Articles tagged with Biofilm Formation
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Researchers used super-resolution imaging and a computational algorithm to study how bacteria multiply and grow into dense biofilms. They found that growth patterns are analogous to urbanization, with individual bacteria forming 'cities' that merge and expand over time.
Researchers at the University of Cambridge discovered that random gene pulsing plays a key role in establishing spatial structures during biofilm development. This process allows for the distribution of cell states within a population, enabling the formation of complex patterns.
Researchers develop model to investigate Candida auris spread, finding it grows faster and colonizes skin exceptionally well. The study establishes a new strategy to prevent biofilm formation, which may lead to new strategies to target the pathogen.
A recent study at Massachusetts General Hospital has uncovered evidence of fimbriae that aid adherence to epithelial cells, an important step in the start of a shigellosis infection. The research team used in vivo-like culture methods and human intestinal organoids to confirm their findings.
Researchers found that nanostructured surfaces reduce bacterial adhesion, making it harder for Staphylococcus aureus bacteria to form biofilms and resist antibiotics. The study suggests optimizing surface topography can minimize bacterial attachment and prevent biofilm formation.
A team of researchers at ICFO have devised a novel technique to prevent biofilm formation on surgical implants by using gold nanoparticles to convert light into heat, killing bacteria. The method has shown promising results in preventing the formation of bacterial biofilms and eliminating the need for antibiotic treatments.
Researchers at Brown University have developed a germ-fighting catheter coating that can kill MRSA bacteria and prevent biofilm formation. The coating, which releases the drug auranofin, has shown promising results in lab tests, inhibiting MRSA growth for up to 26 days.
Researchers propose RNAIII inhibiting peptides as a potential treatment strategy for S. aureus biofilm infections, which are notoriously difficult to treat due to their impermeable nature and enhanced virulence.
Researchers found that certain antibiotics can alter the way bacteria divide and interact with each other, leading to increased competence and the spread of antibiotic-resistant genes. Biofilms play a crucial role in this process, allowing cells to secrete higher concentrations of a peptide that triggers quorum sensing.
Biofilms are a huge medical problem due to their difficulty in treating bacterial infections. Researchers at Yale University have found a key mechanism for biofilm formation, enabling the study of this process in a controlled way.
Researchers discovered that microplastics form stable aggregates with biogenic particles, such as plankton and faecal material, which can sink into deeper water layers. The presence of biofilms on microplastics also facilitates aggregation, potentially affecting the transport and distribution of microplastics in the oceans.
Researchers from Stanford University have developed a technique called biofilm lithography to create intricate designs with bacterial communities. The method involves shining blue light on bacteria that secrete a sticky protein, resulting in sharp images of patterns such as polka dots and circuits.
Researchers at Indiana University discovered bacteria's 'sense of touch' by observing how they detect and cling to surfaces. The study revealed the role of ultra-thin hair-like appendages called pili in forming biofilms, which contribute to up to 65% of human infections.
Researchers at Princeton University have developed a way to control bacterial growth using chemical coatings that communicate with bacteria in their own language. The coatings can inhibit or promote bacterial growth as needed, making them useful for applications such as hospital surfaces and industrial equipment.
Researchers at the University of Texas at Austin have made a breakthrough in understanding how bacterial biofilms form, suggesting a new approach to preventing these deadly infections. By developing coatings for medical devices that block the trigger mechanism, biofilm-related hospital-borne infections could be sharply reduced.
Scientists have developed a new mouse model to study vascular graft infections, revealing that all S. aureus strains form biofilms in vivo, regardless of in vitro results. The study also shows increased inflammation and decreased blood flow velocity at the site of infection.
Researchers found that Legionella pneumophila grows well in warm tap water installations with ample dissolved organic matter, supporting biofilm formation. The study suggests that microgram-per-liter concentrations of biodegradable compounds can induce bacterial growth on surfaces, promoting proliferation of the bacteria.
Researchers at Kiel University have identified natural proteins that can disrupt bacterial communication and prevent biofilm formation. These 'molecular troublemakers' have potential applications in medicine and biotechnology, particularly against antibiotic-resistant pathogens.
A study published in the Journal of Bacteriology found that two genes, ArsS and ArsR, play a crucial role in regulating biofilm formation in H. pylori. The researchers created strains with mutations in these genes and observed that they formed thicker and more rapid biofilms.
A new study reveals that biofilm formation is a common feature of group A streptococcus necrotizing soft tissue infections, leading to higher bacterial loads, extensive inflammation, and more severe tissue damage. Biofilm should be considered as a complicating factor of NSTI.
Researchers used OCT to visualize and assess biofilm on intubated endotracheal tubes in vivo, detecting the presence of pneumonia-related bacteria. The study showed that OCT can measure biofilm thickness and gather information about its extent, potentially leading to reduced infection rates.
Researchers observe 'comet-shaped' structures forming on agar plates, indicating active motility in MRSA, a spherical bacterium with no propulsive tail or appendages. This discovery could have implications for future clinical treatments and open up new avenues of research into Gram-positive bacteria.
Researchers from the University of Southampton used EDIC microscopy to study catheter biofilm development, revealing four distinct stages and a key role for the Proteus mirabilis bacterium. The findings challenge traditional theories and provide new insights into preventing catheter blockages and urinary tract infections.
Researchers develop a new technique to prevent dangerous biofilms on catheters by coating them with an activator that hinders Staphylococcus aureus from forming biofilms. This approach could lead to a major reduction in hospital-acquired disease and death, saving thousands of lives annually.
Researchers have discovered a new technique that can prevent biofilms on catheters and medical implants by coating them with tissue plasminogen activator. This method has the potential to reduce hospital-acquired infections and save thousands of lives annually.
Researchers discovered a messenger molecule that encourages bacteria to colonize catheters in mice, forming biofilms. The study highlights the importance of understanding biofilm formation to develop more effective therapies for infections like those caused by Pseudomonas aeruginosa.
A study published in Chemical Communications suggests that a natural plant chemical called trans-chalcone can help prevent tooth decay. By blocking the action of an enzyme that allows bacteria to thrive, researchers found that trans-chalcone prevents the formation of plaque and biofilms around teeth.
Researchers at the University of Michigan discovered that L-arginine can break down dental plaque, a biofilm that contributes to cavities, gingivitis, and periodontal disease. This naturally occurring amino acid may provide an alternative to current antimicrobial treatments, which can affect taste and stain teeth.
Researchers discovered a compound produced by Pseudomonas protegens that prevents Bacillus subtilis from forming biofilms at low concentrations, blocking spore formation as well. This finding may lead to creating healthy microbial soil communities and boosting agricultural yields.
Researchers found that salivary mucin MUC5B limits biofilm formation by keeping S. mutans suspended in the liquid medium, preventing cavities. Boosting native defenses may be a better way to fight dental caries than relying on exogenous materials.
Researchers at VIB/VUB have created a detailed three-dimensional image of the pores through which curli building blocks cross the bacterial cell wall, shedding light on biofilm formation. This breakthrough could lead to the development of small molecules that inhibit unwanted biofilm growth and pave the way for new applications in fiel...
Researchers have identified six natural-products derivatives that can inhibit oral biofilm formation and quorum sensing in three indigenous oral Gram-positive bacteria. These compounds, structurally similar to S-ribosyl homocysteine, reduce bioluminescence in a Vibrio harveyi QS reporter, indicating inhibition of AI-2 based QS.
A study found that sublethal doses of biocides can enhance antibiotic resistance in bacteria, forming harmful biofilms and increasing survival rates. This poses a risk to public health and highlights the need for proper guidelines on biocide use in food production.
Researchers found that Oxantel inhibits biofilm formation by targeting an enzyme crucial for bacterial growth, offering a potential therapy for periodontitis. Periodontitis is linked to various health risks, including diabetes, heart disease, and certain cancers.
Researchers studied coral skeletons at the nanoscale, revealing three distinct regions formed daily. Understanding these mechanisms is crucial for protecting coral reefs from acidification and rising temperatures.
Researchers discovered a molecular switch regulating biofilm formation, which could help identify new antibiotics and prevent biofilms from forming. The study sheds light on how bacteria shield themselves in a slimy protective layer to evade attacks.
Researchers found that cell death leads to wrinkles in biofilms, while stiffness affects wrinkling patterns. They created artificial wrinkle patterns in bacteria to verify their findings, shedding light on the mechanics of cell, tissue and organ formation.
Researchers at Harvard University have developed a new coating called SLIPS that can prevent the formation of biofilms on surfaces. The technology, which is smooth and slippery due to an immobilized liquid layer, has been shown to reduce the formation of disease-causing bacteria by up to 96%.
A team of researchers discovered that dolomite crystals form under specific conditions in biofilms created by marine bacteria. The study provides new insights into the reconstruction of fossil dolomite deposits and their connection to past environmental conditions.
Researchers have detailed the signaling pathway from nitric oxide to biofilm formation in bacteria, which may aid in developing new treatments targeting biofilms. The study reveals a complex system of response regulators controlling biofilm formation.
Researchers at the University of Pittsburgh have developed a novel way to culture tuberculosis bacteria, which could lead to new treatments and insights into its extraordinary resilience against environmental stresses. The bacteria's ability to form biofilms is thought to be a key factor in its resistance to treatment.
Biofilms expand by swelling and then spreading due to the force generated by the extracellular matrix (ECM). The ECM increases osmotic pressure within the biofilm, causing it to absorb water from its surroundings and swell. This process allows the biofilm to grow and spread horizontally.
Researchers at Texas A&M University have developed a way to control the formation and dispersal of biofilms by manipulating bacterial signals. This breakthrough enables the creation of novel bioreactors that can efficiently produce chemicals and potentially transform the economy.
A new study by researchers at Worcester Polytechnic Institute shows that cranberry juice is more effective than proanthocyanidin extracts in preventing biofilm formation, a precursor to urinary tract infections. The study found that cranberry juice completely prevented biofilm formation, while extracts showed limited ability to reduce it.
Researchers have discovered a unique 'slingshot' motion used by bacteria to move across surfaces and form biofilms. This motion could allow bacteria to travel faster and more efficiently, using less energy, through a sticky substance that shields them.
The study reveals a complex cascade of enhancer binding proteins (EBPs) that initiates the formation of biofilms. Bacterial cells require cooperative behavior similar to higher organisms, and understanding this process is crucial for developing new ways to prevent and treat infected surfaces.
Researchers from the University of Brighton are exploring a new approach to prevent catheter blockage by inhibiting the rise in urinary pH. The study found that biofilm-forming ability may not be the primary factor in catheter blockage, but rather the formation of crystals that can cause blockages.
Researchers developed biodegradable tooth-binding micelles that effectively bind to teeth and inhibit the growth of Streptococcus mutans, a primary cause of tooth decay. These micelles showed promising results in reducing biofilm formation on hydroxyapatite particles.
Researchers at Worcester Polytechnic Institute have found that cranberry juice cocktail significantly reduces the ability of certain bacteria to form biofilms on surfaces. This study has potential applications in developing new antibiotics and making medical devices more resistant to bacterial adhesion.
Researchers at Stevens Institute of Technology are developing novel methods to prevent bacterial infections in orthopedic implants, such as inkjet printing of drug-eluting micropatterns. This technology aims to overcome the challenge of biofilm formation and promote rapid bone healing.
Researchers at Binghamton University identified three key regulators required for biofilm formation, which could lead to new treatments for chronic infections. Biofilms are implicated in over 80% of chronic inflammatory and infectious diseases, and conventional antimicrobial treatments are often ineffective.
Researchers observed paracrine signaling in Bacillus subtilis, a novel mechanism for maintaining two differentiated cell populations within a bacterial community. This discovery opens doors to developing strategies to reverse differentiation in antibiotic persister cells.
Researchers at Texas A&M University have found that certain types of bacteria integrate invading DNA into their genetic makeup to increase their chances of survival. This process allows the bacteria to produce diverse progeny, which is essential for dispersal and adaptation to new environments.
Scientists identify Psl as key component in Pseudomonas biofilm development, enabling bacterial cells to resist efforts to kill them. The discovery offers new potential therapies targeting the sugar to prevent biofilm formation.
A team of University of Cincinnati researchers has found that zinc plays a crucial role in the formation of biofilms that cause hospital-acquired infections. By removing zinc from bacterial cells, they were able to prevent biofilm formation and growth, offering new hope for preventing these infections.
MSU scientist Darla Goeres is developing standardized methods to measure the effectiveness of antimicrobial products against biofilms. This work aims to improve public trust in product efficacy claims.
Researchers have identified a finely tuned control system in Pseudomonas bacteria that enables them to form biofilms, which contribute to chronic infections. The WspR enzyme plays a crucial role in this process, and its regulation helps balance the production of c-di-GMP.
Researchers found that diverse cooperators evolved to use different nutrient resources, reducing competition and increasing biofilm success. This diversity leads to smaller cheats populations and larger biofilm groups.
New research published in Science reveals that specific bacteria present on gold grains precipitate gold from solution, providing a biological mechanism for gold formation. The study identified the bacterium Ralstonia metallidurans as responsible for this process, which has significant implications for the mineral exploration industry.
The IADR/GSK Oral Care Awards recognized three innovative research teams for their work on preventing cariogenic biofilm formation, treating aggressive periodontitis, and targeting IKK/NF-êB to improve oral health. The winning projects focus on developing alternative therapeutic pathways and products to combat tooth decay and periodont...