Articles tagged with Neurons
A team of scientists has generated a human model of Huntington's disease directly from the skin cells of affected patients, providing a new tool for researchers to study the disease and test potential therapies. The re-created neurons will help understand what disables and kills brain cells in people with HD.
Cedars-Sinai researchers created a laboratory model for Huntington's disease using induced pluripotent stem cells from patients' skin cells. The 'disease in a dish' model allows scientists to test therapies directly on human Huntington's neurons, offering a new pathway to identifying treatments.
Researchers at the Buck Institute have corrected the genetic mutation responsible for Huntington's Disease using human induced pluripotent stem cells. The corrected cells generated normal neurons in a mouse model of the disease, offering new hope for cell therapy treatments.
Researchers have identified a process by which misfolded proteins, such as alpha-synuclein, travel from sick to healthy cells in the brain, leading to the progression of Parkinson's disease. The study provides new insights into the disease's pathology and offers potential targets for disease-modifying treatments.
Researchers in Japan have concluded that adult-derived induced pluripotent stem (iPS) cells and mouse embryonic stem (ES) cells demonstrate similar survival and neural differentiation capabilities when transplanted into mouse cochleae. However, iPS cell transplantation is associated with a risk of tumor growth, highlighting the importa...
Researchers discovered a key brain receptor that regulates gastric emptying and food intake. Mice lacking this receptor showed accelerated obesity and faster food consumption.
A study published in Nature Neuroscience found that neurons controlling hunger are also linked to cocaine addiction, contradicting the common assumption that food is a type of drug of abuse. The researchers discovered that mice with decreased interest in food showed increased interest in novelty-seeking and cocaine.
Scientists at the University of Wisconsin-Madison have created cells that mimic the blood-brain barrier, a filter that separates the brain from circulating blood. These cells hold promise for streamline drug discovery and modeling neurological diseases.
Researchers found that neurons follow a simple pattern described by a power law, which explains their tree-like shape and efficient wiring. This pattern is supported by the growth of newborn olfactory neurons in the adult brain.
A new gene-silencing strategy has reversed core symptoms of Huntington's disease in animal models, suggesting a potential treatment approach for the neurodegenerative disorder. The therapy, involving antisense oligonucleotides, produced sustained benefits with minimal side effects.
A new study proposes a communication routing strategy in the brain that mimics the American highway system, with select hubs forming the influential network known as the 'rich club'. This network provides quick and effective communication between billions of brain cells, with long-distance neural pathways favoring rich club connections.
Researchers have developed a device that delivers a genetically engineered neurotrophic factor directly to the brain, treating neurological symptoms in laboratory rats. The study found significant protection against toxicity and reduced striatal lesion size, suggesting promising therapeutic potential for Huntington's disease.
Researchers at Gladstone Institutes successfully transformed skin cells into brain cells using Sox2 gene, potentially leading to better models for testing drugs for devastating neurodegenerative conditions. The breakthrough could accelerate drug development and reduce risks associated with human trials.
Researchers at Columbia University Medical Center have identified a brain receptor called Gpr17 that appears to play a central role in regulating appetite. Blocking the action of this protein, which is also found in humans, could lead to new drugs for preventing or treating obesity.
Researchers have found an imbalance between neuronal excitation and inhibition in individuals with Angelman syndrome, a neurodevelopmental disorder characterized by seizures, cognitive delay, and severe intellectual disability. This imbalance may underlie the high seizure activity observed in AS patients.
Microglia, the brain's emergency workers, use a long-lasting glutamate-driven calcium wave to detect injuries, allowing them to trace the signal backwards until they reach the site of damage. This discovery could lead to new treatments for conditions such as Alzheimer's and Parkinson's diseases.
Researchers at NYU have discovered a new role for non-master pacemaker neurons in regulating circadian rhythms. By studying fruit flies, they found that these neurons suppress signaling of master pacemaker neurons during the evening, allowing them to fire and wake up the fly.
Researchers discovered that astrocytes, which normally nourish and protect neurons, deliver a lethal package containing ceramide and PAR-4 when neurons start producing excessive amyloid protein. This process may contribute to brain-cell death and shrinkage in Alzheimer's disease.
Researchers at Hebrew University of Jerusalem have successfully generated neuronal cells from stem cells of Fragile X patients, paving the way for restoration of normal gene expression. The study identified a chemical compound, 5-azaC, that can clear methyl groups and reactivate FMR1 gene expression in both stem and neuronal brain cells.
A team of physicists and biologists discovered that protein Cdc42 oscillates throughout yeast cells, regulating shape and function. This oscillatory mechanism may be a general strategy among all self-organizing biological systems.
Researchers at the University of Leicester have identified a cellular mechanism underlying tinnitus development after exposure to loud noises. The study suggests that specific potassium channels contribute to nerve cell over-activity, leading to constant noise sensation.
A team of scientists has discovered a new family of six genes that regulate mitochondrial transport in neurons, which is crucial for brain activity and viability. The proteins are highly expressed in the nervous system and may be involved in neurological conditions such as Parkinson's disease and Charcot-Marie-Tooth disease.
Researchers at Georgia Institute of Technology have developed an automated technique to record electrical activity from neurons in the living brain, offering insights into brain cell activities. The robotic system detects cells with 90% accuracy and can determine a cell's shape and genetic profile.
Embryonic stem cells have a rapid suicidal response to DNA damage, eliminating them from the developing embryo. This adaptation prevents mutations from harming the organism and allows scientists to harness their potential for therapeutic use.
Research by IRB Barcelona scientists reveals that glycogen accumulation in neurons is toxic, causing brain damage and reducing lifespan in both flies and mice. This finding has significant implications for understanding Lafora progressive myoclonic epilepsy and other neurodegenerative diseases.
A new drug, BL-7050, is being developed to manage resistant chronic pain caused by nerve or tissue damage. The medication targets potassium channels to prevent hyper-excitability and induce calm in neurons, offering relief to millions of sufferers.
Researchers have discovered that immune cells in the brain use a two-tier approach to combat infections, sending signals to neighboring cells while focusing their attack on infected cells. This finding may help researchers develop new treatments for brain tumors and autoimmune diseases.
Researchers found that low Nav1.1 levels disrupt brain cell electrical activity, leading to memory problems and cognitive decline. Restoring Nav1.1 levels improves learning, memory functions, and lifespan in AD-mice.
Karl Deisseroth, Edward Boyden, and Feng Zhang received the $10,000 award for developing optogenetics to control neural circuits. This technique has revolutionized neuroscience by allowing selective stimulation of neurons associated with behaviors.
Researchers at Max Planck Institute for Chemical Ecology developed a device called Flywalk that measures insect responses to odor signals, revealing specific brain regions for processing attractants and deterrents. The study shows that flies process attractive odors differently depending on gender and reproductive status.
Researchers found that alpha-synuclein protein aggregates in ring structures within neuron membranes, causing cell damage and symptoms of Parkinson's disease. The study provides a step-by-step explanation of how these aggregates form and offers hope for developing drugs to slow disease progression.
Research identifies specific genetic mechanism underlying autism and fragile X syndrome, suggesting gene dosage disruption as key factor in autism development. The study found a strong overlap between autism candidate genes and those linked to fragile X syndrome, with implications for therapy and diagnosis.
Researchers found aged mice showed disrupted sleep behavior and weakened brain network activity in the suprachiasmatic nucleus (SCN), a brain area responsible for setting sleep-wake cycles. Individual SCN cells also exhibited more severe changes, suggesting a new understanding of aging's effects on the brain.
Brown University researchers found that RNA editing enzyme activity varies with temperature, affecting fly behavior in mating and daily routines. High or low self-editing levels can create different personalities, such as wallflowers or pick-up artists, highlighting the significance of this process in animal behavior.
Researchers at the University of Pennsylvania School of Medicine have discovered a novel target for treating stress-linked disorders: a protein called HDAC6. By modulating glucocorticoid signaling in serotonin neurons, HDAC6 may provide a path towards resilience to stress.
Scientists at Lund University have identified a new stem cell type in the adult brain that can form various cell types, including neuronal cells. The discovery holds promise for treating neurodegenerative diseases and stroke by harnessing the stem cell's repair mechanisms.
Researchers at Lund University have identified a new stem cell in the adult brain that can proliferate and form several different cell types, including new brain cells. The discovery has great potential for developing methods to heal and repair brain injury and disease.
Researchers at Northwestern University developed a new brain-machine interface that directly delivers electrical signals from the brain to muscles, enabling complex movement of a paralyzed hand. The device was tested on monkeys and showed promising results, with potential applications for paralyzed patients.
A team studied mice with a mutated form of alpha-synuclein, finding that injected clumps accelerated disease onset and severity. The clumps seemed to hijack brain signals, spreading throughout the brain.
Researchers analyzed 1,000 genes in human and mouse brains, finding high similarity and only 5% difference among humans. The dataset offers insights into neural evolution, cell-to-cell communication, and species-specific functions.
A 'brain-only' mutation has been discovered that causes hemimegalencephaly (HMG), a condition characterized by an enlarged and dysfunctional half of the brain. This mutation is limited to brain tissue and contributes to overgrowth, intellectual disability, and severe epilepsy.
Scientists have discovered rules that relate genes to a neuron's electrical properties and shape, increasing the likelihood of predicting brain structure and function without measuring every aspect. This breakthrough increases the feasibility of modeling the brain in silico and ushering in a new era of predictive biology.
A recent study reverses many Fragile X syndrome symptoms in adult mice using a new compound CTEP. The study found that pharmacologic inhibition of mGlu5 receptor can correct FXS symptoms, including learning and memory deficits and auditory hypersensitivity.
A new study published in Nature has disproved the theory that pigeons' navigation skills are linked to iron-rich nerve cells in their beaks. Macrophages, specialized white blood cells, were found to contain tiny balls of iron instead, contradicting earlier research.
University of Oregon scientists create a new gene tool that allows researchers to control protein synthesis with a pinpoint UV laser beam. The tool enables the study of gene function at precise times and regions in embryonic development, revealing new insights into developmental biology and brain research.
Researchers found that stimulating specific neurons can reverse age-related memory defects in fruit flies, which may have implications for human memory disorders. The study used functional cellular imaging to monitor neuron activity and showed that cold-activated ion channels can rescue intermediate-term memory.
Researchers at CU Boulder have discovered a protein complex involving toll-like receptor 4 and myeloid differentiation protein receptor 2 that triggers unwanted neuroinflammation in response to morphine. This finding has implications for developing new drugs to increase morphine effectiveness while preventing abuse.
Researchers at Rutgers University found a protein defect that leads to axtaxia-telangiectasia, a degenerative disease affecting cerebellum and brain function. Treating the defective protein with TSA restored motor coordination in mice, suggesting potential reversal of symptoms.
The University of Bonn team has successfully derived brain stem cells directly from connective tissue in mice, which can reproduce and be converted into various types of brain cells. This method is faster, safer, and associated with a lower risk of tumors compared to existing approaches.
Researchers have successfully harnessed neurons in mouse brains, allowing them to at least partially control a specific memory. The study advances understanding of how memories form and offers new insight into disorders such as schizophrenia and post-traumatic stress disorder.
The SpikerBox is a low-cost, open-source bioamplifier that allows users to amplify and listen to neurons' electrical activity. This tool has been developed by Backyard Brains to make neuroscience education more accessible.
Researchers have identified a critical mechanism of neuron death in intestinal inflammation that appears relevant to IBD. Blocking the 'pannexins' molecule was shown to prevent gut neuron death in animal models.
A study of a rare neurodegenerative disease has uncovered a mechanism that destabilizes the homeostatic balance of brain cells, leading to fluid accumulation. The discovery identifies a protein GlialCAM as an ion channel subunit regulating chloride ions and potentially paving the way for new treatments.
Researchers found that honokiol down-regulates pro-inflammatory cytokines and enzymes in microglia via Klf4, a protein regulating DNA. Honokiol also reduces inflammation and neuronal death by targeting Klf4 and pNF-kb.
Princeton scientists have identified unique neural activity sequences in the brain's posterior parietal cortex that help form short-term memories used for decision-making. These sequences correspond to whether a mouse turns left or right in a maze, allowing researchers to predict its future actions.
Researchers at Linköping University identified seven key transcription factors that specify the creation of 34 neuron groups in a fruit fly's antenna. This discovery sheds light on the mechanisms that diversify neurons and keep them diverse, crucial for future nerve cell cultivation and replacement.
Researchers developed a mathematical model to test whether neurons communicate individually or as groups. The method filters signals to determine if neurons collaborate flexibly within milliseconds. This breakthrough has the potential to reveal dynamic cell assemblies involved in planning and controlling behavior.
Researchers at McGill University have discovered a critical process in understanding the degeneration of brain cells sensitive to Alzheimer's disease. The study suggests that targeting this process could lead to alternative therapies for treating AD, including drugs that protect neurons from degeneration.
Researchers identified how and where the brain processes frequency-modulated sound signals, which are crucial for understanding language and speech. The study found that these signals begin in the midbrain region of the brain, a surprising discovery that could help with hearing-related disorders.
Research reveals that repeated stress affects memory by reducing glutamate receptors in the prefrontal cortex, impairing high-level cognitive processes. The study provides critical insight into how chronic stress influences mental illnesses and offers potential targets for prevention and treatment.