Research on nerve cells and the circuits they form. Covers neural mapping, brain development, the striatum, and single-neuron recording.
Researchers found that Eph receptors must form groups of three or four to become active, with the ratio of multimers to inactive dimers determining repulsion strength. This understanding can guide cell migration and growth, shedding light on diseases related to guidance system breakdowns.
Researchers found that a protein molecule on stem cells interacts with extracellular matrix and thyroid hormones to promote brain growth. Iodine deficiency in pregnant women can lead to abnormal brain development due to the lack of thyroid hormones.
Stanford researchers have solved a riddle about the inner workings of the brain, revealing a previously unknown process that helps two brain regions cooperate when joint action is required. The study used a new approach to analyze large numbers of neurons and discovered that different regions of the brain keep results localized or broa...
Researchers at European Molecular Biology Laboratory identify microglia cells as major players in brain wiring and behavior. Mice with fewer microglia display weaker connections between neurons and repetitive behaviors associated with autism spectrum disorders.
A study published in Nature Neuroscience suggests that abnormal gene expression resulting from DNA relaxation can be detected in the brain and blood of Alzheimer's patients. The researchers propose that drugs modifying DNA structure may be beneficial for treating Alzheimer's disease, paving the way for epigenetic-based therapies.
Researchers discover that Ataxin-7 anchors a key module in the SAGA complex, which regulates thousands of genes. Without Ataxin-7, this module becomes overactive, leading to misregulation of genes and neurodegeneration in fruit flies.
Researchers at Max Planck Institute found that GDNF promotes the survival of mitochondria, preventing degeneration associated with a Parkinson's-related gene defect. This discovery could lead to more refined GDNF therapies for patients.
A team of researchers at Caltech has identified a new neural circuit in the lateral septum that plays a causal role in promoting anxiety states. Activation of this circuit increases stress hormone levels, suggesting that it acts to increase anxiety rather than reduce it.
Researchers compared ventrolateral frontal cortex connectivity in humans and monkeys, finding many similarities in language and complex thought processes. The study suggests that some uniquely human traits may rely on an evolutionarily conserved neural apparatus.
Researchers found that epsilon toxin from Clostridium perfringens kills brain's myelin-producing cells and targets other cells associated with MS inflammation. The toxin may be responsible for triggering MS in genetically susceptible individuals.
A study published in Nature Neuroscience reveals that non-CpG methylation occurs later and more dynamically in neurons than previously thought, acting as a system of gene regulation. This finding challenges the long-held idea that once genes are silenced by methylation, they remain so forever.
A team of researchers from Caltech identified specific brain cells in male fruit flies that release a hormone promoting aggression. These findings suggest that aggression is genetically controlled and may be linked to personality disorders in humans. The study validates the use of fruit flies as a model for studying human aggression.
City of Hope researchers discovered that breast cancer cells can masquerade as neurons, allowing them to hide from the immune system and spread to the brain. The study found that these cancer cells exploit the brain's chemicals and proteins to deceive the immune system.
Researchers at UC Riverside have discovered how the common fruit fly detects sweet compounds, revealing a new understanding of taste receptors in insects. The study's findings hold promise for developing strategies to block these receptors, potentially helping to control disease-carrying mosquitoes and other pests.
Researchers have discovered a novel method of treating traumatic brain injury by stimulating 'caretaker cells' to reduce swelling. The treatment, using compounds like 2-methylthio-ADP and MRS2365, has shown promise in reducing edema and prolonging the life of neurons.
Researchers from McGill University have identified two transcription factors controlling the expression of genes involved in GBM tumourigenesis. Impairing these proteins could significantly reduce the ability of brain tumour-initiating cells to give rise to brain tumors.
Researchers at Hebrew University deciphered the mode by which neurotransmitter inhibitors work, raising hopes for new and effective drugs for brain disorders. The study used baker's yeast as a model and identified flexible domains in the structure of the vesicular monoamine transporter (VMAT) responsible for tetrabenazine binding.
Researchers at NYSCF and Columbia University Medical Center successfully generated iPS cells from frozen brain tissue, allowing for the study of Alzheimer's disease at a cellular level. The new stem cell lines will enable drug testing on cells from patients with confirmed diagnoses.
Researchers at the Gladstone Institutes found that mutant LRRK2 accumulation leads to cell death in Parkinson's neurons, and that alpha-synuclein plays a crucial role in this process. By understanding the interplay between these two proteins, scientists may develop new therapeutic strategies to target the disease's underlying mechanisms.
Scientists have found odor receptors in lung tissue that can detect cigarette smoke and other irritants, triggering a response to constrict airways. These receptors, called pulmonary neuroendocrine cells, may be responsible for the chemical hypersensitivity characteristic of respiratory diseases such as COPD.
A study reveals that elevated LINE-1 retrotransposition in the brain may contribute to schizophrenia. Abnormal activity of these DNA sequences is thought to disrupt normal gene function, leading to the development of the disorder.
Researchers found that computer users make broader generalizations when it comes to movement learning. Computer-naive individuals converted their generalization patterns after just two weeks of intensive mouse use, suggesting that computer use fundamentally affects neural representation of movements.
A study published in Neuron found that the posterior cingulate cortex (PCC) is active when the brain isn't working hard and quiets down during peak performance. The PCC plays a crucial role in monitoring performance and improving it, particularly in challenging cognitive tasks.
Researchers discovered that the brain reduces data volumes in the primary visual cortex, using image differences to efficiently process sensory information. The study used novel optical imaging methods and found that neurons represent only new or missing elements when the time elapsing between images is longer than 100 milliseconds.
Researchers at Wake Forest Baptist Medical Center are using optogenetics to study the neurochemical basis of addiction. The technology allows them to control specific populations of brain cells using light, providing new direction on patterns of dopamine cell activation that may be most effective to target alcohol drinking.
A team of researchers has identified a critical balance point between tau and a master cellular regulator disrupted by amyloid-beta oligomers, driving adult neurons into cell cycle re-entry and eventual death. The study suggests that the protein complexes mTORC1 and mTORC2 play a key role in regulating this process.
Researchers at UC Irvine's Institute for Memory Impairments and Neurological Disorders have received a grant to develop and study patient-derived stem cell lines. The UCI MIND team will create up to 40 sets of induced pluripotent stem cells to explore the biology of Alzheimer's disease and test novel therapeutic approaches.
Scientists transform skin cells into nerve cells from patients with Alzheimer's disease and test several non-steroidal anti-inflammatory drugs. The results show that these compounds have no effect on the harmful beta-amyloid aggregates in human neurons, unlike in animal models.
Scientists have identified a crucial class of neurons responsible for mosquito attraction to human skin odor, offering potential solutions for effective mosquito control. Researchers discovered that compounds targeting these neurons can inhibit the attraction of mosquitoes, paving the way for new repellents and traps.
Researchers found that certain mosquito nerve cells detect human odors and CO2, attracting mosquitoes to humans. They identified two compounds, ethyl pyruvate and cyclopentanone, that can neutralize or activate these detectors, potentially developing new control approaches for mosquito-borne diseases.
Researchers used induced pluripotent stem cells to test NSAIDs on human neurons, finding they failed to respond despite initial success in cell and animal models. The study highlights the importance of testing compounds directly in authentic human cells for more reliable drug development approaches.
Scientists at UC Riverside identified a key target for disrupting mosquito host-seeking behavior, which could aid in controlling disease transmission. They discovered compounds that can block the mosquito's CO2 and skin-odorant receptors, reducing attractiveness and creating an affordable alternative to traditional CO2-based mosquito t...
Researchers create progerin-induced aging in stem cells, accelerating disease modeling by weeks, not years. This breakthrough opens avenues for preventing and treating late-onset disorders.
Researchers have identified a specific region of the brain that responds to electrical stimulation by inducing feelings of determination and motivation. This region, the anterior midcingulate cortex, is linked to emotions, pain, and decision-making, and its stimulation can help individuals anticipate challenges and overcome them.
A team of scientists found that male katydids can synchronize their chirps in the presence of a masking trill, with the ability to detect low-frequency components. The researchers used tiny hook electrodes to study the neural activity of katydids and discovered that an auditory neuron was involved in detecting these frequency components.
Researchers at UCSB have identified a way to change one cell type into another using transcription factor ELT-7, which was previously thought to be exclusive to early embryonic cells. The discovery opens up new possibilities for regenerative medicine and could potentially allow for the creation of entire organs from scratch.
A recent study found that valproic acid significantly increased Bcl-2 and growth associated protein 43 expression, and reduced c-Jun expression after brachial plexus avulsion in Wistar rats. This suggests that valproic acid can protect neurons and enhance neuronal regeneration following the injury.
Researchers at the University of Bristol discovered that a specific protein called RIM1α is modified by SUMO, acting as a 'molecular switch' to regulate neurotransmitter release. This finding has implications for understanding neurological disorders such as epilepsy and schizophrenia.
A new study in The Journal of General Physiology has shed light on the biophysical processes underlying regulation of circadian rhythms. Researchers found that decreased BK channel activity, particularly a specific variant containing SRKR, contributes to reduced SCN neuron excitability during the day.
A study published in JCI Journals found that circadian clock proteins regulate neuronal redox homeostasis and prevent neurodegeneration. BMAL1-deficient mice showed accumulated astrocytes, neuronal degeneration, and reduced blood flow, highlighting the importance of core clock proteins in maintaining healthy neurons.
Researchers at UNC School of Medicine have identified Engrailed 1 as a protein overexpressed in basal-like carcinomas, which can lead to chemotherapy resistance. A synthetic peptide designed by Adriana Beltran and colleagues can disrupt Engrailed 1's function, causing rapid cell death.
Researchers at Cambridge's Cavendish Laboratory have achieved high coherence in nitrogen-vacancy centers of nanodiamonds, enabling the creation of ultra-precise nanoscale magnetic field and temperature detectors. This breakthrough could enhance our understanding of chemical reactions within single cells and signalling in neural networks.
Researchers from Bonn University discovered that immature nerve cells secrete chemical attractants that prevent mature brain cells from migrating into the brain. Inactivating these attractants improves nerve cell migration in animal models, offering a promising universal approach to treat Parkinson's and Huntington's diseases.
A study investigated the optimal site for cell transplantation to treat spinal cord injury, using laboratory mice with contusive spinal cord injuries. The researchers found that intralesional injection of neural stem/progenitor cells led to motor functional recovery and improved survival rates compared to other sites.
A Yale-led team identified common neural circuits affected by autism-risk genes and when they exert their effects on the developing human brain. The findings suggest new targeted treatments for autism may be possible, focusing on specific neural circuits at specific times.
A new study published in PLOS ONE found that obese mice have fewer taste cells capable of detecting sweetness and react weakly to sweet stimuli. This impairment may contribute to overeating and weight gain by reducing the effectiveness of the body's natural appetite suppressants.
Researchers used genetic engineering to precisely study a key protein's role in familial Alzheimer's disease, discovering that simple loss-of-function doesn't contribute to the inherited form. The findings could help elucidate Alzheimer's mechanisms and inform drug development.
Researchers found significant loss of neurons in the retina's inner nuclear and ganglion cell layers, suggesting Alzheimer's disease presence. The study suggests a potential new way to diagnose or predict Alzheimer's through eye examination, using optical coherence tomography.
Researchers at UC San Diego have developed a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters. This approach enables the generation of more complete genome sequences from single cells, including E. coli and individual neurons from the human brain.
Research suggests hyper-connected neurons may cause social symptoms in autistic children, leading to potential new treatment strategies and early detection methods. The study found a link between brain connectivity and severity of social impairment in individuals with autism.
A traditional Chinese medicine, Buyang Huanwu Decoction, has been shown to improve neurological function in patients with stroke. The decoction increases the number of cells positive for markers of neuronal differentiation and synaptic plasticity in ischemic rat cerebral regions.
Researchers at Johns Hopkins Medicine have identified a critical gene that guides the separation of two types of motion-sensing cells in the retina, shedding light on cellular layering and its implications for brain function.
Researchers have found that oligomeric proanthocyanidin has a protective effect on retinal ganglion cells against oxidative stress-induced injury, providing potential treatment for neural diseases. The compound, enriched in grape seeds, shows promise in preventing cell death in optic neurodegenerative conditions.
A new study reveals that presenilin works with enzyme GSK-3ß to control material transport through neurons. Low levels of presenilin or high levels of GSK-3ß can cause uncoordinated movement, resulting in dangerous blockages. Researchers propose a potential pathway for early intervention through drugs.
A study at Washington University in St. Louis found that a small molecule called VIP can temporarily desynchronize brain cells, but also enables them to re-synchronize more quickly to abrupt shifts in daily light-dark schedules. This effect may be useful for travelers and shift workers who struggle with jet lag.
Researchers found that rhesus macaque monkeys have specialized nerve cells in their brains that respond to images of snakes. This suggests that primates may have evolved to detect and avoid snakes due to the presence of venomous snakes during their ancestors' time.
SMEK1 promotes neural stem cell differentiation and suppresses uncontrolled proliferation, while collaborating with Protein Phosphatase 4 to regulate PAR3 activity. This discovery offers new hope for patients with Alzheimer's, Parkinson's, and other neurodegenerative diseases.
Scientists created induced pluripotent stem cells (iPSCs) from chimpanzee and bonobo skin cells to compare with human iPSCs. They found differences in the regulation of jumping genes, which may have shaped the evolution of their genomes.
Researchers at Clemson University found that increasing mTOR pathway activity in neural stem cells leads to neuron generation and may offer a new treatment for neurodevelopmental disorders. The study, published in Cell Reports, points to the potential benefits of targeting 4E-BP2, a specific mTOR target.
Researchers at Cold Spring Harbor Laboratory have discovered how fruit fly neurons integrate multiple signals to identify one unique smell. The brain uses a group of neurons called Kenyon cells, which have long protrusions that grasp projection neurons with a claw-like structure.