Articles tagged with Neural Stem Cells
Researchers have discovered that neural stem cells in adult mice can respond to Shh signaling and give rise to other neural cell types, including glial cells. The study also found that quiescent stem cells can self-renew after a year, with implications for tissue repair and cancer progression.
A new study by UCI researchers shows that adult human neural stem cells can differentiate into new oligodendrocyte cells and neurons, restoring myelin and improving motor function in mice with spinal cord injuries. The treatment also leads to behavioral improvements, including the ability to step using hind paws.
Scientists have identified four sugar-coated faces made by stem cells as they develop into brain cells, which may help navigate the adult brain and repair brain injury or disease. These glycoconjugate markers could aid in functional recovery and controlling stem cell proliferation.
Research by Yale University scientists reveals GABA's role in regulating neural stem cells. The study suggests that enhancing GABA's function may limit neurogenesis and increase the risk of glioma, a type of brain tumor.
Researchers have created a novel method to propagate mouse brain stem cells, which can either multiply without differentiating or become normal brain cells at the flip of a genetic switch. The technique combines epidermal growth factor and fibroblast growth factor to promote cell growth, enabling scientists to study basic properties an...
Researchers found that a combination of precursor cells and gene therapy led to significant improvements in functional recovery from spinal cord injury. The treatment promoted myelination, resulting in improved mobility and electrical activity in the affected area.
University at Buffalo scientists developed nanoparticles that delivered genes to adult brain stem/progenitor cells in vivo with no observable toxic effect. The technique may allow repairing brain cells damaged by disease, trauma, or stroke. This breakthrough demonstrates the potential for non-viral vectors in gene therapy.
Researchers discovered that neural stem cells can migrate to damaged brain areas and turn off activated immune cells, reducing inflammation. In a breakthrough, mice with MS-like disease showed significant recovery after transplanting, with reduced relapses and myelin damage.
G-CSF has potent cell protective effects on mature neurons, driving neuronal differentiation of adult neural stem cells. It doubles hippocampal neurogenesis even in normal animals, making it a potential treatment for stroke and neurodegeneration.
Researchers at UCI identified a protein called prokineticin 2 (PK2) that directs new neurons created from adult stem cells to specific brain regions. This discovery could lead to targeted therapies for neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as stroke and other brain injuries.
Researchers at the University of Florida have successfully generated brain cells in a dish, a breakthrough that could lead to new treatments for neurological disorders. The discovery identifies the true stem cell, which can be used to produce a limitless supply of brain cells to potentially heal damaged brain function.
A single protein, REST, directs the transformation of embryonic stem cells into mature nerve cells by keeping genes off in non-neuronal tissues. The study reveals fundamental details of how stem cells retain developmental plasticity.
Researchers at Stanford University have successfully differentiated human neural progenitor cells into insulin-producing cells that can respond to glucose. These cells were then transplanted into immunocompromised mice and produced human insulin when stimulated by glucose, paving the way for potential treatment of type I diabetes.
Researchers at Stanford University School of Medicine have developed a new method to transform human neural stem cells into insulin-producing cells. The breakthrough could potentially lead to new ways of transplanting insulin-producing cells into people with diabetes and provide a cure for the disease.
Researchers at the University of Wisconsin-Madison successfully infused rat spinal cords with brain-derived human stem cells that secrete neuron-protecting protein GDNF. This approach has shown promise in protecting healthy neurons and prolonging life in ALS-ridden rats, paving the way for potential treatment of other diseases.
Researchers at Karolinska Institutet have developed a stem cell therapy that improves motor function and sensory function below spinal injury levels. The treatment inhibits the development of astrocytes, which stimulate pain axon growth, allowing for greater production of oligodendrocytes and myelin-coated nerve fibers.
Researchers at UCF have found a compound that improves adult human stem cells' ability to develop into brain cells, offering hope for treating Alzheimer's and other neurological diseases. The study's findings also suggest potential for improving vision in patients with glaucoma.
Researchers have successfully grown functional motor neurons from human embryonic stem cells in a lab, providing a critical breakthrough for treating diseases like ALS. The discovery challenges the long-held assumption that stem cell differentiation occurs in linear fashion.
Researchers at UCSD and Salk Institute have discovered that small carboxyl-terminal domain phosphatases (SCPs) play a crucial role in the maintenance of neural stem cells and silencing of neuronal genes. This finding suggests a way to expand the pool of neuronal stem cells, potentially leading to new treatments for neurological disorders.
Researchers have discovered that neural crest stem cells in human hair follicles can differentiate into various cell types, including neurons and cartilage/bone cells. These findings hold promise for treating conditions such as Parkinson's disease, spinal cord injury, and bone degeneration.
Researchers successfully used iron-labeled neural stem cells to repair damaged myelin in the brains of mice with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. This method could potentially monitor and track transplanted cells in human patients if stem cell therapy becomes available.
A lipid called ceramide helps eliminate potentially harmful cells during brain development, improving the safety and efficacy of stem cell transplants. Researchers found that adding ceramide to embryonic stem cells reduces the risk of teratoma formation, a type of tumor.
Researchers suggest that skeletal-muscle satellite cells can differentiate into neural cell lineages, potentially repairing damaged muscle or nerve tissue. These stem cells were shown to organise skeletal-muscle fibres in rats with spinal-cord injury and differentiate into astrocytes and neurons.
Scientists at Sick Kids Research Institute have identified a new source of stem cells found in adult skin that can transform into neurons, offering hope for treating brain disorders. The discovery was made using mice and has similar findings in human cells.
Researchers found that stem cells in mice with Alzheimer's disease were attracted to abnormal protein bundles called amyloid plaques. This could lead to the development of plaque-busting treatments using adult olfactory bulb stem cells.
Researchers at Thomas Jefferson University have successfully converted adult human bone marrow stem cells into functional dopamine neurons using a novel growth factor-based approach. The newly differentiated cells expressed key markers of dopamine-producing cells and produced essential enzymes, offering a promising source for treating ...
Scientists have successfully used stem cells to restore movement in paralyzed rats by transplanting oligodendrocytes, a type of cell that insulates nerve signals. Additionally, researchers have delivered GDNF, a factor aiding neuron survival, to patients with Parkinson's and Huntington's diseases using genetically modified astrocytes.
Researchers at Medical College of Georgia have discovered a new category of multi-potent cells called VENT cells, which play a critical role in development and contribute to the formation of various human tissues. The discovery challenges long-held notions about what type of cells form specific types of tissue.
Fetal stem cells have shown promise in treating stroke damage, outperforming adult cells and overcoming embryonic cell limitations. Researchers are now exploring the potential of these cells to aid recovery after a stroke.
Researchers found that mouse brain stem cells can develop into blood vessel cells, expressing markers associated with endothelial cells. This discovery keeps the possibility open of harnessing adult stem cells from different organs to prevent and treat neurological disorders.
Researchers have successfully generated nerve precursor cells from adult skin cells using a two-step process involving soluble agents called growth factors. This breakthrough raises the possibility of generating nerve cells from an individual's own skin cells, overcoming issues of rejection.
Researchers at Duke University Medical Center have successfully transformed human fat cells into functional nerve cells using a cocktail of growth factors and induction agents. The newly formed cells demonstrated characteristics similar to developing neuronal tissue and responded similarly to normal nerve cells under certain conditions.
Researchers have found that dental pulp cells can provide support and survival for nerve cells affected in Parkinson's disease, potentially leading to a new cell-based therapy. The study suggests that these cells produce beneficial 'neurotrophic' factors, promoting nerve cell survival.
A subset of neural stem cells has been identified as having the ability to track malignant brain tumors called gliomas. The researchers found that astrocytic progenitors express a chemokine receptor called CXCR4, which is attracted by stromal-cell derived factor-1 (SDF-1) secreted by glioma cells.
A recent study by Dr. Edward Scott and colleagues found that donor cells containing a Y chromosome were present in the brains of three women up to 6 years after bone marrow transplantation. This suggests that bone marrow could be used as a therapeutic source of readily harvestable cells for nerve cell regeneration.
Researchers have discovered a way to convert adult bone marrow cells into brain stem cells, which could potentially restore functioning in individuals with Alzheimer's disease. The process eliminates ethical and logistical issues associated with fetal tissue use and allows for quick conversion within a few weeks.
Researchers successfully converted muscle stem cells into cells showing properties of neurons through the use of an artificial gene. This breakthrough suggests that stem cells may be 'flexible' and able to develop into different cell types, paving the way for potential neuroregeneration techniques.
Researchers at UCSF have identified a new source of adult stem cells in the human brain, potentially leading to breakthroughs in neuroregeneration and glioma treatment. The study found that astrocytes in the subventricular zone can function as neural stem cells, producing fresh neurons and oligodendrocytes.
Researchers at the University of Wisconsin-Madison have found that DHEA significantly increases the division of human neural stem cells, leading to increased neurogenesis. The study's findings provide direct evidence of DHEA's effects on critical human cells, shedding light on the hormone's potential benefits and risks.
Researchers found that adult stem cells can repair nerves, but the process is slow and scar tissue hinders healing. The study suggests that manipulating stem cells and growth factors could stimulate nerve regeneration.
Researchers created immortal human nerve cells by introducing a telomerase gene into progenitor cells, allowing them to continuously divide and produce specific types of neurons. The cells were used to partially repair damaged spinal cords in laboratory animals without forming tumors.
In a groundbreaking study, researchers at NYU School of Medicine found that young nerve cells can rewire their developmental timeline, defying long-held assumptions about brain development. This discovery opens up new possibilities for generating neural tissue for replacement therapies.
Researchers have made a breakthrough in understanding the origin of pediatric brain tumors, finding that they may develop from cells with characteristics similar to neural stem cells. This new perspective on brain cancer could lead to improved diagnostic tests and treatments.
Researchers found that anti-inflammatory drugs can help new neurons form in the hippocampus, a memory center damaged by radiation. The study suggests that these drugs could be used to prevent long-term brain damage after radiation therapy.
Researchers discovered that low levels of lead exposure can significantly impact the proliferation and development of neural stem cells. Dr. Jay Schneider's team found that lead inhibited the differentiation of stem cells into neurons or oligodendrocytes, but increased their ability to become astrocytes.
Researchers found that Bmi-1 is essential for self-renewal in two types of adult stem cells: neural stem cells from the central nervous system and hematopoietic stem cells. This discovery may lead to a better understanding of cancer development, as Bmi-1's overexpression can promote uncontrolled growth.
Researchers at Memorial Sloan Kettering Cancer Center have successfully differentiated stem cells into genetically matched dopamine neurons, mimicking normal brain cell development. The breakthrough could lead to new treatments for Parkinson's-like disease in humans.
Researchers have successfully differentiated adult bone marrow stem cells into functional dopamine-producing cells, similar to those found in embryonic and neural stem cells. This breakthrough holds promise for developing new treatments for Parkinson's disease.
Hirschsprung's disease is caused by mutations in genes expressed in neural crest stem cells that impair their ability to form a normal intestinal nervous system. The study identifies Ret and other genes involved in the disease, offering new insights into its causes.
Researchers discover key mechanism underlying Hirschsprung disease by identifying genes that control neural crest stem cell migration. The findings may lead to potential correction of the disease through transplantation of neural stem cells.
Scientists have identified a signal that triggers half of the stem cells in the developing brain to commit suicide at a certain point in development. This finding may one day help victims of devastating brain diseases such as Alzheimer's, Parkinson's, and stroke by understanding cell death and potential recovery mechanisms.
Researchers at UGA have identified a lipid-protein duo causing massive stem cell death during brain development, but also hinting at potential recovery mechanisms for devastating diseases like Alzheimer's and Parkinson's. The study reveals that this 'deadly couple' leads to the survival of cells destined to form neurons.
Researchers have discovered that brain stem cells can be transplanted without being rejected by the immune system, thanks to their unique properties. This breakthrough could lead to new treatments for eye diseases such as blindness.
Granzyme A, a double-headed protease, is assembled into a dimer with identical catalytic domains connected by a covalent disulfide bond. This unique configuration enables the enzyme to recognize specific sequences and activate cell death machinery in tumor cells and virally infected cells.
Kansas State University researchers successfully transplanted umbilical cord matrix stem cells from a pig into the brain of a live rat without triggering an immune response. The recipient cells survived for over six weeks and began to differentiate into nervous system cells, suggesting a new therapeutic option for Parkinson's disease.
Researchers found that intravenous infusions of human umbilical cord blood stem cells delayed ALS disease progression by at least two to three weeks and improved survival in mice. The cells also circulated to organs outside the central nervous system, suggesting an immune-protective mechanism.
Researchers have developed a method to extend the shelf life of cultured fetal neural stem cells, enabling the generation of enough cells to treat diseases like Parkinson's and ALS. The study characterized long-term neural stem cell lines using gene chip analysis, which may help create customized cells for therapy.
Researchers at the Salk Institute have developed a detailed model of how stem cells produce motor neurons, which could lead to new treatments for spinal cord injuries and diseases affecting motor nerve cells. The study demonstrates an unusually efficient yield of 60 percent motor nerves using two key gene and protein-regulated pathways.
Researchers have identified small chemical molecules that can direct embryonic stem cells to become neurons, paving the way for potential treatments of neurodegenerative diseases like Parkinson's and Type 1 diabetes. The study provides important insights into the molecular mechanism controlling stem cell fate and may lead to new therap...
Researchers have identified 'transcription factors' that control the time of neural cell generation, surprising discovery given earlier spatial control roles. The findings suggest a link between temporal and spatial control mechanisms in neuronal differentiation.