Articles tagged with Yeast Genomes
Researchers found that yeast modify their genomes to produce more ribosomes in response to excess calories, enabling faster replication and optimal growth. This study reveals a new mechanism by which organisms can adapt to environmental changes.
University of Illinois scientists have engineered a 'jailbreaking' yeast that increases wine's health benefits and reduces toxic byproducts. The new technology allows for precise metabolic engineering, enabling the addition of bioactive compounds from other foods and improving malolactic fermentation.
Researchers at Tufts University found that active transcription promotes DNA repeat expansions, leading to human diseases like Freidreich's ataxia and Huntington's disease. The study used baker's yeast to monitor the effects of transcription on repeat expansions.
Researchers at Stanford University School of Engineering have successfully reprogrammed yeast cells to produce opioids in stainless steel vats, eliminating the need for poppy cultivation. The breakthrough could lead to reliable manufacture of essential medicines while mitigating diversion to illegal use.
Researchers at Duke University mapped fragile sites across the entire yeast genome, finding they occur in areas where DNA replication slows or stalls. These sites are linked to genetic abnormalities seen in solid tumors and can lead to chromosome instability.
Researchers at NYU Langone Health have synthesized a fully functioning chromosome in yeast using computer-aided design, overcoming the biggest hurdle in synthetic biology. The seven-year effort built a chromosome with over 270,000 base pairs, enabling new capabilities and traits in yeast cells.
Researchers sequenced genomes of 42 yeast strains, revealing more variation in S. cerevisiae than its wild relative, S. paradoxus. Subtelomeric regions harbor genome variation contributing to differences in traits between strains.
Researchers used biochemical, structural, and global sequencing techniques to study the H3K4 trimethylation mechanism in a cancer-associated protein complex. They found that the methylase's activity was directed towards specific targets through COMPASS factors that bind to the SET1/MLL front end.
A Tel Aviv University study found that moderate caffeine consumption shortens telomeres, a key indicator of aging and cancer risk, while moderate alcohol consumption lengthens them. The research suggests that environmental factors can impact telomere length, which could inform the prevention and treatment of human diseases.
Researchers found that deleting a single gene in yeast cells leads to compensatory mutations in another gene, which could affect genetic analysis in cancer and other fields. This discovery suggests that genomes are highly interconnected and that removing one part can cause another part to warp elsewhere.
Researchers have developed a new method to analyse the genomes of yeast families, which is several hundred times faster than current methods. The new method uses barcode-enabled sequencing and allows for the analysis of tetrad relationships between spores, enabling the study of complex traits.
Researchers at EMBL discovered that each gene can be transcribed into dozens or hundreds of unique mRNA molecules with different boundaries, affecting gene function and protein production. This variation could equip cells to adapt to external challenges.
A team of scientists has identified a prion that triggers epigenetic changes in yeast, leading to the adoption of a multicellular structure for improved survival. This finding suggests that prions may play a role in beneficial traits and could have implications for understanding human diseases such as cancer.
Researchers have found a virus that can adapt to hosts with modified nuclear genetic codes, contrary to the long-held assumption that such changes prevent new viral infections. The discovery provides evidence of co-evolution between viruses and hosts with altered genetic codes.
Research reveals antagonistic pleiotropy is very common in yeast, where genes can harm or benefit depending on environment. The study's findings have broad implications for human genetics and disease treatment.
Researchers identified 33 genes associated with GAA/TTC repeat instability and expansions in yeast. These findings may have implications for human disease due to the conservation of genetic machinery across species.
A study reveals that repressor proteins like Set2 recruit de-acetylases and chromatin remodelers Isw1 to block histone exchange and prevent erroneous transcription. This mechanism is crucial for maintaining accurate gene expression, which is often disrupted in diseases such as cancer.
A novel yeast strain has been developed that can produce bioethanol from xylose, a previously untapped sugar in plants. The hybrid yeast outperforms existing strains in ethanol production and xylose fermentation efficiency.
A new algorithm developed by MIT and Harvard researchers drastically reduces the time it takes to find a particular gene sequence in a database of genomes. The more genomes it's searching, the greater the speedup it affords.
Researchers decode Dekkera bruxellensis genome, gaining insights into its impact on wine taste. The study enables wine producers to control flavor development, leading to potential cost savings and new wine tastes.
Researchers at Stanford University School of Medicine discovered that common baker's yeast has engaged in promiscuous mating in fermentation vats, leading to a genetic mash-up. This unexpected behavior affects the flavor of wine and makes tracing lineage difficult.
Researchers found prions in one-third of wild yeast strains, creating diverse new traits, nearly half of which are beneficial. This discovery suggests that prions may be an inherent survival mechanism, helping yeasts adapt to changing environments and evolve in response to stress.
Scientists have discovered a new gene involved in lipid synthesis of Plasmodium falciparum, the major cause of human malaria. This breakthrough technique allows for the mapping of genes in the parasite, which could lead to the discovery of new medications and a better understanding of the disease.
Researchers engineered a computer-designed yeast chromosome with an inducible evolution system, allowing them to rapidly introduce genetic changes. This allows for the custom design of organisms that can grow better in adverse environments or produce more ethanol.
Researchers have identified Saccharomyces eubayanus as the wild yeast that fused with domesticated yeast to create lager beer. The discovery resolves a long-standing mystery and sheds light on the origins of one of the world's most popular beers.
Researchers at University of Wisconsin-Madison identified a new gene, CtAKR, that improves yeast's ability to consume xylose, a key sugar found in plant biomass. This breakthrough could lead to more efficient production of renewable fuels from biomass crops.
Researchers found that yeast chromosome complement has decreased in all except one event, a whole genome duplication, where chromosomes fused or broke and recombined. This study sheds light on the evolution of chromosome complements in yeast and other organisms.
Researchers discovered that heat shock protein 90 affects a large portion of the yeast genome, revealing multiple traits simultaneously and instantly. This allows for rapid evolution of interdependent traits, leading to a better adaptation to stressful environments.
Researchers at The Wistar Institute found that the three-dimensional structure of a genome exposes genes to regulation and chromosomal crosstalk. This structure positions groups of related genes near each other, allowing for efficient operation of genetic processes.
Researchers at Cornell University have discovered how protein Mec1 acts as a 'guardian of the genome' in yeast cells. The study shows that Mec1 monitors and repairs machinery responsible for replicating DNA, allowing it to restart and continue replicating.
Researchers successfully created a bacterial cell with a synthetic genome, paving the way for designing bacteria for biofuel production and environmental cleanup. The new method uses a combination of chemical synthesis and genetic engineering to create a 'synthetic cell' that can be controlled by a human-made genome.
Researchers have devised a method to identify genetic material responsible for complex traits in millions of yeast cells, shedding light on the missing heritability problem. By studying regions of the genome that cause specific traits in offspring, scientists can detect subtle patterns previously undetectable.
Researchers found genes in yeast that help form veins and arteries in humans, while also fixing cell walls in response to stress. They identified eight genes that contribute to blood vessel formation in animals and several of these genes are also linked to human breast cancer.
Scientists have discovered a new type of genetic variation that suggests natural selection can act on gene networks, maintaining alternative states within a single species. This finding may be crucial for understanding how pathogens adapt to new stresses and could provide significant advantages in the battle against diseases.
Scientists have analyzed the genome structures of bioethanol-producing microorganisms, uncovering genetic clues that will be critical in developing new technologies needed to implement production on a global scale. The studies identified genomic properties of industrial fuel yeasts that likely gave rise to more robust strains.
Researchers at Duke University Medical Center have sequenced the genome of a biofuels yeast that thrives on turning sugar cane into ethanol. The findings could lead to more efficient biofuel production and aid research into converting cellulose from non-food crops like switchgrass into biofuel.
Researchers are harnessing genomics to improve wine production techniques, reducing costs and spoilage by monitoring protein biomarkers in grapevine and yeast cells. The project aims to develop a handheld device for growers to monitor proteins in vines or berries, allowing for more precise management practices.
Researchers used 'barcoded' yeast mutants to identify novel biological processes and potential drug targets in response to nitrogen-containing bisphosphonate (N-BP) cancer drugs. These findings may open up opportunities for the development of new compounds with antitumor activity.
Scientists discovered variable ribosomal RNA genes in yeast, which are essential to all Earth's organisms. The genes show surprise variation despite being vital for cell function, and hybridization of two yeasts re-set their clocks, providing clues on evolutionary history.
Whitehead Institute researchers have identified 24 prion candidates in yeast, shifting the view from biological anomalies to mediators of trait inheritance. Prions in yeast appear to prepare individual organisms for environmental changes, sometimes providing a survival advantage.
Researchers analyzed three decades of yeast studies to find exponential growth in scientific understanding and productivity trends. They discovered that scientists tend to focus on familiar genes and study important genes before less influential ones.
A new study published in Nature reveals significant genetic differences between individual yeast organisms, with variations of up to 4% compared to 1% between humans and chimpanzees. The findings suggest that human activities, such as wine and beer production, have influenced the evolution of yeast strains.
The study reveals that humans have domesticated yeast strains at many points in history from diverse sources, challenging traditional views on the Tree of Life. The analysis also provides insights into yeast probiotics' contribution to gut health and potential applications for cancer treatment.
Researchers have identified the genomic origins of Saccharomyces pastorianus, a hybrid yeast used in lager brewing. The study reveals two independent origins of today's extant S. pastorianus strains, suggesting that each group derived its Saccharomyces cerevisiae portion from distinct ale yeasts.
Researchers at Stanford University School of Medicine discovered that lager beers originated from an unlikely pairing between two species of yeast, including the long-used ale yeast. The study found that the hybridization event occurred twice, with each partner bringing unique advantages to the match.
Researchers have discovered that broken sections of chromosomes can recombine to form new types of chromosomes, leading to genome diversification. This process is mediated by repeated DNA sequences, which account for half of the human genome.
Researchers from the University of New Hampshire and Indiana University have made a groundbreaking discovery about the patterns of mutation in yeast. They found that yeast mutates by changing one base pair for another, which is different from other model organisms like nematode Caenorhabditis elegans.
Researchers have identified 25 genes that regulate aging in both yeast and nematodes, with significant overlap between nutrient-response pathways. These findings suggest that similar mechanisms may contribute to human aging, providing a foundation for understanding age-associated diseases.
Biofuels from renewable biomass feedstocks are being sought as a significant part of the US energy supply due to limitations in corn-based ethanol production. Researchers have developed new ways to engineer yeast and plant materials to produce desirable traits, holding promise for large-scale production.
Maynard Olson receives $500,000 Gruber Genetics Prize for his groundbreaking work on genome mapping and its potential to revolutionize personalized genomics. The prize honors his contributions to breaking down the human genome into manageable pieces.
Researchers at The Wistar Institute have identified a single molecule required for genome compaction in spores and sperm, a process critical for passing genetic information to offspring. Compaction helps protect the genome from damage and is essential for maintaining fertility in higher organisms.
Researchers created a protein chip containing 5573 purified proteins and performed the first global analysis of protein glycosylation in yeast. This effort identified nearly double the known yeast glycome, including over 100 new N-linked glycoproteins.
The study classified duplicate pairs of genes involved in yeast metabolism into four functional categories: back-up, subfunctionalization, regulation, and gene dosage. These mechanisms play a substantial role in maintaining duplicate genes in the genome.
Researchers have developed a new statistical method to identify linked genomic loci influencing gene expression in yeast, revealing 37% of gene expression traits link to two loci. The technique bypasses overwhelming computations and provides insights into the genetic basis of complex traits.
A comparative genomics study highlights the significance of non-protein-coding DNA sequences in complex species, revealing conserved elements outside protein-coding regions. The study also introduces a new computational tool, phastCons, to identify evolutionarily conserved DNA elements.
A comprehensive annotation of Candida albicans genome paves way for improved diagnostics and therapies. The 6,354 gene annotation will aid in understanding the yeast's role in human diseases.
Researchers discovered a positive role for gene recruitment to the nuclear periphery, with significant implications for cell polarity and development. The study's findings suggest a complex interplay between nuclear organization and transcriptional regulation.
Researchers found that when a gene is working at full capacity, it uses up most of the raw materials needed to produce proteins, leaving little for substitute genes. These substitutes only come into play when the original gene is damaged or deleted, and are activated by transcription factors.
Scientists have found a trackway of fossil genes in the Japanese yeast Saccharomyces kudriavzevii, showing how an organism discards traits when they are no longer needed. The discovery provides insights into the process of evolution and how genetic pathways become obsolete.
Scientists have developed a new method to quickly identify the precise landing sites of gene regulators in yeast, which are essential for understanding how genes and their regulators 'talk' to each other. This breakthrough could lead to a better understanding of diseases such as diabetes and cancer.