Articles tagged with Bacterial Strains
Researchers engineer bacteria to target CD47 on cancer cells, inducing local inflammation and boosting T cell activation. The therapy leads to complete tumor regression and reduced metastasis in mouse models.
Researchers at UC Riverside have identified a neurotoxin produced by bacteria that kills Anopheles mosquitoes, which spread malaria. The discovery could lead to the development of a chemical-free insecticide and reduce the risk of resistance.
A study by Boston Children's Hospital scientists reveals that the absence of certain beneficial bacteria in the human gut makes children susceptible to food allergies. Transplanting these bacteria into mice with food allergies prevents the disease and even reverses it, suggesting a new approach to treatments.
A study using whole genome sequencing reveals a single bacterial strain with carbapenem-resistance gene persisted in a Northern California hospital for over 3 years. The strain was transmitted from patient to patient, particularly through lengthy stays in the intensive care unit.
Researchers at City University of Hong Kong have been awarded a $100,000 grant to develop a bioreactor that can cultivate multiple strains of probiotic bacteria simultaneously. The goal is to produce low-cost gut microbial biotherapeutics with a target cost of $0.1 per dose.
Researchers at Stanford University and Mexico isolated two color-changing compounds from scorpion venom that can kill staphylococcus bacteria and drug-resistant tuberculosis. The compounds were synthesized in the lab and verified to be effective against these pathogens.
A 15-year-old girl with cystic fibrosis was treated with genetically engineered bacteriophages to combat a life-threatening, drug-resistant infection. The treatment led to the clearance of skin nodules and improvement in liver function, demonstrating the safety and effectiveness of phage therapy.
A Stanford-led study reveals that once Helicobacter pylori colonizes a pitlike gland in the stomach, it becomes difficult for other strains to dislodge it. The findings raise questions about the effectiveness of probiotic approaches and hint at potentially effective ways to deal with life-threatening H. pylori strains.
Researchers at King Abdullah University of Science & Technology found that bacterial communities can homogenize even with slow flowing water and persistent conditions. They identified a precise flow rate of 3.85 microlitres per second for homogenization to occur.
Researchers at the Wellcome Sanger Institute have sequenced the genome of a non-toxigenic strain of Vibrio cholerae from WWI, showing it is distantly related to strains causing modern pandemics. The strain lacked a flagellum and possessed genes for ampicillin resistance.
Researchers have discovered a causal link between the gut microbiome and anti-tumor immunity, identifying key bacterial strains that activate the immune system to slow melanoma growth. The study also reveals the role of unfolded protein response (UPR) in this process, providing potential markers for patient stratification.
Research found that natural selection favors cheating rhizobia that provide fewer benefits to their host plants, destabilizing mutualisms. The study suggests that beneficial bacteria services vary in natural systems and can be exploited by cheater strains.
Researchers have discovered a novel glycocin, a small antimicrobial peptide with a sugar group attached, produced by the thermophilic bacterium Aeribacillus palladius. The compound has been successfully expressed in E. coli bacteria, making it easier to produce and investigate. This breakthrough could lead to new alternatives for biofu...
Researchers have developed a new mouse model that closely resembles human acne by adding synthetic sebum, allowing them to directly compare 'good' and 'bad' strains of Propionibacterium acnes bacteria. The study found that acne-associated strains caused inflammation and lesions, while health-associated strains had minimal effect.
Researchers found that luminescent bacteria in the squid's light organ change gene expression in other organs, highlighting the importance of bacterial bioluminescence. The study also shows that coordination between the eye and light organ is crucial for the animal's behavior.
Researchers discovered that freshwater bacteria grow faster in daylight and use blue light absorption mechanisms to regulate growth. The study suggests that these bacteria have special genes that allow them to sense light and adjust their metabolism accordingly.
A team of physicists from Immanuel Kant Baltic State University has developed a new method to quickly identify single antibiotic-resistant bacteria cells that are the agents of tuberculosis. The technique uses Raman scattering spectrography to analyze bacterial cells without damaging them.
MIT engineers develop a microfluidic technique to quickly assess bacteria's electrochemical activity, finding a strong correlation between polarizability and electricity production. This breakthrough could lead to new applications in power generation and environmental cleanup.
Researchers found that certain E. coli strains trigger protective immune responses while others evade them, leading to recurrent infections. The study suggests developing broad-spectrum vaccines should consider the diverse pathogens encountered in the community.
A new study found that Streptococcus pneumoniae bacteria that occupy human host tissue first are more likely to thrive than competing strains. The researchers discovered that these 'owners' release toxins to kill intruders, while also releasing protective factors to defend themselves.
Researchers from ITMO University developed nanocontainers that can translate light signals into metabolic changes in bacteria, opening a new way to control bacterial growth. The containers are made of titanium dioxide nanoparticles coated with silver and polymers, and can be used for controlled drug delivery.
Researchers found strains of Enterobacter bugandensis on the ISS with antimicrobial resistance patterns similar to those on Earth. The strains included genes involved in virulence and disease, raising concerns about potential health implications for future missions.
A team of scientists has developed a new method for detecting specific strains of E. coli using molecular electronics, which could lead to rapid and straightforward detection of pathogens and antimicrobial resistant bacterial strains.
Researchers studied bacterial ecological systems using experiments and computer models to investigate population dynamics, identifying key role of stochastic effects in early colony patterning. They also found that interactions between neighboring bacteria can amplify local variation, influencing competition outcomes.
A new study by MIT researchers shows that combining antibiotic drugs with probiotics can eradicate two strains of drug-resistant bacteria that infect wounds. The probiotic bacteria were encapsulated in a protective shell of alginate to prevent them from being killed by the antibiotics.
Researchers have successfully created a blue rose through genetic engineering by expressing pigment-producing enzymes from bacteria in white roses, resulting in a blue color. The team's breakthrough could lead to the mass production of true-blue roses without dye or injections.
Pea aphids can see and avoid virulent bacteria, led by Cornell University researchers who found the bacteria's fluorescent compounds that emit UV light. This ability may lead to organic farmers using pyoverdine or virulent bacteria on leaves to deter pea aphids.
Researchers found that a single mutation in TB bacteria makes them resistant to antibiotics and elicits a weaker immune response, leading to higher mortality rates. The study suggests that the same approach may not work for drug-resistant TB strains.
Scientists have discovered how bacteria, including Clostridium perfringens, pass genetic information to resist antibiotics and produce toxins. The new gene tcpK plays a critical role in this process, allowing bacteria to share genetic instructions with each other.
Researchers identified 40 different Leptospira strains in Uruguay cattle, including rare isolates and serotypes matching those found in human leptospirosis patients. The discovery highlights the need for improved diagnostic tools and vaccination strategies to mitigate the risk of human infection.
A new bacterial strain, Staphylococcus cornubiensis, has been identified from a skin infection in Cornwall. The strain is genetically unique and likely belongs to the Staphylococcus intermedius group, which is also associated with pets.
Researchers are mapping the function of specific enzymes that may facilitate the development of new drugs to fight bacterial infections and cancer. The study could also potentially help against neurodegenerative diseases such as autism, Down syndrome, Parkinson's disease, and Alzheimer's.
Researchers at UH University have won a $3.5M grant to develop technology suggesting the best combinations of antibiotics to kill certain resistant bacteria. The project aims to combat antibiotic resistance, a major public health threat.
Researchers at Mayo Clinic and Arizona State University have discovered that a type of clay can kill certain bacteria causing infections in wounds. The clay's antibacterial properties were tested against various bacterial strains, including those resistant to antibiotics.
A gene study pinpoints how Staphylococcus aureus bacteria can jump between species, acquiring new genes that enable survival in a new host. The research highlights the importance of disease surveillance to spot strains that could cause major epidemics and informs strategies for managing infections.
A recent study published in Eurosurveillance confirms that NDM bacteria can be transmitted between dogs and humans, with the owner of two Finnish dogs also carrying the bacterium. The transmission was established through genome analysis, which revealed identical bacterial isolates from dogs and humans.
Researchers discovered that bacteria can use provoking toxins to increase aggression levels in competing strains, leading to the elimination of weaker strains. This strategy could be exploited to manipulate microbial communities and fight infections, particularly resistant biofilms.
Researchers studied Bacillus bacteria that produce highly resistant spores and found unique genes contributing to their resistance. The discovery sheds light on the challenges of eliminating microbes in clean rooms and spacecraft.
A new platform enables quick discovery of molecules that recognize specific strains of bacteria, overcoming challenges in developing targeted antibiotics. The approach uses phage display with chemically enhanced peptides, resulting in potent and selective probes against two antibiotic-resistant bacterial pathogens.
Researchers at Indiana University have made the first direct observation of bacteria using a 'DNA harpoon' process to rapidly evolve new traits, including antibiotic resistance. The study revealed that pili act like microscopic harpooners to cast their line through pores in the cell's wall and reel in DNA fragments.
A hospital outbreak of carbapenem-resistant Enterobacteriaceae (CRE) revealed that resistance genes were being shared among unrelated bacteria via plasmids and other mobile genetic elements. This finding highlights the need to expand infection control efforts to include multiple strains and species to halt outbreaks.
The Wellcome Sanger Institute has sequenced the genomes of over 3,000 bacteria, including some of the world's most dangerous pathogens. This collection will help researchers better understand antibiotic resistance and develop new diagnostic tests, vaccines, or treatments for deadly diseases such as tuberculosis, gonorrhoea, and cholera.
Researchers at Oregon State University have developed a tool that can accurately predict the flow rate of Arctic rivers based on bacterial abundance and composition. By analyzing microbial profiles, scientists can estimate discharge levels without deploying traditional flow meters in remote areas.
Researchers at Stanford University School of Medicine have shown that manipulating a mouse's diet can favor the engraftment of specific bacterial strains. By adding a carbohydrate-rich compound, they were able to control how much a bacterium grows in the intestine and even introduce new strains into the gut microbiome.
A new machine learning tool can identify genetic changes in emerging strains of Salmonella that are more likely to cause dangerous bloodstream infections. The tool was developed using a dataset of old lineages and identified almost 200 genes involved in determining the pathogen's behavior.
10% of patients infected with the rising European strain experience abdominal pain, a symptom often overlooked by doctors. The study's findings highlight the need to consider this atypical form of meningococcal disease in medical diagnosis.
Researchers at Osaka University found that short trips to developing countries significantly increase the appearance of colistin-resistant bacteria in Japanese travelers. The study tracked 19 participants who traveled for less than 2 weeks and discovered nearly 90% of travel events resulted in resistant strains.
Researchers created a strain of bacteria that can produce bicyclobutanes, high-energy carbon rings useful in chemicals and materials. The bacteria were engineered using directed evolution, allowing them to efficiently create the strained rings under ambient conditions.
The gonorrhea bacterium has developed resistance to multiple antibiotics, with ceftriaxone being the last effective option. Researchers identified mutations that enable resistance to ceftriaxone, which also impairs growth rate, but lab experiments showed resistant strains can quickly outcompete non-resistant strains.
A team of EMBL scientists has developed a comprehensive 'cookbook' for growing and studying 96 diverse gut bacterial strains. The research reveals unexpected nutritional preferences and growth characteristics of these bacteria, providing valuable insights into the human gut microbiome.
A statistical model predicts which bacteria will engraft after fecal transplantation, providing a context for developing synthetic probiotics. The study found that recipient microbiome and immune state play roles in successful FMT, and new bacteria are acquired from both donors and recipients.
A statistical analysis found that most Legionnaires' disease cases in Flint can be attributed to the city's switch to the Flint River water source. The study also identified a specific strain of Legionella isolated from Flint residences that is not easily detectable by common diagnostic tests.
Researchers identify a new source of botulinum toxin in Enterococcus faecium bacteria, which can be transferred between species and has implications for protein therapeutics and monitoring emerging pathogens.
A study by University of Oxford researchers reveals that bacteria approach conflict in a coordinated manner, responding to threats with collective retaliation. The research shows that different strains exhibit varying levels of aggression and can even detect incoming attacks to warn other cells, enabling sophisticated defense strategies.
Plague bacteria survive and replicate for up to 48 hours inside an amoeba, replicating and thriving in a way most bacteria do not. The discovery sheds new light on the persistence of plague outbreaks, which can smolder for years before re-emerging with a vengeance.
A new study found that different strains of the same bacterial species can trigger vastly different immune responses in humans. Researchers discovered that distinct genes in each strain contribute to this variability, and may help explain why individuals respond differently to the same pathogens.
Researchers have shed new light on the diversity paradox by developing a stochastic model of bacteria-virus interactions. Their findings suggest that the coevolutionary arms race between bacteria and viruses leads to diverse populations and boom-bust cycles, preventing any single species from dominating the ecosystem.
A team of Norwegian researchers has developed a tool to monitor bacterial strains in cheese cultures, enabling prompt detection and countermeasures to maintain quality. The tool uses next-generation sequencing to analyze the epsD gene, which is involved in resisting phage and producing exopolysaccharide.
A new meningococcal vaccine, MenB-4C (Bexsero), has been shown to cover up to 91% of bacterial strains causing invasive serogroup B meningococcal disease in children and young adults. The vaccine contains four antigens that induce an immune response against the bacteria.
A new study found that a single strain of bacteria can cause imbalance in the gut microbiota of individuals with Crohn's disease. The findings suggest that preventing this imbalance could lead to promising treatment options for inflammatory bowel diseases.