Articles tagged with Pseudomonas
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A recent study led by Dr. Lucas Hoffman found that Pseudomonas aeruginosa, a common pathogen in cystic fibrosis lung infections, can resist powerful antibiotics due to adapting to the clogged airways. The mutation enables the bacteria to thrive in viscous lung secretions and survive oxidative stress caused by antibiotic treatment.
Researchers found that glycyrrhizin improves the ability of damaged skin to produce antimicrobial peptides, which help prevent bacterial growth and infections. The study suggests that this compound could lead to lower death rates associated with burn-related infections.
Researchers have discovered a promising strategy to break down Pseudomonas biofilms, which form in cystic fibrosis patients and cause lung damage. A negatively charged molecule called aspartic acid polymer can disrupt the molecular bonds that hold together these difficult-to-treat infections.
Researchers at Helmholtz-Zentrum für Infektionsforschung used computer models to identify genetic changes that increase biosynthetics production in Pseudomonas putida bacteria. The study, published in PLOS Computational Biology, aims to develop targeted methods for producing natural materials efficiently.
Researchers found that targeting Streptococcus milleri group (SMG) bacteria can disrupt Pseudomonas aeruginosa bacterial communities, leading to clinical benefits for patients. The approach has shown positive results in treating severe lung infections and may also be a treatment option for individuals with chronic lung infections.
Researchers developed a peptide, D6R, that blocks lethal toxins of anthrax by inhibiting furin activity. The peptide has shown promising therapeutic potential against various bacterial infections, including Pseudomonas aeruginosa and Ebola, without invoking a cytokine response.
Researchers discovered that a genetic mutation in Pseudomonas aeruginosa makes it susceptible to destruction by slightly acidified sodium nitrite, a common food preservative. This finding offers new hope for treating cystic fibrosis airway disease.
Pseudomonas bacteria can detect interferon-gamma, a chemical messenger that triggers the immune system's response. Once detected, the bacteria activate genes that transform them from harmless passengers into deadly invaders.
Researchers found that Pseudomonas aeruginosa biofilms develop faster in the presence of neutrophils, which are sent to fight infections. The biofilms become resistant to antibiotics and the immune system, leading to chronic lung damage and death.
A study found that piercing ear cartilage increased the risk of infection compared to lobe piercing. The authors identified 7 confirmed Pseudomonas aeruginosa infections and 18 suspected cases, with most treated ineffectively with antibiotics.
Researchers have developed a protective coating that prevents deadly post-operative infections from Pseudomonas aeruginosa, a virulent pathogen that kills 100% of untreated mice. The coating, which works by pleasing the bacteria and preventing them from invading the host's bloodstream, has shown promising results in animal studies.
Researchers at the University of Washington used quantitative proteomic analysis to study Pseudomonas aeruginosa bacteria linked to cystic fibrosis. The study found that quorum sensing may help the bacteria adapt in the airway, leading to inflammation and fatal outcomes.
A new peptide, D6R, has been developed by LSUHSC researchers to block the action of an enzyme that activates toxic proteins in bacteria and viruses. The peptide was found to protect cells from lethal toxins without triggering a cytokine response, offering potential as a treatment for sepsis and other infections.
The University of Washington has established a new center to combat deadly microbial pathogens, which threaten human health worldwide. Researchers will focus on developing treatments and vaccines for diseases caused by Pseudomonas aeruginosa, pathogenic protozoa, and other infectious agents.
Adults with cystic fibrosis (CF) are susceptible to cross-infection, including superinfection, from Pseudomonas aeruginosa. Chronic colonization occurs in up to 80% of CF patients, leading to increased illness and death. Genotypic changes in strains suggest social contact is a common mode of transmission.
A team of microbiologists genetically altered Pseudomonas aeruginosa to break its resistance to detergents and antibiotics. The study found that disabling the lasI gene reduced the bacteria's ability to form deadly biofilms.
A consortium of scientists has released a new genome sequencing project for the bacterium P. aeruginosa, which causes chronic lung infections in CF patients. The project aims to increase practical knowledge about the pathogen and develop new drugs for treatment.