Research on disease-causing bacteria and how they spread. Covers waterborne bacteria, Lyme disease ecology, pathogenic genetics, and biofilm treatments.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
A new Legionella species, Legionella bononiensis, has been identified in a hotel facility in northern Italy. The discovery was made by researchers from the University of Bologna using genetic sequencing and mass spectroscopy techniques.
A recent study published in Nature Communications has found a significant imbalance in the gut microbiome of individuals with Parkinson's disease. The researchers discovered that over 30% of micro-organisms and bacterial genes tested had altered abundances, indicating a widespread imbalance in the microbiome.
A study by researchers from the University of Tsukuba found that treating cabbage leaves with multiple amino acids can prevent disease caused by Pseudomonas cannabina pv. alisalensis, a bacterium that causes blight in brassica crops. The amino acids trigger stomatal closure, reducing bacterial entry and disease symptoms.
A UMass Amherst microbiologist is working to develop new treatments for tuberculosis by targeting the bacteria's surface structure. The goal is to create a drug that can disrupt the cell envelope, making the bacteria vulnerable to attack.
Researchers have gained a better understanding of the structures and functions of Andhra gene products, paving the way for custom phages for therapeutic applications. The high-resolution knowledge of the virus structure is crucial for developing targeted treatments against Staphylococcus epidermidis infections.
MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state. The protective molecules, known as glycans, prevent Vibrio cholerae from producing the toxin that usually leads to severe diarrhea.
A new study finds that areas with high levels of arsenic contamination in drinking water have a higher prevalence of antibiotic-resistant Escherichia coli in both water and child stool samples. The study highlights the potential for environmental drivers like arsenic to contribute to antimicrobial resistance.
Researchers developed novel liquid-coated air filters that capture viable bacterial and viral samples for analysis. The filters show promise in improving early pathogen detection and aerosol sampling efforts.
A study found that 'harmless' Listeria innocua strains are developing resistance to temperature, pH, dehydration and other stresses, as well as hypervirulence similar to pathogenic L. monocytogenes. The strains were collected from raw, dried and processed meats at commercial food processing facilities in South Africa.
A new collaborative research centre, DECIDE, will investigate the interactions between pathogens and the human immune system, aiming to improve treatment strategies. The centre combines research on various bacteria, viruses, and fungi, and will involve numerous young researchers.
Researchers discovered antibiotic-resistant bacteria can travel from the gut to the lungs in a patient, highlighting the importance of preventing pathogenic bacteria from translocating to vital organs. The study's findings suggest eliminating resistant bacteria from the gut microbiome could help prevent serious infections.
A study characterizes secreted proteins from Candidatus Liberibacter solanacearum, a newly emerging pathogen of tomato and potato. The proteins, called effectors, offer clues into the manipulation tactics used by the bacterium to subdue its plant host.
Researchers have detected five emerging tick-borne pathogens in Central Canada, including those causing Lyme disease and babesiosis. Climate change and habitat fragmentation contribute to the spread of these pathogens, highlighting the need for increased awareness and protection measures.
A new study by CHOP researchers found that antibiotic-resistant Enterococcus enhances C. difficile virulence by modulating the gut environment, increasing toxin production and nutrient supply. This interaction supports increased colonization and persistence of C. difficile in the gut.
A new study on rhesus macaques reveals a strong link between social connections and the abundance of beneficial gut bacteria. Monkeys with more sociable behavior have a higher presence of microbes like Faecalibacterium, which has anti-inflammatory properties.
Researchers have developed a transport nanoparticle to deliver an anti-inflammatory drug, Necrosulfonamide (NSA), directly into macrophages to combat inflammatory overactivation. The mesoporous silica nanoparticle is fully biodegradable and non-toxic, showing remarkable efficacy in reducing inflammation.
Researchers have found that hypermucoviscous K pneumoniae strains carry higher rates of virulence genes and are less responsive to conventional drugs. These strains are thicker and stickier than previous strains, making them more challenging to treat with antibiotics.
Co-infection with gut parasites increases shedding of respiratory bugs like Bordetella bacterium, leading to higher probability of onward transmission. This study in rabbits has broad implications for human populations and suggests targeting treatment of helminths could be an effective way to reduce disease outbreaks.
A new treatment option for multi-resistant bacteria has been identified by a UNIGE team, which uses the drug edoxudine to weaken the defence mechanisms of Klebsiella pneumoniae, making it easier to eliminate. This approach could be a game-changer in the fight against antibiotic resistance.
A large listeriosis outbreak in southern Spain was linked to contaminated stuffed pork, which led to a public health alert and the implementation of post-exposure prophylaxis for pregnant women. The outbreak resulted in 207 confirmed cases and five miscarriages, highlighting the risk of Listeria contamination in ready-to-eat foods.
Researchers have successfully blocked the adhesion mechanism of Bartonella henselae bacteria, preventing cell infection. The discovery offers a promising new approach to combat highly resistant infectious agents like Acinetobacter baumannii.
Research found that the Black Death drove changes in immune-related genetic variants, affecting disease susceptibility. A specific gene variant, ERAP2, was associated with increased protection against the plague, but also linked to autoimmune diseases like Crohn's disease.
Researchers at ITQB NOVA extract bactericidal mixtures from tomato peels using a fast, simple, and sustainable process. The extracts show effectiveness against pathogenic bacteria, including Staphylococcus aureus and Escherichia coli. This breakthrough has the potential to provide antimicrobial properties to biomaterials.
A study by Osaka University researchers has revealed the molecular details of how Vibrio cholerae secretes its colonization factor TcpF. The mechanism involves the Toxin-coregulated pilus (TCP) system, which allows the bacterium to colonize the human intestine and initiate infection.
A recent study by Zhenzhen Zhao and colleagues found that Arabidopsis plants lacking Acyl Carrier Protein 1 (ACP1) are more resistant to bacterial pathogen Pseudomonas syringae. ACP1 is essential for maintaining hormone homeostasis, which affects plant stress responses.
The WHO European Region sees high mortality rates due to antimicrobial resistance, with countries implementing national actions plans showing lower AMR burden. Developing new treatments and improving hygiene are crucial strategies to combat this growing health threat.
A WVU biomedical engineer is working on a rapid diagnostic tool that can detect tick-borne infections such as Lyme disease via a blood sample on a single chip. The tool uses dielectrophoresis and machine-learning to detect diseases within one to two weeks after onset, reducing the risk of hospitalization and chronic conditions.
Researchers at La Jolla Institute for Immunology have discovered a rare T cell defect tied to the risk of developing MAC disease. People with this defect have fewer specialized Th1* cells, which robs them of an effective immune response to MAC bacteria.
A study by MedUni Vienna's Department of Dermatology reveals that tick saliva inhibits the skin's defense function, making it easier for pathogens to multiply. Climate change increases the danger from ticks, which now pose a threat in higher-altitude regions of Austria and well into late autumn.
Research reveals that symbiotic bacteria, Burkholderia gladioli, produce antifungal compound lagriamide to protect Lagria beetles' eggs, larvae, and pupae from fungal infections. The bacterial community remains intact during molting stages, providing crucial defense against pathogens.
A new study led by NYU researchers has developed a topical gel that targets the succinate receptor to suppress inflammation, reduce bacterial imbalance, and prevent bone loss. The treatment has shown promise in reducing gum disease symptoms, including inflammation and tooth loss.
A new study developed an analytical model that can predict Lyme disease bacteria distribution and abundance on the landscape. The research found that climate and habitat disturbance were key factors in determining infectivity rates.
Researchers at Imperial College London discovered a 'silent' mutation in bacteria that helps them evade antibiotics. The mutation alters the structure of an mRNA intermediate, preventing ribosomes from producing protein, and has arisen independently several times globally.
Researchers at Duke University have discovered a protein called GarD that cloaks Chlamydia bacteria from the host cell's immune system, allowing it to evade detection and elimination. Mutating this protein makes the bacteria vulnerable to destruction, offering new avenues for treatment.
Scientists at Aston University developed a new treatment combining manuka honey with the widely used antibiotic amikacin to treat drug-resistant lung infections. The study found that this combination improved bacterial clearance and reduced side effects, benefiting patients with cystic fibrosis.
Research at Karolinska Institutet reveals the glymphatic system malfunctions during bacterial meningitis, causing a buildup of toxic garbage that damages brain cells. The study found increased signs of neuroinflammation and neuronal damage in rats infected with Streptococcus pneumoniae.
A new study from the University of South Australia shows that captive frogs can be protected from the deadly fungus Batrachochytrium dendrobatidis (Bd) through natural skin shedding processes. However, captivity also reduces skin bacteria diversity and richness, potentially affecting the frogs' resilience to pathogens.
Researchers have discovered the key components in plant cells that trigger 'wartime' protein production in response to pathogens. This mechanism allows plants to rapidly produce defense proteins while balancing resources between growth and defense, a delicate process that could inform strategies for creating disease-resistant crops.
A new class of light-activated hemithioindigo molecules developed by Rice University scientists kill specific Gram-positive bacteria and their biofilms. The molecules induce reactive oxygen species that chemically attack and destroy drug-resistant cells, offering a safer alternative to conventional antibiotics.
Researchers at Rice University have created a new optical tool called homo-FRET that allows them to observe the real-time activity of two-component systems in bacteria. This breakthrough enables scientists to study the behavior of deadly pathogens and antibiotic-resistant bacteria, shedding light on their mechanisms and potential targe...
A recent study led by Eliza Loo found that plant immune receptors and signaling components confer salt tolerance even in plants challenged by non-pathogenic microbes. This suggests that plants can sense and initiate adaptive responses to abiotic stresses upon detecting alterations in cues presented by plant-inhabiting microbes.
Researchers have discovered how Acinetobacter baumannii bacterium attaches to surfaces using ultrathin stretchy fibers, enabling it to colonize medical devices and infect patients. The unique zigzag structure of the fibers plays a crucial role in their secretion and attachment to surfaces.
Researchers captured first image of antigen-bound T-cell receptor complex with bound antigen at atomic resolution. The study reveals no significant structural changes in the receptor after antigen binding, sparking further investigation into the signaling pathway activation mechanism.
A Rutgers scientist has developed a highly sensitive DNA test that can detect Lyme disease in horses, a condition that can cause long-term complications. The test, called genomic hybrid capture assay, was tested on a sick horse and successfully identified the pathogen, allowing for early diagnosis and treatment.
A newly identified species of Liberibacter, a family of bacteria known for causing citrus greening disease, is rapidly evolving its ability to infect insect hosts. The research team found 21 genes associated with infectious qualities and identified mutations affecting pilus proteins that allow the bacteria to move into host insects.
Researchers discovered a novel role for an E. coli enzyme in reducing the toxic effects of hypothiocyanite, a key antimicrobial released by the human immune system. This finding has implications for diseases like cystic fibrosis and inflammatory bowel disease, as it suggests that various bacteria can evade this powerful oxidant.
Research shows higher concentrations of pathogenic dust landing at lower elevations in the Sierra Nevada mountains, carrying fungi and bacteria that can cause crop failures and human respiratory disease. The study highlights the increasing threat of microbe-laden dust as the Earth dries out.
A new study by Johns Hopkins Medicine researchers reveals a promising genetic method for identifying hundreds of disease agents using next-generation sequencing. The Respiratory Pathogen Infectious Diseases/Antimicrobial Resistance Panel (RPIP) system shows near-comparability to traditional diagnostics in identifying pathogens.
A new study published in Applied and Environmental Microbiology suggests that oil formulations with food-grade organic acids can kill dried Salmonella on stainless steel surfaces. This approach has the potential to replace water-based cleaning methods, which promote microbial growth and are often challenging to use.
Researchers have designed a phage combination therapy that precisely targets and suppresses gut bacteria associated with inflammatory bowel diseases (IBD). The team identified effective phages against IBD-contributing Kp strains, which attenuated inflammation and tissue damage in mice models.
Researchers discovered a genetic switch in group B streptococcus that helps it resist metal stress, including zinc and copper. This 'cross-talk' mechanism allows the bacterium to survive in the human body's immune system.
A newly published framework outlines steps for administering probiotics to wildlife, prioritizing native species, effective dosages, and delivery systems. The goal is to restore beneficial bacteria and protect key symbiotic relationships, while considering potential risks and side effects.
Researchers have discovered a new mechanism that some bacteria use to evade rifamycin antibiotics, showing antimicrobial resistance is more complex and evolved than previously recognized. The discovery has implications for finding new antibiotics and combating the growing global health threat of antimicrobial resistance.
Researchers have designed a nano-copper coating with zinc that kills bacteria by rupturing their cell wall, reducing the incidence of bacterial infections on high-touch surfaces.
A study reveals urban waters exhibit distinct microbial signatures compared to rural lakes, indicating humanization and eutrophication's effects on ecosystems. This shift may increase the risk of pathogens and contamination in urban areas.
A new study by Flinders University experts warns that some drinking water treatment methods may be ineffective against certain waterborne pathogens, posing a threat to immune-compromised individuals. Regular maintenance checks and cleaning of shower and tap faucets can help reduce the risk of waterborne infections in home care.
A new study suggests that a unique gene variant supporting cognitive health in older humans may have first emerged to protect against infectious pathogens like gonorrhea. This variant, linked to CD33, allows brain immune cells to break down damaged brain cells and amyloid plaques associated with Alzheimer's disease.
Rice University bioscientists have developed a novel approach to control the expression of 'silent' genes in bacteria using CRISPR technology. This strategy could lead to the discovery of new antibiotics and has potential applications in antifungal and anticancer agents, as well as agriculture.
Researchers at Ben-Gurion University have found a phytochemical derived from broccoli that breaks down biofilms protecting antibiotic-resistant pathogens, enabling eradication rates of up to 94% when combined with antibiotics. The compound also accelerates wound healing and is being further developed for commercialization.