Articles tagged with Dna Synthesis
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
Researchers have repurposed a bacterial DNA synthesis system to enable DNA to act as an active 'field agent' inside living cells. This allows for the creation of programmable DNA fragments that can regulate gene expression and control protein behavior.
Researchers identified NUDT5 as a structural regulator that controls purine synthesis by physically restraining the key biosynthetic step. This mechanism may also explain cancer drug resistance and informs new therapeutic approaches for diseases caused by MTHFD1 deficiency.
Researchers at Aarhus University have developed a method to measure plant roots using DNA technology, revealing their essential role in food production and climate. The new method enables accurate measurement of biomass and species distribution, opening up applications in climate research, plant breeding, and biodiversity analysis.
Researchers at Colorado State University have created a programmable plant circuit that can turn genes on and off, allowing farmers to time harvests and adapt to drought. The breakthrough could lead to automated genetic circuit design through machine learning, revolutionizing agriculture.
The special issue explores challenges and opportunities in managing synthetic genomics risks, introducing a common global baseline for nucleic acid synthesis screening. Review articles provide insights into enhancing gene synthesis security and biosecurity practices of synthetic DNA providers.
Scientists have discovered two new end-replication problems in DNA replication, affecting both the leading and lagging strands. This revelation changes our understanding of telomere biology and may hold clinical implications for individuals with telomere disorders, such as Coats plus syndrome.
A Duke University team has found that retrotransposons use the cell's DNA repair function to create a ring-like shape and then produce a matching double strand. This discovery challenges long-held theories about retrotransposons being byproducts of bad gene copying.
A machine learning framework predicts and quantifies chromosome synthesis difficulties, providing guidance for optimizing design and synthesis processes. The model achieved high accuracy and predictive ability, enabling the development of a Synthesis difficulty Index to explain causes of synthesis difficulties.
Researchers at Weill Cornell Medicine have identified a crucial mechanism that prevents cells from replicating extra DNA, reducing the risk of cancer and genome instability. The study reveals that a licensing protein called CDT1 acts as a brake on DNA replication, preventing it from progressing once licensed sites are established.
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
Researchers develop technique to control pH at microsites, enabling high-throughput biomolecular synthesis and enzymatic DNA synthesis. This allows for increased experimental throughput and speeding up processes in DNA synthesis.
Researchers at Aarhus University have developed an easy and inexpensive method for linking molecules to DNA sequences with desired functions. The method uses sulfonyl azides to introduce various functionalities, avoiding the need for expensive and unstable special phosphoramidites.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A team of researchers has developed a DNA-based data storage platform with an expanded molecular alphabet, enabling the storage of vast amounts of digital information. The new system uses nanopores to distinguish between natural and chemically modified nucleotides, increasing storage density and sustainability.
Cryo-EM study reveals details of DNA repair mechanism translesion synthesis (TLS), allowing cells to survive with mutations. Key protein complex Pol K - PCNA interaction modulated by ubiquitination facilitates recruitment of TLS polymerase to damage sites.
The new method streamlines DNA production by automating the synthesis of phosphoramidites, eliminating manual labor and storage issues. This breakthrough has significant implications for disease identification, drug manufacturing, and other medical applications.
Researchers at ETH Zurich have successfully created biochemical random numbers using DNA synthesis, correcting a long-standing challenge in generating truly random numbers. The team achieved this by synthesizing DNA molecules with randomly placed building blocks, resulting in vast quantities of randomness that can be stored in a small ...
Researchers from Chinese Academy of Science develop a more efficient and cost-effective way to accurately synthesize DNA, increasing accuracy by nearly seven-fold. The new error-correction system uses chemical stabilizers to extend the life of key proteins, reducing costs and labor time.
A novel molecular mechanism for regulating PCNA cycling during DNA replication has been discovered. The ATAD5-RFC-Like-Complex (ATAD5-RLC) is a PCNA unloader that opens the PCNA ring to remove it from DNA.
Researchers developed DASH materials that exhibit metabolism, self-assembly, and organization - key traits of life. The biomaterial autonomously emerges from nanoscale building blocks, grows, and decays, allowing it to perpetuate dynamic processes.
Researchers from UCI and UC Riverside have discovered a vulnerability in DNA synthesis machines that can be exploited for malicious purposes. The acoustic side-channel attack allows hackers to steal genetic blueprints, potentially leading to bioterrorism and unauthorized access to sensitive data.
A team of researchers at the University of California, Riverside, has developed a method to reconstruct what a researcher is doing with a DNA synthesizer by recording its sounds. The technique uses machine learning algorithms to identify patterns in the sound signals and can detect the type of DNA being produced with high accuracy.
Researchers found that certain DNA structures, like G-quadruplexes, can slow down or speed up DNA synthesis, affecting error rates. Non-B DNA regions with specific motifs were associated with increased sequencing errors and human disease susceptibility.
Researchers have developed a new way to synthesize DNA sequences using enzymes, promising to accelerate the pace of science. The innovative approach uses TdT enzyme to add nucleotides in a controlled manner, eliminating drawbacks of existing methods and enabling faster, cheaper and more accurate synthesis.
Scientists at UC Berkeley developed a new DNA synthesis method that uses a natural human enzyme to print long DNA strands in water. The technique offers improved precision and potential for faster research and development of new medicines.
Researchers from Arizona State University reveal a hidden secret of the immortality enzyme telomerase, which holds promise for reversing cellular aging and extending human lifespan. Understanding the enzyme's mechanism may lead to effective anti-aging therapeutics.
Engineers at FAU have successfully produced complex crystal lattices, so-called clathrates, using DNA strands and nanoparticles. The team achieved this by reordering pyramid-shaped gold crystals to form clathrate compounds through a self-assembling process.
Researchers have developed a new CRISPR-Cpf1 technique to modify the fat content of soybean oil by editing two FAD2 genes. This method results in an increase in oleic acid and a decrease in linoleic acid, leading to healthier oil.
Researchers at the Max-Planck-Institute developed a novel pathway for effective carbon fixation, using a new CO2-fixing enzyme nearly 20 times faster than nature's most prevalent enzyme. This breakthrough enables the efficient capture of CO2 and its conversion into valuable products.
Researchers at MIT have developed an algorithm that can build complex DNA nanoparticles automatically, allowing for a broader range of applications in fields such as vaccine development and gene editing. The algorithm, known as DAEDALUS, can build any type of 3D shape with a closed surface, including shapes with holes.
The UK government has announced a £40 million investment in synthetic biology, aiming to create biological 'factories' that produce essential products like medicines and chemicals. Three new research centres will be established in Edinburgh, Manchester, and Warwick to boost national research capacity.
The University of Liverpool has been awarded £2M for a state-of-the-art DNA synthesis facility, GeneMill, to support genome engineering in academia and industry. The lab will provide rapid, cost-effective, and accessible fabrication facilities for DNA parts, enabling researchers to focus on designing and testing re-engineered organisms.
Researchers develop novel two-pronged strategy targeting DNA synthesis to treat leukemia in mice. The approach, which involves blocking both the de novo and salvage pathways, shows promise as a targeted metabolic intervention for acute lymphoblastic leukemia.
University of Minnesota researchers have discovered a series of compounds with anti-HIV activity that block HIV DNA synthesis or induce lethal mutagenesis. The compounds, known as ribonucleoside analogs, stop the replication and spread of HIV by preventing it from reproducing.
Researchers discovered a unique DNA repair mechanism that utilizes a 'desperation strategy' to patch breaks in chromosomes. This process, called break-induced replication, can lead to increased mutagenesis and potentially drive cancer formation.
Scientists have found a unique DNA repair mechanism that leads to increased genetic mutations, potentially contributing to tumor formation and cancer. This 'desperation replication' triggers bursts of genetic instability and can occur in non-dividing cells, making it a potential route for cancer formation.
Researchers successfully synthesized a large DNA molecule and applied a method to scramble its genetic code, yielding insights into DNA structure and trait expression. The achievement represents a significant step towards synthesizing entire eukaryote genomes.
Cold Spring Harbor Protocols presents high-throughput methods for mapping active gene regulatory elements using DNase-seq, and analyzing DNA synthesis with BrdU-IP-chip. These techniques enable genome-wide identification of genetic regulatory elements and analysis of DNA metabolism.
A team of scientists has developed an automated carbohydrate synthesizer, allowing them to build complex carbohydrates in a few hours. This innovation could lead to the creation of new vaccines and treatments for diseases such as malaria and HIV.
Scientists discovered a genetic link between glycolysis and DNA replication in Bacillus subtilis, indicating that metabolic signals influence DNA synthesis and stability. This finding suggests a global regulatory function of central carbon metabolism in adjusting cellular functions to nutritional conditions.
Researchers at Virginia Tech have introduced a DNA targeting component in light-activated molecular systems, allowing for more selectivity in attacking cancer cells. The new system uses visible light to signal the synthesized bioactive molecules to cleave DNA, reducing damage to healthy tissue.
A recent study published in Nature Structural & Molecular Biology has identified a key protein, Upf1, that regulates histone production during cell division. The research suggests that an imbalance in DNA and histone production is lethal for cells and may be crucial in understanding tumor growth.
Researchers have developed a novel method to measure the energies involved in DNA synthesis, providing insights into DNA damage and its repair mechanisms. The study's findings can inform the development of targeted external agents to halt incorrect DNA synthesis.
Researchers have developed DNA enzymes that can produce branched and lariat RNAs, key intermediates in the biological process of splicing. The discovery could provide new insights into RNA splicing and its connection to genetic diseases.