Rna Synthesis

High fidelity keeps human DNA assembly line humming

Researchers have identified a previously unknown quality control station in RNA synthesis that checks NTP loading to maintain accuracy. This discovery has significant implications for understanding cancer, viral infections, and normal human development.

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Chemists create unusual lariat RNA, a key intermediate in biological splicing

Researchers have developed DNA enzymes that can produce branched and lariat RNAs, key intermediates in the biological process of splicing. The discovery could provide new insights into RNA splicing and its connection to genetic diseases.

UB scientists report fast, simple method of generating 'designer' RNA catalysts for proteomics

Researchers from the University at Buffalo have developed a programmable 'Sugazyme' that can efficiently attach unnatural amino acids to proteins. The technology has the potential to aid researchers working in proteomics by expanding the amino-acid repertoire for protein synthesis.

New genetic technique delivers knockout blow to 'Asthma Virus'

Researchers have developed a new genetic technique that can deliver a knockout blow to the Asthma Virus by targeting its RNA. The technique, called post-translational gene silencing, uses specific siRNA molecules to block viral protein production and suppress virus replication.