Articles tagged with Bacterial Genetics
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Researchers have identified a previously unknown mechanism that can reduce the risk of allergies and asthma in children. Certain bifidobacteria produce a substance called 4-hydroxyphenyl lactate (4-OH-PLA), which dampens immune responses to allergens, reducing the production of IgE antibodies.
Researchers discovered a tiny RNA molecule called PreS that helps viruses copy their DNA more efficiently and boost replication in bacterial cells. This discovery provides important insights for designing smarter phage-based therapies against antibiotic-resistant infections.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
Scientists have developed a new strategy to combat antibiotic resistance by studying the competition among plasmids within bacterial cells. By isolating individual cells and measuring intracellular plasmid competition, researchers discovered basic properties of plasmid and bacteria fitness and evolution.
A new organism, Solarion arienae, and its unique predatory structure have been discovered, providing insight into the earliest stages of complex life. The research team identified ancient mitochondrial pathways and established a new phylum, Caelestes, reshaping our understanding of eukaryotic evolution.
Researchers used an experimental evolution approach to map genetic mutations in A. baumannii treated with tigecycline and colistin, confirming and extending existing knowledge on major mechanisms of resistance. The study's findings aim to develop genomics-based predictions of drug resistance and susceptibility.
A recent study found extensive antibiotic resistance in Haemophilus influenzae, a type of bacteria causing up to 200 million childhood infections. Despite this, the team discovered surprisingly little genetic variation, suggesting a universal vaccine targeting shared features could be developed.
Researchers have discovered a promising new antibiotic, pre-methylenomycin C lactone, which is over 100 times more active than the current antibiotic methylenomycin A. This finding provides hope in the fight against antimicrobial resistance (AMR), which affects millions of people worldwide.
The Global Pathogen Analysis Platform (GPAP) will enable low- and middle-income countries to conduct research and surveillance of infectious diseases independently. The platform aims to prevent disease outbreaks from developing into pandemics by detecting genetic sequences of potential pathogens.
A key molecular player, RfaH, has been identified as a protective shield for bacterial genes, enabling them to survive the hostile environment inside the body. The protein ensures transcription runs to completion, making it an anti-terminator that prevents premature termination of gene expression.
A new study reveals rising rates of invasive SDSE infections across Australia, particularly among older Australians and those from remote regions. The research highlights disparities in health outcomes between regions and populations, emphasizing the need for improved surveillance and prevention strategies.
Researchers have developed a new technique called Dual transposon sequencing to rapidly identify genetic interactions in bacteria. This method reveals vulnerabilities that could be targeted by future antibiotics.
A recent study by Michigan Medicine researchers has found that CRISPR-Cas9 forms immune memories in bacteria by boosting spacer acquisition when RNA levels are low. This discovery expands our understanding of how bacteria safeguard their immune memory and may inspire new ways to design CRISPR-based molecular recording tools.
Researchers found that a pandemic clone of Vibrio parahaemolyticus, which causes seafood-related infections, evolved by losing genes involved in putrescine use. This led to stronger biofilms and better human transmission, supporting the virulence trade-off hypothesis.
A new study reveals bacteria can survive inside dust particles transported through desert storms, carrying new genes that may affect human health. The research team identified a beneficial bacterium from the Bacillus subtilis family, which could enhance applications in agriculture, construction, and medicine.
A study published in the International Journal of Food Microbiology identified Cronobacter sakazakii's genetic survival strategies, revealing a higher prevalence of genes associated with DNA recombination and desiccation resistance. The findings suggest that accessary genes may enable the pathogen to persist in various environments.
Scientists identified a unique protein in bacteria that can trap parts of the membrane, causing damage to other bacteria. This discovery reveals a new 'superfamily' of lipid-trapping proteins, which could have implications for antibacterial development and synthetic biology.
Researchers have identified genetic bottlenecks that explain the emergence of pandemic cholera strains. These specific combinations of genes and allelic variants grant an advantage in human intestinal colonization, allowing a small subset of Vibrio cholerae to become deadly pathogens.
The study identified two new families of natural compounds, syrilipamides and secimides, produced by the bacterium. These molecules show remarkable toxicity against competing microorganisms, particularly fungi and amoebae. The discovery also highlights the importance of the SecA enzyme in expanding the chemical repertoire of Pseudomona...
Researchers have identified ten hemagglutinin sub-subclades with distinct antigenic variations, explaining why existing vaccines are ineffective against H9N2 AIVs. Key mutations associated with increased infectivity and pathogenicity in mammals have also been found.
Researchers have found new organisms that can capture carbon dioxide and clean pollutants from the environment. By exploring extremophiles in homes, scientists can gain insights into their unique characteristics and develop sustainable solutions.
Scientists have discovered a new bacterial strain, Bacillus thuringiensis RZ2MS9, that can enhance the growth of soybeans and corn when combined with rhizobia. This partnership reduces fertilizer use, saving Brazilian growers an estimated USD 15 billion annually.
This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
Researchers discovered that sulfur bacteria from the Desulfobacteraceae family work together like a team to break down diverse organic compounds. By analyzing six strains, they found similar molecular strategies and a highly energy-efficient central metabolism pathway, enabling them to thrive in oxygen-free environments.
Researchers discovered that erucamide inhibits Type III Secretion injectisome assembly in Gram-negative bacteria, enhancing plant immunity and reducing disease susceptibility. Exogenous application of erucamide protects crops from bacterial diseases, offering a potential biopesticide for sustainable agriculture.
Lyme disease is a bacterial infection transmitted by ticks, posing an increasing threat in the U.S. Montana State University's Patrick Secor will study adaptations in Borrelia burgdorferi to illuminate how it circumvents its host's immune system. The goal is to discover new vaccine antigens and develop more effective treatments.
Researchers have discovered evidence that plague may have been involved in epidemics a century before the Black Death, challenging previous assumptions about the disease's arrival in Western Eurasia. The study uses historical sources and genetic analysis to propose a new timeline for the plague's emergence.
A Dartmouth-led study reveals that cystic fibrosis disrupts the maturation of the gut microbiome in infants, leading to a depletion of health-associated bacteria and potentially poor health outcomes. The study found that the microbiomes of infants with CF remained stunted or delayed in their development compared to healthy infants.
A new study combines genomic-scale microscopy with a technical innovation to capture genes bacteria turn on in different situations and environments. This technology promises to take the study of bacteria to the next level by providing powerful new insights into bacterial behavior, including gene expression and interactions.
Researchers identified a unique genetic signature that can predict bacterial antibiotic resistance. The finding could help develop precision-based treatments and reduce overuse of antibiotics.
Researchers gather data from 400 women to analyze the effects and interactions of Bacterial Vaginosis on immune cells and vaginal tissue, hoping to develop more effective personalized treatments.
A new study finds that pathogens like Listeria and E. coli can survive on microplastics in wastewater treatment plants. These biofilms, called plastispheres, protect the pathogens from treatment processes, highlighting a challenge for safely reusing treated water.
Researchers have discovered two previously unknown bacterial species in deep-sea corals from the Gulf of Mexico. These bacteria have extremely reduced genomes and lack the ability to break down carbohydrates, surviving on amino acids instead. The discovery provides insights into the unique adaptations of deep-sea organisms.
A new study has identified novel strains of microbes that have adapted to use limited resources in cities, including those found in Hong Kong's subways and skin. These microbes can metabolize manufactured products, posing health risks if they are pathogenic.
A team of researchers discovered a mechanism that determines the spiral shape of Rhodospirillum bacteria, revealing a novel link between cell shape and fitness. The study found that an outer membrane porin-lipoprotein complex modulates elongasome movement to establish cell curvature in R. rubrum.
A team of researchers at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. The antibodies were found to interact with antigens on the bacterial surface and some act synergistically to neutralize the pathogen.
Researchers at Gladstone Institutes have developed a streamlined way to engineer bacteriophages, viruses that naturally kill bacteria. The new technique uses retrons to edit phage genomes, allowing for the creation of numerous variants and paving the way for alternative treatments for antibiotic-resistant infections.
Researchers engineered human skin bacteria to produce less lactic acid, attracting fewer mosquitoes to mice. The engineered microbes reduced mosquito attraction by up to 64.4% and also prevented bites.
A study by Michigan State University reveals that certain proteins and peptides in the nasal and oral environments create lubricants for bacterial colonies to move towards vulnerable sites. The discovery provides new insights into how staphylococcus bacteria spread, shedding light on conditions that accelerate their movement.
A study by Dr. Takanori Sekito and colleagues reveals a strong association between vaginal pathogenic Escherichia coli and recurrent cystitis in postmenopausal women, suggesting that targeting both the urinary bladder and vagina is crucial for effective treatment.
The Xanthomonas cucurbitae pathogen that causes bacterial spot has remained genetically uniform across the Midwest, with most isolates sharing over 99% identical DNA sequences. This lack of diversification may hinder the pathogen's ability to evolve and could be leveraged for developing disease-resistant crops.
A new study in Nature Communications reveals that symbiotic bacteria play a critical role in modulating the profile of root secreted molecules, influencing the assembly of a symbiotic root microbiome. The findings provide valuable insights into the complex interplay between nitrogen nutrition and plant-bacteria interactions.
Researchers at ADA Forsyth Institute discovered a new phage resistance mechanism in the oral microbiome, where ultrasmall bacterial parasites, called Saccharibacteria or TM7, help their host bacteria resist lytic phages. This dynamic ecosystem promotes coexistence between antagonistic organisms.
Researchers found that probiotics in kombucha tea alter fat metabolism in worms, leading to reduced fat stores and lower triglyceride levels. This study suggests possible health benefits of kombucha for humans and informs potential use in complementary healthcare approaches.
Nematode worms can learn to avoid harmful bacteria by exposure to bacterial RNA, and pass on this behavior to future generations. This phenomenon, known as transgenerational inheritance, persists for four generations.
Researchers found a decline in microbial genetic richness in the western Arctic Ocean, with subtle but statistically significant changes in community structure and function. The study suggests that warming and freshening of the ocean risks strengthening the microbial loop, potentially impacting the marine food web.
A tiny bacterium, Vibrio natriegens, has been genetically engineered to increase its ability to extract rare earth elements through biosorption, a sustainable method. This breakthrough could improve the efficiency of processing and bring rare earth element mining back to domestic productivity.
Scientists have identified a key genetic factor, abfA cluster, responsible for improving gut motility and alleviating constipation. The study found that Bifidobacteria longum strains with the abfA cluster can enhance arabinan utilization, leading to improved gastrointestinal transit time.
A new study reveals a multi-drug resistant strain of E.coli, MDR ST131, can outcompete and displace other strains in the human gut. The research provides evidence that certain types of E.coli are more prone to developing antibiotic resistance, posing significant health risks.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
Researchers have discovered a novel enzyme family related to bacterial pathogenicity in Gram-negative bacteria. The study revealed that enzymes involved in OPG synthesis and regulation play crucial roles in bacterial infection capability.
Researchers from UNLV study Shigella bacteria, identifying VirB as a key regulator of virulence. The discovery provides potential new approaches to prevent disease caused by these potentially fatal pathogens.
A new study confirms the presence of deadly Vibrio bacteria in Florida's coastal waters following Hurricane Ian. The research, led by University of Maryland senior author Rita Colwell, found high levels of pathogenic Vibrio parahaemolyticus and Vibrio vulnificus, particularly in oyster samples from Lee County.
A team of scientists has discovered a second toxin produced by the cyanobacterium Aetokthonos hydrillicola, which is highly toxic and similar to substances used in cancer treatment. The findings could lead to the development of new anti-cancer drugs.
Researchers use genomic surveillance to identify distinct sexual networks for syphilis transmission in England, highlighting the presence of drug resistance. The study reveals information beyond standard epidemiological surveillance data, aiding public health strategies to break transmission chains.
Australian researchers analyzed over 1,300 Golden staph strains, linking specific genes to antibiotic resistance and the bacteria's ability to linger in the bloodstream. The study highlights the diagnostic power of integrating clinical and genomic data to develop targeted solutions for deadly superbug infections.
Researchers have provided new insights into the role of lipid droplet-localized CETN-SPDL1-L in regulating cone cell lipid droplet localization, crucial for light sensitivity. The study discovered centrin proteins and SPDL1-L collaborate to maintain correct lipid droplet placement.
Researchers discovered a new mechanism underlying the heat shock response in Escherichia coli. IbpA suppresses σ32 translation, regulating Hsp expression and aiding cell protection under high temperatures. This finding sheds light on bacterial adaptation to harsh environments.
Researchers at KAUST have isolated a desert microbial strain that enhances drought resilience in Arabidopsis and alfalfa, promoting water use efficiency without affecting crop yields. The microbes modify epigenetic status of drought stress genes and actively change plant root architecture.
Researchers at Penn State discovered that bioluminescent bacteria use a small RNA molecule called Qrr1 to coordinate their behavior and colonize the squid's light organ. This mechanism is likely widespread among bacteria, enabling them to exploit quorum sensing pathways.