Researchers deciphered the impacts of sRNA interactions on individual bacterial cells, revealing minor effects from base-pairing interactions and significant effects from disruptions in Hfq binding. The study used high-throughput sequencing and quantitative super-resolution imaging to understand the regulation of gene expression under ...
Scientists have discovered a key mechanism behind SINEUPs, which can amplify protein production by messenger RNAs. The research provides new insights into how these functional non-coding RNAs work and their potential to treat diseases caused by insufficient protein synthesis.
Scientists create drug-like compounds that bind and destroy COVID-19's frameshifting element to stop the virus from replicating. The findings demonstrate the feasibility of directly targeting viral RNA with small-molecule drugs.
Researchers have developed a new CRISPR technique that allows them to target and reduce specific messenger RNA (mRNA) molecules involved in early embryonic development. This approach enables the study of genes that were previously difficult or impossible to manipulate, and has shown promise for understanding infertility and development...
Scientists are developing a model to track mRNA movement through plant systems, aiming to predict and deliver targeted information. The goal is to engineer a method for using mRNA to alter plant responses to environmental stresses.
Scientists developed a new CRISPR screen technology to target RNA, enabling accurate and fast detection of specific RNA targets. The technology uses Cas13 enzymes to identify key genes involved in various diseases, including cancer and sickle-cell anemia.
Researchers developed a biochemical model that reveals novel insights into microRNAs and enables accurate prediction of their effects on genetic expression. The model explains nearly half the variability in miRNA-mediated silencing and greatly surpasses correlative models.
Researchers identified thousands of host mRNAs targeted by gammaherpesvirus microRNAs, revealing significant conservation of miRNA targeting among viruses. The study provides new insights into the function of gammaherpesvirus miRNAs and their role in establishing lifelong infections.
RESCUE, a new CRISPR platform, allows for targeted RNA edits previously impossible, offering a critical gap in the toolbox for treating diverse genetic changes. The technology can modulate protein activity by targeting phosphorylation sites, providing a reversible alternative to DNA-level modifications.
Researchers developed a new molecule, HDO-antimiR, that can silence malfunctioning miRNA with heightened efficacy and lowered toxicity. It has been shown to be 12 times more efficient in binding to targeted miRNA and producing enhanced phenotypic effects in mice.
A new CRISPR platform, RESCUE, has been developed to target RNA edits that were not previously possible. The system allows for precise modifications of cytosine bases in RNA transcripts, enabling the treatment of devastating diseases affecting the brain.
Researchers have developed SABER, a highly programmable method that significantly enhances the sensitivity and customization capabilities of FISH analysis. It enables parallel detection of many targets with high sensitivity and tunability at low costs.
Researchers found that CRISPR base editors can induce widespread off-target effects in RNA beyond targeted DNA, but developed variants with less impact. The SECURE variant significantly reduces unwanted RNA edits while increasing precision of on-target DNA editing.
The study reveals that only one amino acid residue plays a critical role in cleavage function for prokaryotic Ago, whereas its counterpart in eukaryotes has multiple roles. The discovery sheds light on how the cleavage functions evolve from prokaryotes to eukaryotes.
New DNA-based nanomachines can selectively target malignant cells, breaking down vital genes and inducing apoptotic death. The design allows for better interaction with folded RNA molecules, but further experiments are needed to improve specificity.
Researchers developed a versatile vaccine effective in mice against Powassan virus and other tick-transmitted flaviviruses. The mRNA-based vaccine platform shows promise for rapid production of vaccines against emerging flaviviruses.
Researchers at Yale University have made significant breakthroughs in targeting RNA with small-molecule drugs, identifying unique pockets within self-splicing ribozymes found in fungi. This discovery opens up new avenues for treating fungal infections and drug-resistant bacteria.
Scientists have created a nanosized sensing probe for RNA molecules using DNA origami and gold nanorods. The probe can detect concentrations as low as 100 picomolar of the target RNA, making it a promising diagnostic tool for viral infections.
Researchers found that ZFC3H1 helps retain exosome targets in the nucleus, preventing their export to the cytoplasm. This new mechanism involves polyadenylated RNAs accumulating in distinct nuclear foci.
Researchers at Duke University have developed a technique to capture RNA molecules in precise images, revealing new opportunities for drug discovery. The method identifies potential anti-HIV compounds from millions of possibilities, showcasing its accuracy and potential to treat various ailments.
Salk Institute scientists have developed a CRISPR-based tool called CasRx that targets RNA to correct protein imbalances in cells from dementia patients. The tool showed 80% effectiveness in rebalancing tau protein levels, opening up new avenues for treating RNA and protein-related diseases.
A new gene-editing technology has been developed to improve the efficiency of CRISPR/Cas9, allowing for safer and more efficient correction of disease-causing mutations in patients. The system uses a nano-sized porous material to coat the molecular components of CRISPR/Cas9, enabling efficient release into cells.
A study published in PLOS ONE found that double-stranded RNA (dsRNA) treatment can reduce the fertility of adult house flies by interfering with gene expression. The treatment, which targets specific genes involved in the fly's reproductive process, resulted in reduced egg development and oviposition rates.
Scientists have developed a new CRISPR RNA editing tool called REPAIR, which can target and edit RNA with high efficiency and specificity. This tool allows for the correction of mutations in different time windows, including during key developmental periods, and may have disease-modifying potential.
Researchers identify REC3 domain as a master controller of DNA cutting and engineer mutations to improve accuracy without impacting efficiency. The hyper-accurate gene editor, dubbed HypaCas9, retains on-target efficiency while discriminating between on- and off-target sites in human cells.
A team of scientists has made a groundbreaking discovery about the RNA interference (RNAi) machinery, revealing that it can multiply its effect on repressing gene expression. This process is essential for cell survival and regulation of genetic activity.
A CRISPR system targeting RNA has been developed and tested, allowing for precise editing of single-stranded RNA. This breakthrough holds implications for various biological applications, including RNA modification and regulation.
Researchers have characterized a new CRISPR system that targets RNA, enabling temporary changes to be made with greater specificity. This approach has the potential to accelerate progress in understanding, treating, and preventing disease by manipulating gene function more broadly.
Researchers have created a drug candidate that targets and neutralizes the RNA structure causing an incurable progressive disease, spinocerebellar ataxia type 10. The compound, 2AU-2, improves several aspects of cells taken from patients with SCA10, offering new hope for treating dozens of incurable diseases.
Researchers at UC Berkeley developed a faster and more efficient CRISPR-Cas9 editing method for mice, using electroporation instead of microinjection. The new technique resulted in higher success rates and reduced embryo damage.
Researchers at University of California, San Diego School of Medicine successfully targeted RNA in living cells using CRISPR-Cas9. This breakthrough may lead to new therapeutic approaches for diseases linked to defective RNA transport, such as autism and cancer.
Researchers have found that the RNA virus bovine viral diarrhea virus relies on host miRNAs, specifically miR-17 and let-7, to replicate. Inhibiting this interaction may provide an effective target for developing new drugs to control BVDV.
Biologists at the University of Pennsylvania have discovered a new way that messenger RNA is regulated, which affects the production of proteins. The study found that modified mRNAs are more likely to be involved in stress responses and cell cycle control, suggesting a mechanism for dynamic regulation.
Researchers at Tokyo Medical and Dental University developed a novel DNA/RNA heteroduplex oligonucleotide (HDO) that significantly improves gene silencing and reduces liver dysfunction. The high potency of vitamin E-conjugated HDO results in improved delivery to the liver, leading to enhanced therapeutic effects.
Researchers at Harvard University and UC San Diego have developed a new software that predicts the most active guide RNAs for specific gene targets, facilitating faster and more efficient genome engineering experiments. This breakthrough has the potential to accelerate discoveries in gene therapies and basic genetics research.
Researchers have developed a predictive software that can identify the most effective ways to target genes with CRISPR-Cas9. The software hierarchically ranks guide RNA effectiveness based on experimental data from human genomes, speeding up the gene-editing process and improving accuracy.
Researchers at University of California, San Diego, have identified six mRNA isoforms that distinguish ovarian cancer cells from normal cells, offering potential for early diagnosis and targeted therapies. The study's findings may also lead to new therapeutic targets and more effective treatment options.
Researchers at UC Berkeley have identified a new target for cancer drugs in messenger RNA molecules, which carry unique tags that can be targeted to regulate translation. These tagged mRNAs play a key role in controlling cell growth and differentiation, making them potential targets for new anticancer therapies.
Biologists at Scripps Research Institute have described the atomic-level workings of microRNA molecules, which control gene expression in all animals and plants. The findings will help guide the development of therapies that harness microRNA's power to regulate key biological processes.