Articles tagged with Parkinsons Disease
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Researchers at Duke University Medical Center have identified chromosomal regions linked to the age at onset of Alzheimer's and Parkinson's diseases. The study found evidence for age-at-onset genes on chromosomes 10, 1, 4, and 8, which could lead to new avenues of research to delay disease onset.
Researchers found that mice fed a folate-deficient diet developed severe Parkinson-like symptoms, while those with adequate amounts of the vitamin protected their brain cells from damage. Folate deficiency may contribute to increased toxin-induced damage to dopamine-producing neurons.
The American Academy of Neurology has reviewed new drugs for treating Parkinson's disease, but found that they do not offer significant advantages over existing treatments. Current treatment guidelines remain unchanged, emphasizing the importance of individualized treatment decisions.
A protective protein called a chaperone suppresses the toxicity of alpha-synuclein, a protein associated with Parkinson's disease. The study found that augmenting levels of Hsp70 corrected the deficit and overcame the toxic effect of loss of chaperone function.
A team of Penn researchers found that molecular chaperones can block the progression of neurodegenerative diseases like Parkinson's by preventing neuronal decay in Drosophila melanogaster. The study suggests that activating these molecules may be an effective approach to treating several human neurodegenerative diseases.
The largest clinical trial ever of Parkinson's disease will be conducted by Professor Karl Kieburtz, with over 3,000 patients participating from 42 sites across North America. The five-year study aims to test the effectiveness of various substances in slowing disease progression.
A study published in Neurology found that electrical brain stimulation increased 'on' motor function by 29 percent and improved 'off' motor function by 38 percent in Parkinson's patients. The treatment reduced the severity of fluctuations in motor symptoms, allowing patients to complete tasks faster and improve their overall mobility.
The study provides strong evidence that several genes influence the development of late-onset Parkinson's and that age at onset and response to levodopa may be useful discriminators for genetic origins. Researchers detected evidence for genetic linkage to five distinct regions on chromosomes 5, 6, 8, 9, and 17.
A study led by Dr. Jeffery M. Vance found significant evidence of linkage between the tau gene and late-onset Parkinson's in three single nucleotide polymorphisms. The research suggests that normal variations in the tau protein may make individuals more susceptible to the disease.
Researchers at UCSD suggest that naturally occurring molecules called beta-synucleins (b-synucleins) may inhibit the excessive accumulation of Lewy bodies, which are characteristic of Parkinson's disease. In mice studies, b-synuclein was shown to block the formation of these abnormal deposits.
Hopkins researchers found that parkin, aS and synphilin interact, with mutations disturbing this interaction leading to Lewy body formation and nerve cell death. Understanding these interactions may help identify targets for new treatments.
A new NASA study found that the Icelandic low-pressure system affects Arctic sea ice cover, leading to regional variations and an overall decrease in ice extent. The system brings warm air northward, reducing ice cover east of Iceland, while also contributing to climate warming.
Scientists discovered that Alzheimer's and Parkinson's proteins interact to accelerate disease progression, causing cognitive and motor function destruction. The study found that Abeta, a metabolic breakdown product of hAPP, enhances the accumulation of hSYN in brain cells.
Researchers at the Mayo Clinic found a possible link between estrogen and reduced risk of Parkinson's disease. The study reviewed medical records of female patients with Parkinson's disease to examine the association with menopause type, age, and postmenopausal hormone therapy.
A new study reveals that many Parkinson's patients are using alternative therapies, despite a lack of physician knowledge on the topic. The research found no correlation between disease severity and use of alternative therapies, suggesting that patients are seeking these treatments for other reasons.
A study found that younger and more educated Parkinson's patients are more likely to use alternative treatments such as vitamins and acupuncture. These patients are also more likely to be married and have developed the disease at a younger age.
Researchers at Virginia Tech are developing a 'prodrug' to deliver neuroprotective compounds to the brain, overcoming limited solubility issues. The approach aims to inhibit monoamine oxidases and neuronal nitric oxide synthase enzymes involved in Parkinson's disease.
Men with constipation were nearly three times as likely to develop Parkinson's disease over the next 24 years compared to those without constipation. The study suggests a potential link between bowel movement frequency and the risk of developing Parkinson's, highlighting the importance of understanding how the disease progresses.
A new skin patch has shown effective treatment of Parkinson's disease in a large-scale study. Patients who received the medication improved their motor skills by an average of 20-30% compared to those who received a placebo.
A study published by researchers at the University of Chicago Medical Center found that prenatal exposure to methamphetamine increases the risk of brain disorders, such as Parkinson's disease, in male offspring who later take the drug themselves. The toxic effects of methamphetamine can hasten the onset of these conditions.
Researchers found that pramipexole prevented nearly 100% of brain cells from dying in mice with a Parkinson's-like condition. The drug also showed neurotrophic effects by increasing dopamine cell size, suggesting potential as a neuroprotective agent.
A study of 15 professional welders found they developed typical clinical signs of Parkinson's disease 15 years earlier than the general population. Brain imaging scans revealed no significant difference in dopamine levels between the welders and control patients, suggesting a possible environmental link.
Scientists have found a link between the combination of two widely used agricultural pesticides and Parkinson's disease in mice. The study, led by Deborah Cory-Slechta, suggests that everyday environmental factors may play a role in the development of the disease.
A new study published in Neurology found that selegiline, a drug used to treat Parkinson's disease, does not increase the risk of death for patients taking levodopa. The study compared the death rates of 97 patients with Parkinson's who received selegiline treatment with those of 902 people without the disease.
A recent study found that men are twice as likely to develop Parkinson's disease compared to women. The risk of developing the disease increases with age for both men and women. Researchers are still unsure why Parkinson's is more common in men, but one theory suggests that estrogen may protect women from the disease.
A study of 196 people with and without Parkinson's disease found that coffee use was associated with a lower risk of developing the disease. Heavier coffee drinkers exhibited fewer instances of the disease, while tobacco chewers and alcoholics were also less likely to develop the condition.
Researchers found that alpha-synuclein, a key component of Parkinson's lesions, is targeted by oxidative stress, specifically nitration. This discovery provides conclusive evidence for the role of oxidative damage in neurodegenerative diseases like Parkinson's and Alzheimer's.
Researchers used gene therapy to deliver GDNF directly to the brain cells of monkeys, resulting in a dramatic increase in dopamine production and prevention of disease progression. The treatment also reversed functional deficits and symptoms associated with Parkinson's disease.
Researchers found that up to 96% of Parkinson's patients experience serious sleep disturbances, often overlooked by doctors. A new study suggests that cabergoline, a long-acting dopamine agonist, offers significant benefits in improving symptoms of sleep disturbance and daytime sleepiness.
A new study published in JAMA found that initiating therapy with MIRAPEX delayed the onset of motor complications and reduced their incidence compared to patients on initial treatment with levodopa. At two years, 72% of MIRAPEX-treated patients were free from motor complications.
Researchers found that pramipexole, a dopamine agonist, reduces debilitating complications in Parkinson's patients. However, it may not control disease symptoms as well as levodopa, which carries more side effects.
Italian researchers found that workers exposed to hydrocarbon solvents, such as petroleum-based products, were three years younger when first showing symptoms. The severity of Parkinson's disease was directly related to the amount of exposure experienced.
A new study reveals Parkinson's disease is associated with a loss of norepinephrine-producing nerve endings in the heart, improving understanding of the disorder's development and potential prevention. This finding also sheds light on orthostatic hypotension, a common complication characterized by dizziness and fainting.
Researchers have identified a compound in tobacco that inhibits an enzyme that breaks down key brain chemicals, potentially offering protection against Parkinson's disease. The discovery opens up new avenues of research and may lead to the development of neuroprotective compounds.
ReQuip significantly reduces the risk of levodopa-induced dyskinesia in Parkinson's disease patients. The five-year study shows that ReQuip monotherapy can reduce dyskinesia incidence by seven times and effectively control early PD symptoms.
A study published in The New England Journal of Medicine confirms Requip's efficacy in managing early Parkinson's disease symptoms with a low risk of developing dyskinesias. Patients taking Requip alone were seven times more likely to remain dyskinesia-free than those on levodopa alone.
A study by Emory University neurologists found that pallidotomy surgery significantly improves motor function in patients with Parkinson's disease, with persistent benefits extending to both sides of the body. The long-term effectiveness of this treatment has been confirmed through a 36-month follow-up.
Researchers found that people exposed to pesticides were approximately two times more likely to develop Parkinson's disease than those not exposed. In-home exposure to insecticides carried the highest risk of developing the disease.
Researchers found a link between smoking, coffee consumption, and lower Parkinson's disease incidence. Higher dopamine levels in the brain may explain why people with these habits are less likely to develop Parkinson's.
Researchers have discovered that synuclein plays a crucial role in communication between neurons, potentially shedding light on the mechanisms underlying Parkinson's and Alzheimer's diseases. The study provides strong evidence that synucleins control the release of neurotransmitters from nerve cells.
Scientists have identified a tobacco compound that may explain why smokers are less vulnerable to Parkinson's disease. The naphthoquinone derivative works by interfering with an enzyme in the brain that breaks down neurotransmitters.
Researchers have created a fly model of Parkinson's disease, replicating the dense protein inclusions and symptoms of the disease. The flies exhibit loss of dopamine-producing neurons and motor deficits, similar to those found in humans, making them an ideal model for testing new drugs and therapeutic approaches.
Researchers are conducting a national genetic study to identify the genetic markers that contribute to Parkinson's disease. The study aims to enroll 600 pairs of siblings with Parkinson's disease, using information from the U.S. Human Genome Project to isolate genetic markers.
A new transgenic mouse model has been developed to simulate Parkinson's disease and related disorders, including Alzheimer's disease. The model shows impaired motor function and protein deposits in specific brain regions associated with the diseases, offering a new tool for studying and treating these conditions.
A new study found that pallidotomy surgery, a procedure to reduce tremors in Parkinson's sufferers, also improves speech volume in some patients. Seven out of 12 patients with mild speech problems showed significant improvements following the surgery.
Yale researchers have created a new method to record electrical activities within living cells, providing insights into degenerative neurological diseases like Parkinson's. The technique, which allows scientists to study inaccessible parts of cells, has already led to findings on how neurons learn and remember.
A Mayo Clinic study highlights the importance of autopsy in diagnosing Parkinson's disease, suggesting low autopsy rates and nonrandom patterns may skew research findings. The study analyzed 235 deceased patients with parkinsonism diagnoses, revealing important factors influencing autopsy decisions.
A landmark study shows ReQuip reduces dyskinesia risk by 15-fold compared to L-dopa, with comparable symptom control and lower required doses. The treatment has improved patient outcomes and reduced CNS adverse experiences.
A 5-year clinical trial led by Thomas Jefferson University aims to investigate the effects of GM1 ganglioside on improving Parkinson's disease symptoms, delaying disease progression, and restoring damaged brain cells. The study will compare the drug to standard treatments, using advanced imaging techniques to visualize dopamine termina...
Researchers developed a method to identify high-risk individuals with Parkinson's disease using SPECT brain imaging and beta CIT radiopharmaceutical. They differentiated between Parkinson's patients and controls, as well as relatives of Parkinson's patients, with reduced drug binding.
A new Mayo Clinic study finds that parkinsonism affects 7.5% of the population, with men twice as likely to develop it as women. The study reveals that Parkinson's disease accounts for only 42% of all parkinsonism cases.
A laser pointer has been found to help some Parkinson's patients overcome freezing episodes, where their legs temporarily lock in place. The device provides a visual cue that helps patients take the next step towards regaining mobility, offering hope for those struggling with this debilitating symptom.
A recent clinical trial found that fetal dopamine cell implants improved movement control in younger Parkinson's patients, but had no significant impact on older patients or daily activities. PET brain scans revealed increased dopamine activity in those who received the implants, but also showed more severe adverse experiences.
A recent study examining 19,842 white male twins found that genetic factors do not play a significant role in causing the most common form of Parkinson's disease. Instead, undetermined environmental factors are believed to trigger typical PD, particularly among those diagnosed after age 50.
Three university hospitals will receive funding to advance understanding of Parkinson's disease and develop new treatments. Investigators will study the cause of the disease, diagnose and treat it, and provide training for young scientists.
Researchers at Virginia Tech will study the potential connection between pesticide exposure during the Persian Gulf War and an increased risk of developing Parkinson's Disease. The three-year project aims to investigate neurochemical changes in mice exposed to insecticides, which could provide insights into the disease.
Researchers at Emory University have identified a potential new approach for alleviating Parkinson's disease symptoms by blocking glutamate receptors in the brain. This could lead to combination therapies that improve treatment outcomes and reduce side effects.
Researchers discovered a gene-toxin link that may increase the risk of dementia in Parkinson's patients. The study found that exposure to pesticides and a defective gene called CYP 2D6 29B+ increased the likelihood of developing dementia, particularly among those with Parkinson's disease with dementia (PD+D).
Researchers at Thomas Jefferson University found that a naturally occurring substance in the cell membrane, GM1 ganglioside, improved symptoms in Parkinson's disease patients and slowed progression. The study showed significant differences in motor abilities between those who received the drug and those who did not.
Researchers have discovered an imaging agent called Altropane that visualizes nerve loss in Parkinson's patients, providing a faster and cheaper alternative to existing methods. The study suggests that Altropane can help identify presymptomatic patients for experimental treatments and track disease progression.