Articles tagged with Autoimmune Disorders
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Researchers discovered a lesser-known inflammatory signal triggered by proteins TWEAK and Fn14, which amplify inflammation when combined with TNF. Blocking this 'backdoor' pathway could improve RA treatment for up to 80% of patients.
A recent study from Penn State College of Medicine researchers found that helper T cells, typically involved in fighting infections, become overly activated in failing human hearts, causing damage. The activation of these T cells highlights the impact of inflammation and immune dysfunction in heart failure.
Dr. Manuel A. Friese has been recognized for his groundbreaking work studying the interactions between inflammation and nerve cell death, which drives disease progression in multiple sclerosis (MS). His research aims to identify new therapeutic targets and bring the field closer to stopping disease progression.
Researchers are studying microchimeric cells that can play complex roles in a person's body, including healing wounds and regulating the immune system. However, more research is needed to understand their role in health outcomes, particularly pregnancy complications and autoimmune diseases.
New study finds that progenitor cells in the brain continuously produce new myelin-producing oligodendrocytes, despite being inefficient. This process suggests that treatments harnessing their developmental aspects may increase rapid myelin repair for demyelinating diseases like multiple sclerosis.
The review details the dual role of interferon regulatory factors (IRFs) in regulating essential antiviral responses while mitigating excessive inflammation. IRF proteins have distinct roles, with some driving interferon production and others acting as fine-tuners or negative regulators.
Researchers summarize itaconate biology highlighting its chemical reactivity and therapeutic potential in treating infectious diseases, sepsis, autoimmunity, neurodegenerative disorders. Itaconate exerts biological effects through post-translational modifications, altering protein activity and signaling pathways
Researchers at OHSU have identified specific sites on the NMDA receptor that could potentially reverse the progression of the disease if blocked, offering new hope for treatment and early detection. The discovery was made using near-atomic imaging and raises the potential for a blood test to detect the condition.
Research highlights racial-ethnic differences in pregnancy-related high blood pressure risk, with Pacific Islanders and Filipinos more likely to develop a hypertensive disorder. Early identification and treatment can help prevent serious complications for both pregnant individuals and their infants.
Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
Researchers have created a library of over 400 immune-related factors to reprogram rare immune cell populations. This technique allows for the systematic discovery of 'recipes' for specific immune cells, offering hope for unresponsive patients and advancing immunotherapy.
Researchers identify a concrete biological mechanism that triggers MS, focusing on B cells and Epstein-Barr virus. This understanding may help guide future strategies to prevent or treat MS.
Research reveals molecular interaction between environmental and genetic risk factors triggers MS. EBV and gene variants HLA-DR15 haplotype play key roles in disease onset.
A new study from Karolinska Institutet reveals the Epstein-Barr virus can damage the brain and contribute to multiple sclerosis through molecular mimicry. The researchers found that cross-reactive T cells are significantly more common in people with MS, and targeting these cells may lead to new treatments.
Researchers have discovered that certain gut bacteria with similar structures to the protective layer of nerves can misdirect the immune system and cause it to attack its own nervous system. This mechanism accelerates the progression of multiple sclerosis.
Researchers discovered that a missing piece of myelin in nerve cells slows signal transmission to the thalamus, disrupting communication loops and cognitive tasks. This finding sheds light on symptoms associated with grey matter lesions in MS.
Researchers from Brazil confirm the safety and efficacy of Alternanthera littoralis (Joseph's Coat) in reducing inflammation and modulating inflammatory mediators. The study's findings support the plant's medicinal potential and suggest a safety profile at therapeutic doses.
A Stanford Medicine-led study reveals that a signaling pathway controls the immune response, allowing researchers to potentially treat various diseases. The research focuses on peripheral immune tolerance, which prevents inappropriate attacks on healthy tissue.
A Phase III clinical trial found that over half of patients who received ianalumab for primary ITP maintained safe platelet counts without serious bleeding episodes for at least one year. The study suggests a new treatment option with the potential to improve long-term quality of life for patients.
Researchers at University of Cologne identify p35-mediated CDK5 hyperactivity as a central mechanism limiting nerve regeneration in diabetes. Targeted interventions using peptides restore nerve fiber growth, leading to significant motor and sensory improvements.
Researchers explore innovative avenues for regenerating functional β-cells using stem cells and pancreatic progenitor cells. The dual approach of activating endogenous progenitors and transplanting externally differentiated cells represents a powerful, scalable strategy for T1D management.
Researchers found a significant link between type 1 diabetes and an increased risk of bladder cancer, with people being 4.29 times more likely to develop the disease. The new analysis controlled for tobacco smoking, a factor that obscured the heightened risk in earlier studies.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
A clinical trial at UCI Health has tested a new CAR T-cell therapy for lupus patients. The treatment showed significant reversal of symptoms in the first trial participant, offering hope for future treatments.
Researchers at Gladstone Institutes and UCSF have identified the genetic switches that regulate FOXP3 levels in human and mouse cells. In humans, multiple enhancers work together to keep FOXP3 active, while a repressor keeps it off in conventional T cells. This discovery has important implications for developing immune therapies.
Researchers found that the Epstein-Barr virus (EBV) is directly responsible for triggering lupus, a chronic autoimmune condition. Most Americans carry EBV, which resides silently inside their bodies and can activate autoreactive B cells to attack healthy tissues.
Alec Whited's published study reveals a previously unknown cellular pathway that enhances waste removal, potentially treating autoimmune diseases and improving wound healing. The research, coauthored with a UTA doctoral student, was recently published in Genetics, a prestigious journal.
Researchers found that prasugrel may offer an advantage over ticagrelor for individuals with Type 1 or Type 2 diabetes and complex coronary disease. This is because the two medications are not interchangeable, and treatment with prasugrel may provide better benefits in preventing blood clots and adverse cardiac events.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
Autoimmune hepatitis is often associated with other autoimmune conditions, including thyroid disease, type 1 diabetes, inflammatory bowel disease, and rheumatologic disorders. The study highlights the need for precise diagnostic criteria and interdisciplinary management strategies to optimize outcomes in patients with multi-organ autoi...
Scientists from Rockefeller University have developed a powerful upgrade to IVIG therapy, an engineered antibody that delivers the effectiveness of IVIG at a fraction of the dose in mice. The new molecule is synthesized without human plasma and has shown significant improvement over current IVIG treatments.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
Researchers at MSK Cancer Center developed laboratory models of VEXAS syndrome, a confounding inflammatory disease. They identified new insights into the disease's mechanisms and potential therapeutic targets by mapping molecular circuitry and blocking parts of the
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
Researchers aim to understand how type 1 diabetes manifests by studying vascular-associated fibroblastic cells (VAFs), which may play a key role in the autoimmune disease. The new grant will explore how VAFs interact with the immune system and investigate potential therapeutic targets.
Longitudinal research found that severe stress caused by family structure changes like divorce or separation during infancy triples the risk of developing psoriasis. The study, published in Journal of Investigative Dermatology, emphasizes the need to protect young children from stressful life factors.
Researchers have identified 57 unique proteins in urine that can indicate active damage to the kidneys, enabling non-invasive monitoring of lupus nephritis. This breakthrough could transform diagnosis and treatment for millions worldwide affected by systemic lupus erythematosus.
The new guidelines focus on the role of kidney biopsy, combination immunosuppressive treatment, and kidney protective drugs to prevent chronic kidney disease progression. They also address specific guidance for patients with renal response versus those with persistently active or relapsing disease.
Researchers found SGLT-2 inhibitors reduce autoimmune rheumatic diseases by 11% compared to sulfonylureas. The study analyzed over 2 million adults with type 2 diabetes and suggests these drugs may contribute to a lower risk of autoimmune diseases.
Researchers identify disease-associated radial glia-like cells that contribute to persistent inflammation and neurodegeneration in progressive multiple sclerosis. These cells exhibit characteristic features of radial glia and display hallmark features of premature aging, fuelling a toxic environment that accelerates neurodegeneration.
Scientists have identified two compounds, K102 and K110, that could promote remyelination and modulate immune function in multiple sclerosis. These compounds showed promising results in mouse models and human cells, suggesting potential for treating MS and possibly other neurological diseases.
A new study reveals that stevioside can effectively promote hair follicles to enter the growth phase when combined with minoxidil. The natural sweetener enhances skin absorption of the drug, leading to new hair development in a mouse model of alopecia.
A growing number of patients on GLP-1 receptor agonists may experience altered FDG uptake patterns on oncological PET-CT scans, potentially leading to misdiagnosis. Researchers recommend documenting medication histories to inform interpretation and developing national guidance.
Researchers at La Jolla Institute for Immunology discovered that ALS is likely caused by an autoimmune reaction triggered by inflammatory CD4+ T cells targeting specific proteins in the nervous system. Anti-inflammatory CD4+ T cells may slow disease progression and prolong survival times.
The review highlights the critical roles of phospholipids in regulating immune cell migration, differentiation, and survival, as well as their regulatory effects on inflammation. Dysregulated phospholipid metabolism is linked to various diseases, including autoimmune disorders, cardiovascular disease, and cancer.
The NF-κB signaling pathway plays a key role in regulating immune responses, inflammation, cell development, and proliferation. Research into its functions and mechanisms continues to uncover new breakthroughs in immunology and life sciences.
Ana Campos Codo, a Weill Cornell Immunology and Microbial Pathogenesis Ph.D. student, has been selected for the 2025 cohort of the HHMI Gilliam Fellows Program. The program provides $65,000/year support for up to three years to students and their faculty thesis advisors.
Researchers mapped the surface envelope glycoprotein of human endogenous retroviruses, opening doors to new diagnostic and therapeutic opportunities. The study revealed specific antibodies that target the viral proteins, potentially leading to new cancer immunotherapies and treatments for autoimmune diseases.
Research reveals neuroglia play active role in brain function, driving disease progression through atrophy and functional decline. Therapeutic strategies targeting neuroglial signaling may prevent damage following brain injury or protect against neurodegenerative processes.
A large-scale study published in PLOS Medicine found no association between early life antibiotic exposure and the development of autoimmune diseases in children. Researchers analyzed data from over 4 million Korean children and discovered no increased risk of Type 1 diabetes, Juvenile idiopathic arthritis, or other autoimmune conditions.
A new drug delivery system targeting the spleen could provide more effective treatment options for lupus, a debilitating autoimmune disease. The system uses lipid nanoparticles modified with mannose to deliver medicine directly to the spleen and target critical immune cells thought to drive the disease.
Researchers developed a first-trimester blood test that accurately predicts gestational diabetes risk, using just seven biomarkers. The test's strong ability to distinguish high-risk from low-risk pregnancies could enable early interventions and reduce long-term health burdens.
Researchers at Medical University of South Carolina engineered a new type of immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection. This strategy could level the playing field for patients with limited eligibility for organs due to high rejection rates.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Blum investigates how the immune system interprets what we eat, exploring mechanisms of oral tolerance and signaling that help our bodies tolerate most foods. Her research could enable new immunotherapy strategies for preventing or treating food allergies.
Researchers found that neutralizing the TSLP protein significantly improves Eosinophilic Esophagitis symptoms, suggesting a potential new treatment strategy. The study's findings may also have implications for other allergic disorders.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Researchers discovered that our bodies add sugars to RNA, shielding it from the immune system. This 'sugarcoating' prevents inflammation and helps clean up dead cells.
A study of 107 patients found that starting immunotherapy as early as possible can halt the progression of anti-IgLON5 disease, with intravenous immunoglobulins showing superior results. The average age at diagnosis was 64 years, but only one-third of patients were diagnosed within a year of symptoms.
Researchers at Medical University of South Carolina develop a new approach to preventing lupus nephritis by improving kidney cell function. Exposure to serum from patients with lupus nephritis causes inflammation, but simultaneous exposure to L-sepiapterin reduces inflammation and enhances nitric oxide production.