Articles tagged with Yeast Genomes
Ancient human genomes showed differing functional PSPH gene variants, with modern-day phosphoserine phosphatase having the greatest function. The study highlights potential in combining evolution-guided variant prioritization for uncovering functional differences.
A study found that agricultural antifungals, like TBZ, can cause genomic changes in the infectious yeast Candida tropicalis, increasing its resistance. This increase in resistance poses a growing concern for human infections, as many pathogens are becoming resistant to antifungal medicines.
Researchers discovered that whole-genome duplication persists for thousands of generations due to its advantage in growing larger cells and forming bigger clusters, leading to the development of multicellularity. The study provides new insights into how genome duplication contributes to biological complexity.
The final synthetic chromosome unlocks new possibilities in metabolic engineering and strain optimisation, enabling the generation of genetic diversity on demand. The achievement represents a major milestone in synthetic biology and has important implications for future genome engineering projects.
A team of scientists at Gladstone Institutes has developed a new method that enables them to make precise edits in multiple locations within a cell—all at once. They created a tool using molecules called retrons to efficiently modify DNA in bacteria, yeast, and human cells.
A new study by UNC Charlotte Professor Abigail Leavitt LaBella and colleagues reveals that yeasts do not fit the 'jack of all trades, master of none' adage. They found that yeasts with a broad ability to metabolize different carbon sources are actually efficient growers.
Researchers at U of T have mapped the movement of proteins encoded by the yeast genome throughout its cell cycle, identifying patterns of emergence and disappearance or movement to specific areas. The study provides a unique dataset that offers a genome-scale view of molecular changes during cell division.
Researchers have developed a novel tool for the selective and efficient recovery of large DNA molecules using TAR cloning. This technique has been applied to isolate individual gene alleles, study genome architecture and evolution, and engineer synthetic viruses with novel properties, including vaccine development.
A UK-based team has completed construction of a synthetic chromosome as part of a major international project to build the world's first synthetic yeast genome. The synthetic chromosome allows cells to grow with the same fitness level as natural cells, enabling new applications in medicine, bioenergy, and biotechnology.
Researchers successfully combined seven synthetic chromosomes into a single yeast cell, resulting in a strain with more than 50% synthetic DNA. The team's achievement paves the way for engineering biology and understanding the fundamental principles of genome fundamentals.
Researchers have engineered a chromosome entirely from scratch, contributing to the production of the world's first synthetic yeast. The tRNA Neochromosome forms part of a wider project that has successfully synthesised all 16 native chromosomes in Saccharomyces cerevisiae, common baker's yeast.
A new study reveals that autophagy plays a crucial role in the gradual loss of DNA content in diploid Saccharomyces cerevisiae cells undergoing chronological aging. The researchers found that only diploids survived, and autophagy induction was responsible for the DNA loss.
Researchers from Penn State and Ohio State University used structural biology, biophysics, and cell biology to understand how pioneer factors interact with nucleosomes. They found that a specific region of the protein helps it access DNA, making it accessible for proteins involved in gene expression.
Researchers at NIH's National Human Genome Research Institute identified a gene, KTD1, that provides resistance to the K28 toxin in yeast. This discovery sheds light on the molecular mechanisms underlying toxin resistance and has implications for understanding human toxin resistance.
Researchers at Kobe University have successfully identified and disrupted genes in Pichia pastoris yeast to increase its secretory production of useful proteins. Through a series of processes, they developed new host strains that can produce high yields of proteins for industrial enzymes and biomedical antibodies.
A new mathematical framework has been created to study fitness landscapes of regulatory DNA, enabling the prediction of gene expression changes. The framework uses a neural network model trained on millions of experimental measurements to decipher the evolutionary past and future of non-coding sequences.
A study by EMBL researchers sheds light on how gene placement impacts its expression and neighboring genes, revealing general principles for designing genomes. The team found that transcriptional context alters RNA output, even when the sequence itself remains unchanged.
Researchers have compiled the most complete library yet of lanthanides and their potential toxicity by exposing baker's yeast to lanthanide metals. The study found that lanthanides interrupt cell-signaling pathways, disrupting calcium-binding sites in endocytosis and ESCRT machinery.
The Hi-CO technology provides high-resolution genome structural analyses combined with large-scale simulations, showing the arrangements of the genome's spool-like structures affect gene expression. Nucleosome folding influences the inner workings of genes, impacting accessibility of molecules to DNA.
A high-resolution protein architecture of the budding yeast genome was mapped using ChIP-exo, revealing two distinct gene regulatory architectures. The study identifies a surprisingly small number of unique protein assemblages used repeatedly across the yeast genome, expanding the traditional model of gene regulation.
Researchers identified a nontransitive evolutionary sequence in a 1,000-generation yeast experiment. The study found that an evolved clone outcompetes its recent ancestor but loses to a distant ancestor due to multilevel selection acting on both the yeast nuclear genome and an intracellular RNA virus.
Researchers from GEOMAR and Kiel University discovered a deep-sea red yeast with anticancer and antibacterial effects, producing glycolipids with potential applications in medicine and biotechnology. The study found synergistic effects of certain compounds, opening doors to new pharmaceutical development and biotechnological applications.
A team of researchers has developed a model for acid-tolerant yeast that can produce succinic acid, a precursor for industrial polymer production. The model uses gene editing and computational tools to identify the optimal genetic modifications required to maximize succinic acid production.
A study found that gene retention depends on functional and structural entanglement, which measures interdependency between gene structure and function. This suggests that some gene duplicates are retained due to the limitations of their protein products.
Researchers have discovered seven distinct combinations of yeast species in bottles of beer, wine, and cider, highlighting the complexity of brewing traditions. The study found that some yeasts were hybrids of as many as four species, and that specific genetic traits contribute to the characteristics of fermented beverages.
Researchers have found that Saccharomyces boulardii, a probiotic yeast, produces uniquely excessive amounts of acetic acid. This discovery may pave the path towards improved treatments for intestinal diseases. The study also showed that modifying the yeast's genetic basis could enhance its probiotic effects.
Researchers at Montana State University have developed software to analyze pangenomes, which can help identify genetic variations associated with drought tolerance in plants. The tool also shows promise for diagnosing diseases with a genetic component, such as certain types of cancer.
Researchers at The Hebrew University of Jerusalem recreated a 5,000-year-old brew using yeast from ancient beer jugs, shedding light on the Pharaohs' drinking habits and the brewing techniques of ancient civilizations.
Scientists discovered a lineage of budding yeasts that has lost dozens of genes involved in DNA repair and cell cycle processes. These gene losses result in the yeast's genomes changing rapidly, leading to unique biological characteristics.
Researchers discovered a parasitic yeast species that can kill emerging multi-drug resistant yeast pathogen Candida auris. The study identified genes and proteins involved in the predatory behavior of Saccharomycopsis schoenii, which could lead to new biocontrol agents or novel antifungal agents.
Michael Snyder received the 2019 George W. Beadle Award for his contributions to systems biology, including the development of widely-used technology for simultaneous gene analysis. His work has enabled the tracking of RNA molecules, proteins, and genes in humans, paving the way for personalized medicine.
A new study led by Brenda Andrews and Charles Boone uncovers the role of genetic background in shaping trait inheritance. By analyzing yeast strains, they identified modifier genes that affect gene function and predict biological outcomes from genome sequence alone.
Researchers have identified the genetic underpinnings of lager yeast's ability to ferment at cold temperatures and consume all sugars in wort. This discovery could lead to the development of new, cost-effective brewing strains with novel properties.
A recent study by WiKim has identified five yeast strains responsible for forming white colonies on the surface of kimchi. The research uses whole-genome sequencing and NGS technology to confirm that these yeasts do not produce toxin-related genes, making them safe for consumption.
Researchers sequenced and compared the genomes of 332 yeast species, revealing an extensive picture of their evolution over hundreds of millions of years. The study suggests that yeasts evolved through reductive evolution, losing traits to specialize in specific food sources, with modern yeasts having narrower appetites.
A team of evolutionary biologists reconstructed the genomic and metabolic characteristics of a 400-million-year-old common ancestor of more than 1,000 budding yeast species. This ancestor was metabolically diverse, able to live on a third more food sources than modern counterparts.
Researchers found that nucleosomes inhibit Cas9 binding and target DNA cleavage in yeast cells, but not zinc finger nucleases. Nucleosome position maps may improve genome-editing efficiency for certain applications.
A new system called SCRaMBLE allows researchers to transform yeast at the molecular level, enabling fast-tracked engineering cycles and novel genome combinations. This technology has significant implications for industrial biotechnology, including the production of medicines and fuels.
Scientists have developed a rapid and efficient way to transform baker's yeast, enabling the creation of synthetic yeast strains that can be customized on-demand. This breakthrough could lead to mass production of advanced medicines and have significant implications for the future study of DNA.
Researchers use CRISPR-Cas9 to precisely alter hundreds of genes or features in yeast cells with 80-100% efficiency, identifying gene alterations that trigger or prevent specific behaviors. The approach allows for rapid profiling and identification of key genes and DNA sequence variations associated with traits and diseases.
Researchers have developed a novel CRISPR-Cas9 technology that enables precise editing of any gene in the yeast Saccharomyces cerevisiae by deleting single nucleotide changes. This allows for individual gene studies and optimization of genome engineering, potentially increasing productivity in industries such as ethanol production.
Researchers uncover how different genes work together to keep cells alive, revealing surprising partnerships between genes with unrelated functions. The study provides a roadmap for understanding genetic interactions in complex cells and organisms, including humans.
A team of researchers has estimated the number of protein molecules in a simple cell for the first time, revealing around 42 million molecules. The study's findings provide insights into how cells control protein abundance and may help reveal molecular roots of disease.
A recent study using yeast genome sequencing reveals that only 20% of mutations drive cancer-like growth, while the rest are harmless hitchhikers. The research identifies genetic interactions between mutations that increase growth and proposes a new approach for identifying cancer-causing mutations.
A Kyoto University team developed a genome-wide base-editing technology using the CRISPR Nickase system, which reduces inaccurate edits and improves editing accuracy. The system combines a guide RNA and Cas9 nickase to 'nick' the DNA double helix, resulting in faster generation of yeast mutants and increased precision.
Researchers have successfully integrated cutting-edge technologies to produce novel yeast strains for industrial use, as well as reveal a more sophisticated understanding of the yeast genome. The new method enables exploration of all genes in yeast, identifying previously unknown functions.
The Tianjin University team, led by Professor Ying-Jin Yuan, has successfully redesigned yeast chromosomes synV and synX with the goal of creating a designer genome. The team used innovative educational tools, such as the Build-A-Genome (BAG) course, to train students in DNA synthesis and experimental skills.
Researchers at Johns Hopkins Medicine have designed a fully synthetic yeast genome, dubbed Sc2.0, which is smaller and more customizable than the natural yeast genome. The artificial genome allows scientists to study genetic questions that are difficult to answer with natural yeast, enabling new discoveries in biotechnology.
A global research team, led by NYU Langone's Jef Boeke, has built five new synthetic yeast chromosomes, replacing 30% of the organism's genetic material. The breakthrough enables the creation of designer genomes to address unmet needs in medicine and industry.
Scientists construct five new artificial yeast chromosomes, representing over one-third of yeast's entire genome, paving the way for building the first fully synthetic complex organism. The successful assembly demonstrates genetic plasticity and potential applications in gene therapy, biofuel production, and medicine.
Researchers sequenced genomes of 157 yeast strains used in brewing and found that industrial yeast came from just a few ancestral strains. Genetic patterns revealed clues on when yeast was first domesticated and how humans shaped its development.
Researchers found that beer yeasts have been domesticated in the 16th century, leading to stronger signs of adaptation. In contrast, wine yeasts show fewer signs of domestication due to their limited interaction with humans.
A team of researchers has sequenced the genomes of over 29 yeast species, revealing a wider diversity than expected. The study identifies new genetic pathways and enzymes that can be used to produce biofuels and other valuable products from a range of sugars.
Researchers discovered yeast living in the cortex of lichen species, suggesting a possible role in creating large structures and solving the mystery of why macrolichens are hard to grow in the lab. The study found a variety of yeast species associated with different lichen species from around the world.
The domesticated yeast that makes cold-brewed lager beer is a complex mix of two species, with scientists discovering new strains in Europe and the Americas. Genetic analysis reveals the organism's origins are more geographically diverse than initially thought.
Four-stranded DNA (G4) structures were formed in yeast and could potentially contribute to cancer development. A motor protein called Pfh1 unfolds these structures, ensuring genome stability during replication. The study provides insights into G4 structures and their role in maintaining genome integrity.
Sequencing hundreds of wine yeast strains revealed low genetic diversity and high levels of inbreeding, making it challenging to develop improved wine yeasts. Scientists hope to introduce new genes from diverse strains to create hybrids with unique flavor profiles.
A team led by Professor Fritz Roth found that bakers' yeast can identify harmful genetic mutations more reliably than leading algorithms. By testing the effects of human mutations in yeast, they identified 62% of disease variants as damaging, outperforming computational methods.
A new study reveals that lager yeasts originated from a hybrid of two yeast species, Saccharomyces cerevisiae and S. eubayanus, with two independent origin events detected. The findings suggest that domestication for beer making has placed yeast on similar evolutionary trajectories multiple times.
A new study proposes that the common baker's yeast genome was duplicated by mating between two distinct species, contradicting the current widely accepted theory. The researchers used advanced computational methods to study the origins of the whole genome duplication in yeast.