Articles tagged with Bacterial Strains
Researchers have designed a phage combination therapy that precisely targets and suppresses gut bacteria associated with inflammatory bowel diseases (IBD). The team identified effective phages against IBD-contributing Kp strains, which attenuated inflammation and tissue damage in mice models.
Researchers have developed a novel approach to engineering live bacterial therapeutics by using native microbes that can survive in the gut. This method overcomes previous limitations of introducing engineered bacteria into the gut, demonstrating potential for long-term therapy and reversal of disease pathologies in mouse models.
Researchers discovered a specific gut bacterial strain, Klebsiella aerogenes, that produces histamine and triggers abdominal pain in IBS patients. The study found that reducing histamine production by colonizing mice with low fermentable carbohydrates led to decreased pain.
NC State researchers discovered a new way to make the difficult-to-characterize gut bacterium Bifidobacterium more responsive to antibiotics. They also found tiny changes in different strains that reflect large differences in their characteristics, highlighting the need for individualized CRISPR-based genome engineering approaches.
Gut bacteria produce inositol lipids, vital for cellular processes in humans, and these substances impact the symbiosis between bacteria and their hosts. The discovery sheds light on how gut bacteria thrive in their human hosts.
Researchers at Lawrence Berkeley National Laboratory have created a new type of fuel that has higher energy density than traditional heavy-duty fuels. The biofuel, called POP-FAMEs, is produced by bacteria fed with plant matter and can significantly reduce greenhouse gas emissions when burned.
A recent study has found that ocean plastic may be a source of novel antibiotics, with researchers isolating five antibiotic-producing bacteria from plastic debris. The isolated bacteria showed promise against commonly used and resistant bacterial strains, providing hope for an alternative solution to the growing antibiotic crisis.
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
A study found that Brazil's Salmonella vaccine for poultry contributed to the emergence of antibiotic-resistant strains. However, these resistant bacteria have not increased food poisoning cases in humans in the UK.
Researchers at Karolinska Institutet have identified a new vaccine candidate based on nano-sized membrane vesicles that provide protection against multiple pneumococcal strains. The vaccine target two conserved lipoproteins MalX and PrsA, showing serotype-independent cross-protection.
A research team from the Max Planck Institute for Terrestrial Microbiology has identified 1,000 biosynthetic gene clusters, over half of which are previously unknown. These natural products have been found to be eukaryotic proteasome inhibitors that suppress the immune system of insects, as well as other virulence factors.
Researchers studied two strains of Mycobacterium tuberculosis with different lung attack mechanisms, finding that high-transmission strains trigger granulomas that may aid bacterial escape into the airways. In contrast, low-transmission strains cause inflammation that traps bacteria, reducing transmissibility.
Researchers developed a new way to help protect the natural flora of the human digestive tract by engineering bacteria to break down beta-lactam antibiotics. This approach protects the microbiota in the gut while allowing antibiotics to remain effective, reducing the risk of infection and antibiotic resistance.
The study found two DNA defense systems in Vibrio cholerae bacteria that work together to eliminate plasmids and prevent the spread of antibiotic resistance. These defense systems, called DdmDE and DdmABC, are encoded within distinct pathogenicity islands and help the bacteria survive pandemics.
Researchers from OIST found that Escherichia coli bacteria form lanes of genetically similar individuals when constrained to a channel, aligning parallel to the barriers. The study, published in PNAS, used microfluidic platforms and simulations to observe population dynamics over several generations.
Research suggests that genetic material from E. coli bacteria in farm animals may contribute to the evolution of deadly pandemic strains. The study found that ColV plasmids in pigs, cattle, and chickens can increase the likelihood of antimicrobial resistance and extra-intestinal infections in humans.
A study published in JAMA Network Open shows that a comprehensive system to improve antibiotic stewardship in long-term care facilities significantly reduces the use of antibiotics, leading to better patient outcomes and reduced drug-resistant bacterial strains. The program empowered clinicians to make informed decisions about prescrib...
Researchers are exploring how bacteria form biofilms, which can be detrimental to health but also have potential uses in medicine and environmental cleanup. The study aims to understand the mechanisms behind microbial growth in biofilms and develop new materials and treatments.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
SMART researchers identified a novel phage lysin, Abp013, with promising antimicrobial ability against Acinetobacter baumannii and Klebsiella pneumoniae. The study demonstrated Abp013's ability to effectively target complex bacterial environments and could advance treatment methods for multidrug-resistant Gram-negative pathogens.
A new bacterial strain, Noda2021, belonging to Candidatus phylum Dependentiae has been isolated and sequenced, revealing its genetic material and potential ecological significance. This discovery sheds light on the diversity of microorganisms in Japan's microbiological hotspots.
Scientists have found a new energy metabolism in lactic acid bacteria that combines features of respiration with fermentation. This hybrid metabolism enables the bacteria to thrive better and faster, potentially improving gut health by manipulating its growth.
Researchers found that smart windows with dynamic tinting can completely disinfect surfaces within 24 hours, reducing bacterial growth rates and viability. In contrast, traditional windows with blinds blocked almost all daylight, promoting contamination on glass, plastic, and fabric surfaces.
Researchers found that half of Pseudomonas syringae strains benefited from the presence of aphids, but only the honeydew itself boosted bacterial populations. The study suggests using this phenomenon to develop alternative pest control methods.
Researchers have discovered a molecular mechanism that contributed to the emergence of the seventh cholera pandemic. The study found that modified Vibrio cholerae bacteria used their type 6 secretion system (T6SS) to outcompete and kill older strains, leading to their displacement.
Researchers have made significant breakthroughs in understanding the human gut microbiome by focusing on bacterial strains rather than species. By using a new computational method, scientists can analyze the strains of bacteria present in a microbiome sample more quickly and affordably.
A new species of antibiotic-resistant bacteria, Enterococcus innesii, has been discovered by researchers at the John Innes Centre. The strain is resistant to vancomycin and may cause hospital-acquired infections.
The coating protects bacteria during the freeze-drying and manufacturing process, allowing them to be used therapeutically. The researchers tested the coating on a strain of E. coli and another species that aids in digestion of plant starches.
Scientists have developed an enzyme that degrades the capsule surrounding the bacterium that causes anthrax, reducing virulence and protecting mice from infection. The treatment, known as PEG-CapD-CPS334C, is a promising avenue for treating multidrug-resistant anthrax and other bacterial infections.
Researchers at USC developed a new peptide that stimulates the host's immune response to fight bacterial infections, offering an alternative to antibiotics. The peptide, MTD12813, is highly effective in clearing infections and modulates inflammation, reducing the risk of complications.
Researchers at the University of Texas at Dallas have developed a vaccine method against recurrent urinary tract infections (UTIs) using metal-organic frameworks. The new approach produces substantially enhanced antibody production and significantly higher survival rates in mice compared to standard vaccine preparation methods.
Researchers at Hebrew University of Jerusalem discover a 'disrupted' state in bacteria that resists current antibiotics, requiring new pharmacological agents to combat. The breakthrough model predicts bacterial population responses to treatments, offering avenues for better treatments against cancer cells.
A study by Anglia Ruskin University has identified potentially dangerous Pseudomonas bacteria in 21% of wild bird faeces collected from locations near the River Cam. The bacteria, which can be passed on to humans through cross-contamination, were resistant to multiple antibiotics.
A large-scale study characterized 585 strains of the Xanthomonas perforans bacterium in Florida commercial tomato fields, finding associations between farms and transplant facilities as key points of pathogen spread. This research provides insights into the diversity of the pathogen population and potential control strategies for farmers.
Researchers identified a bacterium on healthy cats that produces antibiotics against severe skin infections in humans and pets. The discovery may lead to new treatments for MRSP infections in dogs and potentially other inflammatory skin diseases.
A new hydrogel treatment kills drug-resistant bacteria, including MRSA, and induces the expression of naturally-existing antimicrobial peptides in human skin cells. The gel is non-toxic, biodegradable, and scalable.
Researchers at IOCB Prague have developed a novel antibacterial material called NANO-LPPO that can prevent infection and facilitate treatment of skin wounds. The material combines lipophosphonoxins with a nonwoven nanotextile, which releases active substances in response to bacterial presence.
Researchers at Tel Aviv University have created a system that enables the production of 'good' bacteria capable of eliminating 'bad' bacteria. This breakthrough technology uses a toxin injection system to target specific types and amounts of toxins, offering an alternative to antibiotics.
A mechanical engineering faculty-researcher at RIT is developing a microfluidic device to improve the detection of drug-resistant bacteria in blood, which can cause severe infection and death. The goal is to detect these strains early, allowing for prompt treatment and recovery.
Researchers found that certain species of gut bacteria accumulate human drugs, altering their types, activity, and metabolism. This can change the effectiveness of the drug both directly and indirectly, affecting side effects.
Scientists at Tokyo University of Science discovered endophytic bacteria that can survive extreme conditions within passion fruit seeds. The bacteria were isolated from seedlings grown from cut seeds and found to possess biocatalytic activities related to the metabolism of secondary metabolites, such as resveratrol and piceatannol.
Researchers identified two proteins, HMW1 and HMW2, that stimulate protective immunity against diverse NTHi strains. Immunization with these proteins provides protection against bacterial colonization by other strains, highlighting the vaccine potential for a nontypeable Haemophilus influenzae vaccine.
Researchers at Washington University in St. Louis used comparative metabologenomics to study the genomes of Streptomyces bacteria and identify key factors that influence drug production. The study found that fine-tuning of specific nucleotides can control antibiotic production, offering new insights for next-generation drug discovery.
Phages play a key role in initiating rapid bacterial evolution and the emergence of treatment-resistant superbugs, according to new research from the University of Pittsburgh School of Medicine. The study reveals that phages interact with bacteria and facilitate adaptation, allowing resistant strains to gain an evolutionary advantage.
Scientists at the University of Delaware have made progress on a biological containment strategy using synthetic auxotrophy, keeping a strain of E. coli stable for 100 days. The research also shows promise for treating diseases and cleaning up the environment safely.
A recent study found that genes involved in bacterial signaling play a crucial role in the virulence of Psa3, a highly aggressive biovar of the pathogen Pseudomonas syringae pv. actinidiae. This discovery highlights the importance of understanding the diversity of virulence strategies among closely related bacterial strains.
A new study found that one in ten veterinary workers in the Netherlands carries strains of antibiotic-resistant bacteria, including ESBL-producing bacteria. The study suggests that occupational contact with animals may be a key factor in transmitting these resistant bacteria to humans.
Researchers investigated bacterial persistence in the human gut microbiome, identifying three dispersal strategies and finding that most strains are highly persistent. The study's results will inform targeted probiotic and treatment approaches to maintain a healthy gut microbiome.
Researchers discovered a new bacterium, Dysosmobacter welbionis, present in 70% of the population, which produces butyrate and has anti-inflammatory effects. The bacteria was found to increase mitochondrial activity, lowering sugar levels and weight in mice, suggesting potential for treating type 2 diabetes and obesity.
Researchers at RMIT University have discovered a bacteria-killing compound in Nem Chua that can destroy more dangerous bacteria, potentially leading to a safe and all-natural food preservative. The compound is effective against a wide range of bacteria, including those that cause life-threatening diseases like Listeria.
Scientists have discovered that bacteria found in brackish sediments can 'eat' electricity and absorb climate-warming carbon dioxide. This unusual skill was previously thought to be exclusive to freshwater bacteria, but may be common in marine bacteria.
Researchers have discovered a novel consortium of bacteria that can prevent and treat chronic immune-mediated colitis in humanized mouse models. The treatment targets the source of inflammatory bowel disease, restoring normal gut function and reducing symptoms.
Research finds that a balance between immune-suppressive and non-suppressive bacterial strains in the plant microbiota is crucial for maintaining microbe-plant homeostasis. This balance allows plants to promote growth while preventing excessive defense, reducing disease susceptibility.
Researchers at Hiroshima University engineered a new strain of heat-loving bacteria that thrive in high temperatures and produce acetone efficiently. This breakthrough could simplify and cost-effectively replace traditional methods for producing acetone, paving the way for more sustainable biofuel production.
Researchers developed a microneedle patch that delivers vancomycin directly into the affected skin area, significantly reducing MRSA bacterial population. This innovative approach aims to transform the treatment of skin infections by improving quality of life for patients.
Researchers from NUST MISIS have created innovative multilayer coatings that synthesizes protective properties of nanoparticles, biopolymers, anticoagulants, and antibiotics. The coatings demonstrated excellent bactericidal efficacy against antibiotic-resistant bacterial strains with a prolonged antibacterial effect up to 7 days.
Researchers uncover how tailocins, produced by bacteria under stress, target specific strains with lethal precision. The nanomachines have potential applications in studying microbial interactions and developing new antibiotics.
A five-day fast followed by a healthy diet reduces inflammation and promotes beneficial gut bacteria, improving cardiovascular health. Long-term effects include lower body mass index, reduced blood pressure, and decreased antihypertensive medication use.
A new study has mapped the full evolutionary journey of the bacterium Enterococcus faecalis, a common cause of antibiotic-resistant infections in hospitals. The research shows that antibiotic resistant strains developed earlier than previously thought, influenced by agricultural and early medical practices.
Researchers have identified a small molecule produced by bioluminescent bacteria that plays a key role in establishing the symbiosis between the squid and its light organ. The molecule, cHP-3, is produced during colonization and influences bacterial luminescence, suggesting an important chemical signal specific to this symbiosis.