Articles tagged with Bacterial Genetics
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A new genetic adaptation allowed Yersinia pestis to be transmitted through the bite of an insect, a discovery that sheds light on the evolution of the plague bacterium. The enzyme PLD plays a critical role in the survival of Y. pestis in the midgut of fleas.
Researchers create model that accurately reproduces natural evolution and predicts how bacteria will become resistant to antibiotics. The model shows promise as a possible tool for creating new drugs that can evade bacterial adaptation.
The University of Washington has established a new center to combat deadly microbial pathogens, which threaten human health worldwide. Researchers will focus on developing treatments and vaccines for diseases caused by Pseudomonas aeruginosa, pathogenic protozoa, and other infectious agents.
Biologists at Princeton University discovered a protein that initiates biofilm formation in E. coli bacteria, using a 'touch sensor' mechanism to sense solid surfaces. This finding suggests disrupting this sensing mechanism could be an effective strategy for developing new antibacterial agents targeting biofilms.
Researchers found Pseudomonas aeruginosa thrives in low-oxygen environments of the airways, adapting to remove oxygen and producing protective sugar coatings. This discovery suggests a new strategy to target specific enzymes critical for bacterial survival, offering hope for improved treatment options.
Researchers have discovered a key cell communication gene in modern choanoflagellates, revealing that the genetic tools needed for multicellular animals were already present in single-celled microbes. This finding supports the idea that genes came before their exploitation by organisms.
Researchers discovered a link between the CFTR gene and increased susceptibility to respiratory infections in cystic fibrosis. They found that altered CFTR can change the internal chemistry of lung cells, making them more attractive to certain bacteria.
Scientists have discovered the genetic and molecular means by which roundworms develop resistance to Bt toxins, which are safe to humans but threaten long-term effectiveness. The researchers identified a galactosyltransferase enzyme as key to toxin recognition, enabling the development of strategies to delay or circumvent resistance.
A Phase I study of aerosolized administration of tgAAV-CF showed efficient gene transfer throughout the upper airways of patients with mild CF lung disease. No neutralizing antibodies were detected, suggesting a good safety profile for further development.
Researchers discovered a new enzyme that moves along DNA, separating its sides, and has a unique gait dubbed the 'quantum inchworm'. This finding may aid in building nanomachines for gene delivery and cancer treatment.
Dr. Hultgren's work on pilus genetics, biosynthesis and structure has contributed significantly to understanding bacterial adhesions critical to pathogenesis. His research applications have led to recognition nationally and internationally.