Articles tagged with Granule Cells
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Researchers studied mossy fiber synapses in the hippocampus, a crucial region for memory formation and spatial navigation. They discovered that specific proteins play key roles in encoding and processing distinguishing features to trigger memory retrieval.
A novel human brain organoid model generates all major cell types of the cerebellum, including functional Purkinje neurons. This breakthrough provides a new way to explore cerebellar development and disorders, advancing therapeutic interventions.
Researchers aim to create comprehensive maps of how neurons connect to each other, exploring neural circuits that underlie behavior. By studying connectivity and neural activity, scientists hope to understand the structure of the brain and its role in our sense of self.
Researchers found a mutation in ELOVL4 enzyme impairs communication between neurons, leading to impaired motor control and coordination. The study provides new insights into the essential role of ELOVL4 in motor function and synaptic plasticity, suggesting potential therapeutic strategies for patients with spinocerebellar ataxia.
Researchers at UC Riverside's Brain Injury Lab have received significant federal funding to investigate the molecular mechanisms underlying traumatic brain injury and post-traumatic epilepsy. Two graduate students, Laura Dovek and Susan Nguyen, have each won prestigious fellowships to study the role of immune receptors in the developme...
Researchers have identified a new key player in long-term memory formation, the connection between mossy cells and granule cells in the hippocampus. This discovery sheds light on how new environments are processed and stored in the brain.
Researchers identify granule cells as gatekeepers of the hippocampus, filtering out irrelevant information. These cells also appear to be involved in processing spatial information, converting grid cell activity into place cell activity.
Researchers have discovered a possible physical trace of short-term memory, known as an engram, in the brain's synapses. The study found that vesicles containing neurotransmitters are stored at the pre-synaptic terminal after a granule cell fires, inducing plasticity and strengthening communication between neurons.
Scientists have found that granule cells and interneurons in the brain process incoming signals differently due to their distinct structures and functional characteristics. This discovery sheds light on how malfunctions can arise in information processing, leading to memory impairments and neurological disorders.
Researchers develop a novel methodology for characterizing neurons and their gene expression patterns, uncovering species-specific and age-related differences that could hold major implications for studying human brain disorders.
Newborn granule cells in the dentate gyrus become less excitable after three weeks, a crucial step for mature functioning. The researchers found that functional GIRK channels start to appear at this stage, controlled by G protein signaling, and contribute to lowering excitability of mature dentate granule cells.
Researchers found that frequent nerve signals strengthen dendritic spines in adult-born neurons, allowing them to connect with the existing neural network. This process is crucial for learning and memory formation in the hippocampus.
A recent UTSW study sheds light on the mechanisms underlying Sonic Hedgehog subtype medulloblastoma development, revealing a crucial role for the G protein-coupled receptor Gpr161. The research suggests that Gpr161 acts as a tumor suppressor by preventing excessive granule cell proliferation.
A new control mechanism for the Opitz syndrome gene has been discovered, revealing a previously unknown cell signaling pathway. This finding could lead to the development of new treatments targeting this pathway.
Researchers discovered that neurons deep in the brain's cerebellum are highly active during learning, encoding both external and internal information. This finding may shift our understanding of how the cerebellum processes information.
Adult-born neurons in the dentate gyrus of the hippocampus can form connections with cortical neurons through a competitive process, promoting network plasticity. This redistribution of synapses between old and new neurons may disrupt existing memories and contribute to improved information acquisition.
A Washington State University researcher has identified a mechanism in the cerebellum of the brain that influences an animal's likelihood of heavy drinking. This discovery offers a potential new target for drug therapies aimed at reducing excessive alcohol consumption, particularly among problem drinkers.
Researchers discovered that cutting parallel fibres in normal mice results in three distinct phases of degeneration, hypertrophy, and remodelling. In contrast, mice lacking the GluD2 receptor remain stuck in the degenerative phase. This suggests that GluD2 plays a crucial role in regulating nerve regeneration.
A newly discovered pathway in Alzheimer's disease may provide new treatment approaches by targeting the formation of tau-stress granules. Reducing key stress granule proteins prevents tau aggregation and nerve cell degeneration.
Researchers propose a new model identifying an unanticipated property of newly formed, immature neurons in the dentate gyrus. These cells enhance pattern discrimination by having fewer synaptic connections and high intrinsic excitability.
Scientists have discovered that newly generated brain cells, also known as adult neurogenesis, are required for memory formation and pattern separation. The study found that these cells exhibit unique activity patterns, which help distinguish between different environments.
Scientists at RIKEN have successfully induced human embryonic stem cells to self-organize into a three-dimensional structure resembling the cerebellum. The resulting neurons demonstrated proper responses to currents and inhibition, indicating functional development. This breakthrough could lead to modeling of cerebellar diseases like s...
Researchers at Washington University School of Medicine have identified a group of proteins that program common type of brain nerve cell to connect with another type of nerve cell. This finding is an important step forward in understanding the causes of intellectual disability and autism by learning how developing brain is built.
Researchers at Cold Spring Harbor Laboratory demonstrate a way to observe the activity of inhibitory neurons linking sense of smell with memory and cognition in awake mice. These granule cells provide feedback to alter sensory interpretation based on past experiences.
The study reveals that theta-gamma oscillations in the hippocampus are generated by excitatory and inhibitory synaptic signals, which provide rhythmic signals for temporal coding. The researchers also found that granule cell neurons send signals only at specific times during the cycle of oscillations.
Research reveals that certain brain cells are better equipped to fight off viral infections due to their unique immune defense mechanisms. The study found that granule cell neurons, which rarely become infected, have different gene profiles compared to cortical neurons, making them more resistant to infection.
Researchers at Georgetown University Medical Center have discovered a new mechanism that regulates neuronal activity in the hippocampus, allowing for efficient learning and memory processing. The study reveals that synapses between different groups of neurons act as 'volume control', maintaining optimal levels of neurotransmission.
Researchers at Cincinnati Children's Hospital Medical Center discovered a biological mechanism that causes brain seizures in mice with molecular disruptions in small neurons called granule cells. Treating epileptic mice with a drug that blocks the mTOR pathway stopped seizures, solidifying the link to the PTEN-mTOR pathway.
Research reveals that newborn neurons in adults are more likely to survive if they undergo sensory experience followed by a period of rest. This survival is linked to structural reorganization of the olfactory bulb after feeding, and prior olfactory sensory experience enhances neuronal survival during sleep.
Researchers found that new neurons in adult monkeys take more than six months to mature, which challenges the notion that this process is related to the effectiveness of antidepressant medications. This finding suggests that the human brain may experience even longer maturation periods due to its larger size.
Researchers have identified a protein that corrects errors in the brain's neuronal connections during development. Bone morphogenetic protein 4 (BMP4) helps eliminate incorrect connections, establishing proper specificity in the cerebellum and potentially contributing to neurological disorders like autism.
Researchers created stimulus-specific sustained activity patterns in brain circuits maintained in vitro, revealing the possibility of storing information in isolated brain tissue. The study found that semilunar granule cells played a critical role in this process.
Researchers found that the master gene Math1 is critical to the development of medulloblastoma, a deadly disease that affects children and young adults. Removing or inactivating Math1 may work as a treatment, but its effectiveness depends on the stage of brain development.
A study found that inactivating a specific gene in adult neural stem cells causes nerve cells to form connections in the wrong part of the brain. The research suggests that cdk5, a protein necessary for correct neuron development, is essential for accurate maturation of newborn granule cells.
Researchers at the Salk Institute found that a protein called cdk5 is necessary for correct neural migration and dendritic pathfinding in adult brains. Disabling cdk5 made newborn neurons form connections in the wrong part of the brain, with inappropriate synaptic connections persisting for months after treatment.
Researchers at Rockefeller University successfully differentiated embryonic stem cells into fully functional granule neurons, the most plentiful neuron in the cerebellum. This breakthrough study marks a significant step toward understanding how to regulate embryonic stem cells and potentially use them for cell replacement therapy.
Researchers found that new neurons generated in response to epilepsy have reduced excitability and increased inhibitory connectivity, potentially alleviating the disorder. These findings suggest that therapies aimed at inducing neurogenesis could prove effective.
Researchers at Carnegie Mellon University have made a groundbreaking discovery linking the timing of inhibitory neuron activity to the generation of odor-specific patterns in the brain's olfactory bulb. This finding supports the temporal coding hypothesis, which proposes that odor identity is encoded by the timing of neuronal firing, r...
Researchers at St. Jude Children's Research Hospital identified Cbln1 as a key protein maintaining correct synaptic connections in the adult brain. Without Cbln1, synapses weaken and new nerve connections form, disrupting brain function.
Research reveals that accumulation of amyloid-beta (Aβ) peptides depletes key memory proteins in specific brain regions, worsening disease progression. Increasing Fyn activity further exacerbates this effect, highlighting a potential therapeutic target for Alzheimer's treatment.
Scientists have successfully measured the activity of a single granule cell in an intact brain using patch-clamping technique, confirming predictions made over 30 years ago by David Marr. This breakthrough could lead to better understanding and treatment of movement disorders like ataxia and dysmetria.
A study found that Alzheimer's disease alters a protein called calbindin in brain cells, leading to cognitive deficits. Calbindin levels in granule cells were strongly correlated with cognitive decline in genetically engineered mice and human patients.