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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

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How sleep keeps our memories fresh

Researchers at ISTA discovered that neural activity patterns during sleep reflect recently learned spatial memories and transform into those seen later upon awakening. This 'representational drift' phenomenon optimizes memory representations for long-term storage, allowing the brain to free up resources for new memories.

Unraveling the brain’s hidden motor modules

Researchers discovered a horizontally distributed and modular organization of cortical movement units, with different types of neurons forming functional clusters in distinct regions. The study also found that the brain re-networks and adapts to learn new motor skills.

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First comprehensive maps of infant brains reveal clues to neurodevelopment

Researchers created comprehensive fine-grained functional maps of infant brain networks, providing unprecedented details on brain development from birth to two years old. The study revealed novel insights into when different brain functions develop during infancy and provided valuable references for early brain developmental studies.

Most detailed map of brain’s memory hub finds connectivity puzzle

Researchers created a detailed map of the hippocampus's connections to the rest of the brain, finding fewer links with frontal lobes but more with visual networks. This discovery may change how we think about human memory and cognition, potentially shedding light on why some primates excel at certain memory tasks.

Silence for thought: Special interneuron networks in the human brain

Researchers have discovered a prominent network of silencing interneurons in the human cortex, which could be linked to enhanced working memory and reasoning abilities. This unique network relies on abundant connections between inhibitory interneurons and is distinct from those found in mice.

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Capturing cortical connectivity close-up

Researchers propose a new method to study neural networks using intrinsic signal optical imaging (ISOI), which provides detailed maps of brain activity in living subjects. The study shows that ISOI can reveal cortical architecture at columnar resolution, offering a more accurate picture of brain network activity than existing methods.

How brains form visual maps

Researchers at State University of New York College of Optometry propose a general theory of cortical map formation that explains the diversity of visual maps in nature. The theory suggests that map diversity emerges from variations in thalamic afferent density sampling sensory space, leading to increased cortical areas and sorting of ...

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Sensory and motor brain plasticity is not limited by location

Research reveals brain areas can be repurposed to process information from unrelated body parts, contradicting previous assumptions about body map limitations. Functional MRI scans showed unused hand regions activated by movements of other body parts, suggesting a more dynamic and adaptable brain network.

The sense of touch is formed in the brain before birth

Researchers from UMH-CSIC Institute of Neuroscience found that the brain's somatosensory cortex is formed and functional before birth due to spontaneous electrical activity of the embryonic thalamus. This discovery suggests a critical role for thalamic waves in organizing the cortical map and shaping sensory processing.

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Novel 'top-down' mechanism repatterns developing brain regions

Researchers at the Salk Institute found that altering cortical layout can produce significant changes in connected brain regions, potentially underlying neural developmental problems. This discovery provides insights into the development of autism and other neural disorders.

New invasive imaging technique to monitor brain function

A new invasive imaging technique monitors brain function in patients with diseases such as epilepsy, providing real-time analysis at a higher resolution than current technologies. The procedure uses pre-placed electrodes to image the brain, offering unprecedented insight into its function.

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NeuroImage: Multiplexing in the visual brain

Researchers at Ruhr-University Bochum successfully visualized distinct activity patterns overlaid in primary visual cortex, indicating simultaneous encoding of object orientation and motion direction speed. This breakthrough demonstrates the brain's ability to process multiple visual cues simultaneously.

Innovative 3D-imaging technique captures brain damage linked to Alzheimer's disease

Researchers used a novel 3D mapping technique to analyze MRI data from Alzheimer's patients and those with mild cognitive impairment (MCI). The study found progressive brain atrophy in both groups, but MCI patients showed more cortical damage characteristic of Alzheimer's. This innovative method outperforms existing 3D imaging techniques.

Brain maps perceptions, not reality

Researchers at Vanderbilt University discovered that the brain's cortical map processes touch sensations based on perceived locations, not actual physical positions. This finding challenges long-held theories about the nature of the 'map' in the brain and sheds light on how the brain processes sensory information.

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Mapping the brain

A new brain atlas developed by neuroscientist David Van Essen aims to improve our understanding of the brain's structure and function. The atlas provides a comprehensive map of the brain's cortical and cerebellar regions, which are essential for thought, learning, emotion, perception, sensation, and movement.

New horizons in cortical cartography

Researchers have created detailed maps of the brain's cerebral and cerebellar cortex, which will help physicians understand brain damage and guide neurosurgeons. The maps will be freely available online, revolutionizing the field of neuroscience.