Articles tagged with Bacterial Genetics
Treatment with salicylic acid (SAL) induces activation of the S. aureus stress response gene sigB, downregulating virulence factors and reducing ability to adhere to host cells. This finding represents a new prospect for using aspirin as an adjunct therapy to combat Staphylococcus aureus infections.
Researchers discovered that friendly bacteria and human hormones send cellular signals alerting E. coli to its location, leading to colonization and toxin release. Beta blockers may be developed to block this signaling system, preventing the bacteria from reaching the intestine.
Researchers engineered bacteria to produce bixin, a plant product used in foods and cosmetics, by replicating the plant's biosynthetic pathway. The genetically modified E. coli can produce the same compound as the natural source, providing an alternative for expanding supply and addressing challenges in non-biological synthesis.
Duke University biochemists create sensor proteins that can specifically detect TNT and other chemicals, opening doors for medical and environmental applications. The researchers' computational design method narrows down possible structures to reasonable numbers with days' worth of calculations.
Cecropin A alters bacterial gene regulation, challenging conventional thinking on its mechanism of action. The insect antibiotic's ability to evade resistance raises hope for new therapeutic agents.
Researchers at Texas A&M University have made a groundbreaking discovery in understanding the biological clocks that govern daily rhythms in living organisms. By analyzing the genetic makeup of a simple bacterium called Synechococcus elongatus, the team has created the first structural model of part of the clock's timing device.
A UCI study reveals a new method to identify and track specific sources of water pollution at beaches by combining bacteria sampling with genetic testing. The approach has already led to significant reductions in bacteria levels and beach closures in Catalina Island.
Researchers at UW-Madison have identified genetic elements in soil-dwelling bacteria that produce potent anticancer agents. The discovery enables mass production and manipulation of these chemicals, offering a promising alternative to existing treatments.
A recent study has found that exposure to bacteria significantly increases the expression of genes involved in immune response, reducing the risk of developing allergies in children who grow up on farms. This discovery highlights the potential benefits of living on a farm for children's immune system development.
Victor Nizet's award-winning research focuses on understanding the production of toxins by group A and B streptococcus in children, shedding light on potential treatments and disease prevention strategies. His work also explores anti-microbial peptides and the mechanism behind group B strep's ability to cause meningitis.
A new genetic adaptation allowed Yersinia pestis to be transmitted through the bite of an insect, a discovery that sheds light on the evolution of the plague bacterium. The enzyme PLD plays a critical role in the survival of Y. pestis in the midgut of fleas.
Researchers create model that accurately reproduces natural evolution and predicts how bacteria will become resistant to antibiotics. The model shows promise as a possible tool for creating new drugs that can evade bacterial adaptation.
The University of Washington has established a new center to combat deadly microbial pathogens, which threaten human health worldwide. Researchers will focus on developing treatments and vaccines for diseases caused by Pseudomonas aeruginosa, pathogenic protozoa, and other infectious agents.
Biologists at Princeton University discovered a protein that initiates biofilm formation in E. coli bacteria, using a 'touch sensor' mechanism to sense solid surfaces. This finding suggests disrupting this sensing mechanism could be an effective strategy for developing new antibacterial agents targeting biofilms.
Researchers found Pseudomonas aeruginosa thrives in low-oxygen environments of the airways, adapting to remove oxygen and producing protective sugar coatings. This discovery suggests a new strategy to target specific enzymes critical for bacterial survival, offering hope for improved treatment options.
Researchers have discovered a key cell communication gene in modern choanoflagellates, revealing that the genetic tools needed for multicellular animals were already present in single-celled microbes. This finding supports the idea that genes came before their exploitation by organisms.
Researchers discovered a link between the CFTR gene and increased susceptibility to respiratory infections in cystic fibrosis. They found that altered CFTR can change the internal chemistry of lung cells, making them more attractive to certain bacteria.
Scientists have discovered the genetic and molecular means by which roundworms develop resistance to Bt toxins, which are safe to humans but threaten long-term effectiveness. The researchers identified a galactosyltransferase enzyme as key to toxin recognition, enabling the development of strategies to delay or circumvent resistance.
A Phase I study of aerosolized administration of tgAAV-CF showed efficient gene transfer throughout the upper airways of patients with mild CF lung disease. No neutralizing antibodies were detected, suggesting a good safety profile for further development.
Researchers discovered a new enzyme that moves along DNA, separating its sides, and has a unique gait dubbed the 'quantum inchworm'. This finding may aid in building nanomachines for gene delivery and cancer treatment.
Dr. Hultgren's work on pilus genetics, biosynthesis and structure has contributed significantly to understanding bacterial adhesions critical to pathogenesis. His research applications have led to recognition nationally and internationally.