Articles tagged with Macrophages
Researchers discovered an enzyme called isocitrate lyase (ICL) that allows TB bacteria to persist in macrophages and evade immune attack. A drug targeting ICL may reduce treatment time for chronic infection. The enzyme's crystal structure has been determined, providing clues for designing drugs to attack persistent TB bacteria.
Researchers found that macrophages can recognize foreign cells using the CD47 protein, not MHC class I as previously thought. This discovery challenges an important dogma and has implications for autoimmune diseases and ovarian cancer.
Investigations reveal that matrix metalloproteinases (MMPs) play a crucial role in communication between disc cells and macrophages, facilitating resorption. The discovery may lead to injectable therapies that encourage natural macrophage activity, offering a non-surgical alternative for herniated discs.
Scientists found that apoptosis induces the processing of EMAP II precursor protein, releasing a biologically active form that recruits macrophages. This process is crucial for tissue remodelling and coordinating cell death during embryonic development.
Macrophages may proliferate in response to HIV integration, causing disease through sequential pathogenesis. Researchers identify potential DNA-interacting drugs to treat AIDS dementia.
Researchers identified a molecular link that enhances cell-mediated antiviral response, which is critical for suppressing HIV replication. The CD86 molecule on macrophages plays a key role in this response, and blocking its interaction with CD8+ cells reduces the immune system's ability to fight the virus.
Scientists at Wake Forest University Baptist Medical Center have found a way to inactivate the CCR5 co-receptor, a doorway for early-stage HIV-1 virus, on the surface of macrophages and lymphocytes. This approach could be used to treat early-stage HIV-infected individuals and potentially prevent infection.
Researchers at Washington University School of Medicine discovered that E. coli can live inside immune-system cells lining the bladder wall, making it harder to treat bladder infections. The bacteria use sticky appendages to cling to these cells and evade antibiotics.
A new study reveals that tissue macrophages play a critical role in triggering the production of HIV in patients with AIDS, leading to increased virus levels despite declining CD4 T cell counts. This finding highlights the importance of controlling opportunistic infections to slow the cycle of virus production.
A study by Prof. Michal Schwartz explains why mammals can't regenerate damaged central nervous system tissue, offering hope for treatment development. Researchers found that macrophages play a crucial role in wound-healing, and 'educating' them may help overcome this obstacle.