Articles tagged with Microbial Genetics
Researchers at Duke University discovered that the host determines which genes are open in the gut, while microbes regulate their usage, indicating a cooperative environment where both parties interact to thrive. This study has significant implications for understanding the intricate relationships between hosts and microbiomes.
A new study in the Journal of Clinical Investigation identifies a specific gene expression profile and microbial community associated with Crohn's disease. Pediatric Crohn's disease patients exhibit altered expression of genes DUOX2 and APOA1, as well as a distinct microbial community.
A new approach enables researchers to distinguish between different microbial species in complex communities, allowing for the discovery of previously unknown species and a better understanding of their genomic content. This breakthrough has significant implications for studying the human microbiome and its impact on individual health.
Researchers have developed a simple yet elegant solution to analyze large amounts of soil DNA data, reducing computational requirements by up to 200-fold. This breakthrough enables scientists to extract more science from the noise, paving the way for new discoveries in fields like agriculture and carbon cycling.
African sleeping sickness is caused by single-celled parasites that mate and swap genes through a process known as sexual reproduction. This study reveals sex to be a regular part of the trypanosome life cycle, enabling new combinations of genes that could lead to disease-causing strains.
Deep Carbon Observatory scientists have discovered a method to produce hydrogen more quickly and efficiently than natural processes. The new formula uses aluminum oxide, water, and olivine under high pressure, accelerating the production of hydrogen by 7-50 times.
A team of researchers from Berkeley Lab and the Scripps Research Institute used a new technique to study the role of MutS in DNA's mismatch repair system, providing new insight into genome integrity. The study validated the 'beads-on-a-string' model of DNA repair and revealed details about MutS that could be valuable for drug design an...
Researchers at the University of New South Wales discovered the genetic secrets of Antarctic extremophiles that can thrive in extremely cold and salty water. The study found that these microorganisms engage in extensive DNA swapping, enabling them to coexist despite their vastly different niches.
Researchers collected water samples up to six kilometres below the surface of the Southern Ocean, finding that physical transport in the ocean on currents shapes microbial communities. The study shows that communities connected by ocean currents are more similar to each other, regardless of distance.
A study by researchers at Arizona State University found that global warming may affect the survival of key microbe species in topsoil crusts. The team discovered that two cyanobacteria, Microcoleus vaginatus and Microcoleus steenstrupii, have split their territory between themselves due to temperature differences.
Scientists used a robotic device to gather samples of 1 billion microbes every four hours, creating a time-lapse montage of their daily labors over two days. The study reveals synchronized metabolic gene expression among nonphotosynthetic microbes in response to environmental changes.
Three WHOI projects will investigate the complex interactions between marine microbes, nutrients, and their environments using advanced technologies and methods. The grants aim to improve understanding of microbial communities and their impact on ocean health and productivity.
The American Gut project aims to characterize the microbes living in and on human bodies, with a focus on diet and lifestyle's impact on health. The public is encouraged to participate, and the study will analyze data from tens of thousands of individuals.
Researchers mapped genetic differences between domesticated fungus Aspergillus oryzae and its wild relative, finding extensive genome remodeling. The study suggests microbes undergo metabolic changes for desired functions rather than growth and form alterations.
A new NIST report summarizes efforts to advance indoor microbial sampling, highlighting challenges and future priorities for surface and aerosol analysis. The report explores cross-cutting issues such as education and public awareness, and provides a comprehensive overview of existing resources.
The Dip Chip technology uses genetically modified microbes to detect toxicity in real time, providing a quick and accurate diagnosis. The device can identify overall toxicity levels, picking up on any toxic materials, including those that have not been discovered yet.
A Michigan State University study found that antibiotics in pig feed increase the number of antibiotic-resistant genes in gastrointestinal microbes in pigs. This could contribute to the development of strains of microbes resistant to conventional antibiotics, which are potentially harmful to humans and animals.
Two wine yeasts, S. cerevisiae and Dekkera bruxellensis, have been studied to reconstruct the evolutionary history of ethanol production. They developed similar abilities around 100-150 million years ago, likely driven by environmental pressures such as competition from other microbes.
Canada Research Chair Barbara Sherwood Lollar's research examines the effectiveness of bioremediation technologies in cleaning up groundwater contamination. Her techniques use isotopic signatures to track clean-up progress, providing a critical framework for regulators and practitioners.
Biologists at UC Berkeley have developed a new 'reverse-ecology' tool that analyzes genomes to identify an organism's adaptive traits. The study, using Neurospora crassa bread mold, found variations in two genome regions linked to natural selection and cold tolerance.
A study published in Science reveals nearly 30,000 novel enzymes that can efficiently degrade plant cell wall materials, a major breakthrough for large-scale biofuel production. The discovery sheds light on the molecular machinery used by microbes in the cow's rumen to break down biomass into simple sugars.
A study published in Nature Reviews: Microbiology examines the cellular mechanisms of microbial dormancy and its implications for ecosystems. Dormant microbes can have a significant impact on biodiversity, carbon emissions, and nutrient cycling, making them a key component of ecosystem resilience.
Researchers at UMass Amherst have identified a new cooperative behavior in anaerobic bacteria, allowing microorganisms to form direct electrical connections and pass electrons. This discovery has significant implications for the global carbon cycle and bioenergy production.
Researchers from the USDA have identified a group of enzymes known as feruloyl esterases that can break down key links between plant cell wall polymers. These enzymes, produced by certain microbes, have been isolated and cloned for use in Escherichia coli to improve biofuel production efficiency.
A University of Illinois scientist has identified four genes that increase alcohol tolerance in yeast, leading to higher ethanol yields and productivity. The discovery aims to make biofuel production more efficient and economical by reducing the toxic effects of biofuels on yeast.
A new survey method reveals a broader and more diverse array of metal-driven chemical processes in microbes than previously recognized. The research could lead to innovative biofuels and bioremediation technologies.
A Purdue University researcher has identified a yeast gene that increases the production of a compound slowing aging and delaying microbial decay in tomatoes. This discovery may lead to extended shelf life for most fruits by an additional week, benefiting areas with limited access to fresh produce.
The Human Microbiome Project has launched a centralized database for sequencing microbial genomes, providing a unique resource for future investigations. The HMP has cataloged over 1,400 individual human microbiome projects, enabling researchers to study the interactions between human and microbial cells.
Researchers at NC State will use microbes that thrive in high-temperature environments to produce biofuels directly from carbon dioxide and hydrogen. The project aims to create a more efficient and flexible process for producing biofuels, which could be used in various applications.
Researchers used high-performance computing to locate small genes missed by scientists, uncovering 380 families of undetected gene families. The study used an ephemeral supercomputer to perform an all-to-all sequence search, reducing the search time from nearly 90 years to just 12 hours.
A team of scientists has discovered that rare microbial organisms, once thought to be undetectable, dominate the ecosystem in a unique hydrothermal vent field. The study, led by William Brazelton at the University of Washington, found that microorganisms can remain rare for long periods before becoming dominant when ecosystems change.
Researchers are studying phototrophic extremophiles to understand the evolution of oxygen-evolving high-energy photosynthesis. The study aims to illuminate gaps in genetic data and explore astrobiology connections, potentially revealing clues about extraterrestrial life.
Scientists have discovered a bowl-shaped molecule that can pull carbon dioxide out of the air, offering new possibilities for reducing greenhouse gas emissions. The molecule's unique properties make it suitable for industrial use in removing CO2 from ambient air and potentially even from living organisms.
The development of genome annotation standards is crucial for advancing microbial genomics, but a lack of standards hinders comparisons and discoveries. Kyrpides suggests several innovative approaches to ease the data processing bottleneck, including proxy approaches and pan-genome representations.
A study found that rats in Baltimore form distinct neighborhoods, with each community spanning little more than an average alley. Rats rarely migrate, but neighborhood eradication efforts may backfire by encouraging rodents to repopulate other areas and spread disease.
Researchers have found a way to induce sex in the disease-causing parasite Leishmania by cramming enough parasites into the gut of an insect, potentially leading to new treatments for deadly infections.
Michigan State University has licensed technology that enables plants to use atmospheric nitrogen, resulting in significant growth and yield improvements of up to 90 percent. The microbial fertilizers are cost-effective, environmentally friendly, and have been shown to increase plant resistance to disease.
Researchers have identified a stable, modifiable virus capable of withstanding harsh conditions and can be used as a nanobuilding block. The virus particles are ideal for producing materials on the nanometre scale and can be modified spatially controlled.
The metagenomics field is gaining traction, allowing researchers to reconstruct metabolic profiles of microbes from environmental samples. DOE JGI's advancements in this area are crucial for understanding microbial diversity, as they have characterized many metagenomes across various ecosystems, including acid mine drainage and gut env...
A novel approach extracts single genomes and discerns specific microbial capabilities from mixed community sequence data. The research team characterized biochemical pathways associated with nitrogen cycling and methane utilization in Lake Washington sediments, revealing novel versions of metabolism.
The Genome Sequencing Center at Washington University School of Medicine increased its sequencing capacity with the acquisition of five new Genome Sequencer FLX Systems from Roche Diagnostics. The center will be able to support a wide variety of projects, including transcriptome analysis of individual tumors and human microbiome studies.
Researchers at Michigan State University found that clones with similar genetic traits outperformed those with varied genetics, producing more flowers and potentially increasing reproduction. The study suggests that a gene called Erecta plays a role in this variation, but further research is needed to confirm the findings.
A new comparative metagenomics method reveals that microbes evolve faster in some environments than others, with many lineages remaining loyal to their habitats over time. The study provides insights into the evolution of microorganisms in different ecosystems, shedding light on the invisible life on Earth.
The Microbe experiment on board the space shuttle Atlantis will investigate how three common microorganisms adapt to microgravity, with potential benefits for developing new therapeutics and treatments for infectious diseases. The results will help NASA evaluate risks to astronauts on future missions to the moon and Mars.
Researchers found that mating in microbes reduces asexual reproduction efficiency, but leads to genetic diversity and hardy offspring. This balance between cost and benefit of sex may improve survival chances under harsh environmental conditions.
The DOE is awarding $92 million to develop biology-based solutions to energy and environmental challenges. The funding supports six research projects that aim to harness the diverse capabilities of microbes and microbial communities to address DOE's mission needs.
The Genomics: GTL Roadmap outlines a plan to explore microbial DNA sequences to produce new science needed for clean energy and environmental needs. The roadmap will spur growth in industrial biotechnology sector, using microbes for processes and products that can serve as an engine for economic competitiveness.
Research reveals fungal microbes use tandem repeats in genes to change protein conformations, evading the immune system and causing diseases. The study also explains why certain beers are cloudy or clear, providing new insights into brewing.
Researchers developed Environmental Genomic Tags (EGTs) to assess environment vitality and signal progress in remediating contaminated environments. The EGT approach captures a DNA profile of a particular niche, reflecting the presence and levels of nutrients, pollutants, and other environmental features.
The Bridging the Rift project is a unique collaboration between Arab and Israeli scientists, with 40 researchers from Israel, Jordan, and the US working together. They conducted a joint biological field survey in January, collecting microbes and plants that thrive in the harsh desert environment.
A partnership between OneWorld Health, University of California - Berkeley, and Amyris Biotechnologies aims to produce an inexpensive antimalarial drug using synthetic biology. The goal is to reduce the cost of treatment to under $1 per adult course, making it more accessible to millions in developing countries.
Research reveals that gut microbes suppress fasting-induced adipocyte factor (Fiaf), helping to keep fat cell gates closed. This suppression can lead to increased fat storage and insulin resistance, highlighting the importance of gut microbiota in regulating fat metabolism.
Researchers describe how microbes in the gut form the second largest metabolic 'organ' in the body, influencing disease processes alongside genetic and environmental factors. The discovery of this 'superorganism' could lead to new approaches to treating disease and developing personalized medicine.
The diatom genome project provides insight into the vital role that diatoms play in mediating global warming by absorbing CO2 and producing oxygen. Diatoms also have a unique urea cycle to reduce their dependence on nitrogen, enabling them to thrive in changing ocean conditions.
The discovery of 1.2 million new genes in Sargasso Sea microbes has significant implications for carbon sequestration and alternative energy production. The genes are part of the larger Genomics: GTL program, which aims to develop innovative solutions to address national energy needs.
Researchers sequenced the genomes of three Prochlorococcus and one Synechococcus strains, revealing insights into their metabolic machinery and ecological niches. The discoveries may aid studies on global climate change and sustainable energy production.
Researchers use DNA analysis to identify previously unknown microbe kingdoms, expanding the estimated number of microbial species to about 30. The discovery has potential applications in agriculture and ecology, including understanding soil diversity and improving sewage treatment.
The collaboration aims to extract DNA from diverse ecosystems and sequence it using JGI's capabilities. This will provide a vast resource of genetic material for scientists to study and develop new products, including pharmaceuticals, agricultural solutions, and energy sources.
The Department of Energy has awarded $9 million to IBEA, led by J. Craig Venter, to study microorganisms in the Sargasso Sea and explore their potential for producing hydrogen and reducing carbon dioxide emissions from energy sources like petroleum and coal.
The NIAID's new center will support research on three to 10 important pathogens over the next three years. It will develop new technologies for analyzing gene function, train researchers, and provide resources for the scientific community. The center aims to better understand individual genes and proteins to develop targeted treatments.