Researchers have found that inhibitory neurons play a more critical role in the pathogenesis of STXBP1 disorder. The study's findings suggest that reducing functional STXBP1 protein in GABAergic inhibitory neurons has a more significant impact on symptoms, including early lethality and developmental delay.
SourceTexas Children's Hospital·JournalJNeurosci·DateFeb 26, 2024
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Researchers discovered that parvalbumin interneurons secrete substance P, driving slow vasodilation and increasing blood flow in the brain. This process allows for waste removal and prevention of neurological dysfunctions like dementia.
SourceInstitute for Basic Science·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateApr 24, 2023
A new study from Tufts University School of Medicine and the Graduate School of Biomedical Sciences suggests that the timing of inhibitory neuron cell death may be a key factor in infantile spasms syndrome. Early diagnosis and treatment could potentially prevent significant impairments associated with the condition, offering hope for f...
SourceTufts University·JournalNeuroscience·TypeComputational simulation/modeling·DateFeb 21, 2023
A new study has found that abnormality of intracortical inhibition in patients with progressive myoclonic epilepsy type 1 is associated with the magnitude of genetic change. The results suggest that transcranial magnetic stimulation could be useful in assessing patient prognosis and may have use as a marker of GABAergic impairment.
SourceUniversity of Eastern Finland·JournalEpilepsia·DateJan 11, 2023
A study published in Current Biology found that children exhibit rapid boosts of GABA during visual training, stabilizing new learning and making it more efficient. This discovery suggests that children may acquire new knowledge and skills faster than adults, with implications for teaching and learning strategies.
SourceCell Press·JournalCurrent Biology·TypeObservational study·DateNov 15, 2022
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A new study reveals that the superior colliculus, a lesser-studied region responsible for saccades and facial recognition, dynamically changes its clustering of neurons depending on the mouse's conscious state. This finding suggests that the brain optimizes visual information processing based on its awake or anesthetized state.
SourceKyoto University·TypeExperimental study·DateDec 27, 2021
Researchers at Nagoya University have uncovered a novel brain circuit for hunger responses during starvation, revealing the role of neuropeptide Y signals in controlling heat production by brown adipose tissue. The study found that inhibitory GABAergic inputs from medullary reticular neurons inhibit BAT thermogenesis.
SourceNagoya University·JournalCell Metabolism·DateJan 25, 2017