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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Urea: The hidden fuel for ocean microbes

A new study reveals that ammonia-oxidizing archaea rely on urea as a nitrogen source, enabling them to flourish in open ocean waters. This discovery challenges existing understanding of nitrification rates and highlights the crucial role of urea in sustaining ocean productivity.

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Ancient clues to modern cytoskeleton development

A new study reveals that ancient microbes like Asgard archaea may have played a crucial role in the evolution of the cytoskeleton. The researchers discovered two proteins, FtsZ1 and FtsZ2, which behave differently and may represent an intermediate stage in the development of modern cytoskeletal networks.

Archaea can kill bacteria with new antibacterials

Researchers identified peptidoglycan hydrolases in archaea that kill bacteria, highlighting the importance of surveying diverse microbes to discover new antimicrobials. These proteins were found in 5% of surveyed archaeal species and show promise as novel antibacterial compounds.

AI uncovers new antibiotics in ancient microbes

Researchers at the University of Pennsylvania used AI to identify previously unknown compounds in Archaea that could fuel the development of next-generation antibiotics. The study, published in Nature Microbiology, found that 93% of the identified archaeasins demonstrated antimicrobial activity against drug-resistant bacteria.

Geobiology: Iron, sulfur, heat – and first life

LMU researchers recreated the first metabolic process of life on Earth, using iron and sulfur reactions to produce energy. The single-celled organism Methanocaldococcus jannaschii grew exponentially, utilizing hydrogen gas as an energy source.

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Origin of life: How microbes laid the foundation for complex cells

Researchers have found a previously unknown group of microbes, known as Asgard archaea, which possess structures similar to those found in eukaryotic cells. These discoveries suggest that Asgard archaea may be the missing link between archaea and eukaryotes, challenging our current understanding of the three domains of life.

Without oxygen: How primordial microbes breathed

Ancient bacteria can respire carbon dioxide and hydrogen into acetic acid to produce ATP. A new mechanism involving sodium ions is activated when acetic acid is produced, driving a molecular turbine that generates energy.

Novel bacteria parasitizing archaea

Researchers at Hokkaido University have successfully cultivated an ultrasmall bacterial strain that parasitizes methanogenic archaea, inhibiting their growth. This discovery represents the first successful cultivation of such bacteria and proposes a new phylum Minisyncoccota, advancing our understanding of microbial ecology.

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Ancient Antarctic microorganisms are aggressive predators

Researchers discovered a new type of parasitic behavior in ancient Antarctic archaea, which can kill their hosts and impact ecosystem balance. The study provides insights into these unique microorganisms' role in supporting Earth's ecosystems and holds promise for biotechnological applications.

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Archaea can be picky parasites

Researchers discovered that certain archaea parasites selectively consume lipids from their host, altering its membrane structure. This change enables the parasite to survive while also affecting the host's response to environmental changes.

Deconstructing the structural elements of a lesser-known microbe

The study reveals that rod shapes are crucial for effective swimming, enabling microbes to navigate their environments efficiently. Advanced microscopy visualized the behavior of proteins inside the cell, confirming the importance of specific proteins in shifting cell shape.

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Limitations of asteroid crater lakes as climate archives

Researchers analyzed dolomite rocks and found a high proportion of C-13, indicating strong methane formation by microorganisms in water with low sulphate content. The sediment's chemical development is controlled by crater floor cooling and water supply, not climatic changes.

Looking for ‘LUCA’ and the timing of cellular evolution

Researchers use molecular dating approach to estimate moment of LUCA's split into bacteria and archaea, as well as eukaryotes' emergence. The study reveals archaea are younger than previously thought, with some potentially living hidden on Earth.

Extracellular cytochrome nanowires appear to be ubiquitous in microbes

Researchers discovered that extracellular cytochrome nanowires are widespread in prokaryotic microbes, including both bacteria and archaea. The findings suggest that these nanowires, composed of a long chain of cytochrome proteins, play a crucial role in microbial metabolism by facilitating efficient electron transfer.

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Archaea in a warming climate become less diverse, more predictable

Soil archaea in a warming climate become less diverse and more predictable, according to a long-term experiment led by Jizhong Zhou. The study found that experimental warming altered the community structure of soil archaea, reducing their taxonomic and phylogenetic diversity.

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Microbes could be used by farmers as natural fertilizer for poor soil

Researchers identified hundreds of microorganisms associated with plant roots and soil, showing potential for developing biological substitutes for phosphorus-based fertilizers. The discovery highlights the importance of microbial communities in supplying essential nutrients like nitrogen.

Shedding light on the origin of complex life forms

Researchers at the University of Vienna and ETH Zurich have successfully cultivated a representative of the Asgard archaea, a group believed to be the closest relatives of eukaryotes. The newly developed model organism, Lokiarchaeum ossiferum, exhibits unique cellular characteristics, including an extensive cytoskeleton and complex cel...

New method reveals marine microbes’ outsized role in carbon cycle

A new study reveals that only a small fraction of marine microorganisms consume oxygen and release carbon dioxide, with less than three percent accounting for up to a third of the process. This discovery has significant implications for our understanding of the ocean's carbon cycle.

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Ending a 50-year mystery, scientists reveal how bacteria can move

Researchers used advanced imaging techniques to understand the structure of bacterial propellers, which are made of a single protein. The study reveals that bacteria push themselves forward by coiling these appendages into corkscrew shapes, and that similar structures have evolved independently in archaea.

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DNA evolves at different rates, depending on chromosome structure

A recent study by Indiana University researchers found that the structure of DNA storage in archaea affects its evolution rate. The study discovered that compacted DNA compartments change at a faster rate than less compacted ones. This discovery has potential impacts on research on genetic diseases like cancer.

Chromatin originated in ancient microbes one to two billion years ago

Researchers at the Center for Genomic Regulation (CRG) found that chromatin, a genetic architecture that protects DNA and regulates gene expression, originated in ancient microbes between 1-2 billion years ago. This eukaryotic innovation has been essential for life since its emergence.

Cover crops not enough to improve soil after decades of continuous corn

Researchers found that short-term cover crop use cannot reverse decades of soil microbial dynamics in response to unsustainable practices. Long-term fertilization disrupted nitrogen cycling communities, while cover crops enhanced biodiversity but had both positive and negative effects on soil microbes.

Origin of complex cells started without oxygen

Eukaryotes emerged in an anoxic environment in the ocean, and their mitochondria-bearing cells likely resulted from a merger between archaea and bacteria. This finding contradicts the long-held view that oxygenation of Earth's surface environment led to eukaryogenesis.

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Predatory bacteria

Researchers have identified Velamenicoccus archaeovorus, an ultramicrobacterium that devours Methanosaeta cells in sewage treatment plants, leading to a new understanding of biomass conversion and recycling in deep sediments. The giant protein encoded by the gene enables it to dissolve cells.

Exeter biologists investigate smallest propeller on earth

Researchers have discovered a new type of tiny propeller used by archaea, with implications for human health and technology. The study found that the filament is made up of thousands of copies of two alternating proteins, enabling it to move and propel the cell at high speeds.

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Untangling a DNA replication mystery may lead to new antimalarial drugs

A team of scientists has discovered that the enzyme DNA topoisomerase VI plays a critical role in removing chromosome tangles in plants, which may lead to new antimalarial drug targets. The study provides unprecedented insight into the mechanism of action of this enzyme and its potential applications in plant breeding.

Microbes produce oxygen in the dark

Researchers have discovered that certain microorganisms, such as Nitrosopumilus maritimus, can produce oxygen in the absence of sunlight, possibly deep below the ocean surface. These microbes play a crucial role in the nitrogen cycle and remove bioavailable nitrogen from the environment.

From the oilfield to the lab: How a special microbe turns oil into gases

Researchers have successfully cultivated an archaeon called Methanoliparia from an oil production facility, which can convert oil into methane and carbon dioxide on its own. The microbe's unique genetic make-up gives it the ability to break down various hydrocarbons and activate enzymes that produce methane.

Microorganisms produce elemental carbon

Researchers discovered that certain microorganisms can form elemental carbon without high temperatures and pressures, challenging current scientific understanding. The formation of this carbon is believed to be linked to the symbiotic relationship between archaea and their partners.

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New insights into how the CRISPR immune system evolved

Researchers at Aarhus University have discovered that a part of the CRISPR-Cas system originated from toxin genes in bacteria and archaea, providing new insights into its evolutionary process. The study reveals an ongoing battle between microorganisms and viruses, with the discovery of anti-CRISPR proteins blocking the immune system.

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New ethane-munching microbes discovered at hot vents

Researchers at the Max Planck Institute for Marine Microbiology have discovered a new microbe, Ethanoperedens thermophilum, that eats ethane and grows faster than previously known microbes. The discovery sheds light on the mechanism of ethane degradation and its potential for biotechnological applications.

Light driven proton pump in distant relative

Researchers discovered a novel light-sensitive protein in Asgard archaea that functions as an inward proton pump, opening possibilities for controlling pH levels in cells or microorganisms with light. This finding could lead to the development of new biomolecular tools and applications in optogenetics.

Acid-loving microbe can improve understanding of past climate

Researchers from Dartmouth College used an acid-loving microbe to improve the accuracy of past climate records by studying its response to food and energy availability. The findings suggest that factors other than temperature can influence the membranes of single-celled archaea, adding complexity to paleoclimate studies.

CalDigit TS4 Thunderbolt 4 Dock

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Mystery of marine recycling squad solved

Researchers have solved the mystery of marine nitrogen cycling, discovering that abundant nitrite oxidizing bacteria, Nitrospinae, are more active and efficient than previously thought. This reveals a key to their low abundance despite being crucial in the process.

How cells get moving

A research team has identified essential proteins for archaeal motility and its structure, revealing a complex protein complex that enables archaella to swim. The discovery provides insights into the unique mechanism of archaeal movement, distinct from bacterial flagellum-based locomotion.