Articles tagged with Macrophages
A research team led by Wake Forest and Johns Hopkins universities found that mutations in the MSR1 gene are associated with an increased risk of aggressive prostate cancer, particularly in African-American men. The study identified seven potentially important mutations of the MSR1 gene, including one that leads to rapid metastasis.
Researchers found that blocking interleukin-1 can prevent additional brain tissue damage, suggesting a new potential treatment for traumatic brain injury and neurodegenerative diseases. By inhibiting IL-1, macrophage activation is reduced, leading to less inflammation and cell death.
Researchers at MGH identified a key immune system molecule, PGRP-LC, essential for recognizing and ingesting gram-negative bacteria like E.coli. The protein plays a crucial role in the macrophage's response to infection.
Researchers used DNA arrays to understand macrophage responses, revealing that specific bacterial components can activate the immune system. This knowledge will help design therapeutics with fewer side effects and improve disease treatment.
The amyloid beta protein found in plaques stimulates the production of toxic substances that attract new surrounding cells, causing brain cell death. Astrocytes, normally involved in maintaining brain structure, slow down these processes and protect against inflammation.
New research suggests that macrophages are an underappreciated reservoir of virus in HIV infection. Macrophages continue to produce large amounts of an HIV-like virus even after CD4+ T cells are depleted, providing new insight on how the virus survives. This discovery may lead to new strategies for eliminating the virus from the body.
Researchers discovered an enzyme called isocitrate lyase (ICL) that allows TB bacteria to persist in macrophages and evade immune attack. A drug targeting ICL may reduce treatment time for chronic infection. The enzyme's crystal structure has been determined, providing clues for designing drugs to attack persistent TB bacteria.
Researchers found that macrophages can recognize foreign cells using the CD47 protein, not MHC class I as previously thought. This discovery challenges an important dogma and has implications for autoimmune diseases and ovarian cancer.
Investigations reveal that matrix metalloproteinases (MMPs) play a crucial role in communication between disc cells and macrophages, facilitating resorption. The discovery may lead to injectable therapies that encourage natural macrophage activity, offering a non-surgical alternative for herniated discs.
Scientists found that apoptosis induces the processing of EMAP II precursor protein, releasing a biologically active form that recruits macrophages. This process is crucial for tissue remodelling and coordinating cell death during embryonic development.
Macrophages may proliferate in response to HIV integration, causing disease through sequential pathogenesis. Researchers identify potential DNA-interacting drugs to treat AIDS dementia.
Researchers identified a molecular link that enhances cell-mediated antiviral response, which is critical for suppressing HIV replication. The CD86 molecule on macrophages plays a key role in this response, and blocking its interaction with CD8+ cells reduces the immune system's ability to fight the virus.
Scientists at Wake Forest University Baptist Medical Center have found a way to inactivate the CCR5 co-receptor, a doorway for early-stage HIV-1 virus, on the surface of macrophages and lymphocytes. This approach could be used to treat early-stage HIV-infected individuals and potentially prevent infection.
Researchers at Washington University School of Medicine discovered that E. coli can live inside immune-system cells lining the bladder wall, making it harder to treat bladder infections. The bacteria use sticky appendages to cling to these cells and evade antibiotics.
A new study reveals that tissue macrophages play a critical role in triggering the production of HIV in patients with AIDS, leading to increased virus levels despite declining CD4 T cell counts. This finding highlights the importance of controlling opportunistic infections to slow the cycle of virus production.
A study by Prof. Michal Schwartz explains why mammals can't regenerate damaged central nervous system tissue, offering hope for treatment development. Researchers found that macrophages play a crucial role in wound-healing, and 'educating' them may help overcome this obstacle.