Articles tagged with Brain
Fragile X protein FMRP suppresses protein production, but its mechanism was unclear. Researchers discovered that FMRP works with CYFIP1 to control protein production at synapses. Disruption of this regulation leads to diseases like Fragile X syndrome and Autism.
Researchers identified eEF2K as a key player in enabling the rapid production of Arc protein, crucial for long-term memory formation. The paradoxical mechanism involves eEF2K inhibiting protein translation while also facilitating Arc protein synthesis.
Researchers used fMRI scans to study how listeners' brains predict speaker's words before hearing the final sound. The team found that the brain considers multiple possible words with similar sounds and meanings before settling on the correct word.
New research finds that adolescent brains exposed to painkillers like Oxycontin can sustain permanent changes in their reward system, making them more vulnerable to addiction later in adulthood. Adolescent mice self-administered the drug less frequently than adults, and re-exposed adult mice had higher dopamine levels.
A study found that people with higher vitamin B12 levels were six times less likely to experience brain shrinkage compared to those with lower levels. Researchers suggest adjusting diets to consume more vitamin B12 may help prevent brain shrinkage and save memory.
A recent study found that 3T MRI is better at detecting and characterizing structural brain abnormalities in patients with focal epilepsy than 1.5T MRI, leading to a better diagnosis and safer treatment options. This improvement was seen in the detection of lesions and accurate characterization of abnormalities.
A new study reveals that experienced Zen meditators can quickly clear their minds of distractions compared to novices. After being interrupted by a word-recognition task, experienced meditators' brains returned faster to their pre-interruption condition.
Research reveals that as we age, our brains struggle to ignore irrelevant information and process information rapidly, leading to decreased memory formation. This breakdown occurs early in visual processing and persists despite attempts to suppress extraneous information.
Researchers use high-speed imaging to study fruit fly evasive maneuvers, finding that the fly's tiny brain calculates threat location and places legs in optimal position within 100 milliseconds. The team also identifies an optimal method for swatting flies by aiming forward of their starting position.
A long-term study found that sudden vision loss leads to rapid changes in the visual cortex, enabling it to process touch. The brain's adaptability was revealed to be greater than previously thought, with potential implications for other sensory losses and brain injuries.
New research suggests that babies' early language skills are rooted in the brain's ability to recognize repetition patterns. The study found increased brain activity in response to words with repeating syllables, indicating a possible hard-wired mechanism for language acquisition.
A study published in PLOS Biology suggests that sleep is crucial for brain function, allowing the brain to regroup after a hard day of learning. The research proposes that sleep enables the brain to consolidate new memories and 'forget' random impressions, making it essential for continued learning.
A Monash University scientist has discovered that appetite-suppressing cells in the human brain degenerate over time, leading to increased hunger and potential weight gain. The research found that free radicals attack these cells after eating meals rich in carbohydrates and sugars.
Astrocytes undergo reorganization and may engulf attacking T cells, which could improve therapy for viral infections, brain tumors, and neurodegenerative disorders. This novel response mechanism offers new insights into brain cell defenses against immune cells.
Biologists at the University of Virginia discovered a switching mechanism in the eye that regulates sleep/wake cycles in mammals. The finding demonstrates that light receptor cells play a key role in setting the brain's primary timekeeper, leading to potential new treatments for sleep disorders and visual impairments.
A study published in JCI Journals suggests that a yeast protein called Hsp104 may hold the key to treating Parkinson's disease. The protein was found to inhibit alpha-synuclein aggregation, which is thought to contribute to PD pathology.
Researchers found that individuals with lower educational achievement and smaller head sizes were more likely to develop Alzheimer's disease, suggesting an early sign of the illness. The study suggests that brain damage related to Alzheimer's may begin earlier in life, compromising intellectual ability and leading to reduced education.
A study published in Nature Neuroscience identifies GABA as a key player in regulating energy balance, leading to leaner mice with increased energy expenditure and resistance to diet-induced obesity. The discovery suggests that targeting GABA release may be an effective strategy for tackling obesity and metabolic disease.
Scientists are studying zebra finches, a type of songbird, to understand how hormones like estrogen impact brain function and behavior. The research aims to uncover the role of synaptically produced estrogen in learning, memory, and neuroprotection.
A study published by the American Academy of Neurology found that eating broiled or baked tuna and other fish high in omega-3 fatty acids can help prevent silent brain infarcts, which are associated with dementia and stroke. The risk was lower for those who ate these types of fish regularly.
A recent study published in PNAS found that the human brain's perception of fast-moving objects is biased by the slow-paced world around us. This affects our ability to catch balls and make decisions in high-speed environments, with implications for road safety and robotic vision systems.
Research suggests that schizophrenia may be a by-product of human brain evolution, driven by increased metabolic demands. The study found molecular mechanisms involved in the evolution of human cognitive abilities and identified changes in gene expression and metabolite concentrations in both healthy humans and individuals with schizop...
A study by UC San Diego researchers found that telemedicine leads to better treatment decisions for stroke patients compared to telephone consultations. The STRokE DOC technology enabled doctors to make correct decisions over 98% of the time, resulting in improved patient outcomes.
A small sample of adults with mild age-related memory loss showed increased brain metabolism and normalized brain function after taking Aricept for 18 months. The study suggests treating early symptoms of memory loss may protect the brain and help with mild age-related cognitive decline.
Brain plays a key role in appetite regulation by using fat as fuel, with oxygen-free radicals playing a crucial role. The study suggests that antioxidants could help control weight, and taking them at the right time may affect satiety.
Researchers discovered a mechanism in mouse brains that may explain why human mothers develop depression after childbirth. The study found that a GABA receptor subunit fluctuates during pregnancy and postpartum, impairing the brain's ability to adapt to hormone fluctuations.
Bapineuzumab showed potential efficacy signals in treating Alzheimer's disease without a clear dose response. Post-hoc analyses revealed statistically significant benefits in subgroups, including ApoE4 non-carrier patients.
Black patients receiving kidneys from black cardiac donors showed better long-term survival compared to those receiving non-black donor kidneys. The study suggests that increased utilization of kidneys donated after cardiac death can help reduce racial disparities in kidney transplantation.
The Alzheimer's Disease Research Center at Washington University School of Medicine will lead a six-year, $16 million international collaboration to study inherited forms of Alzheimer's disease. Researchers hope to identify biomarkers in individuals with known mutations to shorten diagnosis time and develop new treatments.
Researchers report rapid improvement in verbal fluency and aphasia following perispinal etanercept administration in a novel immune-based treatment for Alzheimer's disease. The study suggests that elevated TNF-alpha levels may interfere with neural communication, which can be reversed using this approach.
A team of scientists from MIT, Harvard, and McGill has designed a new tactile illusion to investigate perception and how different senses work together. The illusion produces changes in touch perception that are independent of changes in the stimulus, shedding light on brain function and conscious experience.
A study found that immunization with Aβ42 reduced brain amyloid-β plaque formation and improved cognitive function in mice, but failed to prevent dementia progression in humans. Despite clearing associated brain plaques, immunized patients did not show improved survival or increased time to severe dementia.
Researchers discovered how suckling babies stimulate the release of oxytocin, a hormone linked to trust and love. The study found that dendrites play a crucial role in coordinating oxytocin production, leading to synchronized bursts of activity.
Researchers reduce Aβ42 deposits by overexpressing NEP enzyme in fruit flies, suppressing outright neuron death and plaque accumulation. However, chronic overexpression leads to age-related axon degeneration and shortened lifespan.
A recent study found that people with higher physical fitness levels had larger brains compared to those with lower fitness, suggesting exercise may preserve brain function and reduce cognitive decline in early Alzheimer's disease. The study also revealed no relationship between fitness and brain changes in healthy individuals.
Researchers at Washington University in St. Louis found that humans inspect objects more thoroughly when their hands are near them, indicating a new insight into brain wiring that could impact rehabilitative therapy techniques and prosthetic design.
Researchers found that autism mutations may disrupt specific genes vital to the developing brain, which are turned on and off by neuronal activity. Disruption of this refinement process may be a common mechanism of autism-associated mutations.
The study found that early fossil members of both the New World and Old World anthropoid lineages had small brain sizes, leading to independent brain size increase in isolated groups. The research provides new insights into the genetic controls on encephalization and its effects on skull growth and shape.
A University of Sussex-led study found that the brain responds more strongly to piano sonatas played by musicians than by computers. The researchers discovered that the brain's electric activity increases when the music is performed with emotional expression, indicating a deeper understanding of musical meaning.
Researchers identify key role of endogenous opioids in alcoholism-related cognitive impairment. Innovative therapies may improve or prevent alcohol-induced memory problems in patients with alcohol dependence.
Chronic stress can affect the adult brain's ability to generate new cells. Stress is associated with reduced neurogenesis, a process critical for developing novel antidepressant drugs.
Researchers found a genetic change in the dopamine transporter protein that makes it behave as if amphetamine is present, leading to altered dopamine signaling and contributing to ADHD symptoms. The altered function supports a role for dopamine signaling in the disease.
New research from Vanderbilt University has found that mental imagery--what we see with the "mind's eye"--directly impacts our visual perception. The study, published in Current Biology, discovered that a short-term memory trace formed by imagery can bias future perception.
A new study from Baycrest Centre for Geriatric Care overturns the notion that brain noise decreases with maturity. Brain maturation leads to more stable and accurate behavior in memory tasks, but also correlates with increased brain signal variability.
Researchers found that compact, bedside brain-activity monitors, called amplitude-integrated EEG (aEEG) monitors, can detect most seizures in at-risk infants. The monitors are more portable and affordable than conventional EEG devices, but may require training to interpret.
A study published in The FASEB Journal found that gerbils given specific compounds increased brain synapses and improved cognitive tasks. Researchers discovered more brain synapse activity consistent with higher intelligence after dissecting mouse brains.
In a study published in PLOS Biology, researchers found that parietal neurons selectively track target location during visual search tasks. Adding distractors decreased parietal neuron firing rates, reducing target-related response and correlating with increased reaction times.
University of Florida researchers have developed a neural implant that can learn and adapt with the brain, enabling devices to improve their performance over time. The system uses goal-setting and rewards to teach rats to control a robotic arm with their thoughts, demonstrating its potential for paralyzed patients and amputees.
Octopus brains utilize activity-dependent long-term synaptic potentiation (LTP) to store and recall memories, with findings suggesting a segregation of short and long-term memory systems. This process is comparable to that discovered in vertebrate brains, yet operates differently due to the octopus's unique brain anatomy.
Research shows that people with temporal arteritis, an inflammatory artery disease, are three times more likely to experience blindness due to swollen arteries restricting blood flow. The disease is often accompanied by symptoms like headaches and jaw soreness, and if left untreated can lead to severe vision loss or stroke.
Researchers used PET imaging to assess the effects of methylphenidate on brain function in healthy adults. The study found that MP improved performance in those who needed it, but deteriorated it in others.
Research reveals that olfactory bulb volume changes in response to individual sense of smell changes. Patients with reduced or lost sense of smell show varying increases and decreases in olfactory bulb size. The correlation between olfactory bulb volume and function may aid in predicting disease prognosis.
Scientists are using a powerful supercomputer to create a model of normal human language that can read, comprehend, and repeat basic words. The 'Chatter Box' project aims to understand how the brain supports language function and how it breaks down after brain damage.
A study found Mexican Americans and women are more likely to experience subarachnoid hemorrhage due to differences in tobacco use and hypertension treatment. Researchers identified 107 cases over seven years among 29,907 people in southeast Texas.
Researchers identified a genetic variation associated with an earlier age of onset in Alzheimer's disease, which affects the brain's tau protein levels. The study suggests that these variations lead to higher tau levels in cerebrospinal fluid and earlier cognitive problems once amyloid plaques form.
A unique case study found a 115-year-old woman had an essentially normal brain with little evidence of Alzheimer's disease. The findings question the inevitability of cognitive decline in elderly individuals and suggest potential for preserving brain function.
The study creates a computational model predicting brain activation patterns for thousands of concrete nouns, with accuracies significantly greater than chance. The model uses text corpus data to identify basic building blocks the brain uses to represent meaning.
A review of scientific evidence found that only a minority of children with hyperactivity are affected by their diet, suggesting a combination of factors is more likely to be involved.
Researchers mapped and digitized smells, discovering a multidimensional map of odors that reveals the distance between molecules. The study found that the brain recognizes this map, similar to musical scales, supporting the theory that there are universal laws governing smell perception.
Researchers identified a gene that controls the proper development of synapses in fruit flies, which may help explain how they go wrong in humans. The findings suggest that a protein complex helps regulate synaptic growth by decommissioning receptors that respond to pro-growth signals.