Articles tagged with Aorta
A team of scientists at WashU Medicine has discovered that the enzyme dipeptidyl peptidase I plays a critical role in promoting the growth of abdominal aortic aneurysms. Without this enzyme, mice do not develop aneurysms due to reduced recruitment of inflammatory cells.
A large follow-up study of over 50 families has identified more genetic perturbations in Loeys-Dietz Syndrome, providing clearer picture for diagnosis. The study emphasizes the importance of comprehensive clinical evaluations when diagnosing the disease.
Researchers found that 90% of patients who survived emergency surgery and hospitalization for aortic dissection would be alive three years later. Those without pre-existing heart and blood vessel problems were more likely to survive, with a quarter having hypertension and nearly 25% having atherosclerosis before their dissection.
Researchers at the University of Cincinnati found that delaying aortic trauma repair can lead to better survival outcomes for patients with certain injuries. Dr. Amy Reed's study analyzed 51 cases and found that 54% of patients who underwent delayed endovascular repair survived, compared to 38% of those who received immediate open repair.
A study published in Science has found that losartan can prevent the development of aortic aneurysms and potentially reverse damage in mice with Marfan syndrome. This breakthrough discovery increases the likelihood of losartan serving as an effective treatment for humans, offering new hope for those affected by the genetic condition.
Researchers have developed a novel technique using standard surgical stents and synthetic endografts to effectively treat patients with severe blunt thoracic aortic trauma, reducing the risk of death from blood loss. The method provides a reliable way for emergency surgeons to repair difficult injuries using readily accessible materials.
A new study by Michigan Medicine researchers demonstrates that a minimally-invasive procedure called endovascular thoracic aortic repair (ETAR) can successfully treat many patients with upper aorta problems, offering an alternative to open-chest surgery. The procedure uses stent-grafts inserted through small incisions in the leg or belly.
Researchers isolate causes of cognitive loss following coronary artery bypass surgery, finding that minimal aortic movement significantly reduces neurological deficits. The study suggests that emboli are the cause of cognitive problems, and patients who did not use the heart-lung machine had fewer emboli.
A study found that EBCT outperforms traditional angiography in identifying coronary artery abnormalities, particularly those that pose a risk of blockage. The imaging modality's accuracy was confirmed through joint review by cardiologists and radiologists.
Researchers have identified gene mutations that cause life-threatening aortic aneurysms and dissections, providing a new molecular pathway for therapy development and early warning signs. The study found four families with variations in the TGFBR2 gene, which alters protein structure and sends incorrect signals.
Researchers at Michigan Medicine have made significant discoveries on the formation of abdominal aortic aneurysms (AAAs), a leading cause of death worldwide. Two new studies suggest that neutrophils, a type of white blood cell, play a crucial role in AAA formation, particularly in the early stages of the condition.
Researchers at Johns Hopkins Medicine have discovered a new syndrome characterized by wide-set eyes, cleft palate, or split uvula, and aggressive swelling of the aorta. Early diagnosis and treatment can prevent aortic rupture and save lives, with surgery often successful if performed promptly.
Researchers found that estrogen significantly reduces MMP-9 enzyme activity in male rat aortas, leading to smaller aneurysms and less damage. The study suggests that host environment is the critical factor in aneurysm formation, with male rats more prone to AAA development.
Researchers identified gene clusters that predict severe disease severity and location of atherosclerotic lesions in human aorta samples. The study used DNA microarray analysis to reveal 208 genes associated with severe disease and 28 genes related to disease location, showing promise for personalized medicine approaches.
A study by Mayo Clinic researchers found that high-sensitivity C-reactive protein (hs-CRP) is associated with the presence of atherosclerotic plaques in the arteries, even if symptoms are absent. Elevated hs-CRP levels may indicate an increased risk of cardiovascular events like heart attacks.
For the first time, a US patient's entire aortic arch has been successfully repaired using this technique. The procedure minimizes complications and allows patients to recover quickly, with a lower risk of death or complications compared to traditional open surgery.
A new study has identified specific molecules whose genetic regulation is altered during aging, contributing to vascular remodeling. The study found that inflammatory-associated adhesion molecules ICAM-1 and VCAM-1 had significantly increased expression at older ages.
The study found that uninsured patients with abdominal aortic aneurysms are more likely to be diagnosed late, leading to a higher mortality rate. Insured patients who received timely treatment had lower death rates, highlighting the importance of access to regular medical care.
Researchers found a significant reduction in micro-emboli during off-pump coronary bypass surgery compared to traditional pump-assisted procedures. This decrease was associated with lower rates of neurological complications and cognitive decline after surgery.
A new imaging technique combining transesophageal magnetic resonance (TE MRI) with standard cardiac MRI provides better views of plaque buildup in the aorta. The combined approach revealed more detailed images of plaque thickness, area, and volume than individual techniques, showing promise for improved diagnosis.
Researchers found that exposing rats to low levels of carbon monoxide significantly reduced intimal hyperplasia and leukocyte accumulation, indicating a protective effect against arteriosclerosis. The study suggests potential therapeutic benefits for treating vascular diseases.
Researchers found that switching from traditional cannulation in the aorta to the axillary artery significantly reduced the risk of stroke and brain damage during bypass surgery. This innovative approach deflected debris away from the brain, markedly limiting postoperative neurological complications.
Researchers developed a computer model of blood flow in the aorta, identifying areas prone to disturbed flows that could lead to atherosclerosis. The model uses CAT scan images and predicts where oscillating flows may cause damage, allowing doctors to assess heart disease risk.
A new study suggests that smaller aneurysms are often safer left untreated, with potential benefits including reduced risk of complications and cost savings. The research found nearly 98% survival rate among patients undergoing AAA surgery at participating VA hospitals.
A new study has found that cocaine use is associated with an increased risk of aortic dissection, a potentially fatal condition. The research, led by UCSF cardiology fellow Priscilla Hsue, highlights the importance of healthcare providers being aware of this potential risk factor and recognizing early signs of the condition.
Aortic dissection is a life-threatening condition that can occur in people who have used crack cocaine, particularly those with high blood pressure or Marfan syndrome. Researchers found that 29% of cocaine users died from the condition compared to 17% of non-users.
Researchers report significant advancements in sutureless vascular graft surgery, reducing operating time by up to 90%. The new techniques enable quicker connections of blood vessels and minimize damage to the heart, paving the way for minimally invasive surgery on the beating heart.
A Mayo Clinic study found that over one-third of adults aged 45+ had plaque buildup on their aortic valves, increasing the risk of hardening and narrowing of the aorta. Lifestyle changes can help prevent life-threatening complications. Risk factors include male gender, high blood pressure, obesity, and elevated homocysteine levels.
The Kantrowitz CardioVad System is a new category of cardiac assist device that boosts the patient's own heart while preserving independence. By taking over up to 50% of the heart's function, patients can release themselves for short periods without compromising their condition.
A new nonsurgical technique using stent-graft placement has been shown to be effective in treating people with life-threatening aortic dissection. The catheter-delivered procedure involves inserting a wire mesh tube to force open and maintain the blocked aorta, reducing complications and mortality rates.
A study found that thickening of the aorta at its attachment to the heart increases the risk of stroke and death. Researchers identified moderate and severe atherosclerosis as major risk factors, with higher mortality rates among patients with more advanced disease.
A recent study published in Circulation found that consuming garlic supplements can lower the stiffness of the aorta by up to 15% in healthy individuals. The study suggests that eating garlic may be beneficial for cardiovascular health, particularly as people age.
A study published in Circulation found that smoking causes the aorta to stiffen, reducing its ability to relax and widen. This can lead to increased pressure on the left ventricle, which pumps blood throughout the body.