Articles tagged with Transposable Elements
Researchers at the University of Barcelona have identified new genes in the BEX/TCEAL cluster that are related to autism spectrum disorder and other neurological diseases. The study used animal models to describe molecular mechanisms involved in the development of the neocortex in humans and other placental mammals.
Researchers discovered a mechanism where histone variant H3.3 is replenished to silence transposons in pluripotent stem cells, potentially linked to cancer tumorigenesis
Scientists discovered that transposable elements influence human brain development by partnering with two specialized proteins known as Krép-el-associated box-containing zinc finger proteins. These partnerships regulate gene expression in neurons and influence the development and function of adult organs.
Scientists from the University of Tsukuba found that retrotransposons may change how genes are expressed in melons. In a study published in Communications Biology, researchers discovered that retrotransposons had a role in altering gene expression when melon genomes were diversifying and affecting fruit ripening.
Researchers at OIST Graduate University have identified previously unknown sections of DNA that are silenced by epigenetic regulation in plant cells. The study reveals a crucial role of these sites in suppressing the activity of disruptive 'jumping genes' called transposons, which can threaten genome integrity.
A new study reveals that transposable elements contribute to cell-specific chromatin looping, gene regulation, and species divergence. The researchers developed software MapGL to track physical gain and loss of genetic sequences across species, shedding light on the evolutionary influences of structural variations.
Researchers identify over 4,500 novel transcripts in fruit fly genome that regulate networks of genes and contribute to genetic disorders. These findings shed light on the 'dark' portion of human genome, which accounts for 98% of its content.
A novel parasitic gene in fruit flies is responsible for destroying eggs in ovaries, similar to human genomes filled with mobile parasitic genes called transposons. The discovery may lead to a better understanding of how human genomes are shaped by transposons and the small RNA molecules used to silence them.
Researchers at EMBL developed a new variant of the Sleeping Beauty transposase with improved biochemical properties, allowing for direct protein delivery and autonomous cell penetration. This breakthrough enables efficient and stable genome modifications in target cells on demand.
A recent study by Cold Spring Harbor Laboratory has made significant strides in understanding the role of proteins called TDP-43 in ALS. The researchers found that TDP-43 aggregates in nerve cells can cause a toxic effect, leading to paralysis. This discovery opens up new avenues for developing effective treatments and therapies.
Researchers discovered that jumping genes cause genetic changes in some patients with undiagnosed neurodevelopmental diseases. Diagnoses were achieved for three previously undiagnosed children, helping their families access support and understand disease risks.
The genome comparison of almond and peach trees sheds light on their evolutionary history and the role of mobile genetic elements in diversification. The study found that transposons may have driven the differences between the two species, including variations in flavor and fruit quality.
Researchers at Michigan State University are using $2.8M in NIH grants to study the piRNA pathway and its role in controlling male fertility. They hope to identify new targets for male contraception, addressing a significant reproductive health issue affecting one in ten couples.
Researchers dispute the long-held belief that heterochromatin is a reliable guardian of the human genome. A study by University of Arizona researcher Keith Maggert reveals that heterochromatin can flicker on and off, allowing transposons to cause mutations and damage. This instability has significant implications for our understanding ...
Researchers have discovered that drought stress triggers the activity of Rider retrotransposons, potentially leading to new trait variations in crops. The study highlights the potential of transposons as a source of crop improvement, particularly in breeding more resilient crops against climate change.
Cells use a molecular safety mechanism to smuggle genetic information molecules around the cell, which are then used to recognize and shut down parasites. This discovery provides new insight into how animal genomes defend themselves against DNA parasites and reveals a previously unknown RNA transport route.
Researchers successfully studied DNA methylation loss in human cells, revealing the activation of transposons that can lead to serious diseases. The study provides new insight into how changes in DNA methylation contribute to diseases and opens up potential for a new understanding of genome function.
Researchers at NYU Abu Dhabi have identified a new way the liver regenerates itself, involving the redistribution of epigenetic marks. By removing key epigenetic regulators, they found that genes were activated early and sustained during regeneration, providing a significant advance in understanding liver regeneration.
Seeds with extra genomes undergo interploidy seed abortion due to defective endosperm development. Researchers found that RNA Pol IV silences gene expression from transposons and repetitive DNA, playing a key role in seed abortion.
A study by EPFL researchers found that the KRAB domain-containing zinc finger protein Zfp30 initially repressed a retrotransposon, but later evolved to activate genes involved in fat-cell formation instead, surprising scientists
Researchers found that KZFP proteins domesticate regulatory sequences in transposable elements, minimizing their impact on early embryonic development. This process allows for the incorporation of transposable element-based controlling sequences into transcriptional networks.
A recent study reveals that transposable element insertions drive rapid phenotypic variation in plants, enabling them to adapt to novel environments. Researchers found that transposable elements are enriched in the gene promoter regions of a plant species with limited genetic variation, associated with changes in gene expression.
Researchers from the University of Rochester discover that LINE1 retrotransposons become more active with age, triggering inflammation and age-related diseases. By understanding the impacts of these genomic parasites, scientists can develop strategies to inhibit them and combat aging.
A new study found that an HIV drug reduces age-related inflammation and signs of aging in mice, holding promise for treating Alzheimer's and other diseases. The drug works by halting retrotransposon activity in old cells, which are linked to age-associated disorders.
Researchers have developed new techniques to identify which of our genes are influenced by ancient viral DNA snippets, revealing complex interactions between viruses and human genetic material. The study found that a single transposon can control multiple genes, increasing the complexity of its impact on health and disease.
Researchers discovered that retrotransposons and nonhomologous end-joining (NHEJ) interacted to create a selection pressure that helped lead to the emergence of advanced life. This interaction enabled eukaryotes to mix and match genes, creating more complicated functions.
Researchers from the University of Cambridge found that epigenetic marks are reprogrammed from one generation to the next, contradicting previous theories. Only a small percentage of variably-methylated transposable elements showed evidence of epigenetic inheritance.
Research reveals that genetic copy-and-paste activity is increased in fruit fly models of tauopathies, leading to neuron death. Lamivudine, an anti-retroviral drug, decreases gene copying and reduces brain cell death.
A study has revealed that heterochromatin Protein 1a (HP1a) is crucial for the repression of transposons in germline cells, protecting the genome from instability and infertility. The piRNA pathway plays a vital role in silencing transposons, and HP1a's function in this process was previously unknown.
A new study in mice reveals that a 'jumping gene' plays a critical role in the first stages of embryonic development. High levels of LINE1 RNA expression are necessary to regulate gene activity and enable embryos to progress past the two-cell phase.
Researchers found a strong link between Tau protein accumulation and genomic instability, which may lead to cell death in Alzheimer's disease. The study identified activated transposable elements as a potential trigger for this process.
LINE-1 retrotransposons play a pivotal role in genome evolution and are involved in processes such as aging, brain activity, cancer immunology and cancer development. The study highlights the importance of cell cycle regulation and the DNA replication complex in LINE-1 cellular localization and activity.
Researchers at Osaka University found that GTSF1 is essential for regulating piRNA-mediated cleavage of target RNA, preventing retrotransposon overactivity. This mechanism safeguards the genome in male germ cells.
A new study reveals that pups with less maternal care have more repeated genetic sequences in their neurons. The researchers found a link between maternal care and transposon replication in the hippocampus, but not in other brain regions or organs.
Researchers at EMBL have unraveled the molecular basis of a major antibiotic resistance transfer mechanism and developed molecules to block its movement. This could help control the spread of antibiotic resistance genes in bacteria, including those that are part of our normal microbiome.
A team of geneticists has discovered a mechanism that enables plants to count their chromosomes, solving a century-old problem. They found that small RNA molecules, called miR845, trigger the synthesis of secondary RNAs that silence key genes, preventing viable seeds from forming.
Researchers use a new method called magic pools to study hundreds of transposon systems in parallel, speeding up the process of identifying functional transposons. This approach enables scientists to test multiple genetic variants simultaneously, reducing the trial and error process and accelerating the development of new genetic tools.
Researchers have detected mobile genetic elements that can switch off gene expression, altering protein production in eukaryotic organisms. These elements are prevalent in genomes of plants and fungi, but their impact is often negative, leading to degeneration and reduced productivity.
Genetic research reveals swamp wallabies are part of the Macropus genus, which includes grey and red kangaroos. The study found shared retrotransposons with woodland wallabies, indicating a common ancestry around five to seven million years ago.
A recent study published in Cell Stem Cell has discovered a mechanism to prevent genetic chaos caused by transposons in early human development. The research found that endosiRNAs, a type of small interfering RNA, play a crucial role in regulating transposon activity during epigenetic reprogramming.
Researchers at Michigan State University have identified the PNLDC1 gene as a key player in regulating sperm production, providing a genetic foundation for male birth control. The study's findings suggest that silencing this gene can lead to infertility in mice, making it a promising approach for human male contraception.
Researchers found that each transposon family interprets cell signals uniquely and uses distinct strategies to determine jumping timing. This study sheds light on the complex interactions between host cells and jumping genes.
Scientists from Helmholtz Zentrum München have found that retrotransposons, particularly LINE1 elements, regulate global chromatin accessibility in the early mouse embryo. This study identifies a novel role for retrotransposons in shaping the chromatin landscape necessary for correct developmental programming.
Researchers at UC Davis and Cold Spring Harbor Laboratory have mapped the 'jumping genes' of maize, identifying transposable elements that regulate gene expression and impact plant traits. The new genome sequence enables a deeper understanding of the complex relationships between these elements and the diversity of the genome.
A team from Cold Spring Harbor Laboratory has discovered small RNA fragments that protect the genome from retrotransposons during epigenetic reprogramming in preimplantation embryos. These fragments, consisting of 18 and 22 nucleotides, are perfect complements of sequences within retrotransposons.
Rotifers have been found to use Terminons, giant DNA sequences, to shield their chromosomes from degradation, which is linked to aging. This finding may help researchers better understand the mechanisms of aging.
A family of ~350 human proteins has been found to establish complex interplay with transposable elements, creating largely human-specific gene regulatory networks. These networks influence all of human biology, both in health and disease, and are likely to have profound implications for understanding human development and physiology.
A recent study by Brown University researchers has found that the RNA pathway operates in a non-reproductive body tissue, called the fat body, in flies and helps sustain life. The study also shows that blocking components of the pathway leads to increased DNA damage, shorter lifespan and poor health.
A new Illinois study makes detailed predictions about an intriguing mechanism of genomic evolution. The researchers modeled the interaction between Alu and L1 elements as a stochastic process, predicting oscillations similar to predator-prey interactions.
The Japanese morning glory genome has been fully decoded, revealing genes that determine flower and leaf shapes, as well as flower colors and patterns. The research also identified a gene involved in plant hormone biosynthesis disrupted by transposons in mutants.
The tarsier genome analysis confirms that tarsiers belong to the dry-nosed primate category, sharing recent transposon families with humans and bushbabies. The study also identified 192 genes linked to the tarsiers' unique traits, which may be associated with human diseases.
A new study strengthens the links between transposons and aging, showing that increased transposon activity correlates with decreased lifespan in fruit flies. The study also reveals that manipulating genes involved in heterochromatin repression can lengthen lifespan, suggesting a potential therapeutic target for age-related diseases.
Researchers at UNC School of Medicine discovered that tight DNA packaging in chromosomes mainly guards against virus-like genetic elements known as transposons or 'jumping genes,' which can copy and paste themselves throughout the genome, potentially destroying important genes. The discovery clarifies the role of heterochromatin and ad...
Scientists have created a four-step process to determine accurate signatures of human embryonic stem cells, relating them to precise developmental stages. The key steps involve analyzing transposable elements and DNA methylation state to assess pluripotency.
Researchers at the University of Illinois have observed transposon activity in real-time using fluorescent microscopy. The study reveals that jumping gene activation is dependent on environmental factors such as food availability.
A 'jumping gene' mutation, a type of transposable element, is responsible for the dark form of peppered moths that emerged during Britain's industrial revolution. The mutation was independently dated to around 1819 and is consistent with historical records.
A new type of transposable element was discovered in certain bird genomes, which also occurred in nematode worms that are human parasites. The finding reveals that these modern human parasite species were birds from 25-17 million years ago.
Researchers at Salk Institute and Cambridge University found that grafted plants can share epigenetic traits, enabling them to communicate with each other. This discovery may allow growers to exploit epigenetic information to improve crops and yields.
Researchers have identified the protein Panoramix, which enables cells to silence specific genes and prevent transposons from disrupting genomes. This discovery provides new insights into the innate defense mechanisms against genetic elements that can cause sterility in animals.
Researchers at EMBL Grenoble have found a way to identify and silence 'jumping genes' that can alter the genetic code, using tiny RNA molecules called piRNA. These piRNAs guide proteins to destroy the genes, preventing uncontrolled changes in DNA.