Articles tagged with Noncoding Rna
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Scientists have engineered B cells to synthesize and deliver microRNA, a non-coding RNA that can be used to introduce or inhibit specific proteins. This achievement may lead to new therapeutic applications, including vaccination and cancer treatment.
Researchers identified epigenetic disruption of a small non-coding RNA pathway as a hallmark for testicular tumor development. This aberration compromises the function of these RNAs, contributing to cellular transformation.
Researchers at The Wistar Institute discovered a mechanism by which long non-coding RNA-activators promote gene expression in early embryonic development. These RNA molecules help create a loop of DNA, opening up genes for transcription.
Researchers have broadened the understanding of how cells regulate silencing of the X chromosome, finding indications of gene activity inside and outside the Xist cloud. The study's findings suggest a more subtle regulation mechanism than previously thought, with potential implications for cancer therapy and non-coding RNA function.
Scientists have discovered that the controlled release of microRNA miR-675 slows down placental growth before birth, regulating a key factor in healthy pregnancy. This finding has important implications for understanding how environmental signals and diet may influence fetal development.
Researchers have found that non-coding RNA molecules can detect the presence of viruses in cells, providing a potential tool for developing new treatments. The discovery was made using deep sequencing technology and has been used to identify infected cells with 100% accuracy.
A team of scientists has discovered that two competing noncoding RNAs play a crucial role in regulating FLO11 gene expression in yeast cells, allowing them to adapt to different environments. This finding provides new understanding of location-dependent gene expression and its significance in various biological processes.
Researchers at UC San Diego School of Medicine discovered that non-coding RNAs TUG1 and NEAT2 relocate genes to activate their function in response to growth signals. This process provides a new understanding of the interaction between regulated genes and human diseases.
Researchers at Cold Spring Harbor Laboratory discovered that two non-coding RNAs, MENε and MENβ, trigger the formation of nuclear subcompartments called paraspeckles. Paraspeckles are believed to serve as storage depots for pre-made protein-coding RNA, allowing cells to respond faster to stress.
Researchers have discovered a crucial mechanism for regulating gene expression, where noncoding RNAs interact with DNA to silence specific genes. This breakthrough sheds light on the complex interactions between epigenetic regulation and noncoding RNA molecules.
This article features protocols for investigating histone demethylase activity, including methods for detecting cytosine methylation in RNA using bisulfite sequencing. These methods enable researchers to measure histone demethylase activity in tissues and cell lysates, identify novel enzymes, and screen for inhibitors.
Research by Jhumku Kohtz finds Evf2 RNA controls gene expression in brain regions involved in GABAergic interneurons. Altered Evf2 levels may contribute to mental disorders with long-lasting effects through adulthood.
Researchers have discovered that two noncoding RNAs, MENε and MENβ, play a critical role in maintaining the structure of paraspeckles, a compartment within the cell nucleus. This discovery sheds light on the functional roles of noncoding RNAs in regulating gene activity and responding to stress signals.
Researchers have discovered a novel mechanism in gene expression where non-coding RNAs create access to DNA, allowing transcriptional activation proteins to initiate gene expression. This process involves the transient synthesis of non-coding RNAs that unfurl tightly wound DNA, enabling gene expression.
A new study reveals that noncoding RNAs play a significant role in human cancer, with altered expression of ultraconserved noncoding RNAs consistently found in leukemias and carcinomas. The findings suggest a model where both coding and noncoding genes cooperate in tumorigenesis.
Researchers at Stanford University School of Medicine have discovered that large, seemingly useless pieces of RNA play a crucial role in regulating gene activity across vast portions of the human genome. This finding suggests that ancient RNA molecules can influence cancer development and stem cell maintenance.
Scientists at Thomas Jefferson University have identified a new mechanism for controlling gene expression in fruit flies, involving non-coding RNAs that regulate HOX genes. This discovery could lead to improved understanding of diseases like ALL and its connection to misregulated HOX genes.
Researchers discover non-coding RNA transcript Kcnq1ot1 is essential for paternal-specific gene silencing in mice. The study suggests that mammals have co-opted multiple transcriptional regulatory mechanisms to control imprinted genes, supporting the idea that imprinting evolved gradually over time.
Researchers characterize 161 unique RNA genes in introns of protein-coding genes, revealing new insights into developmental processes and regulatory mechanisms in nematodes.
Researchers at Scripps Research and GNF develop a strategy to identify functions of noncoding RNAs, which are abundant in human cells. The team screened a library of noncoding RNAs and identified eight that appeared to have functional roles, including one that regulates nuclear factor of activated T-cells (NFAT) signaling.