Articles tagged with Bacterial Defenses
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Researchers at University of South Carolina develop a new method to restore antibiotics' power, using protective polymers to combat bacterial defenses. The approach has shown promise in lab tests, particularly against hospital-associated strains of MRSA.
A single molecular switch governs production of protective mucus lining intestinal walls, which can be breached by failure of immune system, leading to diseases like inflammatory bowel disorders and metabolic conditions.
Researchers followed the evolution of E. coli bacteria in the presence of macrophages, observing the rapid emergence of pathogenic traits. The study reveals that the movement of small DNA fragments drives bacterial adaptation to evade immune defenses.
Researchers discovered that symbiotic bacteria inside beetles suppress plant defenses against chewing insects, allowing beetles to thrive. The findings suggest a new way plants can be vulnerable to insect attacks.
Researchers found that bacteria form micro-colonies in a pattern similar to economic systems, where a small number of lucky cells have access to resources. This process enables biofilms to develop, making infections potentially deadly. The study may lead to new treatment options using incentives and communication.
Researchers at UCLA, Northwestern University, and the University of Washington have identified the strategy by which bacteria form initial colonies in biofilms. The study reveals that a small number of 'lucky' cells become the elite cells that start the colonies, organizing in a pattern similar to wealth distribution in the US economy.
Researchers found that T2R38 is expressed in upper respiratory tract cells and activated by bacteria, correlating with increased susceptibility to sinus infections. Genetic variation in the T2R38 gene contributes to individual differences in respiratory infection risk.
Researchers propose that certain dietary fats encourage the growth of harmful bacteria, leading to low-level inflammation and chronic disease. Unsaturated fats, like omega-3 fatty acids, have strong antimicrobial properties, weakening bacterial cell membranes.
A team of researchers discovered that human alpha-defensin 6 (HD6) forms 'nanonets' around microbial surfaces to disable microbes, providing clues to inflammatory bowel diseases like Crohn's disease. The study provides new insights into the body's innate defense system and its role in intestinal health.
A new rapid-cooling process can extend egg shelf life by up to 12 weeks, maintaining protein quality and preventing bacterial invasion. The technology uses liquid carbon dioxide to cool eggs quickly, reducing the risk of salmonella illnesses.
Researchers at the University of Texas at Austin have uncovered the mechanism behind V. cholerae's resistance to human immune responses. The discovery could lead to the development of a new class of antibiotics that target the bacteria's defenses, rather than directly killing them.
Bacteria use riboswitches to detect and counteract the effects of fluoride, a key component of toothpaste. The discovery sheds light on how microbes overcome fluoride toxicity, potentially leading to new treatments for dental health issues.
A recent study by NYU School of Medicine reveals that hydrogen sulfide (H2S) plays a crucial role in protecting bacteria from various antibiotics. By targeting bacterial gas defenses, researchers aim to develop new strategies for increasing antibiotic efficacy and combating antibiotic resistance.
Researchers discovered a transporter system in bacteria that protects itself from immune attack by transporting molecules meant to destroy it away from its inner membrane target. This mechanism helps bacteria survive in the host, but also presents an opportunity for developing novel antibiotics.
Researchers at Indiana University School of Medicine have discovered that innate immune system proteins can induce bacterial cell walls to self-destruct. The proteins, called Peptidoglycan Recognition Proteins (PGRPs), target bacteria by exploiting a defense mechanism used by the bacteria themselves.
A team of researchers led by Malak Kotb has found that as dominant members of a bacterial community surrender to host immune defenses, they are replaced by a hyperaggressive, mutant minority population that thrives and takes over. This study provides new insights into the dynamics of bacterial evolution in live species.
Bacteria have a CRISPR defence system that can be passed down to future generations, providing immunity against viral attacks. This system could be exploited to give bacteria 'flu jabs' to protect them against real-world threats, increasing industrial productivity and reducing costs.
Researchers at the University of California, San Diego, have discovered that flesh-eating bacteria can survive and spread in the body by degrading a key immune defense molecule. By inactivating this molecule, white blood cells become slower and weaker, allowing infections to spread out of control.
Researchers have solved the structure of two proteins that enable bacteria to develop resistance to various types of antibiotics, providing insights into their evolution and design strategies for new drugs. This discovery could aid in developing effective treatments against antibiotic-resistant infections.
Researchers have discovered a weakness in the defenses of the anthrax bacterium that could be exploited to produce new antibiotics. Nitric oxide is a critical part of Bacillus anthracis's defense against the immune response, and disrupting this system could make it vulnerable to attack by macrophages.
Researchers at NIAID discovered a survival mechanism in gram-positive bacteria that protects it from antimicrobial peptides, which are defense molecules sent by the body to kill bacteria. The discovery may help chart a path to designing new drugs to bolster our antimicrobial treatment options.
The Burroughs Wellcome Fund has awarded $8 million to 16 researchers investigating infectious diseases, including HIV, Pseudomonas aeruginosa, and Plasmodium falciparum. The awards aim to support multidisciplinary approaches to understanding the interaction between humans and pathogens.
Researchers developed a new system to monitor disease dynamics in mice infected with meningococci, offering insights into the disease's progression and potential for improved vaccines. The study found that modified bacteria lacking certain adhesins could not attach to mucous linings, providing a clearer picture of infection processes.
Researchers discovered a new immune defense mechanism that produces a highly effective antibacterial compound called hypothiocyanite. However, this process is defective in airway tissue and cells containing the CF gene mutation, suggesting that thiocyanate levels may be low in CF patients.
Scientists have redefined the role of plant pores in defense against bacterial pathogens, discovering that stomata can sense danger and respond by shutting down. The study found that some bacteria produce a phytotoxin to reopen shut-down ports, highlighting a key step in the attack.
New antibiotics mimic bacterial cell wall components to deactivate key defense mechanism, potentially effective against vancomycin-resistant MRSA and other bacterial strains. More studies needed to verify mechanism and determine its potential as a new line of defense against antibiotic resistance.
A new study reveals how bacteria, such as Haemophilus influenzae, stimulate the immune system to eliminate competitors like Streptococcus pneumoniae. The findings also suggest that antibiotics and vaccines targeting one microbe can impact interactions among other species present.
Researchers show that HIF-1 alpha regulates bactericidal agents and enhances expression of bacteria-killing cells. Increasing HIF-1 activity increases the killing capacity of phagocytes, providing a novel approach to treating bacterial infections.
Researchers solved the three-dimensional crystal structure of CD14, providing insights into its binding to LPS. The receptor has a large hydrophobic pocket that accommodates various ligands, including LPS and other microbial products.
A substance called poly-gamma-DL-glutamic acid (PGA) has been shown to protect Staphylococcus epidermidis bacteria from natural human defenses. The discovery could lead to new treatments for S. epidermidis infections, which can cause serious conditions like sepsis and endocarditis.
The study reveals that Strep bacteria employ a dual strategy to outsmart the immune system: producing a toxic 'sword' called hemolysin to kill immune cells, and an antioxidant 'shield' made of carotenoids to protect itself from oxidative damage. This unique approach makes GBS a more lethal pathogen.
Researchers at the University of Rochester Medical Center have discovered that S. mutans, the primary bacterium responsible for tooth decay, has a vulnerable gene called fabM that enables it to withstand acidic environments. By targeting this gene, scientists may be able to develop new compounds to kill S. mutans and reduce cavities.
A recent University of Pittsburgh study found that women with bacterial vaginosis (BV) are nearly twice as likely to get herpes simplex virus type 2 (HSV-2). The study, which involved over 1,200 sexually active women, suggests that more comprehensive screening and treatment could reduce susceptibility to HSV-2.
Scientists have identified a mechanism by which neutrophils can neutralize disease-causing bacteria like Shigella and Salmonella. Elastase, an enzyme produced by neutrophils, destroys virulent proteins in bacteria, allowing for the mobilization of other defenses that can destroy the bacteria.
Jayraman et al. used fluorescent indicators to measure ASL salinity in normal human and CFTR-/- mice, finding no significant difference between the two groups. This noninvasive approach may provide new insights into lung diseases with poorly understood ASL properties.
Researchers at the University of Wisconsin-Madison have designed a new type of molecule that exhibits wide-spectrum antimicrobial activity, including effectiveness against resistant bacteria. The synthetic beta-peptides mimic naturally-occurring peptides found in nature and have shown promise in laboratory tests.
Researchers found that when E. coli attaches to the bladder lining, it triggers a natural defense mechanism where bladder cells commit suicide and slough off, but some bacteria can avoid being removed by invading deeper tissue. This could explain why patients experience recurrent bladder infections despite antibiotic treatment.
A University of Michigan study analyzes data from various studies to show that whole-body metabolic rate changes over the course of the menstrual cycle, becoming about 7 percent lower after menstruation. This metabolic cycling saves an amount of energy equivalent to six days' worth of food over four menstrual cycles.
Researchers found that nitric oxide activates genes directly, controlling basic life processes down to the gene level. The discovery suggests a universal signaling molecule with far-reaching implications for health and disease.
Researchers find nitric oxide controls genes, influencing myriad body functions. The discovery offers a new approach to developing antibiotic drugs to disarm invasive bacteria.