Articles tagged with Bacterial Pathogens
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Thanatin, a natural insect antibiotic, eliminates bacteria by preventing the formation of their outer protective shield. This unprecedented mechanism offers a new way to develop effective antibiotics against dangerous pathogens like Pseudomonas aeruginosa and Escherichia coli.
Researchers found that bacterial toxins from Staphylococcus aureus reduce the number of cells suppressing the immune response, leading to excessive immune responses. Weakened enterotoxins could potentially be used to induce stronger immune responses in cancer treatment.
A team of chemists has identified key enzymes in the metabolism of staphylococci, which could be targeted to starve bacteria and develop new antibiotics. The researchers used a novel methodology to isolate and analyze these enzymes, discovering previously unknown targets for new antibiotic development.
A study by Hannah Frank and colleagues reveals humans play a significant role in changing infection patterns, including spillover from animals to humans.
A study by the Julius Kühn Institute and BfR found antimicrobial-resistant bacteria with multiple transferable resistance genes on fresh produce, including mixed salads, arugula, and cilantro. Consumers can minimize risk by washing raw vegetables thoroughly and considering heat treatment for immunocompromised individuals.
Researchers found that bacteria can affect a bubble's longevity, causing it to last up to 10 times longer than an uncontaminated one. The team discovered that bacterial secretions act as surfactants, extending the lifetime of contaminated bubbles by reducing surface tension and making them more resistant to perturbations.
A study published in Immunity found that the gut bacterium Lactobacillus plantarum produces excessive lactic acid when its receptor protein PGRP-SD is disrupted, leading to oxidative stress and accelerated aging. Increasing PGRP-SD levels prevents this effect and extends lifespan.
A new system, CAMR-R, can measure antimicrobial resistant phenotypes at single-cell resolution from clinical samples in three hours without cell propagation. The instrument uses D2O-feeding Raman Microspectroscopy to quantify AMR levels and has potential applications in diagnosing clinical pathogens.
Researchers found that pneumolysin can interact with a special receptor in immune cells, triggering an anti-inflammatory response. This allows the bacteria to hide from further attack and grow, eventually giving rise to pneumonia. The study's findings may lead to new strategies for tackling pneumococcal infections.
Researchers at the University of Liverpool have uncovered a novel mechanism by which Streptococcus pneumoniae bacteria evade immune defenses. Pneumolysin toxin binds to a host cell receptor called Mannose Receptor C type-1 (MRC-1), suppressing inflammation and protective immunity, allowing the bacteria to survive in the airways.
A research study shows that the microbiomes of sea stars play a critical role in the progression of the disease. The study found that an imbalance of beneficial and disease-causing bacteria contributes to the severity of the illness, with healthy animals hosting more helpful microbes.
Researchers identified a novel anti-inflammatory bacterial protein, Aeromonas immune modulator (AimA), that reduces gut inflammation and delays death by septic shock in zebrafish. The study suggests that AimA acts as a mutualism factor, promoting both bacterial colonization and host survival.
Researchers found that supermarket produce is a reservoir for transferable antibiotic resistance genes, which can evade traditional detection methods. The study highlights the importance of characterizing the resistome in produce and emphasizes the need for improved detection methods.
Two Virginia Tech professors, Amy Pruden and Marc Edwards, are leading studies on antibiotic resistance in recycled water and plumbing. Their research aims to identify effective disinfectants and designs for preventing the spread of resistant bacteria in water systems, a growing concern that affects public health.
Researchers found that gut bacteria partially recovered six months after antibiotic treatment, but with a loss of sensitive bacterial species. Resistance genes also increased in the remaining bacteria. Over time, good microbes like bifidobacteria took over, normalizing the microbiome.
A team of scientists has developed a new method for detecting specific strains of E. coli using molecular electronics, which could lead to rapid and straightforward detection of pathogens and antimicrobial resistant bacterial strains.
A genetic scan of 4,578 TB samples from China revealed just two dominant strains account for 99.4% of cases, with strain L2 spreading widely due to internal movement allowing its spread. The study also found that strain Lineage 4 was introduced via the silk trade between 1084 and 1336 A.D.
Research reveals that healthy plants host diverse fungi and oomycetes in roots, but a balanced bacterial community prevents illness; certain bacteria promote plant health by limiting fungal growth.
New research reveals that Mycoplasma pathogens produce DNA building blocks using a metal-free process, which may enable them to survive and multiply despite a lack of metals. This unique strategy has been found in bacteria that infect mucosal surfaces in the respiratory and genital tracts.
A new study reveals that the unique compositions of bacteria in mice' guts are inherited from parents and remain stable over generations. The dominant mode of transmission is vertical inheritance, but some bacterial pathogens can be transmitted horizontally, possibly due to increased oxygen tolerance.
Researchers developed a machine learning approach to identify and predict antibiotic resistance genes in Mycobacterium tuberculosis. The approach identified 33 known and 24 new resistance genes, which could aid in personalized treatment for different strains of the bacteria.
A new investigational antibiotic, cefiderocol, has been found effective against drug-resistant Gram-negative bacteria in a phase 2 randomised trial. The study suggested that patients treated with cefiderocol had a higher and more sustained level of pathogen eradication compared to those treated with imipenem-cilastatin.
Researchers analyzed 250,000 cells from six mammalian species to chart the evolution of antiviral and antibacterial immunity. They found that genes involved in the immune response have highly variable activity in different cells within an individual's tissue.
Researchers at McMaster University discovered a new way bacteria evade the human immune system by shutting down flagella expression, making it difficult for the immune system to detect and respond. This finding has significant implications for understanding antibiotic resistance and developing new treatments.
The BacCapSeq platform detects signs of antibiotic resistance and virulence in 4.2 million genetic probes, outperforming traditional methods in sensitivity and speed. It has the potential to reduce mortality, morbidity, and healthcare costs by providing accurate, early differential diagnosis of infectious diseases.
A new agent has been developed to combat anthrax by reprogramming the human immune system's siderocalin protein to neutralize a special iron complexing agent produced by the bacterium. This approach is expected to provide an effective treatment against the life-threatening infection.
A newly discovered toxin, Tre1, produced by bacteria, targets vital proteins in host cells, causing disease-like symptoms. The discovery provides insights into bacterial biodefense strategies and the evolution of toxins.
Researchers have identified a novel subclass of metal-free ribonucleotide reductase enzymes used by bacterial pathogens to replicate their DNA without the required metal ions. This discovery could drive the development of new, more effective antibiotics that target this enzyme.
A new study by MIT researchers shows that combining antibiotic drugs with probiotics can eradicate two strains of drug-resistant bacteria that infect wounds. The probiotic bacteria were encapsulated in a protective shell of alginate to prevent them from being killed by the antibiotics.
Case Western Reserve researchers discover small molecules that block toxin formation in bacteria, allowing infected mice to survive. The breakthrough could lead to a solution for the global threat of antibiotic resistance.
Infants who were breastfed for at least six months had a smaller number of resistant bacteria in their gut than babies who were breastfed for a shorter period. Antibiotic treatment of mothers during delivery increased the amount of antibiotic-resistant bacteria in the infant gut.
Researchers found that up to 12% of bacteria on average were alive and able to reproduce in dark rooms. In contrast, only 6.8% of bacteria exposed to daylight and 6.1% of those exposed to UV light remained viable. This suggests that daylight can reduce the risk of dust-borne infections by killing dust-dwelling bacteria.
Researchers developed a virus nanoparticle vaccine against anthrax and plague, providing complete protection in animal models. The dual vaccine was effective even when animals were exposed to lethal doses of both pathogens.
A new study reveals that urban farmers in African cities are unknowingly spreading disease by irrigating vegetables with wastewater rich in virulent human pathogens. The risk of spreading bacteria and antimicrobial resistance among humans and animals is high, posing a significant health threat to millions of people.
Carnegie Mellon University researchers identified a molecule called BriC that plays a key role in bacterial communication and infection. BriC helps pneumococcus produce biofilms, making infections more robust, but may also be a target to render bacteria more sensitive to antibiotic treatment.
UCSB, UCSD, and SBP researchers developed a method to track sepsis development on a molecular level, revealing different pathways depending on host responses to various pathogens. Boosting anti-inflammatory activity or blocking TLR-4 activation showed potential as therapeutic approaches.
Researchers have discovered that host responses during sepsis progression can vary in important ways based on pathogen type. Boosting anti-inflammatory enzymes or using neuraminidase inhibitors showed therapeutic approaches, indicating a potential direction for drug development.
A University of Guelph researcher has developed a novel three-in-one vaccine targeting E. coli, Shigella, and Campylobacter jejuni, providing immunity against all three pathogens in mice tests. The vaccine may save lives in developing countries where these pathogens kill over 100,000 children under age five annually.
Children in low-resource countries are suffering from unnoticed infections that are stunting their growth and mental development, with lifelong consequences. Up to 30% of these children are carrying harmful infections that prevent them from reaching their full potential.
Researchers at NC State have developed self-sterilizing antimicrobial materials that can inactivate bacteria and viruses using only visible-wavelength light. The new approach opens the door to a range of new products aimed at reducing the transmission of drug-resistant pathogens.
Researchers at Rutgers University have discovered a new delivery system that can effectively combat bacterial infections. The nanostructured silica particles contain payloads of an antimicrobial agent and were found to be more effective at killing bacteria than the agent alone.
Research found that gram-negative bacteria, excluding Pseudomonas, increase mortality, ICU admission, and vasopressor use in hospitalized patients with interstitial lung diseases (ILD). Patients infected with these organisms had higher 30-day mortality rates compared to those infected with other pathogens.
A study by UIC researchers found that long-term exposure to periodontal disease bacteria causes inflammation and degeneration of brain neurons similar to Alzheimer's disease. Chronic infection leads to neural effects, including senile plaque formation and brain inflammation.
ETH Zurich researchers have created a molecular recording system that writes transcriptional events into DNA, allowing permanent storage and later access. The CRISPR-Cas system records genetic information about pathogens infecting the cell, storing it in a specific stretch of DNA known as a CRISPR array.
A recent study found that a new bacterial pathogen, Erwinia tracheiphila, emerged from the introduction of foreign crop plants to North America. The pathogen's genome shows dramatic changes, suggesting it has recently evolved as a pathogen, primarily affecting cucurbits grown in intensive monocultures.
Researchers found that polymers in airway mucus physically push on bacterial cells, causing stress responses that make them tolerate higher levels of antibiotics. This stress response is triggered by mild DNA damage, slowing down bacterial growth and making it harder to kill with antibiotics.
A mathematical model explains why some bacteria cause disease in small doses while others require thousands of bacteria, attributing it to the scale of their attack mechanisms.
Researchers discovered that fossil ants preserved in amber had specialized structures to support bacteria that produced antibiotics, helping them combat crop diseases. This ancient ant-bacteria symbiosis evolved independently three times and may hold clues for reducing antibiotic resistance in humans.
Researchers at Umeå University discovered that Vibrio cholerae uses nitrate respiration to control its population expansion and survival, even in the absence of oxygen. This smart metabolic mechanism allows the bacterium to thrive in the intestine's low-oxygen environment.
Researchers discovered that a small portion of pathogenic bacteria can go dormant, avoiding antibiotic effects. This 'hibernation' mechanism allows them to survive and resume regular functions when safe. Understanding this process is crucial for developing new antibiotics targeting the dormant state.
A new study finds that DNA islands can be engineered to disable Staphylococcus aureus bacteria, which are often resistant to antibiotics. The 'drone-like' vehicles deliver genetic payloads to bacterial populations, killing the bacteria and rescuing treated animals.
A new study from the University of Texas at Austin finds that exposure to glyphosate, a common weed killer, reduces healthy gut microbiota in honey bees and makes them more vulnerable to infection. This compromise can lead to bee deaths, particularly when exposed to opportunistic pathogens.
Lyme borreliosis is a vector-borne disease in Europe caused by Borrelia burgdorferi sensu lato complex. A recent study found that infection can occur within 24 hours of an adult tick bite and as soon as 12 hours for nymph bites, highlighting the importance of prompt removal of infected ticks.
Enterococcus faecalis relies on manganese acquisition systems for virulence, which are essential for growth in manganese-restricted environments. Inactivating these transporters led to a loss of virulence in animal models, making them promising targets for new antimicrobial therapies.
Researchers developed a novel immunochromatographic method to detect multi-resistant bacteria in blood cultures with 100% certainty. The new method reduces testing time from up to 72 hours, enabling faster treatment and potentially curbing the spread of resistant pathogens.
Researchers have identified a key step in how plant cells respond to pathogens, revealing an enzyme called SIK1 that connects detection and action. The discovery opens up new avenues for treating plant diseases and breeding resistant crops.
Researchers at the McGill University Health Centre have identified a new cellular target that can weaken P. aeruginosa, a bacterium responsible for thousands of deaths in cystic fibrosis patients. The discovery could lead to more effective antibiotics and improve treatment outcomes for these patients.
Scientists discovered that hundreds of bacteria, including pathogenic and probiotic species, generate electricity in the human gut. This discovery could lead to new ways to create living batteries from microbes, such as those found in waste treatment plants.
A mathematical model developed by international researchers predicts that temperature-dependent phages can affect the spread of melioidosis in Southeast Asia. The study reveals opportunities for disease control, including rescheduling work on rice fields and using protective gear during high-risk periods.
Researchers developed a mathematical model to predict the spread of melioidosis in Southeast Asia, highlighting the impact of bacteriophages on bacterial populations. The study found that phage-free bacteria numbers are highest during cooler periods, and using fertilizers can kill off phages, posing a risk of more frequent infections.