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Automated, accurate reporting for NGS-based clonality testing

Researchers have developed an automated calling algorithm for determining B and T cell clonality from NGS data with greater sensitivity than previous models. The new model increases the assay's sensitivity in detecting clonality, allowing for more accurate diagnosis and monitoring of lymphoproliferative disorders.

SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateMay 16, 2023

Inadequate supply of protein building blocks may explain pregnancy failures in bovine cloning experiments

A study found that amino acid concentrations were reduced in cloned embryos compared to in vitro fertilized pregnancies. This may explain developmental abnormalities and complications leading to embryo death. The findings highlight the importance of researching maternal-embryo interactions.

SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalCellular Reprogramming·DateOct 26, 2011