Articles tagged with Yeast Mutations
A Penn study found a genetic link between Parkinson's disease genes and manganese poisoning, with the PARK9 protein protecting cells from toxic effects. Manganese poisoning is an environmental risk factor for a Parkinson's-like syndrome.
Scientists express human CLN3 gene mutations in yeast cells to study Batten disease, finding that mutated cells' severity parallels human symptoms. The study also opens new avenues for investigating therapeutic compounds to treat the disease.
Researchers from the University of New Hampshire and Indiana University have made a groundbreaking discovery about the patterns of mutation in yeast. They found that yeast mutates by changing one base pair for another, which is different from other model organisms like nematode Caenorhabditis elegans.
Penn researchers use a novel yeast model to identify segments of mutated TDP-43 protein causing disease. The approach allows for rapid genetic screening to find proteins that can reverse the harmful effects of ALS and FTD.
Scientists at the University of Southern California have achieved a 10-fold life span extension in baker's yeast through dietary and genetic changes. The study, published in PLOS Genetics, suggests that calorie restriction and specific gene mutations may hold the key to controlling cell longevity and preventing age-related diseases.
A mutation in RNA polymerase III enzyme disrupts organ growth in zebrafish, with specific tissues like the intestine being severely affected. The study provides hope for a therapeutic application against cancer by targeting the enzyme's role in protein production.
Researchers found that when a specific helicase is defective, yeast chromosomes become more prone to exchanging strands during DNA repair, increasing the risk of chromosomal rearrangements. This fundamental insight into DNA-break repair may provide new avenues for understanding early-onset cancer syndromes like Bloom's syndrome.
Researchers identified a genetic network in yeast that guards against lethal DNA damage, which could lead to new therapies for human diseases such as cancer and aging. The study used a technology called dSLAM to map the interactions between genes involved in DNA repair, replication, and cell cycle progression.
The GeneDesign program guides the design of DNA segments with exacting specifications required for studying gene function and genetically engineering cells. It automatically diagnoses design flaws in the sequence of bases making up the gene, simplifying the creation of artificial genes.
Researchers at USC discovered that deleting the SIR2 gene can extend life span up to six times longer than normal when combined with caloric restriction. Human cells with reduced SIR2 activity also confirm its pro-aging effect, pointing to a new direction for human anti-aging research.
Researchers at UCSD map yeast gene circuitry to predict new functions and identify disease-causing combinations. The technique, which uses synthetic lethal interactions, could be applied to humans to develop more sophisticated drugs and gene therapies.
Researchers engineered mutations to 700 yeast genes and used computerized analysis to predict gene functions. The developed yeast strains are now commercially available for other researchers.
Researchers used genetically modified yeast to pinpoint mutations responsible for antibiotic resistance in Pneumocystis jirovecii, a pathogen causing severe pneumonia. The study reveals potential targets for designing new drugs to prevent resistance.
A single amino acid change in Rad50 can have far-reaching effects on genetic information transmission, impairing stem cell populations and predisposing to cancer. Mice with the mutation display genomic instability, partial embryonic lethality, and a higher risk of lymphoma development.