Articles tagged with Rheumatoid Arthritis
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Researchers identify fibroblast TGFβ signaling as a key driver of treatment-resistant rheumatoid arthritis. Advances in technology enable precision medicine approaches, promising to improve patient outcomes and quality of life.
A new study by King's College London found that early treatment with abatacept can delay rheumatoid arthritis (RA) onset in people at high risk for several years. The benefits persist even after treatment has stopped, potentially reducing the number of years people live with symptoms and complications.
Two first-in-class antibodies, C01 and C04, have been developed to inhibit inflammation in autoimmune diseases by blocking the high-affinity IgG receptor FcγRI. The antibodies were discovered using a unique immunization method and exhibit higher affinity for FcγRI than human IgG.
A University of Houston researcher identifies a protein that may reduce high ketone levels in diabetic patients, potentially improving health outcomes. The study also shows that the protein promotes muscle ketolysis and running capacity in mice.
Researchers have identified 57 unique proteins in urine that can indicate active damage to the kidneys, enabling non-invasive monitoring of lupus nephritis. This breakthrough could transform diagnosis and treatment for millions worldwide affected by systemic lupus erythematosus.
A new study reveals that population aging is the largest contributor to musculoskeletal disorders globally, accounting for approximately one third of countries and territories. The research highlights the need for targeted public health strategies and healthcare resource allocation to alleviate the burden of these disorders.
Researchers have developed an artificial cartilage material that responds to pH changes in the body, releasing anti-inflammatory drugs precisely where and when needed. This approach could improve arthritis treatment outcomes by continuously delivering pain-relieving medication.
A new study from the University of Birmingham has found that immune ageing may be a driver of rheumatoid arthritis rather than a consequence of the disease. The research detected features of immune system ageing in the earliest stages of RA, even before clinical diagnosis, suggesting that early intervention is possible.
Researchers found that methotrexate significantly lowers systolic blood pressure in people with rheumatoid arthritis. The study suggests that this could be a new benefit of the drug beyond its usual role in treating inflammation, and may also provide protection against heart disease.
Researchers mapped the surface envelope glycoprotein of human endogenous retroviruses, opening doors to new diagnostic and therapeutic opportunities. The study revealed specific antibodies that target the viral proteins, potentially leading to new cancer immunotherapies and treatments for autoimmune diseases.
Researchers found two types of peripheral helper T cells in inflamed joints: stem-like and effector cells. Stem-like cells live in immune hubs and help activate B cells, while effector cells cause inflammation outside the hubs. Targeting stem-like cells may offer new treatment hope for RA patients.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Nanoparticles containing calcitriol and a protein fragment from aggrecan have been shown to regulate dendritic cell activity, reducing inflammation and swelling in RA. The treatment also delays disease onset and reduces joint damage when combined with other medications.
Researchers have discovered a primate-specific cytokine called IGFL2 that plays a crucial role in regulating inflammation in rheumatoid arthritis. IGFL2 boosts the production of autoantibodies and activates immune cells, further amplifying inflammation and joint damage.
A new study by Bournemouth University reveals that spinning can improve recovery outcomes and reduce clinical time needed for physiotherapy treatment compared to standard care. The cycling and education classes prove more cost-effective, contributing to reducing NHS waiting times for hip osteoarthritis patients.
Researchers found that certain antiviral genes become less active with age in people with lupus, leading to fewer inflammatory proteins. This reversal of 'inflammaging' may explain why symptoms improve in some older patients, allowing them to approach healthy aging.
Researchers explore the biological mechanisms of myopenia in RA, finding it affects individuals of all ages, with notable muscle mass loss without concurrent fat loss. The review highlights the diagnostic and therapeutic relevance of myopenia in RA, emphasizing the importance of early detection and tailored management strategies.
Researchers create map of T cell responses to Chikungunya virus, shedding light on chronic disease triggers. They found that people with chronic disease have T cells targeting the same viral epitopes as those who cleared the virus.
Queen Mary University of London scientists have invented a method to predict patient response to biological therapies, reducing the risk of ineffective treatments and improving patient wellbeing. The approach uses gene sequencing and machine learning on joint tissue samples to forecast treatment outcomes.
A groundbreaking study has uncovered the unique architecture of cells and signals inside the joint as inflammation takes hold in children with arthritis. The research provides a new way forward for understanding this condition, which affects over 10,000 children in the UK.
Researchers analyzed immune cell transcriptomes to understand JIA's pathogenesis. Monocytes, monocyte-derived dendritic cells, and platelets are increased in JIA patients, while B-cell responses differ between sJIA and non-sJIA subtypes.
A new protocol has been developed to establish a safer standard for medication use during breastfeeding. The study focuses on the concentration of prednisolone and metformin in breast milk and infant plasma, addressing a significant knowledge gap in human lactation studies.
Researchers at La Jolla Institute for Immunology discovered that CD4+ T cells target Chikungunya virus, leading to chronic inflammation and joint pain. The study suggests that these monofunctional T cells may be the culprits behind arthritis-like symptoms in CHIKV patients.
Researchers have shown that good gut bacteria can manipulate the immune system's response, leading to rheumatoid arthritis. The study found that T cells in the gut can transform into super-powerful and potent cells that attack the body's tissues.
Preet Chaudhary and Michael Selsted, USC innovators, recognized by the National Academy of Inventors for their work on harnessing the power of the immune system. Their research aims to develop new treatments for diseases such as cancer, rheumatoid arthritis, and sepsis.
Fan Zhang's lab uses computational machine learning to analyze large-scale clinical and preclinical single-cell datasets, identifying new markers for prediction. Her team aims to pinpoint changes in the immune system associated with progression from preclinical RA arthritis to symptoms.
New guidelines support safe and efficient use of JAK inhibitors for treating chronic inflammatory diseases like rheumatoid arthritis, psoriasis, and Crohn's disease. The updated consensus statement considers safety concerns, including cardiovascular disease and cancer risk, to ensure individualized treatment decisions.
A study found that misdiagnoses of autoimmune diseases like lupus and vasculitis can lead to increased depression, anxiety, and lower mental wellbeing in patients. Clinicians are calling for greater awareness and support for patients affected by these misdiagnoses.
A recent study by York University researchers has identified a genetic mutation that can shut down an overactive immune response, dramatically reducing inflammation in mice. This discovery may pave the way for a new class of drugs to treat rheumatoid arthritis and other inflammatory diseases.
A study investigates the efficacy of EFC as a potential treatment for RA, showing anti-inflammatory effects on fibroblast-like synoviocytes and alleviating disease severity in animal models. The findings highlight the therapeutic potential of PDIs in RA management.
Research finds ELK3 inhibits ferroptosis and proliferation of rheumatoid arthritis fibroblast-like synoviocytes, affecting their biological activity. ELK3's molecular mechanism involves regulating kelch-like ECH-associated protein 1.
A recent study published in Helion found that individuals who experienced childhood abuse, neglect, or domestic abuse were at a significantly higher risk of developing rheumatoid arthritis and psoriasis. The study used a database of over 16 million Electronic Health Records to analyze the incidence rates of these diseases over a 26-yea...
A new AI model developed by researchers at Penn State College of Medicine can predict the progression of autoimmune disease among those with preclinical symptoms up to 1,000% more accurately. The GPS model integrates data from large genetic studies and electronic health records to identify individuals at high risk of disease progression.
Researchers will analyze tissue samples from 100 patients over three years to understand why some respond better than others to biologic and targeted therapies. The study aims to improve matching of treatments to individual patients, reducing the guesswork and cost associated with ineffective treatment.
A new study from the University of Leeds found that eating oily fish, fruits, cereals, and drinking moderate amounts of beer can lower the risk of rheumatoid arthritis. The research suggests that a tailored diet approach may be more effective for people with autoimmune diseases.
Research found that individuals at risk of developing rheumatoid arthritis have distinct gut microbiome compositions, including an overabundance of Prevotellaceae species. This microbial signature correlates with traditional risk factors and is most pronounced in those who progress to the disease.
A longitudinal study found that bacteria associated with inflammation in the gut increases ten months before patients develop clinical rheumatoid arthritis. Researchers are exploring potential treatments at this early stage to prevent disease progression.
A team of researchers, including Binghamton University's Ahyeon Koh, is working on an innovative project to treat inflammatory bowel diseases like Crohn's and ulcerative colitis. The goal is to create a 'cell factory' in the body that can produce pharmaceuticals to alleviate symptoms.
Researchers have identified two genes, ATXN2L and MMP14, linked to both rheumatoid arthritis and osteoporosis. These genes play a role in apoptosis, immune regulation, and bone metabolism.
A new study reveals that couples living with rheumatoid arthritis who engage in joint problem-solving and emotional support experience lower depression and anxiety. The research highlights the importance of dyadic coping in improving relationship quality and patient well-being.
A comprehensive study found that patients with rheumatoid arthritis pay an average of $3,383 more per year on healthcare expenditures than those without the disorder. The disease also reduces mobility and quality of life, highlighting the need for better support systems and policies.
Researchers propose a better understanding of inflammation in rheumatoid arthritis, identifying an early pathogenic macrophage cell/gene signature that shapes the inflammatory environment. This discovery offers a unique opportunity for early diagnosis and therapeutic intervention, potentially leading to improved patient outcomes.
A recent study has revealed that oral bacteria, specifically Aggregatibacter actinomycetemcomitans, can exacerbate rheumatoid arthritis. The study found that the infection led to increased inflammation and joint damage in animal models.
In this study, researchers found that aged Treg cells exhibit decreased activity and inhibitory function, which is associated with enhanced type I IFN signaling. This leads to impaired Treg cell function contributing to the pathology of elderly-onset rheumatoid arthritis.
A machine-learning tool can effectively and efficiently subtype pathology samples from patients with RA. This may help scientists find ways to improve care for the complex condition by distinguishing between three subtypes of RA. The tool has also yielded new insights into treatment effects in mice, such as reduced cartilage degradation.
Inflammation in RA leads to altered lipid and lipoprotein profiles, with elevated triglycerides, total cholesterol, and LDL-cholesterol levels. Proinflammatory HDL complexes contribute to the proatherogenic phenotype.
Researchers at UVA discovered an unknown cause of long COVID inside lung tissues, promoting chronic inflammation that drives lasting respiratory symptoms. They found that immune cells can go haywire and promote tissue scarring, leading to conditions like interstitial lung disease.
A study of 140 adults with rheumatoid arthritis found a link between inflammatory activity and specific cognitive impairments, including diminished visuospatial abilities and executive functions. Cognitive impairment was recorded in 60% of patients compared to 40% of volunteers.
The WISDOM project aims to integrate healthcare and research data to combat CIMDs through AI-driven models. The initiative hopes to improve disease diagnosis, treatment, and patient outcomes by sharing data securely across borders.
Researchers have discovered several rare types of helper T cells associated with immune disorders such as multiple sclerosis and rheumatoid arthritis. The study found that genetic variants in bidirectional enhancer DNA are linked to specific immune-mediated diseases, including inflammatory bowel disease.
Researchers found that strengthening blood vessel integrity with S1PR1 can prevent inflammation and damage in joints. The study suggests a new therapeutic strategy that could be used in combination with existing immunosuppressive drugs.
Researchers have established a molecular profile of Rheumatoid Arthritis patients who are at increased risk of cardiovascular events. The study analyzed blood serum samples from over 300 patients and identified three groups with similar patterns, revealing that one group is more likely to develop cardiovascular diseases.
Researchers have discovered that metabolism plays a crucial role in the balance between T and B cells, leading to autoimmune diseases. The study suggests that targeting the interaction between immune cells and metabolism could lead to more effective treatments for conditions like rheumatoid arthritis and lupus.
Researchers have identified a suite of genes that activate abnormal growth of sensory neurons in tissues cushioning affected joints, leading to pain without inflammation. The findings may lead to new treatments for patients who do not respond to anti-inflammatory drugs.
Researchers have developed a statistical method called SCENT to establish links between regulatory elements and genes, pinpointing probable causal gene loci for common and rare diseases. The study applied SCENT to multimodal single-cell datasets from various human tissues, discovering insights into DNA regulation in specific cell types.
Researchers identified six blood biomarkers associated with increased cardiovascular risk in patients with rheumatoid arthritis. These biomarkers improved the ability to predict arterial inflammation, an indicator of cardiovascular risk, compared to standard clinical indices.
Research published in RMD Open journal found a strong association between sinusitis and rheumatic disease, with the highest risks for blood clotting disorder and Sjögren’s syndrome. The study used data from Rochester Epidemiology Project and included 1729 adults diagnosed with various rheumatic diseases.
Researchers found no clear link between weather conditions and muscle and joint pain, debunking a long-standing medical myth. High temperatures, low humidity, and dehydration may increase the risk of gout flares.
A Phase 2b clinical trial published in The Lancet found that abatacept reduces progression to rheumatoid arthritis and can also ease symptoms. After a year-long treatment, patients treated with abatacept showed significant reductions in disease onset and inflammation.
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.