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The Lancet Infectious Diseases: New gene that makes common bacteria resistant to last-line antibiotic found in animals and patients in China

Researchers found a new gene, mcr-1, that enables bacteria to resist polymyxins, the last line of defence against infections. The gene is widespread in E coli and K pneumoniae strains from pigs and patients in south China, suggesting its potential to spread rapidly into human pathogens.

SourceThe Lancet·JournalThe Lancet Infectious Diseases·DateNov 18, 2015

Dietary fat impacts autoimmune flare-ups in mice

A study published in Immunity suggests that dietary fat impacts the severity and duration of autoimmune flare-ups in mice. Short-chain fatty acids were found to alleviate symptoms by promoting regulatory T cells, while long-chain fatty acids exacerbated inflammation.

SourceCell Press·JournalImmunity·DateOct 20, 2015

KAIST's mathematician reveals the mechanism for sustaining biological rhythms

Jae Kyoung Kim's research uses mathematical modeling and synthetic biology to understand how biological circuits generate and sustain stable rhythms. The study found that a novel bacterial circuit generates robust rhythms under various conditions, providing insights into the fundamental mechanism of rhythm generation in biological syst...

Bacteria may cause type 2 diabetes

Researchers at the University of Iowa have found that prolonged exposure to Staphylococcus aureus bacteria causes insulin resistance and glucose intolerance in rabbits, mirroring the symptoms of type 2 diabetes. Anti-bacterial therapy or vaccines may hold promise for preventing or treating the disease.

Bacterial memories

The study found that Listeria monocytogenes adapts its metabolism specifically to the host genotype, correlating with the severity of symptoms in infected mice. Bacteria retain a 'memory effect' that reverts to a common metabolic fingerprint after laboratory cultivation.

Understanding the personalities of bacteria

Research by Professor Peter Young and his team reveals that bacterial strains are unique, with different genes and capabilities, similar to human individuals having unique genetic makeup. This study sheds light on the importance of understanding bacterial communities and their functioning through metagenomics.

SourceUniversity of York·JournalOpen Biology·DateJan 13, 2015

Drug developed at Pitt proves effective against antibiotic-resistant 'superbugs'

A treatment pioneered at the University of Pittsburgh Center for Vaccine Research is far more effective than traditional antibiotics in inhibiting the growth of drug-resistant bacteria. The new drug, called engineered cationic antimicrobial peptides (eCAPs), inhibited growth in about 90% of test bacterial strains.

SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalAntimicrobial Agents and Chemotherapy·DateDec 10, 2014

Impact of whooping cough vaccination revealed

A comprehensive genomic analysis of Bordetella pertussis bacteria reveals the impact of vaccination on its spread and diversification. The study shows that vaccination has dramatically reduced rates of infection and loss of life from whooping cough, but strategies used to date have not completely eradicated strains of the bacteria.

Resistance is not futile

Researchers at Joint BioEnergy Institute have successfully introduced a pair of genes into E. coli bacteria to confer tolerance to ionic liquids, enhancing the production of terpene-based biofuels. This breakthrough could eliminate a bottleneck in biofuels production and pave the way for more economical fermentation conditions.

SourceDOE/Lawrence Berkeley National Laboratory·JournalNature Communications·DateMar 26, 2014

Sponge bacteria, a chemical factory

Researchers have discovered a new type of bacterium in sponges that produces bioactive substances, including polyketides and peptides. The discovery, published in Nature, sheds light on the complex symbiotic relationships between sponges and bacteria, and could lead to breakthroughs in medical treatment.

SourceETH Zurich·JournalNature·DateJan 29, 2014

Staph stoppers

Researchers at the University of Iowa have developed a new vaccine that targets staph toxins, providing almost complete protection against staph infections. The vaccine was tested in an animal model and found to be effective even against high doses of bacteria.

SourceUniversity of Iowa·JournalThe Journal of Infectious Diseases·DateDec 20, 2013

Discovered diversity of antiviral bacteria

Researchers have identified diverse strains of Wolbachia bacteria that offer strong antiviral protection against diseases like dengue, but may come with a cost to the host's lifespan. The study found that certain strains replicate more quickly and reach higher concentrations in flies, potentially reducing their lifespan.

SourceInstituto Gulbenkian de Ciencia·JournalPLOS Genetics·DateDec 16, 2013

From friend to foe: How benign bacteria evolve to virulent pathogens

In a groundbreaking study, researchers found that benign E. coli bacteria can evolve to become pathogenic within 500 generations or 30 days when confronted with macrophages. The bacteria adapted by developing resistance to being killed by immune cells and acquiring traits similar to those of deadly pathogens.

SourcePLOS·JournalPLOS Pathogens·DateDec 12, 2013