Articles tagged with Bacterial Pathogens
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Scientists have recovered a genome of Treponema pallidum from 5,500-year-old human remains in Colombia, pushing back the genetic record of this pathogenic species by over 3,000 years. The discovery sheds new light on the evolutionary history of treponemal pathogens and their occurrence in human populations.
The study provides direct evidence of large-scale human mortality during the Plague of Justinian and offers insight into how people moved, lived, and became vulnerable within ancient cities. The mass grave at Jerash, Jordan, helps resolve a long-standing puzzle about ancient community dynamics.
Researchers at the University of Chicago have discovered a light-sensitive signaling cascade in Pseudomonas aeruginosa that suppresses biofilm formation and virulence. The study, published in Nature Communications, identifies a small protein called DimA as the key trigger for this process.
Researchers discovered that GBS interacts with C. albicans, increasing the risk of severe and fatal infections in newborns and making standard treatments less effective. The co-infection can also reduce the effectiveness of existing GBS treatments.
The study will select the exact phage that is appropriate for each patient's bacteria, and aims to reduce antibiotic use and healthcare costs. Bacteriophages have been shown to be effective against resistant bacteria causing urinary tract infections.
A SickKids-led study reveals how bile acids can bind to block C. diff's most dangerous toxin, leading to the development of a new compound that neutralizes the toxin directly in the gut. This approach preserves gut health and targets the toxin with precision, offering hope for safer treatments.
The new guideline recommends full-time infection prevention staff, comprehensive training, and support for all staff, as well as partnerships with hospitals and public health agencies. This guidance aims to reduce the risk of infections in nursing homes, saving lives and money.
Researchers have developed a novel vaccine strategy using biomaterial scaffold vaccines to protect against Staphylococcus aureus infections in orthopedic device implants. The vaccines, made with immune cell-attaching molecules and S. aureus-specific antigens, create a beneficial immune response that significantly lowers bacterial burden.
Researchers have discovered a promising new antibiotic, pre-methylenomycin C lactone, which is over 100 times more active than the current antibiotic methylenomycin A. This finding provides hope in the fight against antimicrobial resistance (AMR), which affects millions of people worldwide.
Researchers extracted DNA from Napoleon soldiers' teeth and identified Salmonella enterica and Borrelia recurrentis as causes of enteric fever and relapsing fever. The discovery sheds new light on the factors contributing to the army's downfall.
The Global Pathogen Analysis Platform (GPAP) will enable low- and middle-income countries to conduct research and surveillance of infectious diseases independently. The platform aims to prevent disease outbreaks from developing into pandemics by detecting genetic sequences of potential pathogens.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Researchers from Ateneo de Manila University have identified key proteins produced by Helicobacter pylori that can trigger a strong immune response. By analyzing these proteins using immunoinformatics, the team has pinpointed potential vaccine targets to prevent stomach ulcers and cancer.
Researchers at UMC Utrecht discovered that converting monoclonal antibodies from IgG to IgM isotype can significantly broaden their ability to recognize and bind multiple human-relevant bacterial pathogens. This finding could guide the future design of antibody therapies against bacterial infections.
Researchers at the University of Houston discovered that T. phoenicis can enter dormancy to evade detection, highlighting the resilience of spacecraft-associated microbes and raising concerns about planetary protection. The findings may lead to better detection methods and more effective sterilization strategies in various industries.
A new study reveals rising rates of invasive SDSE infections across Australia, particularly among older Australians and those from remote regions. The research highlights disparities in health outcomes between regions and populations, emphasizing the need for improved surveillance and prevention strategies.
Researchers at DTU have discovered a way to combat antibiotic-resistant bacteria by nourishing special bifidobacteria that is naturally occurring in the gut. Special lactic acids produced by bifidobacteria play a key role in keeping antibiotic-resistant bacteria at bay.
The IMPACT-CETR aims to develop preventive strategies against antibiotic-resistant pathogens Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The project seeks to harness immunity in these bacteria to prevent infections and reduce the emergence of resistance.
A rat discovered on a flight from Miami to Berlin revealed hidden global health risks, including the presence of a methicillin-susceptible Staphylococcus aureus strain nearly identical to human variants. The study highlights the importance of standardized pathogen screening for animal stowaways and rats as indicators of ecosystem health.
Marcos de Moraes will study the molecular mechanisms and evolutionary roles of bacterial deaminase toxins, which can alter genetic material. He aims to develop tools for genome engineering and biotechnology while creating a lab environment accessible to students with disabilities.
Diphtheria is still being reported in Europe, with cases higher than before 2020, affecting vulnerable populations like homeless individuals, migrants, and those who use or inject drugs. ECDC recommends tailored public health response measures to protect these groups.
Researchers identified two natural products, pandorabactin A and B, produced by Pandoraea bacteria to complex iron. These molecules may play a role in the survival of these pathogens in iron-poor environments.
Scientists at the Stowers Institute and University of Georgia discover how Cryptococcus neoformans thrives, identifying over 300 potential targets for novel antifungal drugs. The study provides an atlas for developing new therapies to combat this lethal fungus.
Researchers have discovered that a bacterial probiotic helps slow the spread of stony coral tissue loss disease (SCTLD) in already infected wild corals in Florida. Applying the probiotic treatment across entire coral colonies helped prevent tissue loss, providing a more lasting protection than traditional antibiotics.
A recent study reveals the diphtheria epidemic in Western Europe is primarily caused by contamination during migratory travel or in destination countries, not in the countries of origin. The researchers emphasize the importance of maintaining high levels of vigilance and public health support among vulnerable populations.
Scientists have discovered that leprosy, caused by bacteria Mycobacterium lepromatosis, has been infecting humans in the Americas for at least 1,000 years. The study analyzed DNA from ancient human remains and recent clinical cases, confirming that the disease was already widespread in North and South America before European colonization.
Researchers identified seven bacteria with a potential barrier effect against vancomycin-resistant enterococci. The addition of the bacterial mixture reduced the proliferation of pathogenic bacteria in mice, suggesting a promising therapeutic approach.
A recent study found that Metagenomic next-generation sequencing (mNGS) can detect pathogens in 86% of cases, outperforming conventional microbiological tests which identified pathogens in only 67% of cases. mNGS guides treatment decisions and improves patient outcomes by detecting rare/atypical pathogens.
Researchers found that cholera bacteria acquired multiple distinct immune systems protecting them from diverse types of phages. These defense systems, including WonAB, GrwAB, and Vc SduA, contribute to the bacterial population's resistance spectrum.
Roundworm C. elegans avoids deceased conspecifics due to olfactory cues from metabolites AMP and histidine, leading to reduced fitness and increased egg laying. The detection of these signals may be an evolutionarily maintained mechanism for detecting cellular death.
A new method using artificial intelligence and DNA decoding can predict how well disease-causing bacteria like Listeria tolerate disinfectants. The research may lead to smarter hygiene strategies and faster responses when pathogenic bacteria are present in food production.
A new study found that many home washing machines are insufficient for decontaminating healthcare worker uniforms, allowing antibiotic-resistant bacteria to survive. The researchers propose revising laundering guidelines or using on-site industrial machines to improve patient safety.
Researchers have discovered a protein, Mfd, that promotes bacterial resistance and spontaneous mutations. A new compound, NM102, has been developed to block this protein, reducing the bacteria's ability to develop resistance and effectively combat antibiotic-resistant strains.
Researchers at UMass Amherst's New England Center of Excellence in Vector-borne Diseases have identified a new strain of Rickettsia bacteria that causes spotted fever infections in humans. The discovery in Maine suggests rabbit ticks could be a zoonotic vector for serious infections, contradicting the usual dog tick vector.
Researchers found that pathogenic bacteria like Pseudomonas syringae produce glycosyrin, a molecule that blocks plant immune surveillance. Plants have evolved countermeasures to strip away sugars from flagellin, but this bacterial strategy disrupts these defenses and creates conditions favorable for bacterial growth.
Researchers detected widespread contamination of retail chicken meat in Bangladesh with antibiotic-resistant E. albertii, a lesser-known but deadly pathogen. The study highlights the need for improved hygiene measures and stricter regulations to prevent foodborne infections.
A new study confirms copper-based fungicides as a reliable solution for aerial stem rot in potatoes. The research found that copper fungicide treatments consistently slowed disease spread and improved yields over a 10-year period.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Researchers have developed an effective approach to tackle intestinal pathogens by administering oral vaccinations combined with harmless bacteria that starve out pathogenic microbes. This method has shown promising results in preventing colonization with salmonella and effectively tackling established E. coli bacteria.
A study analyzing over 3 million bacterial samples found that antibiotic resistance initially rises but stabilizes over time, reaching an equilibrium in most species. The study suggests that continued increase in antibiotic resistance is not inevitable and provides new insights to monitor drug resistance.
The BfR conference discusses the role of microorganisms in food production, focusing on both beneficial and pathogenic properties. The event explores topics such as E. coli, Listeria monocytogenes, and the importance of food microbiology in ensuring public health.
The European Centre for Disease Prevention and Control (ECDC) reports a rise in tuberculosis cases among children and adolescents in the EU/EEA, with a slight increase in the notification rate from 2.0 to 2.5 per 100,000 population. The highest proportion of paediatric TB was observed in children aged 1 to 4 years old.
Researchers have discovered a family of genes essential for tuberculosis survival during airborne transmission, providing new drug targets. The study sheds light on the bacterium's protective mechanisms, which could prevent infection spread and treat existing cases.
A recent study in Nature Communications reveals that white blood cells employ a novel mechanism to dislodge bacteria from human tissues using brute force and integrin-based adhesion rings. The research, led by Xuefeng Wang, has significant implications for understanding the role of macrophages in cleaning up environmental pollutants.
Researchers discovered that erucamide inhibits Type III Secretion injectisome assembly in Gram-negative bacteria, enhancing plant immunity and reducing disease susceptibility. Exogenous application of erucamide protects crops from bacterial diseases, offering a potential biopesticide for sustainable agriculture.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
Research finds over 25% of Egyptian milk and dairy products contain E. coli, with one strain causing a Japanese school outbreak; experts hope for effective treatment and prevention methods.
The University of Cambridge has launched an Engineered Pandemics Risk Management Programme to address the urgent challenge of managing future engineered pandemics. The programme aims to build a network of experts from academia, government, and industry to understand social and biological factors that drive engineered pandemic risks.
A team of scientists has developed a cutting-edge technology to analyze bacterial sexually transmitted infections (STIs) using genome sequencing. The 'target enrichment' method enables high-resolution analysis of Chlamydia trachomatis and other pathogens, revealing new insights into their transmission and development pathways.
Researchers discovered symbiotic bacteria accompanying single-celled protists in the ocean's upper layer. The bacteria, including close relatives of pathogenic species like Coxiella and Rickettsia, may aid or harm their protist hosts, depending on context.
A recent study found that cold temperatures allow the bird pink eye pathogen to survive on bird feeders for up to seven days, causing more severe disease in birds compared to warmer temperatures. Regular cleaning of feeder surfaces with bleach can help mitigate the spread of the disease.
Carbapenem-resistant Enterobacterales, including K. pneumoniae and E. coli, pose a significant risk to EU/EEA patients and healthcare systems. The epidemiological situation has deteriorated since 2019, with high-risk lineages spreading in hospitals.
Recent studies have found that new antibiotics are prone to rapid development of resistance, even before they are widely used. This raises concerns about the effectiveness of these treatments in the long run. To address this issue, researchers call for a shift in antibiotic development prioritizing novel modes of action and responsible...
A study found a link between oral microbiome and dementia risk, with certain bacteria associated with better executive function. A nitrate-rich diet may favor beneficial oral bacteria, potentially delaying cognitive decline.
According to hygiene expert Dr. Heidi Wichmann-Schauer, small negligence in everyday life can transfer pathogens to food, causing serious illnesses and fatalities, especially among vulnerable groups. The BfR advises proper kitchen cleanliness, handwashing, and cooking meat thoroughly to prevent cross-contamination.
A new Dartmouth study reveals that 50% of adult blacklegged ticks in the Northeast carry the bacteria that causes Lyme disease. The study found small changes in tick abundance but a significant increase in pathogen prevalence over 30 years, highlighting the need for continued prevention measures.
Researchers discovered that bacteria use cell wall fragments as an alarm signal to initiate protective biofilm formation. Biofilms provide protection from immune cells, antibiotics, and viruses, highlighting universal survival strategies across bacterial species.
Researchers have discovered a new target for antibiotics, the methylerythritol phosphate pathway, which is essential for bacteria's energy metabolism. By blocking this pathway, bacteria can be killed without affecting human cells.
The University of Arizona College of Medicine – Tucson laboratory is working on discovering new ways to neutralize harmful microorganisms using copper. The researchers aim to understand how copper kills bacteria by flooding their environment with excess copper, tricking them into building essential proteins with the wrong materials.
Researchers found that a person's microbiome signature can predict the likelihood of Enterobacteriaceae colonization. Fiber-rich foods support the growth of beneficial Faecalibacterium, which produce short-chain fatty acids protecting against infection.