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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Notre Dame researchers develop computational model to simulate bacterial behavior

Researchers at the University of Notre Dame have developed a computational model that simulates the mechanical behavior of biofilms, which can be used to study issues such as blood clotting and waste treatment systems. The new model allows for the simulation of complex behavior, including viscoelastic properties, and can be adapted to ...

Recruiting bacteria to be technology innovation partners

A Harvard team has created a novel protein engineering system called BIND to engineer bacteria into living foundries for the production of biomaterials with specific functions. The researchers have demonstrated the ability to fuse multiple proteins to create multifunctional biofilms that can be programmed to perform various tasks.

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Catheter innovation destroys dangerous biofilms

Duke University engineers have developed a new urinary catheter design that can eliminate nearly all hard-to-kill biofilm from the catheter's walls using physical deformation. The design features an inflation channel that forces the thin wall into the urinary tract, leaving the outer dimensions intact.

Researchers develop a novel antibacterial orthodontic bracket cement

A new antibacterial orthodontic cement containing dimethylaminododecyl methacrylate (DMADDM) inhibits biofilm formation and reduces lactic acid production. The results show that the DMADDM-containing cement is promising for reducing demineralization in enamel around orthodontic brackets.

Extracting energy from bacteria

Researchers have developed a new method to extract energy from bacteria, which can convert carbon dioxide in seawater into fuel and electricity. This process involves the use of electrode reactions catalyzed by microorganisms, resulting in highly efficient energy production.

GSA Today science: Biofilms, MISS, and stromatolites

Biofilms interact with sediment dynamics to form distinctive structures called microbialites. Stromatolites, with their multilayered structure, are a well-known example of microbial activity in early Earth's history. However, the formation mechanisms and differences between stromatolites and microbial induction of sedimentary structure...

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How do bacteria clog medical devices? Very quickly

Researchers at Princeton University found that bacteria can clog medical devices like stents in a short period of time by forming sticky biofilms. The study used controlled environments with rough surfaces and pressure-driven fluid, demonstrating the need for real-world conditions to understand device failures.

Mighty mesh

Biofilms expand by swelling and then spreading due to the force generated by the extracellular matrix (ECM). The ECM increases osmotic pressure within the biofilm, causing it to absorb water from its surroundings and swell. This process allows the biofilm to grow and spread horizontally.

Researchers develop new method of cleaning toxins from the oilsands

Researchers at the University of Calgary have isolated biofilms that can detoxify tailings water by removing toxins and metals. These microorganisms are highly tolerant to stress associated with pollutants, making them a promising solution for cleaning oilsands-related water.

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New fluorescent imaging sorts microbiome in human mouth

Researchers developed a new fluorescent labeling technology to sort the human oral microbiome. The system revealed unexpected interactions between Prevotella and Actinomyces species, suggesting central roles in biofilm production.

A pesky bacterial slime reveals its survival secrets

Scientists at Harvard University have made a groundbreaking discovery about biofilm colonies, which exhibit an unprecedented ability to repel liquids and vapors. The researchers believe that the secret to their resiliency lies in their unique liquid-repellent surface.

New lab-on-a-chip measures mechanics of bacteria colonies

Researchers at the University of Michigan have devised a microscale tool to study biofilms' mechanical properties, which could lead to designing medical equipment that is more difficult for bacteria to adhere to. The new device measures resistance to pressure and found elasticity and strain hardening responses in bacterial colonies.

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Strategy discovered for fighting persistent bacterial infections

Researchers have discovered a promising strategy to break down Pseudomonas biofilms, which form in cystic fibrosis patients and cause lung damage. A negatively charged molecule called aspartic acid polymer can disrupt the molecular bonds that hold together these difficult-to-treat infections.

Turning on cell-cell communication wipes out staph biofilms

University of Iowa researchers have successfully wiped out established Staphylococcus aureus biofilms by activating the bacteria's quorum-sensing system. The discovery offers insight into a dispersal mechanism for biofilms and might help identify new therapeutic targets to combat chronic infections.

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Snottites, other biofilms hasten cave formation

Researchers discovered that biofilms in caves increase the rate of cave formation by using sulfur for energy, producing strong acid. Cave biofilms also provide food for various cave creatures and have similarities to dental biofilms and steel ship hull corrosion.

Diversity promotes cooperation among microbes

Researchers found that diverse cooperators evolved to use different nutrient resources, reducing competition and increasing biofilm success. This diversity leads to smaller cheats populations and larger biofilm groups.

Search on for treatment of slow-healing wounds

Researchers at Montana State University's Center for Biofilm Engineering have received a $2.9 million grant to study the role of biofilms in chronic wounds. Biofilms, which are bacteria that form protective slime, can interfere with the healing process and contribute to amputations in diabetics.

Koo receives IADR Young Investigator Award

Dr. Koo has received the IADR Young Investigator Award, a prestigious honor recognizing his groundbreaking work on microbial biofilms in dental and oral craniofacial research. The award, supported by Procter & Gamble Co., is designed to stimulate basic research in all dental disciplines.

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UI researchers and colleagues identify genetic changes in bacterial biofilms

Researchers have identified a subset of genes in Pseudomonas aeruginosa that behave differently when the bacteria exists as a biofilm. These findings may lead to the development of new therapies targeting antibiotic resistance in biofilms. The study found that certain genes were repressed or activated in response to antibiotic treatmen...