Articles tagged with Bacterial Strains
A multidisciplinary study has identified a novel biofilm regulatory protein called Biofilm Architecture Regulator (BatR) and its role in Pseudomonas aeruginosa infections. The discovery may lead to new targets for anti-infective treatments, including those for people with cystic fibrosis.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers propose a voluntary labelling scheme using 'STABILISED' to indicate products with minimal risk of Listeria infection. The scheme aims to help consumers choose safe products and reduce the number of people falling ill with Listeria infections.
Researchers uncovered the genetic history of Acinetobacter baumannii, tracing its evolution over decades to identify key resistance traits and global spread. The study provides valuable insights for guiding policies on antibiotic use and combating this serious healthcare threat.
Researchers have discovered how wall teichoic acids control bacterial growth, providing insights into the nature of Earth's earliest life forms. The study reveals that eliminating these acids rapidly arrests cell wall synthesis and activates enzymes that promote rod-shaped growth.
Researchers have catalogued a new collection of bacteria-eating viruses to combat the growing threat of hospital superbug Klebsiella pneumoniae. The open-source phage library offers scientists a valuable resource to develop new treatments and improve understanding of phages and bacteria interactions.
Researchers at the University of Houston discovered that T. phoenicis can enter dormancy to evade detection, highlighting the resilience of spacecraft-associated microbes and raising concerns about planetary protection. The findings may lead to better detection methods and more effective sterilization strategies in various industries.
A National Institutes of Health (NIH)-supported clinical trial found that two intravenous doses of the antibiotic dalbavancin seven days apart are as good as daily IV doses of conventional antibiotics over four to six weeks for treating complicated Staphylococcus aureus bloodstream infections. The study results provide clear evidence f...
Researchers found that new strains of Cutibacterium acnes, a species believed to contribute to acne development, are acquired during the early teenage years. This transitional stage could be the best window for introducing probiotic strains of C. acnes to prevent acne.
Researchers at UMass Amherst's New England Center of Excellence in Vector-borne Diseases have identified a new strain of Rickettsia bacteria that causes spotted fever infections in humans. The discovery in Maine suggests rabbit ticks could be a zoonotic vector for serious infections, contradicting the usual dog tick vector.
A novel selective medium was developed to isolate Escherichia albertii, a previously uncharacterized species. The CT-PS-XR-MacConkey agar selectively differentiated E. albertii from other bacteria, including those in food samples. This finding has significant implications for the identification and study of this pathogen.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
A new study maps how specific lactic acid bacteria can reduce off-flavours and degrade anti-nutrients in plant-based dairy alternatives. Fermentation with these bacterial strains increases nutrient bioavailability and enhances product nutritional profiles.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
Researchers discovered that a drug-resistant type of bacteria has adapted to produce antimicrobial genetic tools, eliminating its cousins and replacing them as the dominant strain. The finding validates a system developed at Pitt and UPMC for detecting infectious disease outbreaks.
Researchers have discovered a protein called MdfA that enables bacteria to shut down into dormant spores under extreme conditions. This process allows bacteria to survive in uninhabitable places and evade hospital cleaning, making them potentially deadly superbugs.
Researchers discovered that sulfur bacteria from the Desulfobacteraceae family work together like a team to break down diverse organic compounds. By analyzing six strains, they found similar molecular strategies and a highly energy-efficient central metabolism pathway, enabling them to thrive in oxygen-free environments.
A groundbreaking study has identified a dual-target approach that significantly prevents the development of resistance in bacteria. This approach combines membrane disruption with an additional critical cellular pathway, offering a potential solution to mitigate the escalating threat of antimicrobial resistance.
Research finds over 25% of Egyptian milk and dairy products contain E. coli, with one strain causing a Japanese school outbreak; experts hope for effective treatment and prevention methods.
A team of scientists has developed a cutting-edge technology to analyze bacterial sexually transmitted infections (STIs) using genome sequencing. The 'target enrichment' method enables high-resolution analysis of Chlamydia trachomatis and other pathogens, revealing new insights into their transmission and development pathways.
Researchers at Hokkaido University have successfully cultivated an ultrasmall bacterial strain that parasitizes methanogenic archaea, inhibiting their growth. This discovery represents the first successful cultivation of such bacteria and proposes a new phylum Minisyncoccota, advancing our understanding of microbial ecology.
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
Recent studies have found that new antibiotics are prone to rapid development of resistance, even before they are widely used. This raises concerns about the effectiveness of these treatments in the long run. To address this issue, researchers call for a shift in antibiotic development prioritizing novel modes of action and responsible...
A University at Buffalo-led team has identified a strain of bacteria that can break down and transform at least three types of PFAS, as well as some of the toxic byproducts of the bond-breaking process. The bacteria, Labrys portucalensis F11, metabolized over 90% of perfluorooctane sulfonic acid (PFOS) after a 100-day exposure period.
Biofilm produced by Pseudomonas alcaligenes has unique structural properties and thermal stability, exhibiting antioxidant, emulsification and flocculation activity. The EPS can be used as a natural additive for the pharmaceutical and food industries with potential applications in developing sustainable or ecofriendly additives.
Researchers at UMass Amherst have developed a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors. The therapy uses genetically engineered strains of Salmonella that can target tumors and control the release of cancer-fighting drugs inside cancer cells.
Researchers analyzed 7,000 S. aureus samples to identify key genetic changes that enable bacterial survival in humans. The study revealed mutations associated with nitrogen metabolism and immune system evasion strategies.
A recent study found that multidrug-resistant Klebsiella pneumoniae exhibits distinct characteristics in Saudi Arabia, with molecular factors contributing to increased virulence and severity. The researchers highlight the need for tailored surveillance programs and new antimicrobial agents to address this local threat.
Researchers develop innovative hybrid control strategy to improve product yields in biosynthetic processes. The new approach combines model-based optimization with in-cell feedback control, outperforming traditional methods and promising reduced costs and environmental impact.
Researchers identify two strains of bacteria producing colibactin as a potential link to colorectal, bladder, and prostate cancers. Targeting these strains with vaccines or probiotics could reduce cancer risk and infection burden.
A new strain of antibiotic-resistant bacteria, ST164, has been spreading widely across Asia, posing significant challenges to global public health. Researchers discovered that 80.9% of A. baumannii bacteria found in patients were CRAB, with ST164 accounting for 40.2% of samples.
Researchers at Houston Methodist have identified a new strain of bacteria, Streptococcus dysgalactiae subspecies equisimilis (SDSE), linked to increasingly severe human infections. The study used integrative analysis to investigate the genome, transcriptome, and virulence of SDSE strains, shedding light on their molecular pathogenesis.
New research from the University of Chicago shows that gut bacteria can acquire a gene that shuts down their own deadly weapon and activates a new one, allowing them to outcompete other bacteria. This transfer of genes enables the bacteria to carve out niches in the tightly packed recesses of the gut.
A new study has identified novel strains of microbes that have adapted to use limited resources in cities, including those found in Hong Kong's subways and skin. These microbes can metabolize manufactured products, posing health risks if they are pathogenic.
Researchers from Duke University have discovered the mechanism behind the discrepancies in how resistant infections react to combination treatments. The study found that bacteria with a higher level of 'selfishness' are more likely to thrive after treatment, while less selfish strains benefit more.
Researchers have discovered a new class of natural antimicrobials called microcins that can target specific strains of bacteria causing cholera, inflammatory bowel disease, and colon cancer. Microcins are highly selective and can potentially remove unwanted bacteria without disrupting the human gut microbiome.
Four plants eaten by western lowland gorillas in Gabon, also used by local traditional healers, show antibacterial and antioxidant properties. Researchers identify four plant species with promising targets for treating multidrug-resistant infections.
Researchers have identified two compounds with strong antivirulence activity from actinobacteria in the Arctic Sea, targeting EPEC bacteria that cause severe diarrhea. The compounds inhibit virulence factor formation and binding to host cells, reducing disease severity and potential for resistance.
Researchers discovered a unique probiotic strain, Bifidobacterium bifidum BB1, that strengthens intestinal barrier function and protects against harmful bacteria. This strain may lead to the development of novel therapies for patients with inflammatory bowel disease and other inflammatory conditions.
A team of researchers at UC Davis Health discovered a novel bioelectrical mechanism that allows Salmonella bacteria to navigate the gut lining and find vulnerable entry points. The study found that Salmonella bacteria detect electric signals in FAE, which helps them move towards openings in the gut where they can enter.
Researchers sequenced the complete genomes of Lyme disease bacteria representing all 23 known species, tracing the origins back millions of years. The study provides valuable tools and insights for combating the rising public health threat of Lyme disease.
A clinical trial found that fecal microbiota transplants can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers. The study identified specific bacterial strains associated with better or worse responses, and showed promise for improving treatment outcomes.
A new study reveals that Cutibacterium acnes can persist in biofilms on implants for weeks, invading deep bone networks and causing chronic infections. The bacteria's ability to invade osteocyte lacuno-canalicular networks provides a novel mechanism for treating difficult-to-treat bone infections.
A pilot study found evidence of human co-infections with Bartonella and Babesia odocoilei in six out of seven patients with chronic, non-specific illness. The discovery could lead to better diagnoses and treatments for patients with these infections.
Researchers have identified a novel type of T cell that can recognize and respond to multiple bacterial strains in the gut. This breakthrough finding has significant implications for treating diseases such as cancer and inflammatory bowel disease. The discovery was made by Kazuki Nagashima, winner of the NOSTER & Science Microbiome Prize.
Researchers analyzed genomic data and human travel patterns to understand the spread and evolution of Streptococcus pneumoniae. The study found that a pneumococcal vaccine reduced antibiotic resistance but allowed non-targeted strains to gain a competitive advantage, suggesting short-lived protection.
A recent study found that antibiotic-resistant strains of bacteria endemic to the UK and Norway are not prevalent in Pakistan despite widespread use of antibiotics. The study used genomic surveillance to map different strains of Escherichia coli, highlighting the importance of understanding bacterial threats in specific regions.
Researchers have gained insight into how a deadly strain of salmonella adapts to invasion, flourishing in hostile environments and evading immune defenses. The study sheds light on the role of fluid shear forces in bacterial behavior, which may accelerate the design of new therapies for life-threatening infections.
Researchers found that many bacterial strains present in infants at 3 weeks, months, and 12 months originated from the father, not the mother. This discovery highlights the importance of physical and social interactions between newborns and their fathers, as well as with other family members.
A novel antibacterial lipopeptide produced by Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus. The lipopeptide targets the cell membrane, causing lesions and cell death.
Researchers developed a prodrug delivery method using a commensal Lactobacillus strain that binds specifically to cancer cells, releasing the chemotherapy drug SN-38 directly at the tumour site. This approach reduces tumour growth by 67% and increases chemotherapy drug effectiveness by 54% in preclinical models of nasopharyngeal cancer.
A team of POSTECH and ImmunoBiome has discovered a dietary-derived bacterial strain, IMB001, that induces nutritional immunity and boosts anti-tumor responses. The strain works by skewing tumor-infiltrating macrophages toward an inflammatory phenotype, leading to increased cell death of rapidly multiplying tumor cells.
Researchers identified a unique two-part defense system that destroys plasmids, protecting the bacterial strain from evolution and contributing to its longevity. This discovery could lead to new treatments or prevention strategies against severe symptoms.
Researchers discovered that two species of marine bacteria work together to produce vitamin B12, essential for metabolism and survival of many marine organisms. The bacteria release building blocks into the water, which are then combined to form the vitamin through a complex process involving viral infection.
Researchers at the University of California San Diego developed a biodegradable form of thermoplastic polyurethane (TPU) filled with bacterial spores from Bacillus subtilis. The material breaks down in compost environments within five months, even without additional microbes.
The study reveals the RNA microarray gene expression profiles of two critical superbugs, Klebsiella pneumonia and Pseudomonas aeruginosa. It identifies shared significant genes and drug resistance genes, highlighting their divergent evolution and potential association with resistance mechanisms.
Researchers analyzed well-preserved microbiomes from 4,000-year-old teeth in Ireland, providing a snapshot of oral health in the past. The study found evidence of dysbiosis and an unusual abundance of S. mutans bacteria, suggesting that our ancestors' mouths differed significantly from ours.
A new vaccine developed by UCLA researchers demonstrates high protection against melioidosis, a tropical disease that causes 89,000 fatalities annually. The vaccine was tested in mice and found effective even against a highly lethal strain of the bacteria.
A team of researchers has developed a reliable method to define bacterial species and strains by analyzing genetic diversity. The study found that natural gaps in genetic diversity can be used to differentiate between species, with members of the same species showing high levels of genetic relatedness.