Research on disease-causing bacteria and how they spread. Covers waterborne bacteria, Lyme disease ecology, pathogenic genetics, and biofilm treatments.
Researchers identified Porphyromonas gingivalis as a bacterial pathogen driving Alzheimer's disease pathology in the brains of patients. The study found that Pg infection led to increased production of amyloid beta and neuroinflammation.
Researchers identify Porphyromonas gingivalis as a key driver of Alzheimer's disease pathology and demonstrate potential for small molecule inhibitors to block the pathogen. The discovery paves the way for Cortexyme's lead compound COR388, which shows promising results in preclinical experiments.
Researchers at Osaka University found that common bacterial metabolites pyruvate and lactate activate the intestinal immune response, enhancing dendrite protrusion in macrophages. This discovery has multiple clinical applications, including improving oral vaccines and eliminating intestinal pathogens.
A new technique examines environmental factors controlling disease transmission to a single aerosol particle and bacterium. The study finds that environmental factors, such as humidity and light, can significantly impact bacterial viability.
The study suggests that letting beneficial microorganisms thrive could aid in fighting infectious diseases, as conventional methods may interfere with their natural containment. By adopting a more diverse approach to health, researchers hope to create stronger defenses against pathogens.
A study by Northwell Health found that ultraviolet disinfection technology can eliminate up to 97.7% of pathogens in operating rooms. The technology, using a focused multivector ultraviolet (FMUV) device, reduces human and product error in pathogen proliferation.
Researchers developed a mobile CRISPRi system to study antibiotic function in various bacteria, including those that cause disease and promote health. The system allows scientists to screen for antibiotic targets thousands of genes at once, providing clues on how to improve existing antibiotics or develop new ones.
Researchers found that lethal disease can occur without viral replication in EHEC-infected mice. The study suggests potential novel treatments for EHEC and life-threatening kidney complications in children.
Researchers have designed a new Cas9 enzyme, ProCas9, that can be controlled by specific enzymes present in cells or viruses. This allows for more accurate and precise gene editing with added security. The technology has potential applications in treating diseases and improving crop resistance to viral pathogens.
C-Path and TGen will develop a framework enabling state institutions to respond to antimicrobial resistance with a genomic surveillance system. The Prevent HAARM system aims to monitor and track antimicrobial resistant pathogens, providing rapid feedback to clinicians and public health professionals.
Researchers have discovered a previously unknown strain of bacteria in ancient Irish soil that effectively inhibits the growth of four top-six multi-resistant pathogens. The strain, Streptomyces sp. myrophorea, has shown promise against gram-positive and gram-negative bacteria, providing new hope for combating antibiotic resistance.
Researchers at University of Basel discover how Pseudomonas aeruginosa attaches to tissue within seconds and spreads using motile spreaders and virulent stickers. The bacterium exploits a simple business model: settle, grow, expand.
Researchers at Virginia Tech have developed a novel drug delivery system that uses attenuated bacteria cells to transport anti-cancer drugs directly to cancer sites, showing up to 100-fold improvements in distribution and retention. This innovative approach has the potential to revolutionize cancer treatment options.
A recent study found that colistin-resistant Escherichia coli (CR-E) was prevalent among residents in rural communities in Vietnam, with 70.4% of residents carrying the bacteria. This widespread dissemination raises concerns about the potential for 'nightmare bacteria' to spread globally and render antibiotics ineffective.
Researchers discovered that some bacteria use multi-component flagella to manoeuvre out of small spaces, enabling them to escape and infect. The study's findings could lead to the development of new methods to block the transmission of harmful infections.
A promising compound discovered by Swiss TPH researchers is highly effective against Buruli ulcer, both in vitro and in vivo. The study found that compound Q203 has an activity level exceeding the current most active antibiotic rifampicin, potentially leading to a shorter treatment regimen with fewer adverse side effects.
Researchers developed a biodegradable edible film made with plant starch and antimicrobial compounds to control the growth of foodborne pathogens on seafood. The film successfully killed vibrio and salmonella bacteria, which are linked to gastrointestinal problems when consumed.
Researchers propose RNAIII inhibiting peptides as a potential treatment strategy for S. aureus biofilm infections, which are notoriously difficult to treat due to their impermeable nature and enhanced virulence.
A new study reveals that fecal bacteria from sewage are thriving in near-shore sediments of the Hudson River, with potential health risks for swimmers and kayakers. The researchers found high levels of bacteria in both water and sediment at some sites, suggesting an interchange between the two.
Researchers discovered that septins can detect where bacteria will split for division and prevent it from doing so by forming cage-like structures around the bacteria. This finding provides new clues to stop the spread of deadly infections, including Shigella, a 'superbug' deemed a priority by the World Health Organization.
Researchers found predictable patterns of fluid movement in stationary biofilms, enabling the drawing of distant nutrients. Biofilms can generate strong currents capable of pulling in nutrients, regardless of bacterium orientation.
A DNA study found that stethoscopes are loaded with diverse bacteria, including those that cause healthcare-associated infections. Standardized cleaning methods were more effective in removing bacteria than practitioners' usual methods.
A new study found that Streptococcus pneumoniae bacteria that occupy human host tissue first are more likely to thrive than competing strains. The researchers discovered that these 'owners' release toxins to kill intruders, while also releasing protective factors to defend themselves.
A new study has detected bacteria from humans in Antarctic and Subantarctic marine birds, revealing the fragility of polar ecosystems. The research highlights the risk of massive deaths and extinctions of local fauna populations due to pathogens introduced by human activity.
A UK-wide consortium led by the John Innes Centre aims to enhance surveillance and response to Xylella fastidiosa, a devastating bacterial plant pathogen. The £4.85m BRIGIT programme will improve diagnosis and detection methods, identify potential factors for its spread, and prepare to minimize its impact on the UK.
A recent study has discovered over 6,000 antibiotic resistance genes in bacteria that inhabit the human gut, revealing a vast and previously unknown diversity of resistant genes. The researchers used a novel method to identify these genes by comparing their three-dimensional structures to proteins produced by gut bacteria.
Researchers discovered that the Cas10 enzyme, part of the type III CRISPR-Cas system, can selectively target foreign genetic material while avoiding its own DNA. This dynamic regulation enables bacteria to maintain a robust immune response even when invaders mutate their genetic sequences.
Researchers have identified a set of genes that enable S. epidermidis to cause disease in certain circumstances, making it a major concern for those undergoing surgery. The study aims to identify patients at high risk of infection before surgery, reducing the risk of post-operative infections.
A team of researchers has conducted a comprehensive survey of healthy corals, revealing that coral bacteria form complex associations with different sections of the coral body. The study found that distinct microbial communities exist in each tissue type, with the hard skeleton containing the greatest diversity of bacteria.
Researchers identified a more pathogenic strain of S. aureus associated with increased biofilm formation and transmission risk, linked to postoperative infections. Decolonizing patients and maintaining hand hygiene compliance are crucial in controlling the spread of this strain.
Researchers have discovered a new chemical process in bacteria that could lead to the development of new antibiotics. The biosynthetic pathway includes an enzyme called carboxylase, which adds CO2 to a precursor molecule producing a highly unusual antibiotic called malonomycin.
Researchers have discovered a previously unknown protein called TarP that helps multi-resistant bacteria evade the human immune system. This breakthrough could lead to new therapies against MRSA and other resistant pathogens.
Researchers found DNA translocase Mfd accelerates mutations in bacteria, promoting antibiotic resistance. A new class of anti-evolution drugs targeting Mfd could complement existing antimicrobials and address the growing antimicrobial resistance crisis.
A team of chemists has identified key enzymes in the metabolism of staphylococci, which could be targeted to starve bacteria and develop new antibiotics. The researchers used a novel methodology to isolate and analyze these enzymes, discovering previously unknown targets for new antibiotic development.
A study by Hannah Frank and colleagues reveals humans play a significant role in changing infection patterns, including spillover from animals to humans.
A study by the Julius Kühn Institute and BfR found antimicrobial-resistant bacteria with multiple transferable resistance genes on fresh produce, including mixed salads, arugula, and cilantro. Consumers can minimize risk by washing raw vegetables thoroughly and considering heat treatment for immunocompromised individuals.
Researchers found that bacteria can affect a bubble's longevity, causing it to last up to 10 times longer than an uncontaminated one. The team discovered that bacterial secretions act as surfactants, extending the lifetime of contaminated bubbles by reducing surface tension and making them more resistant to perturbations.
Thanatin, a natural insect antibiotic, eliminates bacteria by preventing the formation of their outer protective shield. This unprecedented mechanism offers a new way to develop effective antibiotics against dangerous pathogens like Pseudomonas aeruginosa and Escherichia coli.
Researchers found that bacterial toxins from Staphylococcus aureus reduce the number of cells suppressing the immune response, leading to excessive immune responses. Weakened enterotoxins could potentially be used to induce stronger immune responses in cancer treatment.
A study published in Immunity found that the gut bacterium Lactobacillus plantarum produces excessive lactic acid when its receptor protein PGRP-SD is disrupted, leading to oxidative stress and accelerated aging. Increasing PGRP-SD levels prevents this effect and extends lifespan.
A new system, CAMR-R, can measure antimicrobial resistant phenotypes at single-cell resolution from clinical samples in three hours without cell propagation. The instrument uses D2O-feeding Raman Microspectroscopy to quantify AMR levels and has potential applications in diagnosing clinical pathogens.
Researchers at the University of Liverpool have uncovered a novel mechanism by which Streptococcus pneumoniae bacteria evade immune defenses. Pneumolysin toxin binds to a host cell receptor called Mannose Receptor C type-1 (MRC-1), suppressing inflammation and protective immunity, allowing the bacteria to survive in the airways.
Researchers found that pneumolysin can interact with a special receptor in immune cells, triggering an anti-inflammatory response. This allows the bacteria to hide from further attack and grow, eventually giving rise to pneumonia. The study's findings may lead to new strategies for tackling pneumococcal infections.
A research study shows that the microbiomes of sea stars play a critical role in the progression of the disease. The study found that an imbalance of beneficial and disease-causing bacteria contributes to the severity of the illness, with healthy animals hosting more helpful microbes.
Researchers found that supermarket produce is a reservoir for transferable antibiotic resistance genes, which can evade traditional detection methods. The study highlights the importance of characterizing the resistome in produce and emphasizes the need for improved detection methods.
Two Virginia Tech professors, Amy Pruden and Marc Edwards, are leading studies on antibiotic resistance in recycled water and plumbing. Their research aims to identify effective disinfectants and designs for preventing the spread of resistant bacteria in water systems, a growing concern that affects public health.
Researchers found that gut bacteria partially recovered six months after antibiotic treatment, but with a loss of sensitive bacterial species. Resistance genes also increased in the remaining bacteria. Over time, good microbes like bifidobacteria took over, normalizing the microbiome.
Researchers identified a novel anti-inflammatory bacterial protein, Aeromonas immune modulator (AimA), that reduces gut inflammation and delays death by septic shock in zebrafish. The study suggests that AimA acts as a mutualism factor, promoting both bacterial colonization and host survival.
A genetic scan of 4,578 TB samples from China revealed just two dominant strains account for 99.4% of cases, with strain L2 spreading widely due to internal movement allowing its spread. The study also found that strain Lineage 4 was introduced via the silk trade between 1084 and 1336 A.D.
A team of scientists has developed a new method for detecting specific strains of E. coli using molecular electronics, which could lead to rapid and straightforward detection of pathogens and antimicrobial resistant bacterial strains.
Research reveals that healthy plants host diverse fungi and oomycetes in roots, but a balanced bacterial community prevents illness; certain bacteria promote plant health by limiting fungal growth.
New research reveals that Mycoplasma pathogens produce DNA building blocks using a metal-free process, which may enable them to survive and multiply despite a lack of metals. This unique strategy has been found in bacteria that infect mucosal surfaces in the respiratory and genital tracts.
Researchers developed a machine learning approach to identify and predict antibiotic resistance genes in Mycobacterium tuberculosis. The approach identified 33 known and 24 new resistance genes, which could aid in personalized treatment for different strains of the bacteria.
A new investigational antibiotic, cefiderocol, has been found effective against drug-resistant Gram-negative bacteria in a phase 2 randomised trial. The study suggested that patients treated with cefiderocol had a higher and more sustained level of pathogen eradication compared to those treated with imipenem-cilastatin.
A new study reveals that the unique compositions of bacteria in mice' guts are inherited from parents and remain stable over generations. The dominant mode of transmission is vertical inheritance, but some bacterial pathogens can be transmitted horizontally, possibly due to increased oxygen tolerance.
Researchers analyzed 250,000 cells from six mammalian species to chart the evolution of antiviral and antibacterial immunity. They found that genes involved in the immune response have highly variable activity in different cells within an individual's tissue.
Researchers at McMaster University discovered a new way bacteria evade the human immune system by shutting down flagella expression, making it difficult for the immune system to detect and respond. This finding has significant implications for understanding antibiotic resistance and developing new treatments.
The BacCapSeq platform detects signs of antibiotic resistance and virulence in 4.2 million genetic probes, outperforming traditional methods in sensitivity and speed. It has the potential to reduce mortality, morbidity, and healthcare costs by providing accurate, early differential diagnosis of infectious diseases.
A new agent has been developed to combat anthrax by reprogramming the human immune system's siderocalin protein to neutralize a special iron complexing agent produced by the bacterium. This approach is expected to provide an effective treatment against the life-threatening infection.
A newly discovered toxin, Tre1, produced by bacteria, targets vital proteins in host cells, causing disease-like symptoms. The discovery provides insights into bacterial biodefense strategies and the evolution of toxins.