Articles tagged with Biofilm Infections
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A team of scientists at KAUST has developed a novel approach for cleaning biofouled membranes in anaerobic bioreactors, combining UV irradiation with bacteriophages to eliminate bacteria. The method improved upon individual treatments and was proven effective over four cleaning cycles.
Researchers at CRG and Pulmobiotics have created the first 'living medicine' to treat antibiotic-resistant bacteria growing on medical implants. The experimental treatment successfully treated infections across in vitro, ex vivo, and in vivo testing methods.
Researchers have created a flexible polymer composite microneedle array that can effectively pierce biofilm in chronic wounds, delivering oxygen and bactericidal agents simultaneously. This innovation has the potential to improve treatment outcomes for millions suffering from diabetic foot ulcers.
A team of researchers characterized different bacterial populations isolated from the International Space Station's potable water system, exploring their functional properties and long-term interactions. The study aimed to improve microbial risk assessments for human-built environments in space and on Earth.
Research from Anglia Ruskin University found that common artificial sweeteners like saccharin and sucralose can make previously healthy gut bacteria pathogenic. The study discovered that these pathogenic bacteria can invade intestinal cells and cause damage.
Two types of coating made from new coordination polymers with silver effectively kill bacteria, including those that form biofilms. The most promising coating destroys 99.99% of bacteria, offering a breakthrough in antibiofilm applications.
Researchers aim to understand the form and function of dry biofilms using probiotic cleansers. They hope to demonstrate how friendly bacteria interacts with bad bacteria and remove dry biofilms without harsh chemicals.
The researcher aims to identify common mechanisms among persister cells and their unique metabolic processes. The goal is to develop new strategies for understanding and combating bacterial persistence.
Researchers at Temple University Health System found that bacterial biofilms in the urinary tract can trigger autoimmune reactions in lupus patients. The study identified a link between chronic bacterial infections and increased frequency of lupus flares, suggesting a potential new approach to controlling flare-ups.
Researchers discovered that biofilms can generate large structural deformations on soft materials, compromising host physiology and potentially promoting a new mode of infection.
Researchers aim to develop molecular support for detecting biofilms in chronic wounds, enabling early diagnosis and effective treatment. Biofilms can significantly delay healing by reducing antibiotic susceptibility and damaging tissue.
Researchers at the University of Warwick have discovered a medieval remedy that shows promise in fighting biofilm-associated infections. The Bald's eyesalve mixture, made from onion, garlic, wine, and bile salts, demonstrates effective antibacterial activity against a range of Gram-negative and Gram-positive wound pathogens.
A study by VIDO-InterVac researchers discovered that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals. Similar amyloid proteins have been associated with neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.
Researchers have developed a novel approach to prevent and treat chronic and recurrent bacterial diseases caused by biofilms. The technology targets the DNABII family of DNA-binding proteins, which are common to all biofilms and disrupts them.
Biosurfactant from yeast dissolves Pseudomonas aeruginosa biofilms, weakening interaction between biofilm and surface and breaking internal cohesiveness, leading to disruption. Combination with chemical surfactants demonstrates stronger antibiofilm effects at lower concentrations.
GlycoNet researchers have identified a key enzyme, Agd3, critical for biofilm formation in Aspergillus fumigatus. Without this enzyme, the biofilm does not form, and the fungus is weakened. The team has also discovered a new family of carbohydrate-processing enzymes that has not been previously characterized.
Researchers at the University of Bristol have developed a new drug formulation that significantly improves the activity of fluconazole against Candida biofilms. The study uses bacterial signals to improve fluconazole's effectiveness, offering a potential alternative to current antifungal treatments.
Researchers have made significant strides in understanding the mechanisms of cholera biofilm formation and hyperinfectivity. Biofilms are found to be highly infectious due to primed virulence factors, with bacteria already producing toxins before infection occurs.
Researchers at Temple University Health System have developed a new monoclonal antibody that can break apart communities of harmful bacteria, allowing for more effective treatment of infections. The therapy has shown promise in eradicating biofilms on medical devices and reducing the risk of sepsis.
Researchers develop model to investigate Candida auris spread, finding it grows faster and colonizes skin exceptionally well. The study establishes a new strategy to prevent biofilm formation, which may lead to new strategies to target the pathogen.
Researchers at Newcastle University have found that layering Manuka honey between layers of surgical mesh acts as a natural antibiotic, inhibiting bacteria growth and preventing infection. The study showcases the potential benefits of infusing medical implants with honey, offering an alternative to antibiotics.
Researchers have developed 'clever drugs for slimy bugs' to combat staph infections by destroying biofilms that prevent conventional antibiotics from working. Hybrid antibiotics have been shown to kill bacteria directly or leave them susceptible to killing in lab-grown biofilms.
Researchers found that bacteria living in biofilms develop unique adaptations to resist antibiotics, whereas free-floating bacteria become more resistant but vulnerable to other classes of antibiotics. This discovery highlights the importance of studying bacteria in their natural lifestyle.
Researchers discovered a significant association between pedicle screw loosening and the presence of low-virulent pathogens on spinal implants, with coagulase-negative staphylococci being the most commonly found. Long surgery times were also linked to a higher rate of implant infection, suggesting that preventing perioperative implant ...
A team of researchers at ICFO have devised a novel technique to prevent biofilm formation on surgical implants by using gold nanoparticles to convert light into heat, killing bacteria. The method has shown promising results in preventing the formation of bacterial biofilms and eliminating the need for antibiotic treatments.
Researchers at Indiana University School of Medicine have developed an electric field-based dressing that can disrupt and treat bacterial biofilms, which are responsible for many wound infections. The dressing, combined with other medications, shows promise as a potential game-changer in treating antibiotic-resistant infections.
Researchers developed a dispersion method to effectively kill biofilm bacteria by depleting pyruvate, making resident bacteria susceptible to antibiotics. The method showed improved treatment of infected wounds and enhanced efficacy of conventional antibiotic therapy.
Researchers at Case Western Reserve University have identified a novel probiotic mix that can weaken and break apart stubborn microbial biofilm communities in the gut, which are often resistant to antibiotics. The study suggests this probiotic could help patients with gastrointestinal diseases avoid harmful biofilms that worsen symptoms.
Researchers at Stevens Institute of Technology have developed a self-defensive surface for medical implants that releases micro-doses of antibiotics when bacteria approach. The microgels' behavior is regulated by electrical charges and can be applied to various medical devices, potentially reducing surgical infections.
Researchers at Ohio State University have discovered a new way to destroy bacteria that can prevent wounds from healing. By using electroceutical bandages, the team found that electrical impulses can break down biofilms and kill bacteria, leading to faster wound healing.
Researchers propose RNAIII inhibiting peptides as a potential treatment strategy for S. aureus biofilm infections, which are notoriously difficult to treat due to their impermeable nature and enhanced virulence.
Researchers at the University of Texas at Austin have developed a near-infrared laser that can change the size and shape of a block of gel-like material while human or bacterial cells grow on it. This tool holds promise for biomedical researchers seeking to shed light on how to grow replacement tissues and organs.
Biofilms are a huge medical problem due to their difficulty in treating bacterial infections. Researchers at Yale University have found a key mechanism for biofilm formation, enabling the study of this process in a controlled way.
A team of researchers at the University of Illinois has developed a system that harnesses the power of bubbles to destroy microbial biofilms. The system uses diatoms loaded with an oxygen-generating chemical, which creates microbubbles that propel tiny particles through the surfaces of tough films and deliver an antiseptic deathblow to...
Researchers have developed a drug-free method for detecting and destroying the bacteria that cause dental plaque. The approach uses nanoparticles made of hafnium oxide to target and kill harmful bacteria, reducing biofilm burden and preventing conditions like cavities and cardiovascular disease.
Researchers have created coatings using essential oils like Tea Tree Oil, showing good antibacterial properties and potential as a low-cost alternative to synthetic antibiotics. The technology has the added benefit of being environmentally friendly and transparent.
Researchers at Michigan State University found that triclosan, a common antibacterial substance in toothpaste, can kill Pseudomonas aeruginosa bacteria by up to 99.9 percent when combined with tobramycin. This combination therapy offers a new potential treatment option for cystic fibrosis and other biofilm-related infections.
Orman aims to identify and explore mechanisms that lead to dormant cell formation to discover new therapeutic strategies against persister cells. Using E. coli as a model organism, he will perform high-throughput screening to find candidate genes regulating cell dormancy.
A new study from the University of Copenhagen reveals that a garlic compound can destroy important components in bacteria's communication systems, which involve regulatory RNA molecules. This discovery has led to further development of a potential treatment for patients with cystic fibrosis and other chronic infections.
Bacteria access oxygen for energy production in crowded, oxygen-deprived environments through a specific terminal oxidase and phenazine molecules. This discovery could inform the development of new therapies for cystic fibrosis infections.
Researchers at Ohio State University Wexner Medical Center developed an electric bandage that can prevent bacterial biofilm infections, combat antibiotic resistance, and enable healing in infected burn wounds. The bandage generates a weak electric field without any external power supply and is already FDA-cleared.
Researchers at Colorado State University have developed a new biomaterial that effectively prevents the formation of biofilms by Pseudomonas aeruginosa, a virulent superbug. This breakthrough could lead to the creation of antibacterial surfaces for wound dressings and other medical applications.
A recent study by Nationwide Children's Hospital scientists has identified a new method by which nontypeable Haemophilus influenzae builds its biofilms, resulting in improved therapeutic options for respiratory diseases such as sinusitis and pneumonia.
Scientists at McGill University Health Centre develop novel enzyme technology that prevents and breaks down biofilms, exposing microbes to antibiotics and host defenses. This approach has huge potential to combat biofilm-associated infections responsible for thousands of deaths across North America.
A team from Ireland developed a collagen scaffold loaded with an antibiotic to prevent bacterial biofilm formation, successfully targeting Escherichia coli and Staphylococcus epidermidis. The discovery marks a significant step forward in combating implant infections, which can cause long hospitalization periods and additional surgeries.
Researchers at the University of Texas at Austin have made a breakthrough in understanding how bacterial biofilms form, suggesting a new approach to preventing these deadly infections. By developing coatings for medical devices that block the trigger mechanism, biofilm-related hospital-borne infections could be sharply reduced.
Researchers found that a harmful bacterium in the lungs of cystic fibrosis patients produces substances that enhance the growth of other bacteria, known as streptococci, which can inhibit the harmful bacterium's biofilm. Streptococci adhesins play a crucial role in this process.
Researchers at INRS-Institut Armand-Frappier Research Centre have developed a strategy to increase the antimicrobial activity of cationic peptides against biofilms. The modified peptide demonstrated a 60-fold enhanced antimicrobial effect, paving the way for potential therapy combinations with clinically relevant antibiotics.
A breakthrough has been made in preventing biofilm formation by staphylococci on medical devices. The research team discovered a small blocking molecule that targets the SdrC protein, stopping bacterial attachment and growth.
A new dental implant has been developed with a built-in reservoir that gradually releases antimicrobial drugs to prevent the formation of biofilms. This helps reduce the risk of infections in patients with traditional dental implants.
Scientists have developed a new mouse model to study vascular graft infections, revealing that all S. aureus strains form biofilms in vivo, regardless of in vitro results. The study also shows increased inflammation and decreased blood flow velocity at the site of infection.
A team of researchers at Caltech and the University of Oxford identified a protein that degrades and inhibits biofilms of Pseudomonas aeruginosa, the primary pathogen in cystic fibrosis infections. This discovery offers a new approach to inhibit biofilm development and has promise for treating antibiotic-resistant biofilm infections.
A team of researchers found that polysorbate 80, a safe food additive, can slow the toxic effects of E. coli poisoning by attacking its protective biofilm and rendering it harmless. This approach could provide an effective alternative to traditional antibiotics without driving antimicrobial resistance.
A novel nanofiber coating with antibiotic-releasing properties has shown promise in preventing serious bacterial infections related to total joint replacement surgery. The coating was found to completely eradicate infection and prevent bone loss, a common complication that leads to prosthetic loosening and failure.
Researchers tracked a single bacterial cell as it grew into a mature biofilm of 10,000 cells. They found that the bacteria secrete a glue-like substance to keep from getting washed away and protect themselves from competing bacteria. A key gene, RbmA, plays a crucial role in developing a denser, stronger biofilm.
Researchers aim to create a sensor that can coat medical implants and use X-ray beams to detect localized bacterial infections. The goal is to cure these infections early, reducing costly and tedious surgical procedures.
Researchers at Worcester Polytechnic Institute and the University of Massachusetts Dartmouth discovered flavonols in cranberry juice significantly reduce E.coli adhesion, which can cause bacterial infections. The findings may lead to new antibiotic drug targets and alternative treatments for 'superbugs'.
A new study reveals that biofilm formation is a common feature of group A streptococcus necrotizing soft tissue infections, leading to higher bacterial loads, extensive inflammation, and more severe tissue damage. Biofilm should be considered as a complicating factor of NSTI.
Researchers have developed a novel approach to disrupting bacterial biofilms, which are nearly impossible to eradicate when pathogenic. The technique targets extracellular DNA and DNABII proteins in biofilms, resulting in the collapse of bacterial communities and bacterial clearance.
Researchers found that tobacco smoke increases the likelihood of certain bacteria like Porphyromonas gingivalis colonizing the body. Biofilms formed by these pathogens can be difficult to eradicate and promote antibiotic resistance.