Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
A mouse study reveals that antibiotics can kill off gut bacteria and stop new brain cell growth in the hippocampus. However, probiotics and exercise have been shown to improve memory and neurogenesis by balancing the communication between the brain, immune system, and gut.
Researchers have identified brain cells in fruit flies that regulate sleep drive, which becomes more active when flies are kept awake. These findings may offer insights into human sleep disorders and potential new strategies to promote long-lasting sleep for those with chronic insomnia.
Brandeis scientists have developed a method to genetically identify and manipulate individual cell types in the mouse brain, revealing over 150 distinct brain cell types. This breakthrough enables researchers to activate or deactivate specific genes to study their function without affecting other cells.
A new study suggests that conventional repeated radiation treatments for brain tumors may kill important support cells and cause more damage than single dose radiation therapy. This can lead to cognitive problems in patients after treatment.
The study reveals that MCUR1 acts as a scaffold for the MCU complex, binding to both MCU and EMRE to protect cells from calcium overload. MCU complex assembly is disrupted by mutations in MCUR1/MCU binding regions, but small molecules may promote MCU complex assembly despite these mutations.
Researchers at McGill University have discovered a crucial role of NG2-glia cells in the median eminence in regulating appetite and body weight. The cells support and shelter leptin receptor neurons, enabling them to instruct the body when to stop eating, leading to potential new targeted anti-obesity approaches.
Researchers found that nerve damage changes epigenetic marks on immune cells in the nervous system, suggesting a 'memory' of the initial injury. This discovery may provide new insights into why chronic pain persists despite the underlying injury or disease having gone.
Researchers developed HuMiX, a human microbiome research tool that accurately models the complex interactions between human cells and bacteria. The model allows for the study of metabolic processes, including communication between the intestine and brain, and has potential applications for understanding neurodegenerative diseases.
Researchers in China report that fetal mice infected with the Asian Zika virus strain display characteristic features of microcephaly. The study found that neural progenitor cells were initially infected, followed by neurons, and that almost all cell death occurred in neurons, not progenitor cells.
Researchers have discovered biomarkers in the brain that could help scientists develop effective treatments for single-sided deafness. The study used multi-modal imaging techniques to analyze changes in brain structure and function in response to the condition.
Researchers found that neurons in a small brain area, the orbitofrontal cortex, assign values to options and re-map to make different decisions when circumstances change. This neural circuit is remarkably stable while allowing for flexibility in individual neurons.
Researchers have discovered how Zika virus blunts brain development by hijacking the human immune system. The study found that activating a specific protein called TLR3 triggers genes that block stem cell differentiation and lead to increased cell suicide.
Researchers found that Zika virus activates the innate immune receptor TLR3, which leads to cell death in neural stem cells. However, inhibiting TLR3 helps infected cells survive and function normally.
Researchers identified two distinct neuronal cell lineages expressing Nplp1, driven by different spatiotemporal cues and converging on a common terminal selector cascade. The study provides new insights into neuronal cell fate specification and the role of feed-forward loops in regulating gene expression during development.
A study found that human responses and statistical calculations align in making decisions, indicating an objective calculation of confidence. The model suggests that the brain produces feelings of confidence inform decisions like computers pull patterns from data.
Researchers have identified a core group of neurons in the suprachiasmatic nucleus that share information during resynchronization, while those outside this central hub behave like acquaintances. Understanding the SCN's neural network structure is crucial for tackling illnesses like diabetes and posttraumatic stress disorder.
Researchers obtained images of the NMDA receptor in active, non-active, and inhibited states using x-ray crystallography and single-particle electron cryomicroscopy. The study reveals the complex movements of the receptor's subdomains during activation and provides insights into designing novel therapeutic compounds.
Researchers at the University of Copenhagen have made a groundbreaking discovery about the role of salts in the brain controlling our sleep-wake cycle. By influencing salt levels, it is possible to control a mouse's sleep-wake cycle independently of neuromodulators like adrenalin.
Researchers at Gladstone Institutes successfully reprogrammed human skin cells into beating heart cells and neural stem cells using chemical cocktails. This breakthrough could lead to new treatments for heart failure and neurodegenerative diseases.
Researchers from KU Leuven measured individual brain cell responses to animal and human body images, finding that each cell specializes in recognizing specific features. The findings suggest a collaborative process where different cells work together to recognize bodies.
A cancer drug has improved learning and memory in mice with fragile X syndrome by coaxes neural stem cells to generate neurons critical for cognitive function. The treatment targets the MDM2 enzyme, which is overactive in FMRP-deficient cells, leading to enhanced proliferation but reduced differentiation.
Researchers at UNC-Chapel Hill have identified a brain circuit controlling binge drinking, connecting two regions with corticotropin-releasing factor. Inhibiting this circuit in mice protects against binge alcohol drinking.
The Allen Institute has released a comprehensive dataset on the aging brain and traumatic brain injury, providing unprecedented access to data on over 100 aged brains. Researchers can explore this unique resource to identify molecular signatures of disease and develop novel diagnostic strategies.
A powerful genetic regulator, miR-9, has been identified as a risk factor for schizophrenia, controlling the activity of hundreds of genes involved in fetal brain development. The study, led by Kristen Brennand and Gang Fang, found that miR-9 was under-expressed in brains of schizophrenic patients, leading to miswiring of neurons.
Researchers discovered that when people sleep in an unfamiliar place, one hemisphere of the brain stays more awake to keep watch. This phenomenon is related to the difficulty a person experiences in falling asleep and can be reduced by bringing familiar comforts.
Researchers developed a compound called KUSs that may help prevent nerve damage in glaucoma, allowing patients to maintain near-normal vision. Early tests in mice showed promising results, suggesting these compounds could slow down disease progression and potentially treat other neurodegenerative diseases.
Researchers at Drexel University have discovered that the pre-Bötzinger complex in the brainstem generates the breathing rhythm through mixed-mode oscillations. This finding challenges previous theories and may impact how scientists research and clinicians treat respiratory disorders.
Researchers found that neural stem cell transplantation increased M2 microglial proteins, contributing to anti-inflammatory effects and reducing axonal injury. The study suggests a potential therapeutic strategy for treating traumatic brain injury.
Researchers found that uncontrolled fluctuations in Retinoic acid levels can lead to disruptions in brain organization during development. Identifying the protein that interacts with RA to reduce noise may improve understanding of developmental disorders and guide future studies.
Human cytomegalovirus (HCMV) infection can cause abnormal brain development in the fetus by activating a key signaling pathway. Studies have found that HCMV substantially reduces the rate of neurons generated by neural stem cells.
Researchers created a mathematical model that reproduces the animals' internal calculations, revealing the existence of a 'separatrix angle' that changes throughout the day. The model predicts real-life behaviors in flight simulators and provides insights into monarch navigation.
Scientists at University of Maryland School of Medicine identified a key pathway for regulating the 'switch' between wakefulness and sleep. The study found that BK potassium channels play a critical role in encoding circadian rhythm in the brain, particularly during inactivation.
Researchers at the University of Bergen have found a link between a gene defect and Alzheimer's disease, identifying protein PITRM1 as a crucial factor in disease development. The study suggests that reduced levels of this protein may lead to increased amyloid deposition in the brain.
Researchers found a novel neuron regeneration pathway in C. elegans that could lead to treatments for human spinal cord injury and paralysis. The discovery sheds light on the adult human nervous system's ability to regenerate, which is essential for restoring health to people with permanent neurological damage.
Researchers at UCSB have mapped the network of circadian neurons that communicate to re-establish synchronization, finding a 'small-world structure' with hubs and short paths for communication. This discovery sheds light on how the suprachiasmatic nucleus (SCN) regulates essential functions like sleep and hormone release.
Salk scientists discovered that specific immune receptors in the brain play a crucial role in clearing both healthy and dying neurons. In their absence, new neurons increased dramatically in certain regions, suggesting that these receptors may also target living but dysfunctional cells.
The study found that the AXL surface receptor is highly abundant on human neural stem cells, but not on neurons in the developing brain. This discovery suggests that the Zika virus may be able to hijack this receptor to infect vulnerable cells, leading to devastating cases of microcephaly and eye lesions.
A study by Carnegie Mellon University researchers suggests that neuronal feedback in the visual system can alter our perception of optical illusions. The study found that 20% of visual cortex activity is due to feedback from higher cortical areas, which may explain why we see completed shapes like the Kanizsa triangle.
EPFL researchers demonstrate that ion channels can be explained by the Coulomb blockade law, a principle governing electron transport in quantum dots. The discovery sheds light on how ions travel through nanopores, a fundamental aspect of cellular function.
Researchers have deciphered an early step in the process of stem cells transforming into neurons, revealing a fundamental understanding of stem cell differentiation. The discovery identifies a new pathway, known as the PAN axis, which plays a crucial role in determining a stem cell's final form.
MeCP2 binds genome-wide using DNA sequence features, revealing diverse modes of binding largely independent of methylation status. Local MeCP2 activities explain gene expression patterns in neurons.
A new study at Rockefeller University uses magnetic forces to control neurons in mice, finding the brain plays a vital role in glucose metabolism. By targeting specific cells, researchers can activate or inhibit neural activity, offering potential therapeutic applications for metabolic and neurologic diseases.
Researchers found that transcranial direct current stimulation causes synchronized calcium surges from astrocytes, reducing depressive symptoms and increasing neural plasticity. This effect is absent when blocking astrocytic calcium surges, highlighting their importance in therapeutic outcomes.
Researchers at IUPUI have successfully identified cellular processes related to glaucoma using stem cells derived from human skin cells. The study found that skin cells from individuals with glaucoma became unhealthy and died off faster than those of healthy individuals when reprogrammed into retinal ganglion cells.
Scientists have developed a novel approach to track neural stem cells using microscopic iron beads and magnetic resonance imaging, allowing for non-invasive tracking without harming the cell. The findings focus mainly on neural stem cells but also show potential for use with mesenchymal stem cells.
Researchers at RIKEN have discovered that calcium inside neurons regulates slow-wave sleep, with seven genes identified as critical for controlling sleep duration. The study's findings could lead to new treatments for sleep disorders and neurologic diseases associated with them.
Researchers have developed a CRISPR-Cas9 based method to track the movement of RNA in living cells. This approach enables the study of disease-related RNA processes and may support therapeutic approaches to correct disease-causing RNA behaviors.
Scientists have created a new technology that converts adult tissue-derived stem cells into human neurons on 3-D scaffolds, which were injected into mouse brains with promising results. The goal is to develop a dense circuitry of neurons that can replace diseased cells and improve therapeutic benefits.
Researchers Qi-Long Ying and Austin Smith won the 2016 McEwen Award for Innovation for their discovery of inhibitory molecules that can mimic embryonic stem cells' ability to generate different cell types. Their work has opened new avenues of exploration towards understanding or treating human disease.
A new method detects multiple diseases via methylation patterns of circulating DNA from dying cells, identifying cell death in specific tissues and offering a minimally-invasive window for monitoring and diagnosis. The approach has vast possibilities for diagnostic medicine and can be adapted to identify cfDNA derived from any cell type.
Researchers have identified a new genetic mutation responsible for Spinocerebellar ataxia (SCA), a degenerative and fatal movement disorder. The mutated Cav3.1 protein, encoded by the CACNA1G gene on Chromosome 17, was found to cause abnormal Calcium ion flow in nerve cells.
The study reveals that protein misfolding in the brain can be toxic, even before visible amyloid fibrils form. Researchers used super-resolution microscopy to observe how alpha-synuclein proteins interact and found that excess soluble protein can cause toxic effects.
Researchers have identified a new molecular mechanism underlying neurodegeneration, which may lead to new diagnostics or therapeutic approaches for ALS. Cells construct protein clumps to protect against neurodegenerative diseases.
Researchers at UCL have made significant discoveries about the brain's role in imagination and navigation. Grid cell activity has been observed in healthy volunteers imagining moving through an environment, suggesting a potential link between grid cells and Alzheimer's disease.
Researchers at Thomas Jefferson University discovered that malfunctioning mitochondria can cause cell death due to excessive calcium uptake, leading to heart attacks and strokes. Inhibiting this calcium overload could provide a novel treatment strategy for these conditions.
Researchers found neurons in a color-recognizing region of the brain that can infer gravity direction from visual cues. These cells provide critical information for object physics, balance, and posture., The study suggests these cells help humans orient themselves and predict object behavior.
Researchers have pinpointed the effects of Huntington's disease on a specific brain area responsible for complex movements, such as talking or playing music. The study suggests that reintroducing normal patterns of activity in this area may be sufficient to restore normal behavior, offering potential therapeutic targets.
Researchers at UVA University have successfully used a synthetic gene to manipulate the behavior of mice and zebrafish by applying magnetic fields. The breakthrough could lead to new treatments for neurological diseases such as schizophrenia and Parkinson's disease.
Researchers found that the Zika virus directly targets human embryonic cortical neural progenitors, leading to cell death and stunted growth. The discovery provides critical insight into the link between the virus and birth defects like microcephaly.
Researchers have developed FlashTag technology to isolate and visualize newborn neurons, revealing the genetic origin of these cells. This discovery sheds light on how brain development occurs and may lead to new treatments for neurodegenerative diseases such as autism and schizophrenia.