Articles tagged with Bacterial Rna
Researchers at Johns Hopkins Kimmel Cancer Center identified the missing link in how a common gut bacterium, B. fragilis, triggers colon cancer. The team found that BFT toxin binds to host receptor claudin-4 before causing damage, revealing a potential strategy for preventing colon damage and cancer.
Researchers at Arizona State University discovered two new forms of bacterial movement: swashing and shifting strategies. Bacteria can move across moist surfaces using currents created by fermentation, while other types use the type 9 secretion system to glide across surfaces.
A recent study by Michigan Medicine researchers has found that CRISPR-Cas9 forms immune memories in bacteria by boosting spacer acquisition when RNA levels are low. This discovery expands our understanding of how bacteria safeguard their immune memory and may inspire new ways to design CRISPR-based molecular recording tools.
Researchers at Rutgers University have created a biosensor using RNA molecules that can detect tiny chemicals relevant to human health. The technology has the potential to improve disease detection and environmental monitoring.
Researchers at Vanderbilt University Medical Center discovered how C. diff converts a poisonous compound into a usable nutrient, increasing its competitive advantage in the infected gut. The findings point to novel therapeutic strategies, including targeting the TudS enzyme to preserve healthy gut microbiota.
A new RNA barcoding method allows researchers to track gene transfer in bacterial communities without disrupting their natural environment. The technique has potential applications in predicting antibiotic resistance outbreaks, engineering microbiomes for pollution cleanup, and programming microbes for specific tasks like producing bio...
A study published in iScience reveals that bacterial species are transferred between both individuals during sexual intercourse, and these species can be traced to a partner's unique genital microbiome. This discovery may provide a new tool for identifying perpetrators of sexual assault.
Biomedical engineers at Duke University have developed a new technique that traps together cellular machinery to increase protein production rates. This approach uses synthetic disordered proteins to form compartments called biological condensates, which enhance the rate of protein production by bringing together biomolecular machinery...
A new study combines genomic-scale microscopy with a technical innovation to capture genes bacteria turn on in different situations and environments. This technology promises to take the study of bacteria to the next level by providing powerful new insights into bacterial behavior, including gene expression and interactions.
A team of researchers has uncovered the three-dimensional structure of a ribozyme called SAMURI, which can chemically modify other RNA molecules and influence their function. The study's findings could provide new directions for the development of RNA-based therapeutics.
Researchers at Hokkaido University discovered that deep-sea hydrothermal vent bacteria can reduce nitrous oxide through an efficient energy metabolism mechanism. The study found that denitrification genes are negatively regulated by transcriptional regulators, suggesting a potential approach to mitigate climate change.
A pioneering AI model has been developed to understand the genetic 'language' of plants, allowing for precise predictions about RNA functions and identification of functional patterns. This breakthrough has significant implications for crop improvement and the next generation of AI-based gene design.
A new study discovered how TRIM25, a cellular superhero, finds and binds to viral RNA to activate an immune response. The researchers found that this binding is critical for TRIM25's antiviral activity and its ability to target regions of viral RNA.
A new study has identified novel strains of microbes that have adapted to use limited resources in cities, including those found in Hong Kong's subways and skin. These microbes can metabolize manufactured products, posing health risks if they are pathogenic.
For the first time, researchers have demonstrated how mechanical forces affect gene expression by showing that RNAP polymerase remains on the DNA template and can be pulled to start a subsequent cycle of transcription. This force-directed recycling mechanism can change the relative abundance of adjacent genes.
A Cornell University-led collaboration has developed a machine learning model that uses cell-free molecular RNA dregs to diagnose pediatric inflammatory conditions, including Kawasaki disease and Multisystem Inflammatory Syndrome in Children. The diagnostic tool accurately determines the patient's condition while monitoring organ health.
Researchers have developed two new methods to produce circular RNAs, which can silence genes and serve as templates for making therapeutic proteins. These circular RNAs display enhanced stability and biological activity in heart muscle cells and neurons.
Researchers from University of Maryland discovered RNA mechanisms that can lead to more effective and durable RNA-based drug treatments for conditions like high cholesterol, liver diseases, and cancers. The study highlighted the need to consider drug resistance when developing these treatments.
Researchers have developed a new method called PUMA that uses CRISPR-Cas12 nucleases to detect RNA biomarkers. This technology overcomes limitations of existing methods by reprogramming tracrRNAs to recognize specific RNA targets, enabling precise detection without requiring a specific recognition sequence.
Researchers at U of T have harnessed CRISPR to efficiently and precisely control RNA splicing, enabling the systematic interrogation of gene functions and correction of splicing deficiencies in diseases. This new tool allows for targeted activation or repression of alternative exons with high specificity.
A recent study reveals that a cellular process called transfer Ribonucleic acid (tRNA) modification influences the malaria parasite’s ability to develop resistance. This breakthrough discovery could help researchers develop new drugs to combat resistance and better tools for studying RNA modifications.
Researchers developed a novel statistical approach to accurately estimate RNA decay rates, finding that bacterial RNAs have significantly shorter half-lives than previously thought. This discovery has implications for understanding gene expression and protein production in bacteria.
A research team identified a specific regulatory RNA molecule that influences the bacterium's sensitivity to tetracycline antibiotics, providing new insights into bacterial adaptation and informing strategies for preventing collateral damage to beneficial bacteria.
Researchers have developed a cost-effective approach for identifying L. pneumophila using whole genome sequencing, which can analyze available specimens without culturing. This method has already been used to identify the source of deadly Legionnaires' disease outbreaks, including a 2015 outbreak in New York City.
Soil microbes were analyzed near the Centralia mine fire, revealing new insights into how bacterial communities respond to intense environmental change. The team found that species that were active or dormant changed after the fire, but some populations recovered with new bacteria being blown in by wind.
Researchers at John Innes Centre used cryo-EM to visualize the structural architecture of chloroplast RNA polymerase and build a detailed atomic model. The study reveals new insights into transcription, a fundamental step in making photosynthetic proteins, and how these proteins interact with DNA and mRNA.
Yiliang Ding's pioneering work on RNA structure and function has led to breakthroughs in plant virus treatment, increasing structural understanding of this crucial molecule. Her award-winning research has the potential to drive scientific innovation in agriculture and human health.
Researchers discover a central chromosomal domain that enables dormant spores to revive and activate essential genes, shedding light on bacterial survival in harsh conditions. The study's findings have broader implications for sustaining long-term transcriptional programs across diverse organisms.
Researchers at Oak Ridge National Laboratory used quantum biology and artificial intelligence to sharpen the CRISPR Cas9 genome editing tool, improving its efficiency on microbes. The new model revealed key features about nucleotides that enable better guide RNA selection.
Researchers have identified a new mechanism by which phages evade CRISPR-Cas immune systems in bacteria, revealing a potential approach to make gene editing safer and more efficient. This discovery could lead to the development of bespoke anti-CRISPRs to neutralize CRISPR-Cas systems and provide an alternative to antibiotics.
The new approach boosts immunity by engineering nanoparticles and antigens to stimulate a stronger immune response. The vaccine induces a strong immune response when delivered intranasally, potentially leading to longer-lasting immunity and reduced costs.
Researchers discovered a new mechanism underlying the heat shock response in Escherichia coli. IbpA suppresses σ32 translation, regulating Hsp expression and aiding cell protection under high temperatures. This finding sheds light on bacterial adaptation to harsh environments.
Scientists have discovered an additional source of genetic mutations that cause rare conditions like Huntington's disease. Expanded CAG repeat RNA can form aggregates that reduce global protein synthesis and lead to neurotoxicity.
A new method called 5PSeq has been developed to quickly assess bacterial response to antibiotics, with potential implications for treating antibiotic-resistant infections. The method measures mRNA translation and decay, revealing how bacteria interact with environmental factors and stressors.
Researchers at KAIST have developed a new sRNA tool that can effectively inhibit target genes in various bacteria, including both Gram-negative and Gram-positive bacteria. The BHR-sRNA system was shown to suppress pathogenicity in antibiotic-resistant pathogens and improve industrial strains for high-value-added chemical production.
James Chappell, a Rice University bioscientist, has won a National Science Foundation CAREER Award to create RNA programming methods for microbial communities in natural habitats. His research aims to improve human health and the environment by genetically manipulating microbial communities.
Researchers at Rice University aim to create genetically encoded antibiotics that selectively kill pathogenic bacteria while sparing beneficial microbes. The goal is to develop targeted, tailored RNA antibiotics to combat antibiotic resistance and improve treatment outcomes.
A team of researchers led by Ohio University professor Jennifer Hines has uncovered a new class of compounds that can target RNA and disrupt its function. The discovery identified a chemical scaffold that could be used to develop RNA-targeted medicines for various diseases.
Researchers at Cornell University have discovered a new CRISPR system called Craspase, which has the potential to develop promising antiviral and tissue engineering tools in animals and plants. The study uses cryo-electron microscopy snapshots to explain how Craspase identifies RNA targets and activates proteases.
Researchers at Rice University have developed cells that can store and process information similar to computer RAM. The cells will be programmed to synthesize redox-active molecules that carry information to and from the outside world, allowing for quick read and write capabilities.
Researchers used a new tool to capture hundreds of undiscovered mechanisms of gene regulation in MRSA, revealing a previously unknown layer of gene regulation. The study identified a regulatory RNA that promotes an enzyme involved in cell wall thickening, potentially identifying new targets for antibiotic treatment.
A heat-loving bacterium's Cas13 protein enables specific detection of SARS-CoV-2 and other viruses in a one-pot assay. The technology has been patented and clinically validated, with the aim of mass production and commercialization.
Researchers from the University of Würzburg have developed precision antibacterials using mRNA technology, targeting specific genes in uropathogenic Escherichia coli. The study shows that these active agents can effectively block only one specific gene, and reducing their size to nine base pairs can minimize non-specific binding.
Scientists at Scripps Research developed Pytheas, an open-source app that automates the analysis of modified RNA molecules using mass spectrometry. The tool speeds up the process of characterizing and quantifying RNAs in basic research and drug-development settings.
A new study found a bi-directional relationship between gastrointestinal issues and internalized symptoms in children with autism, highlighting the importance of the gut-brain axis. The research aims to develop personalized treatments for individuals with autism experiencing gastrointestinal problems.
A new technique called Operational Genomic Units (OGU) allows for improved resolution and simplicity in analyzing microbiome samples. By using individual genomes as basic units, researchers can pinpoint biologically relevant characteristics such as age and sex with greater accuracy.
Researchers led by Cynthia Sharma explore a vast universe of RNA-binding proteins in bacteria, which play crucial roles in stress response and virulence control. The team aims to advance understanding of these proteins, revealing fundamental biological principles that could lead to novel biotechnological methodologies or antimicrobial ...
A recent study identified specific RNA biomarkers linked to gastrointestinal symptoms in children with autism. The findings could lead to the development of personalized treatments to ease the pain of these individuals. The research has implications for precision medicine, enabling healthcare providers to track medication effectiveness...
Legionella pneumophila secretes small regulatory RNA molecules that mimic eukaryotic microRNAs, downregulating RIG-I protein to diminish host immune response and promote replication. This mechanism enables the bacterium's survival and development during infection.
A team of scientists at the University of Würzburg has identified a previously unknown RNA sponge, OppX, that mimics a key regulator of bacterial membrane permeability. The discovery sheds light on how bacteria evade antibiotics and could lead to the development of new therapeutics.
Scientists have discovered a new layer of regulation in plant-microbe interactions using peanut studies. An antisense long-noncoding RNA, DONE40, was found to bind to a protein involved in epigenetic control, suggesting a conserved function across plants and animals.
A study of Edo-era Japanese skeletons reveals a prevalence of periodontal disease similar to modern times, with distinct bacterial species. Researchers analyzed dental calculus from 12 human skeletons and compared their oral microbiomes to modern samples, shedding light on the evolution of the oral microbiome.
An international research team discovered that intestinal bacteria can distribute their metabolic products throughout the body via the bloodstream using membrane vesicles. The study found that these vesicles can overcome the blood-brain barrier and enter brain cells, suggesting a new method for delivering drugs or vaccines.
Researchers discovered a small RNA molecule that regulates both the production of the cholera toxin and the metabolism of the cholera bacterium. This finding provides a new target for developing treatments against cholera and has implications for biotechnological applications.
Researchers at Penn State have imaged a protein facilitating RNA modification, allowing them to reconstruct the process. The study reveals how a chemical tag is added to tRNA, improving its ability to translate messenger RNA into proteins.
Researchers developed a cutting-edge method to analyze how individual immune cells respond to Mtb, the bacteria that cause tuberculosis. The study found an almost perfect correlation between the fitness status of the bacterium and the transcriptional profile in the host cell.
Targeting an RNA sequence in pathogenic bacteria could make them more sensitive to antibiotics, offering a new avenue for treating drug-resistant bacteria. The study found that eliminating this regulatory RNA sequence had an impact on urinary tract infections related to E. coli.
A UNIGE team has identified an RNA helicase regulator in Pseudomonas aeruginosa that significantly reduces its infectious power and virulence. The absence of this protein makes the bacteria almost harmless while remaining alive.
A global study has discovered over 10,000 previously unknown bacteria and viruses in public transit systems and hospitals worldwide. The researchers mapped urban antimicrobial resistance and identified potential city-specific signatures for some genes.
Researchers at Penn State discovered a new mechanism for terminating transcription of DNA into RNA in bacteria, facilitated by proteins NusG and NusA. The study found that these proteins together facilitate termination at about 88% of intrinsic terminators, expanding our understanding of gene regulation and potential antibiotic targets.