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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Scientists find a place on Earth where there is no life

A French-Spanish team of scientists has confirmed the absence of microbial life in Dallol's multi-extreme ponds. The researchers used various methods to detect and classify microorganisms, including massive sequencing of genetic markers and chemical analysis.

Archaea hold clues to ancient ocean temperatures

Scientists have identified proteins that allow archaea to adapt to extreme water temperatures, providing a new method for estimating historic ocean temperatures. The discovery resolves uncertainties in the use of archaeal lipids as paleotemperature proxies.

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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.

Tungsten as interstellar radiation shielding?

Researchers discovered a nanoscale tungsten-microbial interface that enables the growth of heat-loving microorganisms. This finding has implications for the survivability of microorganisms in outer space and the potential use of tungsten as interstellar radiation shielding.

Marine microbiology -- Successful extremists

A new study reveals that Archaea, particularly the ammonia-oxidizing Thaumarchaea, dominate oxygen-poor deep-sea sediments due to their efficient metabolic system. This discovery sheds light on the importance of these microorganisms in the geochemical carbon and nitrogen cycles.

Necrophagy: A means of survival in the Dead Sea

Researchers from UNIGE discovered that bacteria can thrive in the Dead Sea's sediments, surviving extreme conditions by feeding on ancient corpses. This finding has significant implications for searching for life on other planets and highlights the importance of understanding how microorganisms adapt to hostile environments.

New key players in the methane cycle

Researchers have identified new key players in the methane cycle, discovering widespread metabolic pathways in archaea. The study found that different variants of methane metabolism are common in these microorganisms, suggesting a greater importance in global carbon balancing than previously thought.

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Study of archaeal cells could teach us more about ourselves

Scientists studying archaeal microorganisms discovered essential genes critical for their growth, which may hold clues to the origin of eukaryotic cells. The research also found that archaea have unique surface structures that provide protection, contradicting previous beliefs.

Small but versatile

New research reveals that marine ammonia oxidizing archaea can use cyanate and urea as alternative energy sources, enhancing their metabolic capabilities. This discovery sheds light on the remarkable adaptability of these microorganisms, which play a key role in the marine nitrogen cycle.

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A microbe's membrane helps it survive extreme environments

Stanford researchers discovered a protective lipid-linked cellular membrane in archaea, allowing them to thrive in highly acidic habitats. The discovery could provide new evidence about the evolution of life on Earth and shed light on molecular fossils.

Not in the DNA: Epigenetics discovered in single-celled archaea

University of Nebraska-Lincoln researchers found epigenetic traits in Sulfolobus solfataricus, a species of archaea that thrive in acidic environments. The discovery could accelerate the study of epigenetics in humans, potentially leading to new insights into trait inheritance and management.

Smallest life forms have smallest working CRISPR system

Researchers found a compact CRISPR gene-editing machinery in ancient microbes, dubbed Cas14, which is smaller than other Cas proteins and has the potential to improve rapid diagnostic systems for infectious diseases, genetic mutations, and cancer. The discovery of Cas14 could provide a powerful addition to diagnostic tools.

'New life form' answers question about evolution of cells

Researchers from University of Groningen and Wageningen University created a micro-organism with a mixed membrane, contradicting the idea that this was an unstable mixture of lipids. The new life form was stable and grew at normal speed, supporting the hypothesis that a mixed membrane can be stable.

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Incentive to move

Researchers have identified the structure of a central protein used by archaea to determine direction, revealing significant differences from bacteria. This discovery sheds light on how archaea can adapt to extreme environments and colonize new habitats.

Cellular division strategy shared across all domains of life

The study reveals that archaea use the same mechanism to regulate cell size as bacteria and budding yeast, with some variability in precision. The researchers found that Halobacterium salinarum controls its size by adding a constant volume between two events in the cell cycle.

Fossil evidence of early Archaea

Researchers have discovered fossil evidence of early Archaea life forms in Western Australia's Apex chert formation, dated to approximately 3.5 billion years ago. The findings suggest that methane cycling between producer and consumer organisms was a significant component of the early biosphere.

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Techniques used in forensic science help discover new molecular fossils

Researchers have discovered new molecular fossils of archaea using forensic science methods, providing insight into the distribution and timeline of these ancient microorganisms. The study used gas chromatography-mass spectrometry to analyze sedimentary rock samples from southern China, revealing previously unknown fossils.

Origins of DNA folding suggested in archaea

A study published in Science reveals that archaeal DNA folding is identical to the process found in more complex organisms, suggesting an early prototype for the eukaryotic nucleosome. This discovery sheds light on the evolutionary origins of genome folding and raises questions about the common ancestor of life.

New insights into the ancestors of all complex life

A team of scientists has provided a new evolutionary tree for Archaea, resolving their deepest relationships. The study suggests that early Archaea likely used the Wood-Ljungdahl pathway to make energy, dating back over 3.5 billion years.

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Which genes are crucial for the energy metabolism of Archaea?

A study on Nitrososphaera viennensis reveals that specific genes and adaptations enable terrestrial archaeal ammonia oxidizers to thrive. The research provides insights into the energy metabolism of Archaea and its implications for agricultural soils and potential medical applications.

Life as we know it most likely arose via 'long, slow dance'

Researchers propose that eukaryotic life arose through a gradual transfer of molecular machinery from archaea to bacteria. The discovery of Lokiarchaeum's genome reveals a complex organization, sparking debate about the earliest stages of eukaryogenesis.

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Nano power grids between bacteria

Researchers have found nano-wire connections between thermophilic AOM consortia, enabling energy transfer between archaea and sulphate reducers. These direct power wires facilitate the growth of sulphate reducers, providing insight into the anaerobic oxidation of methane.

Scientists unlock the secrets of a heat-loving microbe

Researchers discovered how Sulfolobus, a superbug that thrives in 80°C environments, transfers its genetic material to new cells during cell division. This finding sheds light on the origins of life and may lead to breakthroughs in understanding life beyond Earth.

Lab experiments question popular measure of ancient ocean temperatures

Researchers found that sediment-entombed marine archaea's growth varies based on changes in ocean oxygen levels, affecting the accuracy of past ocean temperatures. This discovery highlights the need to consider oxygen levels when interpreting the TEX-86 index, a popular method for measuring ancient ocean temperatures.

Closer look at microorganism provides insight on carbon cycling

Researchers discovered novel enzymes in microorganisms called archaea that break down organic matter into carbon dioxide, with implications for climate change. The study found that an increase in ocean temperature accelerates this process, releasing more carbon dioxide and methane into the atmosphere.

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Surprise from the deep ocean

A new study has uncovered Lokiarchaeota, a missing link in the evolution of eukaryotes, revealing unexpected complexity in its genome. The discovery provides insights into the emergence of organelles and cellular structure in early eukaryotic cells.

The 'intraterrestrials': New viruses discovered in ocean depths

Scientists have discovered a new virus infecting archaea beneath the ocean floor, which selectively targets one of its genes for mutation. The study also reveals that these microorganisms use a novel mechanism to accelerate genetic adaptation, targeting at least four distinct genes, and this process may be key to their survival.

Surviving in hostile territory

A team of UC Santa Barbara scientists discovered a new virus that selectively targets one gene for mutation, allowing it to thrive in extreme environments. They also found that some archaea do the same, targeting multiple genes and accelerating genetic variation through guided mutation.

Our ancestor's 'leaky' membrane answers big questions in biology

Researchers at UCL used mathematical modeling to find that life's Last Universal Common Ancestor (LUCA) had a 'leaky' membrane, enabling it to harness energy from its surroundings. This discovery answers two big questions in biology: how cells harvest energy and why bacteria and archaea have different cell membranes.

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Vitamin water: Measuring essential nutrients in the ocean

University of Washington researchers used new tools to measure and track B-12 vitamins in the ocean, finding that marine archaea can supply this essential vitamin. The results show that B-12 is present in small amounts in all water samples, with low concentrations indicating potential deficiency among tiny marine algae.

How Archaea might find their food

A German-American research team identified a sensor protein called MsmS in the microorganism Methanosarcina acetivorans. MsmS may serve as a 'food sensor' to detect energy sources, similar to bacteria but with potential differences in signal transduction systems.

4 cells turn seabed microbiology upside down

Scientists have retrieved four seabed archaeal cells and mapped their genome, revealing they live on protein degradation. This breakthrough opens up new knowledge for microbiologists, allowing them to study individual microorganisms directly from nature.

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UGA researchers shed light on ancient origin of life

University of Georgia researchers discovered essential genes in archaea that shed light on the history of microorganisms and the origins of life. The study found unique DNA synthesis systems, essential genes necessary for methane production, and insights into cell formation.

Revealing the secrets of motility in archaea

Researchers from Berkeley Lab and Max Planck Institute analyze unique microbial motor, revealing a dynamic play among its components. The study found that the archaellum consists of two parts, with a globular C terminal domain connected to a more variable N terminal domain.

Synchrotron infrared unveils a mysterious microbial community

Scientists unveil the biochemistry of a unique microbial community living together in a cold sulfur spring, revealing symbiotic relationships between archaea and bacteria. The study uses synchrotron infrared to identify metabolic activities and protein structures, shedding light on a previously unknown lifestyle.

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Dust-plumes power intercontinental microbial migrations

A recent study published in Applied and Environmental Microbiology reveals that transpacific dust plumes carry thousands of unique microbial species to North America. The researchers detected archaea at high altitudes, which has potential applications in biotechnology and medicine.

Scientists document first consumption of abundant life form, Archaea

A team of scientists from Oregon State University has documented for the first time that animals can consume Archaea, a type of single-celled microorganism. This finding adds a wrinkle to scientific understanding of greenhouse gas cycles and opens up new avenues of research into the roles of Archaea in ecosystems.

Crystal structure of archael chromatin clarified in new study

Researchers have elucidated the crystal structure of Alba2-DNA complex in archaea, revealing a hollow pipe-like structure that compacts DNA. This discovery provides valuable clues into the evolution of chromatin structure and its connection to diseases.

Last universal common ancestor more complex than previously thought

Researchers found that the polyphosphate storage site represents the first known universal organelle, present in bacteria, archaea, and eukaryotes. This discovery challenges traditional definitions of bacterial organisms, suggesting LUCA was more complex than previously thought.

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Hot springs microbe yields record-breaking, heat-tolerant enzyme

Researchers found a microbe in a Nevada hot spring that can digest cellulose at temperatures near boiling point, producing a record-breaking hyperthermophilic cellulase. The enzyme is the most heat-tolerant found in any cellulose-digesting microbe, with applications for biofuels production and industrial processes.

Old life capable of revealing new tricks after all

A type of Archaea, Methanosprillum hungatei, has been found to contain highly efficient energy-storage structures that can store 100-fold more energy than the entire cell. These granules could potentially be used as a chemical battery for engineered synthetic cells.

Caltech researchers reveal unexpected sources of nitrogen fixation

Researchers at Caltech have discovered that methane-consuming archaea are actively fixing nitrogen and sharing it with their bacterial neighbors. This finding may help explain the discrepancy between known sources and sinks of fixed nitrogen in the global nitrogen cycle.

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Proteins strangle cell during division

Researchers discovered a new mechanism for cell division in Sulfolobus acidocaldarius, revealing three proteins that form a band-like structure over the cell equator. This unique process could lead to new insights into ESCRT proteins and their role in protein transport within cells.

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Bold traveler's journey toward the center of the Earth

Researchers found a unique microorganism, Desulforudis audaxviator, living in complete isolation with no sunlight, oxygen, and extreme heat. The bacterium survives by harnessing energy from hydrogen and sulfate produced by radioactive decay of uranium, and has a remarkable genome with 2,157 protein-coding genes.

Researchers see history of life in the structure of transfer RNA

A new study reveals that transfer RNA (tRNA) preserves the earliest events of evolutionary history in its structure. The researchers used detailed data to reconstruct the tRNA family tree and determine the order of emergence for viruses, archaea, bacteria, and eukarya.

Ancient organisms discovered in Canadian gold mine

Scientists have found evidence that archaea and other life domains coexisted for at least 2.7 billion years, challenging current understanding of the history of life on Earth. The discovery was made in a deep Canadian gold mine, where oily lipid remains of ancient archaea were analyzed using advanced techniques.